Microtubule motor cytoplasmic dynein. Medical search. Frequent questions

Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport . (wikipedia.org)
A family of microtubule-associated proteins (or 'MAPs' for short) bind to microtubules and assist in organising the filaments, but it is not clear how they work. (elifesciences.org)
The experiments also found that oMAP4 can create links between different microtubules and act as a brake to prevent the filaments being moved excessively by motor proteins. (elifesciences.org)
It is thought that motor or adaptor proteins recognise different features on the surface of mRNPs with different affinities. (europa.eu)
It is still not known which RBPs or adaptor proteins are essential to recruit microtubule-binding motor proteins to mRNPs and to which extend this varies between different transported mRNAs. (europa.eu)
Mutations affecting zipcodes, RBPs or motor-proteins required for neuronal mRNA localization were shown to lead to severe neurodegenerative diseases as ALS, FXTAS and FXS (7), underlining the need to understand the mechanisms that drive neuronal mRNA transport. (europa.eu)
Also in this specific case, it is not understood how RBPs, potential adaptors and motor proteins, which are essential for the transport of CaMKIIa-mRNA are mechanistically contributing to its correct localisation. (europa.eu)
What started as an informal meeting among a handful of labs involved in intracellular trafficking has grown to include tens of labs, both young and established, all interested in understanding the cytoskeleton and motor proteins in the context of intracellular trafficking. (silverchair.com)
Using lysate-based single-molecule motility assays and live-cell imaging in primary neurons, we show that JNK-interacting proteins 3 (JIP3) and 4 (JIP4) are activating adaptors for dynein that are regulated on autophagosomes and lysosomes by the small GTPases ARF6 and RAB10. (bvsalud.org)
Our contribution to the third edition of the Encyclopedia of Biological Chemistry is a further reading section on microtubule plus and minus end binding proteins. (mechanochemistry.org)
The 33-residue LIS1 homology (LisH) motif is found in eukaryotic intracellular proteins involved in microtubule dynamics, cell migration, nucleokinesis and chromosome segregation. (embl.de)
Kinesin and dynein superfamily proteins and the mechanism of organelle transport. (embl.de)
Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. (embl.de)
This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins. (embl.de)
u003cbr /\u003e Cytoplasmic dynein and kinesin are microtubule-dependent motor proteins responsible for transport of a variety of organelles and vesicles. (soken.ac.jp)
2001). The assembly and the functions of the spindle apparatus are tightly regulated by the orchestrated interplay of dynamic microtubules and motor proteins (Wittmann et al. (uni-konstanz.de)
2020). Higher expression of dynein proteins over the course of spermatogeneisis in C. gigas (Dheilly et al. (github.io)
Differential abundance of dynein proteins was found in shotgun proteomic characterization of C. gigas ctenidia (Timmins-Schiffman et al. (github.io)
2018). Unfertilized sea urchin eggs contain several dynein proteins (Pratt 1980, Porter 1988). (github.io)
The motor protein belongs to the ATPase family of proteins associated with diverse cellular activities and plays a critical role in transporting cargoes to the minus end of the microtubules. (mun.ca)
The DYNC1H1 gene provides instructions for making a protein that is part of a group (complex) of proteins called dynein. (medlineplus.gov)
Two heavy chain proteins bind together to form the core of the dynein complex. (medlineplus.gov)
Based on cellular and biochemical evidence, recent studies suggest that HIV-1 capsid hijacks both dynein and kinesin-1, via the adaptor proteins BICD2 and FEZ1 respectively, for active transport along microtubule network. (edu.au)
Subsequently, we reconstituted the motor-adaptor-cargo complexes (DDBC and KFC) using recombinant proteins as well as components isolated from native tissues. (edu.au)

Many viruses use the microtubule transport system to transport nucleic acid/protein cores to intracellular replication sites after invasion host the cell membrane. (wikipedia.org)
Dyneins can be either axonemal, facilitating the movement of cilia and flagella, or cytoplasmic, transporting several intracellular cargos along microtubule tracks. (neurodegenerationresearch.eu)
The cytoskeleton and associated motors play an important role in the establishment of intracellular polarity. (dundee.ac.uk)
The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. (utsouthwestern.edu)
Microtubules are essential for chromosome segregation, intracellular transport, positioning of organelles, directed cell migration and differentiation. (mechanochemistry.org)
My lab focuses on the mechanisms that generate specific microtubule arrays in polarised cells, the dynamic interactions of microtubule tips with intracellular structures and the cell cortex to control cell shape changes and the transport along microtubule arrays mediated by dynein and kinesins. (mechanochemistry.org)
Cargo transport by teams of molecular motors: basic mechanisms for intracellular drug delivery. (mpg.de)

