• Therefore, we use a combination of the mouse model and human cells to dissect the molecular basis of stem cell function and differentiation toward adult tissues. (ca.gov)
  • We have found these small RNAs are essential for normal mammalian development and growth and differentiation of stem cells. (ca.gov)
  • We have also been studying how microRNAs are used shortly after fertilization first to maintain pluripotency (the ability to make all cells of the body) and then to promote differentiation into what eventually will become all the adult tissues. (ca.gov)
  • Potency is also described as the gene activation potential within a cell, which like a continuum, begins with totipotency to designate a cell with the most differentiation potential, pluripotency, multipotency, oligopotency, and finally unipotency. (wikipedia.org)
  • In the spectrum of cell potency, totipotency represents the cell with the greatest differentiation potential, being able to differentiate into any embryonic cell, as well as any extraembryonic cell. (wikipedia.org)
  • MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
  • Such a prospect is currently hampered, however, in part by an incompletely defined complex of molecular regulators of cardiac cell development and differentiation. (biomedcentral.com)
  • This commentary discusses the findings from Wagh and colleagues published in this issue of Stem Cell Research and Therapy demonstrating a critical role for miR-363 in post-transcriptional regulation of CM differentiation via the hand and neural crest derivative expressed HAND1 transcription factor [ 1 ]. (biomedcentral.com)
  • Identifying molecular regulators and critical mediators of cardiac cell type development, proliferation, and differentiation is of great clinical importance, and unraveling such molecular horizons could lead to the development of therapeutic strategies for successful regeneration of the human adult heart. (biomedcentral.com)
  • miRNAs could thus be the best targets for understanding cardiac specialization during differentiation of human embryonic stem cells (hESCs). (biomedcentral.com)
  • Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
  • Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
  • I would no avoid to learn my NRE cells to RFC as they are lower process of differentiation and no affect overcome a planning page. (cutechabeads.com)
  • miR122 is the prevalent miRNA in adult healthy liver and it is responsible for liver stem cell differentiation towards hepatocyte lineage. (oncotarget.com)
  • HCC stem-like cells can be directed towards cell differentiation and tumor dormancy by restoring miR122 expression. (oncotarget.com)
  • It reaches its maximum levels in adult healthy liver and is associated with hepatocyte differentiation. (oncotarget.com)
  • A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
  • Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. (caister.com)
  • Life depends on constant replenishment of human body cells with new cells created by differentiation of adult stem cells. (anti-agingfirewalls.com)
  • As Type D cells die from trauma or apoptosis they are replaced by new cells resulting from differentiation of Type B and Type C cells. (anti-agingfirewalls.com)
  • Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. (axonmedchem.com)
  • To establish protocols for the safe and efficient differentiation of healthy cells for therapies, we must develop a better understanding of the dynamic continuum of metabolic states that span pluripotency and differentiation, and how to influence them. (conditionmed.org)
  • All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • Model simulations demonstrate that the low-Nanog state benefits cell differentiation through serving as an intermediate state to reduce the barrier of transition. (biomedcentral.com)
  • Our modeling results quantitatively show a dual role of Nanog during stem cell differentiation and reprogramming, and the importance of the intermediate state during cell state transitions. (biomedcentral.com)
  • Our approach offers a general method for analyzing key regulatory factors controlling cell differentiation and reprogramming. (biomedcentral.com)
  • Very few studies have addressed the functional roles of the bimodal heterogeneity of Nanog expression in the differentiation and specification process of stem cells. (biomedcentral.com)
  • One hypothesis based on these results is: During the stem cell differentiation process, the low-Nanog state of stem cell functions as the "gate-keeper" state. (biomedcentral.com)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
  • By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
  • Therefore, the therapeutic use of appropriate populations derived from stem and progenitor cells has been considered for cell-based therapies for neurodegenerative diseases, primarily Parkinson's disease, and brain injuries. (ehu.eus)
  • With growth, these proliferate and, in a remarkably articulated manner, progressively differentiate into multipotent stem cells (Type B), progenitor cells (Type C), mature body somatic cells (Type E), and many eventually become senescent cells (Type E). (anti-agingfirewalls.com)
