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  • stability
  • Vinca alkaloids, such as vincristine and vinblastine, are a group of natural product antimitotic drugs that disrupt microtubule stability and induce mitotic arrest and apoptosis ( 5 ). (aacrjournals.org)
  • The research group has ascertained that a molecule known as MAP1A connects NMDA glutamate receptors as they are being transported to the synapses to the microtubules, stabilizing the receptors and preventing them from becoming "derailed," and playing a role in improving the overall efficiency and stability of the transport process. (eurekalert.org)
  • Evaluation of photoreceptor axonemes from mice with targeted disruptions of the Rp1 gene shows that Rp1 proteins that contain the DCX domains also help control axoneme length and stability in vivo . (jneurosci.org)
  • gene
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • In the present work we analyze the structure and evolution of the ASAP gene, as well as the domain composition of the encoded protein. (biomedcentral.com)
  • The human gene is strongly expressed in brain and testis as a 2.6 Kb transcript encoding a ~110 KDa protein. (biomedcentral.com)
  • phenotype
  • Analyses of mutants, antibody microinjection in tissue culture cells and expression of truncated proteins with a dominant negative phenotype, have shown that inhibition of a single protein inactivates the checkpoint (reviewed by Amon, 1999 ), allowing for sister chromatid separation in the absence of microtubules. (biologists.org)
  • MAP1A
  • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). (rcsb.org)
  • hippocampal
  • Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model," Clinical Laboratory , vol. 56, no. 3-4, pp. 127-136, 2010. (hindawi.com)
  • PMID
  • JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [ PMID: 14718537 ], and may be involved in microtubule-dependent transport of the GABA-B receptor [ PMID: 17532644 ]. (ebi.ac.uk)
  • tissues
  • Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. (ebi.ac.uk)
  • Microtubule-associated protein 4 (MAP4) transcripts vary in different mouse tissues, with striated muscle (skeletal and cardiac) expressing 8- and 9-kb transcripts preferentially to the more widely distributed 5.5- and 6.5-kb transcripts (West, R. W., Tenbarge, K. M. and Olmsted, J. B. (1991). (biologists.org)
  • Tissue expression of ASAP revealed a high expression in brain and testis, two tissues rich in microtubules. (biomedcentral.com)
  • assembly
  • Aspartic proteinases from human immunodeficiency virus type 1 (HIV-1) and avian myeloblastosis virus (AMV) were found to interfere with microtubule assembly. (nih.gov)
  • degradation
  • May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). (rcsb.org)
  • We demonstrate that, unlike MP in whole-cell extract, microtubule-associated MP is not ubiquitinated, which strongly argues against the hypothesis that microtubules target the MP for degradation. (asm.org)