[11] Not much is known about virus' motor-specific binding sites, but it is known that some viruses contain proline-rich sequences (that diverge between viruses) which, when removed, reduces dynactin binding, axon transport (in culture), and neuroinvasion in vivo. (wikipedia.org)
Her laboratory focuses on the motor cytoplasmic dynein and its activator complex dynactin. (nih.gov)
GTP-bound ARF6 promotes formation of the JIP3/4-dynein-dynactin complex. (bvsalud.org)
Overexpression of dynamitin,which is known to disrupt dynein-and dynactin-dependent organelle movement, inhibited autophagosome movements. (soken.ac.jp)
In addition, endogenous LC3 colocalized with dynein-dynactin complex. (soken.ac.jp)
These results indicate that autophagosomes are linked with the dynein-dynactin comples through the interaction between LC3 and dynein intermediate chain. (soken.ac.jp)
u003cbr /\u003e From these results, I concluded that 1) autophagosome movement is dependent on icrotubule and dynein/dynactin motor complex, 2) this movement is necessary for targeting of autophagosomes to lysosomes in mammalian cells,and 3) LC3 plays an important role in assembly of the transport machinery. (soken.ac.jp)
Dynein is turned on (activated) by attaching (binding) to another complex called dynactin. (medlineplus.gov)
This dynein-dynactin complex binds to various materials within cells. (medlineplus.gov)
Using energy provided by molecules called ATP, the dynein-dynactin complex moves material along a track-like system of small tubes called microtubules, similar to a conveyer belt. (medlineplus.gov)
The dynein-dynactin complex is necessary for protein transport, positioning of cell compartments, movement of structures within the cell, and many other cell processes. (medlineplus.gov)
When synaptic vesicles are passed from one neuron to another, the dynein-dynactin complex transports the vesicle from the edge of the cell to the nucleus, where the chemical message is received. (medlineplus.gov)

Two major classes of dyneins, axonemal and cytoplasmic, have been identified. (wikipedia.org)
They are divided into two subgroups of axonemal and cytoplasmic dyneins. (utsouthwestern.edu)

Analysis revealed a non-sense mutation in cytoplasmic dynein heavy chain 1 (dync1h1), a critical subunit in Dynein1, to underlie the cannonball phenotypes. (nih.gov)
The study, entitled "Novel mutations in the DYNC1H1 tail domain refine the genetic and clinical spectrum of dyneinopathies," unlocks new insights into motor neuron diseases such as Spinal Muscular Atrophy. (neurodegenerationresearch.eu)
The 'Legs at odd angles' (Loa) mouse has a missense 'T' to 'A' point mutation in the cytoplasmic dynein heavy chain gene (Dync1h1), resulting in a phenylalanine to tyrosine substitution at position 580. (figshare.com)
The DYNC1H1 gene mutations that cause SMA-LED replace single protein building blocks (amino acids) in the heavy chain subunit of the dynein complex. (medlineplus.gov)

Coimmunoprecipitation and GST pull-down assay showed that LC3 directly interacts with the intermediate chain of cytoplasmic dynein, which is a subunit of dynein motor comples. (soken.ac.jp)
The presented work analyzes the structure-activity relationship (SAR) of dynapyrazole A and B, as well as ciliobrevin A and D, in their various protonated states and their 46 analogues for their binding in the AAA1 subunit, the leading ATP hydrolytic site of the motor domain. (mun.ca)

[2] [3] Dynein carries organelles, vesicles and possibly microtubule fragments along the axons of neurons toward the cell body in a process called retrograde axonal transport . (wikipedia.org)
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. (utsouthwestern.edu)
It's been reported the fact that series (K/R)XTQT represents a conserved cytoplasmic dynein light string (LC8) binding theme, some the microtubule-associated motors involved with minus-end aimed axonal transport, through which it could play some function in viral retrograde transport [16-18]. (techuniq.com)

Several microtubule-associated molecular motors including several kinesins and cytoplasmic dynein produce opposing forces that regulate spindle and chromosome positioning during mitosis. (crispr-reagents.com)
mRNAs are transported along microtubules (MTs) by different kinesins and cytoplasmic dynein and get anchored at the actin cortex, intermediate filaments or unknown structures (1, 3). (europa.eu)