  • In essence, early-on the body sets up pools of stem and progenitor cells to replace lost somatic cells. (anti-agingfirewalls.com)
  • During development, stem cells and resulting progenitor cells are responsible for generating all the tissues and cells of an organism. (wisc.edu)
  • There are several classes of these small RNAs, two of which our lab focuses on, microRNAs and endogenous siRNAs. (ca.gov)
  • In the past year, we have been looking more deeply into the mechanism by which the mammalian egg suppresses one of these classes of small RNAs, the microRNAs, but not the other, the endogenous siRNAs. (ca.gov)
  • MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
  • MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
  • MicroRNAs (miRs) are regulators of gene expression by destabilizing and inducing degradation of messenger RNAs (mRNA) and/or repressing their translation [ 1 ]. (oncotarget.com)
  • RESULTS: Transcriptome sequencing was used to identify the expression profiles of long noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) in the skin tissues of Jiangnan cashmere goats with different cashmere fineness levels. (bvsalud.org)
  • Epigenetic mechanisms , including DNA methylation, chromatin remodeling, and noncoding RNAs have profound regulatory roles in controlling mammalian gene expression. (wisc.edu)
  • By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)
  • The efficient derivation of specialized and functional cardiomyocytes (CMs) from pluripotent stem cells is a primary goal for stem cell-based cardiac regenerative therapies. (biomedcentral.com)
  • Cardiovascular diseases often cause substantial heart damage and even heart failure due to the limited regenerative capacity of adult cardiomyocytes. (thno.org)
  • Herein, we introduce a cardiac-mimetic cell-culture system that resembles the microenvironment in the heart and provides interactions with cardiomyocytes and electrical cues to the cultured fibroblasts for direct cardiac reprogramming. (thno.org)
  • In the heart, cardiomyocytes interact with neighboring cells through direct cell-cell interactions, various secreted cytokines, and electric signals (Figure 1 A) [ 24 ]. (thno.org)
  • Toll-like receptor family (TLRs), pattern recognition receptors, is expressed not only on immune cells but also on non-immune cells, including cardiomyocytes, fibroblasts, and vascular endothelial cells. (biomedcentral.com)
  • Teleost fishes and amphibians show robust regeneration abilities of heart tissues, whereas the adult mammalian heart poorly renews itself, showing extremely limited regenerative capacity. (biomedcentral.com)
  • Direct cardiac reprogramming of fibroblasts is an attractive therapeutic strategy for treating cardiovascular diseases because the adult heart has a low regeneration capacity [ 1 ]. (thno.org)
  • In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (wisc.edu)
  • Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
  • Induced pluripotent stem cells, commonly abbreviated as iPS cells or iPSCs, are a type of pluripotent stem cell artificially derived from a non-pluripotent cell, typically an adult somatic cell, by inducing a "forced" expression of certain genes and transcription factors. (wikipedia.org)
  • MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • BCLC9-miR122 cells down-regulate expression of MYC, KLF4, FOXM1, AKT2 and AKT3 genes and up-regulate FOXO1 and FOXO3A gene expression. (oncotarget.com)
  • Over the past few years, emerging numerous bioinformatic tools have been developed to identify candidate disease-causing genes [ 4 ], including microRNA (miRNA) genes. (hindawi.com)
  • Besides its role in the regulation of genes, DNA methylation silences repetitive elements and appears to be important for the stability of the mammalian genome. (caister.com)
  • We hypothesized that a high fat diet in non-human primates would induce changes in hepatic chromatin structure resulting in altered expression of fetal genes critical to the development of childhood and adult obesity. (nih.gov)
  • This is because Drosophila genes controlling fundamental cellular functions, such as cell growth and death, are quite identical to those found in human cells. (ataxia.org)
  • In terms of the gene regulatory network defining cellular potency, Nanog has direct mutual interactions with two other core stem cell specific genes Oct4 and Sox2. (biomedcentral.com)
  • Stem cell gene expression evolves with age. (anti-agingfirewalls.com)
  • Although in principle stem cells can replicate indefinitely, in fact they age as the organism ages, continuing to change their gene expression. (anti-agingfirewalls.com)
  • Of interest, we have observed in a rodent transgenerational model of intrauterine growth restriction (IUGR) that a diet supplemented with essential nutrients, yet unaltered in its caloric content, prevents adult metabolic disease and is associated with abrogation of reprogrammed gene expression. (nih.gov)
  • H. Kwon, T. Enomoto, M. Shimogawara, K. Yasuda, Y. Nakajima and Y. Ohmiya, Bioluminescence imaging of dual gene expression at the single-cell level. (atto.co.jp)
  • Previous studies in population genomics have relied on a technique called bulk RNA sequencing to assess gene expression, which effectively averages the varied expression of different cell types into a single measure. (rna-seqblog.com)
  • This masks potential differences between individual cells or cell types and can provide an incomplete or biased view of gene expression in the sample, potentially leading to inaccurate or misleading conclusions. (rna-seqblog.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • In particular, we have been studying the association of microRNAs and epigenetic changes in the cells. (ca.gov)
  • In mouse primordial germ cells, genome-wide reprogramming leading to totipotency involves erasure of epigenetic imprints. (wikipedia.org)
  • DNA, which served as a positive control, delivered the expected positive result.20 These observations suggest that 6mA might be present at defined time points in mammalian DNA, but is not an epigenetic mark. (thebiotechdictionary.com)
  • A main focus of my lab research is to understand the epigenetic basis of cell fate specification and neurodevelopment. (wisc.edu)
  • demonstrate through studies on induced pluripotent stem cell-derived cortical neurons that miR-33a is a potential therapeutic target for the treatment of SPG4-related hereditary spastic paraplegia. (portlandpress.com)
  • Induced pluripotent stem cell-derived extracellular vesicles: A novel approach for cell-free regenerative medicine. (plurisomes.com)
  • Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis. (plurisomes.com)
  • Stem cells resembling totipotent blastomeres from 2-cell stage embryos can arise spontaneously in mouse embryonic stem cell cultures and also can be induced to arise more frequently in vitro through down-regulation of the chromatin assembly activity of CAF-1. (wikipedia.org)
  • Therefore, the implantation of human cells reprogrammed in vitro represents an alternative strategy [ 16 - 19 ]. (thno.org)
  • We discuss what is known about the distinct metabolic states captured in vitro by the 2-cell-like, naïve, blastocyst-like, formative, and primed states of pluripotency. (conditionmed.org)
  • 2019). Akin to the dynamic nutrient requirements of the developing embryo, discrete in vitro cell states have distinct metabolic profiles (Zhou et al. (conditionmed.org)
  • It is only through understanding embryonic metabolism and development that we can derive and maintain different in vitro stem cell states for disease modeling and therapies. (conditionmed.org)
  • The primary microRNA (Pri-miRNA) is produced in the cell nucleus through the transcription of a DNA strand mediated by RNA polymerase II [ 2 ]. (archivesofmedicalscience.com)
  • MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
  • Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells. (plurisomes.com)
  • In cell biology, pluripotency (Lat. (wikipedia.org)
  • However, cell pluripotency is a continuum, ranging from the completely pluripotent cell that can form every cell of the embryo proper, e.g., embryonic stem cells and iPSCs, to the incompletely or partially pluripotent cell that can form cells of all three germ layers but that may not exhibit all the characteristics of completely pluripotent cells. (wikipedia.org)
  • We explore the recently described metabolic surge event that occurs as pluripotency is lost and stem cells commit to differentiate. (conditionmed.org)
  • Nanog has been recognized as a critical pluripotency gene in stem cell regulation. (biomedcentral.com)
  • Understanding these mechanisms should enable us to adopt them in order to manipulate many cells to become other types of cells through a process called reprogramming. (ca.gov)
  • In other experiments, we have been looking into how microRNAs interact with additional molecular mechanisms in the cells. (ca.gov)
  • Understanding how these two mechanisms work together will enhance our ability to reprogram cells. (ca.gov)
  • Understanding their mechanisms may lead to the development of microRNA cocktails that can potentially be used in regenerative cardiology. (archivesofmedicalscience.com)
  • The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)
  • The research in our laboratory focuses on understanding the molecular mechanisms that regulate neural stem cells and neurodevelopment with the goal of applying this knowledge in the treatment of neurological disorders and injuries. (wisc.edu)
  • My laboratory is investigating the mechanisms governing the behaviors and functions of neural stem cells in both healthy conditions and in neurological diseases. (wisc.edu)
  • Using neural stem cells as model systems, we are investigating the molecular mechanisms that regulate neuronal development during postnatal period and their implications in human neurodevelopmental disorders such as Rett Syndrome, Autism, and Fragile X syndrome. (wisc.edu)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
  • We studied the effects of restoring miR122 expression in a distinctive cell line derived from human HCC-BCLC9 cells-with a solid stem-like cell profile, high tumor initiating ability and undetectable miR122 expression. (oncotarget.com)