The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation. (elifesciences.org)
The Molecular Motors, Transport and Trafficking (M2T2) meeting serves as a platform for both Indian and global scientists working on the cytoskeleton, cytoskeletal motors and membrane trafficking to gather and discuss the latest developments in the field. (silverchair.com)
The 2019 edition of the meeting, held from 18-20 October at the National Brain Research Centre (NBRC), Manesar, India and organised by Mahak Sharma (Indian Institute of Science Education and Research, Mohali) and Anindya Ghosh Roy (NBRC), was witness to stimulating research on a range of topics related to the cytoskeleton, including cytoskeletal organization, motor protein function and regulation, mechanical forces and vesicular transport, and trafficking in health and disease. (silverchair.com)
We study cell biology within the Perelman School of Medicine at the University of Pennsylvania , researching molecular motors and the cytoskeleton, autophagy and mitophagy, the cell biology of the neuron, and neurodegeneration. (upenn.edu)

Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome . (wikipedia.org)
We found that the UCDs and their orientation at the ascidian third cleavage rely on the spindle tilting in an anisotropic cell shape, and cortical polarity domains exerting different effects on spindle astral microtubules. (elifesciences.org)
These deviations from the length-dependent spindle positioning mechanism are usually due to local alteration of microtubule-associated forces by polarity domains. (elifesciences.org)
1993) Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domain. (ucdavis.edu)
To fulfill this task cells rely on a specialized microtubule-based structure called the mitotic spindle (Wittmann et al. (uni-konstanz.de)
Notably, this kinesin is required to slow down the oscillatory movements of chromosomes happening in prometaphase after their binding to kinetochore-microtubules and to increase their switch rate across the spindle equatorial region, ultimately leading to the correct chromosome positioning at the metaphase plate (Stumpff et al. (uni-konstanz.de)

Most notably, oMAP4 is required for paraxial microtubule organisation in muscle cells and prevents dynein- and kinesin-driven microtubule-microtubule sliding. (elifesciences.org)
1988) Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains. (ucdavis.edu)
1989) Quantitative analysis of sea urchin egg kinesin-driven microtubule motility. (ucdavis.edu)

Since the discovery of an evolutionary conserved cytoplasmic dynein complex protein LIS1 as a responsible gene for smooth brain syndrome (type 1 lissencephaly), accumulating evidence has supported the model that the nucleus is pulled forward by dynein motor activity along the microtubules extended from the leading process. (biologists.com)
Regulation of cytoplasmic dynein behaviour and microtubule organization bymammalian Lis1. (embl.de)
Here we showthat Lis1 is enriched in neurons relative to levels in other cell types,and that Lis1 interacts with the microtubule motor cytoplasmic dynein.Production of more Lis1 in non-neuronal cells increases retrogrademovement of cytoplasmic dynein and leads to peripheral accumulation ofmicrotubules. (embl.de)
These changes may reflect neuron-like dynein behavioursinduced by abundant Lis1. (embl.de)
Lis1 deficiency produces the opposite phenotype.Our results indicate that abundance of Lis1 in neurons may stimulatespecific dynein functions that function in neuronal migration and axongrowth. (embl.de)

The nucleus is translocated by actin and microtubules, yet the actual force generated by the interplay of these cytoskeletons remains elusive. (biologists.com)
In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. (biologists.com)
MK & YW For better understanding of the complicated interplay between microtubule- and actin-dependent mechanisms driving nuclear migration in CGCs, we performed a high spatiotemporal resolution imaging using spinning-disk confocal microscopy. (biologists.com)

Purified oMAP4 aligns dynamic microtubules into antiparallel bundles that withstand motor forces in vitro. (elifesciences.org)

Dynein is a ~1.2 MDa cytoskeletal motor protein that carries organelles via retrograde transport in eukaryotic cells. (mun.ca)