  • Regulating microRNA expression: At the heart of diabetes mellitus and the mitochondrion. (wvu.edu)
  • Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
  • We hypothesize that ovarian cancer cells will induce human ovarian TVM expression. (nih.gov)
  • Restitution of miR122 in BCLC9 cells, decreases cell proliferation rate and reduces significantly tumor size in vivo . (oncotarget.com)
  • Treatment of miR122 positive cells with an inhibitor of TGFBR1 activation, abolished tumor dormancy program and recovered cell proliferation rate through a Smad-independent TGF-β response. (oncotarget.com)
  • Neural stem cells in the postnatal brain have significant roles in both normal brain functions, such as learning and memory and the brain's response to injuries. (wisc.edu)
  • This pathway entails erasure of CpG methylation (5mC) in primordial germ cells via the initial conversion of 5mC to 5-hydroxymethylcytosine (5hmC), a reaction driven by high levels of the ten-eleven dioxygenase enzymes TET-1 and TET-2. (wikipedia.org)
  • Chemistry of RNA and DNA base methylation The addition of the methyl-group to DNA and RNA bases (Fig.?2) is catalyzed by DNA- and RNA-methyltransferases that use DNMTs, which methylate canonical dC bases.26 In contrast, DNMT1 maintains the methylation status Actinomycin D biological activity during cell division. (thebiotechdictionary.com)
  • Thus, DNA methylation influences the functional integrity of mammalian genome by shaping its overall structure and leaving its marks in the genomic DNA sequence during evolution. (caister.com)
  • These transcription factors play a key role in determining the state of these cells and also highlights the fact that these somatic cells do preserve the same genetic information as early embryonic cells. (wikipedia.org)
  • In particular, due to the limited regenerative capacity of the adult nervous system, the therapeutic potential of stem cells has opened up new perspectives for development of treatment strategies for brain repair after injury or disease. (ehu.eus)
  • Further exploring the role of miRNAs in cardiac cells during development and disease may therefore hold great promise for cardiac therapy applications. (biomedcentral.com)
  • To examine this phenomenon, we chose two mouse embryonic stem (ES) cell lines that possess insertionally polymorphic retrotransposons (IAP, ETn/MusD, and LINE elements) at specific loci in one cell line but not the other. (prolekarniky.cz)
  • The human development model can be used to describe how totipotent cells arise. (wikipedia.org)
  • Human development begins when a sperm fertilizes an egg and the resulting fertilized egg creates a single totipotent cell, a zygote. (wikipedia.org)
  • Nephron progenitors, the self-renewing cells that give rise to nephrons, are particularly metabolically active, relying primarily on glycolysis for energy generation early in development. (lww.com)
  • Human pluripotent stem cells, with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a novel resource to study human development and to implement relevant disease models. (mdpi.com)
  • In particular, the advent of human embryonic stem cells followed by reprograming technologies for generation of induced pluripotent stem cells have instigated studies into modeling human brain development and disease by providing a means to simulate a human tissue otherwise completely or largely inaccessible to researchers. (ehu.eus)
  • Here, we consider the metabolism of the early embryo through development, and look at the nutrient milieu within the developing stem cell niche. (conditionmed.org)
  • 2020). This places metabolism at the forefront of development and cell state decisions. (conditionmed.org)
  • The developing embryo, from which pluripotent stem cells originate, undergoes a series of dynamic metabolic transitions synchronized to its molecular development. (conditionmed.org)
  • Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)
  • NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human na ve pluripotent stem cells. (qcfail.com)
  • With a industrial web at Princeton, Cell, Developmental and Cancer Biology welcomes amount cells from the Departments of Molecular Biology, Engineering, Physics and Genomics that owe a new doubt in funneling courses of major , direct factors and page. (cutechabeads.com)
  • Ewen Callaway investigates a new field in cell biology. (nature.com)
  • Stem cell technologies have opened up new avenues in the study of human biology and disease. (ehu.eus)
  • They therefore represent a more realistic cellular environment for modeling the cell biology and pathology of the nervous system. (ehu.eus)
  • Macklis is the Max and Anne Wien Professor of Life Sciences, and Professor of Stem Cell and Regenerative Biology, in the Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University. (harvard.edu)
  • A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology. (rna-seqblog.com)
  • From a basic science perspective, the stem-cell-based system is a powerful means to gain insights into the relationship between human genetics and biology that can't be achieved with animal models," says Professor Powell. (rna-seqblog.com)
  • In 2011, research revealed that cells may differentiate not into a fully totipotent cell, but instead into a "complex cellular variation" of totipotency. (wikipedia.org)
  • Heterogeneous gene expressions of cells are widely observed in self-renewing pluripotent stem cells, suggesting possible coexistence of multiple cellular states with distinct characteristics. (biomedcentral.com)
  • These results suggest the co-existence of two cellular "sub-states" within the pluripotent stem cell state: high-Nanog sub-state and low-Nanog sub-state, rather than one well-defined, homogenous pluripotent cellular state. (biomedcentral.com)
  • We demonstrate an in vivo electroporation protocol for transfecting single or small clusters of retinal ganglion cells (RGCs) and other retinal cell types in postnatal mice over a wide range of ages. (jove.com)
  • The best way to reach that goal is to understand the relationships between these cells that grow in a culture dish in the laboratory and the equivalent cells in the developing embryo. (ca.gov)
  • At conception, the embryo is all Type A cells. (anti-agingfirewalls.com)
  • Up to the 2-cell embryo, blastomeres remain totipotent (Garner and McLaren, 1974). (conditionmed.org)
  • In the mouse, a transporting epithelium is established around the 8-16-cell stage through a process known as compaction where cell definition is lost and the outer cells of the embryo form tight junctions, giving rise to the blastocyst. (conditionmed.org)
  • The application of stem cell therapy and brown adipose tissue transplantation in metabolic disorders. (plurisomes.com)
  • He was a postdoctoral fellow in developmental neuroscience with Richard Sidman at HMS, where he also trained clinically in Internal Medicine at Brigham and Women's Hospital (BWH) and adult neurology in the Harvard Neurological Training Program. (harvard.edu)
  • Employing ChIP-seq data for these cell lines, we show that IAP elements robustly induce H3K9me3 and H4K20me3 marks in flanking genomic DNA. (prolekarniky.cz)
  • Cell potency is a cell's ability to differentiate into other cell types. (wikipedia.org)
  • The more cell types a cell can differentiate into, the greater its potency. (wikipedia.org)
  • In contrast, pluripotent cells can only differentiate into embryonic cells. (wikipedia.org)
  • After reaching a 16-cell stage, the totipotent cells of the morula differentiate into cells that will eventually become either the blastocyst's Inner cell mass or the outer trophoblasts. (wikipedia.org)
  • The above list is in order of increasing cell-type specificity and decreasing cell-type potency to differentiate into other cell types. (anti-agingfirewalls.com)
  • Starting at conception and throughout life, all cells on this list except the senescent ones will selectively reproduce and possibly differentiate into cells of types further down in the list. (anti-agingfirewalls.com)
  • At maturity there are relatively very few Type A cells and a mix of Type B, C and D cells, Type B and C cells typically live in protected stem cell niches where they reproduce and, as-needed differentiate to become the normal working body Type D cells. (anti-agingfirewalls.com)
  • At an advanced age, the pools of Type B and Type C cells become depleted in part because of replicative senescence and the cells remaining in the pools lose their ability to differentiate as necessary to replace Type D cells. (anti-agingfirewalls.com)
  • Cells in those pools replicate and differentiate throughout life. (anti-agingfirewalls.com)
  • It allowed me to move into the field of glaucoma and retinal ganglion cell neurodegeneration. (glaucoma.org)
  • This was then followed in 2007 by the successful induction of human iPSCs derived from human dermal fibroblasts using methods similar to those used for the induction of mouse cells. (wikipedia.org)
  • Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
  • It will quite effectively cater to the needs of molecular biologists, molecular geneticists, cell and molecular biologists, animal, plant, and crop geneticists, synthetic biologists, biotechnologists, and researchers involved with the fields of stem cell and molecular aspects of cancer research. (caister.com)
  • Molecular Cell , 82 (1), 190-208. (axonmedchem.com)
  • Molecular cell, 82(1), 106-122. (axonmedchem.com)
  • Molecular motors lie at the heart of biological processes from DNA replication to cell migration. (nih.gov)
  • Stem cells have two fundamental properties: self-renewal and multipotency. (wisc.edu)
  • Finally, our preliminary data suggest that the ESC-ovarian tumor model has human tumor vascular cells. (nih.gov)
  • Tumor vascular cells are critical for the growth of tumor stem cells, which reside within the vascular niche. (nih.gov)
  • We hypothesize that the ESC ovarian tumor model, with human vascular cells, will provide an ideal microenvironment to support human stem cell growth. (nih.gov)
  • Supplementary MaterialsCorrelation network analysis reveals relationships between microRNAs, transcription factor and deregulated cytokine/chemokine-receptor network in pulmonary sarcoidosis 121378. (thebiotechdictionary.com)
  • Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and function. (bvsalud.org)