By implementing the methods described researchers will be able to design and carry out a variety of assays for studying forces produced by MT-associated molecular motors. (crispr-reagents.com)
These movements are bi-directional, and the majority require microtubules along with their associated molecular motors, conventional kinesin and cytoplasmic dynein. (northwestern.edu)
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. (utsouthwestern.edu)
External forces influence the elastic coupling effects during cargo transport by molecular motors. (mpg.de)
Elastic coupling effects in cooperative transport by a pair of molecular motors. (mpg.de)
Network complexity and parametric simplicity for cargo transport by two molecular motors. (mpg.de)
Co-operative transport by molecular motors. (mpg.de)
Molecular Motors: Cooperative Phenomena of Multiple Molecular Motors. (mpg.de)
Distinct transport regimes of two elastically coupled molecular motors. (mpg.de)
Different Modes of Cooperative Transport by Molecular Motors. (mpg.de)
Molecular motors propel cellular components at velocities up to microns per second with nanometer precision. (humantechnopole.it)
We explore the molecular mechanisms that lead to the coordinated activity of molecular motors during long-distance transport. (upenn.edu)

Dynein function is essential in higher eukaryotes, yet its basic mechanisms of action including coupling to cargo and cellular regulation remain to be determined. (nih.gov)
These findings highlight the complex coordination of motor regulation during organelle transport in neurons. (bvsalud.org)
All these processes require the organisation of microtubules into arrays with different geometry and density and the proper regulation of dynamics and interactions at the microtubule ends. (mechanochemistry.org)
It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly. (embl.de)

Several studies show evidence that genetic mutations in dyneins underlie some neurodegenerative disorders such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and motor neuron diseases. (neurodegenerationresearch.eu)
Heterozygotes display motor neuron degeneration and muscle spasms. (utsouthwestern.edu)
We have proposed a model whereby these features of the axonal and dendritic microtubule arrays are established within the cell body of the neuron. (silverchair.com)

Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
Muscles contain the synaptic connection between lower motor neurons and muscle fibers, i.e., the neuromuscular junction (NMJ), as well as specialized sensory nerve endings (e.g., muscle spindles). (frontiersin.org)
While it is clear, that RNA distribution patterns in neurons are created by active transport processes of mRNPs along microtubules, the essential enzymatic activities required are not known. (europa.eu)
Consistent with this idea, there were significantly fewer free ends of microtubules in the cell bodies of neurons that had been injected with the katanin antibody compared with controls. (silverchair.com)
Motor neurons also show increased levels c-Fos however this can be induced by starvation, indicating their enhanced susceptibility to stress. (figshare.com)
Neurons are highly polarized cells, with axons that can extend up to one meter, making them uniquely dependent on motor-driven transport. (upenn.edu)
Dynein helps neighboring nerve cells (neurons) communicate by transporting sac-like structures called synaptic vesicles that contain chemical messengers. (medlineplus.gov)
Decreased synaptic vesicle transport in neurons that control muscle movement (motor neurons), leading to impaired neuronal growth, is thought to contribute to the muscle weakness and atrophy experienced by people with SMA-LED. (medlineplus.gov)
It is unclear whether the site of the mutation is associated with the location in the body most affected by the disease, with SMA-LED-associated mutations primarily affecting motor neurons and intellectual disability-associated mutations primarily affecting neurons in the brain. (medlineplus.gov)

Dynein is a microtubule motor protein that uses the energy contained in ATP (adenosine triphosphate) molecules to move. (neurodegenerationresearch.eu)
Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. (utsouthwestern.edu)
While single molecules of dynein are predominantly static or diffusive on single microtubules, they walks processively on the microtubule bundles they form. (mechanochemistry.org)

Dynein transports various cellular cargos , provides forces and displacements important in mitosis , and drives the beat of eukaryotic cilia and flagella . (wikipedia.org)
Axonemal dynein causes sliding of microtubules in the axonemes of cilia and flagella and is found only in cells that have those structures. (wikipedia.org)
V1 and V2 impaired dynein-2 motility in vitro and perturbed IFT88 distribution within cilia. (nature.com)
7 IFT is an important bidirectional transport of multisubunit protein complexes (IFT particles) along the axonemal microtubules that is essential to normal cilia assembly, function, and maintenance. (nature.com)

Here we sought to determine whether the microtubule-severing protein known as katanin mediates microtubule release from the neuronal centrosome. (silverchair.com)

In vitro assays were developed to validate the variants identified (fibroblast assay, induced pluripotent stem cell [iPSC] derived retinal organoids, and a dynein motility assay). (nature.com)
We have successfully demonstrated both the dynein- and kinesin-dependent transport of HIV-1 capsid along microtubules in vitro using a TIRFm based single molecule motility assay. (edu.au)

Utilizing the refined structure of the motor domain obtained through protein conformational search in this study exhibits that Arg1852 of the yeast cytoplasmic dynein could involve in the "glutamate switch" mechanism in cytoplasmic dynein 1 in lieu of the conserved Asn in AAA+ protein family. (mun.ca)

Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene. (wikipedia.org)
A study published in the journal Human Mutation revealed new genetic mutations in a domain of a dynein gene. (neurodegenerationresearch.eu)
Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), characterized by debilitating motor and non-motor symptoms. (bvsalud.org)

Dynein1 is a large minus-end directed, microtubule motor protein complex that has been implicated in multiple, essential cellular processes. (nih.gov)
Therefore, the next challenge is to understand how other processes-such as the selective stabilisation of some microtubules and the movement of cell materials along the microtubules-cooperate to control muscle fibre formation. (elifesciences.org)
Context and state of the art mRNA transport in general: Cytoplasmic mRNA transport and local translation are essential for many processes requiring symmetry breaking such as embryonic development, cell migration and neuronal differentiation (1). (europa.eu)
A striking example is the Drosophila oocyte, where microtubule-dependent processes govern the asymmetric positioning of the nucleus and the localization to distinct cortical domains of mRNAs that function as cytoplasmic determinants. (dundee.ac.uk)
It may be that katanin severs microtubules throughout the cell body to keep them sufficiently short to be efficiently transported into developing processes. (silverchair.com)
The microtubules within these processes have a consistent 13-protofilament lattice and are tightly regulated with regard to their polarity orientation. (silverchair.com)

By moving cargoes along microtubules, dyneins ensure proper cell division, regulate exchange of materials between organelles, and contribute to the internal organization of eukaryotic cells. (humantechnopole.it)

While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)

Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell. (wikipedia.org)
Microtubule-based transport is required in many cell types for the asymmetric localization of mRNAs and organelles. (dundee.ac.uk)
Cytoplasmic dynein is a retrograde motor protein complex that carries cargo such as organelles and growth factors along microtubules from the cell periphery towards the peri-nuclear region. (figshare.com)
In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)

1994) A slow homotetrameric kinesin-related motor protein purified from Drosophila embryos. (ucdavis.edu)

Cytoplasmic dynein, found in all animal cells and possibly plant cells as well, performs functions necessary for cell survival such as organelle transport and centrosome assembly. (wikipedia.org)
[1] Additionally, dynein motor is also responsible for the transport of degradative endosomes retrogradely in the dendrites. (wikipedia.org)
We propose a model in which the cooperation of dynein-mediated microtubule transport and oMAP4-mediated zippering of microtubules drives formation of a paraxial microtubule array that provides critical support for the polarisation and elongation of myotubes. (elifesciences.org)
Since the first discovery of cytoplasmic mRNA transport almost three decades ago, several essential questions could not be answered mostly due to the complexity of the in vivo situation and the approaches available. (europa.eu)
Before we can understand how overall distributions of thousands of mRNA are generated, we first need to understand how any specific mRNA can be transported along microtubules - a question unanswered since the first MT based mRNA transport was observed more than 2 decades ago. (europa.eu)
however, the precise role of plus- and minus end-directed microtubule-based transport in axis formation is not yet understood. (dundee.ac.uk)
transport is driven by the microtubule motor protein cytoplasmic dynein, with motor activity regulated by a sequential series of adaptors. (bvsalud.org)
Either knockdown or overexpression of RAB10 stalls transport, suggesting that this GTPase is also required to coordinate the opposing activities of bound dynein and kinesin motors. (bvsalud.org)
u003cbr /\u003e To assess whether microtubule-dependent movement is neccessary for the autophagic delivery of cytoplasmic components to lysosome, I established a novel transport assay using fluorescence recovery after photobleaching (FRAP). (soken.ac.jp)
Several lines of evidence suggest that microtubules are nucleated at the neuronal centrosome, and then released for transport into axons and dendrites. (silverchair.com)
Cytoplasmic dyneins transport cellular components from the periphery toward the center of the cell. (humantechnopole.it)
Cytoplasmic dynein would be involved in organelle transport. (github.io)
In this thesis we aim to expand our understanding of how interactions between the capsid and host cell factors regulate viral activities, with chapter 4 and 5 specifically focusing on the cytoplasmic transport process. (edu.au)
Our work validated the proposed models for the cytoplasmic transport of HIV-1 capsid and demonstrated the minimum requirement for this process. (edu.au)

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains. (mpg.de)

1984) Isolation of microtubules and a dynein-like MgATPase from unfertilized sea urchin eggs. (ucdavis.edu)

Dr. Holzbaur is interested in the mechanisms of microtubule-based motility. (nih.gov)

To investigate the interactions between HIV-1 capsid and the motor adaptors, we applied a fluorescence fluctuation spectroscopy based binding assay and a total internal reflection microscopy (TIRFm) based binding assay. (edu.au)

Dynein polarity-sorts microtubule bundles by selectively sliding anti-parallel microtubules apart. (mechanochemistry.org)
Their force output doubles on microtubule bundles and we propose a model whereby the separation of the motor domains during crossbridging activates the motor. (mechanochemistry.org)
The role of microtubule pivoting in formation of complex structures such as microtubule bundles and mitotic spindles. (irb.hr)

Microinjection of an antibody that inactivates katanin results in a dramatic accumulation of microtubules at the centrosome, indicating that katanin is indeed required for microtubule release from the centrosome. (silverchair.com)
These results indicate that microtubule-severing by katanin is essential for releasing microtubules from the neuronal centrosome, and also for regulating the length of the microtubules after their release. (silverchair.com)

We report that KIF1C is a strong processive motor with a stall force of 5.7 pN and characterise two pathogenic mutations P176L and R169W that cause hereditary spastic paraplegia and cerebellar dysfunction. (mechanochemistry.org)
Both mutations reduce microtubule binding, but are fast and processive motors in single molecule assays. (mechanochemistry.org)
The cytoplasmic dynein complex is centred around two homodimerised heavy chains, within which multiple mutations have been identified in human neurological diseases. (figshare.com)

However, the precise interplay and relative contribution of actomyosin and microtubules during nuclear migration have remained to be elucidated. (biologists.com)

cytoplasmic dyneins and axonemal dyneins , which are also called ciliary or flagellar dyneins. (wikipedia.org)
Dynein heavy chain 5, axonemal: Associated with sperm (flagellar and cillar) motility). (github.io)

Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division. (wikipedia.org)

Our chapter in the kinesin superfamily handbook describes the largest subfamily, kinesin-3, a group of motors recently shown to be superprocessive and working as cellular long-distance transporters. (mechanochemistry.org)

THis FRAP assay showed that microtubule-dependent movement is necessary for targeting of peripherally-formed autophagosomes to lysosomes localizing to perinuclear region. (soken.ac.jp)

u003cbr /\u003e In the present study,Ishowed that a movement of autophagosome along microtubules is required for its targeting to lysosomes, and that IL3, an autophagosome binding protein,is a key molecule in assembly of autophagosome, dynein motor, and microtubules. (soken.ac.jp)

Does dynein generate force by the linker swing? (nii.ac.jp)

These findings indicate that autophagosome moves along microtubules. (soken.ac.jp)

2005). Kif18A is a member of the kinesin-8 protein family characterized by its unique dual functionality, which couples a highly processive motor activity with the ability to destabilize microtubules by specifically depolymerizing them at their plus end (Mayr et al. (uni-konstanz.de)
However, two or more dynein motors bound to the same cargo display unidirectional and highly processive motility, indicating that dynein motors can function effectively in teams Mallik et al. (tastefactoryuk.com)

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. (wikipedia.org)
DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al. (wikipedia.org)
Ddynein heavy chain 1, 8, 12, cytoplasmic dynein 1 heavy chain 1-like, dynein heavy chain 1, and cytoplasmic dynein 2 heavy chain 1-like contained DML in C. virginica gonad (Venkataraman et al. (github.io)
The parts (subunits) of a dynein complex are classified by weight as heavy, intermediate, light intermediate, or light chains. (medlineplus.gov)

1987) Correlation between the ATPase and microtubule translocating activities of sea urchin egg kinesin. (ucdavis.edu)
Characterization of microtubule motility and ATPase. (ucdavis.edu)

Its conserved core structure, the axoneme, contains nine microtubule doublets, each comprising a full A-microtubule and an incomplete B-microtubule. (humantechnopole.it)

In this study, we identify a previously uncharacterised isoform of microtubule-associated protein MAP4, oMAP4, as a microtubule organising factor that is crucial for myogenesis. (elifesciences.org)

Dynein pulls the microtubules and chromosomes to one end of the cell. (wikipedia.org)

Dynein drives the cargo to minus-end of microtubules, while kinesin drives to plus-end of microtubules. (soken.ac.jp)

Anatomy20

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Dynactin12

Axonemal and cytoplasmic2

DYNC1H14

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LIS15

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