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  • molecules
  • Whereas the roles of proteins as regulatory factors in development and adaptation to the environment are well known, the involvement of regulatory small RNA molecules is just emerging ( Carrington and Ambros, 2003 ). (plantcell.org)
  • MicroRNAs (miRNAs) are a new class of regulatory molecules implicated in type 2 diabetes, which is characterized by insulin resistance and hepatic glucose overproduction. (diabetesjournals.org)
  • Arabidopsis
  • Floral initiation and floral organ development are both regulated by the phytohormone gibberellin (GA). For example, in short-day photoperiods, the Arabidopsis floral transition is strongly promoted by GA-mediated activation of the floral meristem-identity gene LEAFY . (biologists.org)
  • Here, we report that Arabidopsis ( Arabidopsis thaliana ) embryos mutant for strong alleles of DICER-LIKE1 , the enzyme responsible for the biosynthesis of microRNAs (miRNAs), mature earlier than their wild-type counterparts. (plantphysiol.org)
  • Members of the Arabidopsis SBP-box gene family of transcription factors have been implicated in promoting the floral transition in dependence of miR156 and, accordingly, transgenics constitutively over-expressing this microRNA are delayed in flowering. (springer.com)
  • In an attempt to identify novel and abiotic stress regulated miRNAs and siRNAs, we constructed a library of small RNAs from Arabidopsis seedlings exposed to dehydration, salinity, or cold stress or to the plant stress hormone abscisic acid. (plantcell.org)
  • These findings suggest that a large number of miRNAs and other small regulatory RNAs are encoded by the Arabidopsis genome and that some of them may play important roles in plant responses to environmental stresses as well as in development and genome maintenance. (plantcell.org)
  • MicroRNAs (miRNAs) of Arabidopsis thaliana are involved in mediating cell proliferation in leaves, stress tolerance, and root development. (mdpi.com)
  • novel
  • We used deep sequencing of small RNAs from root apexes and nodules of M. truncatula to identify 100 novel candidate miRNAs encoded by 265 hairpin precursors. (plantcell.org)
  • Targeting specific microRNAs may represent a novel intervention opportunity to improve outcome and reduce hemorrhagic transformation after mechanical reperfusion for acute ischemic stroke. (nih.gov)
  • Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS. (jneurosci.org)
  • Therefore, through this work the researchers have identified a novel way of regulating helper T cell development and controlling the immune response. (rvc.ac.uk)
  • inhibits
  • Chen Y, Zhang Z, Luo C, Chen Z, Zhou J (2016) MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1alpha-mediated glycolysis. (springer.com)
  • The analyses suggest that microRNA-9 indirectly inhibits Pax6 expression by suppressing Meis2 expression. (jneurosci.org)
  • 20,21 For example, microRNA (miR-221) inhibits endothelial migration in vitro by repressing c-kit, 18 miR-130 induces endothelial migration in vitro through inhibition of the homeobox gene HoxA5 , 22 and let-7f may decrease expression of the angiogenesis inhibitor thrombospondin-1. (ahajournals.org)
  • microarray
  • Through a microarray approach, we identify the subset of microRNAs (miRNAs) modulated by ERalpha, which include upregulation of miRNAs derived from the processing of the paralogous primary transcripts (pri-) mir-17-92 and mir-106a-363. (nih.gov)
  • roles
  • Second, can micro-ribonucleoproteins (microRNPs), in general, up-regulate translation under growth-arrest conditions, thereby switching between repressing and activating roles in response to the cell cycle? (sciencemag.org)
  • however, it is likely that a number of other miRNAs play important roles in regulating myogenesis as well. (springer.com)
  • transcription
  • cDNA synthesis was performed for each RNA sample using a Reverse Transcription system (Promega Corporation, Madison, WI, USA), and oligo dT from the system was used to prime cDNA synthesis. (spandidos-publications.com)
  • Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression. (ahajournals.org)
  • 19 Although miR-126 plays a prominent role in vascular biology, the transcription factors that regulate miR-126 in endothelial cells have not been defined. (ahajournals.org)
  • The E26 transformation-specific sequence (ETS) factors are a family of transcription factors that share a highly conserved DNA binding domain and regulate cell development, senescence, death, and tumorigenesis. (ahajournals.org)
  • role
  • Callegari E, Elamin BK, Sabbioni S, Gramantieri L, Negrini M. Role of micrornas in hepatocellular carcinoma: A clinical perspective. (springer.com)
  • miR-9-5p/3p are brain-enriched miRNAs known to regulate development and their changes have been implicated in several neurological disorders, yet their role in mature neurons in mice is largely unknown. (jneurosci.org)
  • SIGNIFICANCE STATEMENT Despite the abundant expression of the brain-specific microRNA miR-9-5p/3p in both proliferating and postmitotic neurons, most functional studies have focused on their role in neuronal development. (jneurosci.org)
  • However, knowledge on the role of microRNAs (miRNAs) during nodule development is lacking. (biomedcentral.com)
  • The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. (umass.edu)
  • Chan, Elizabeth, "The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. (umass.edu)
  • complementary
  • First, is binding of the AGO2-FXR1 complex, which activates translation, directed by a microRNA complementary to the ARE? (sciencemag.org)
  • A bioinformatic screen identified five microRNAs in miRBASE with seed regions complementary to the TNFα ARE, not including miR16 ( 5 )[see supporting online material (SOM) text]. (sciencemag.org)
  • Genomics
  • Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. (jneurosci.org)
  • Atrophy
  • Objectives To investigate GDF-15 and microRNA expression in patients with ICUAW and to elucidate possible mechanisms by which they cause muscle atrophy in vivo and in vitro. (bmj.com)
  • Conclusions GDF-15 may increase sensitivity to TGF-β signalling by suppressing the expression of muscle microRNAs, thereby promoting muscle atrophy in ICUAW. (bmj.com)
  • Moreover
  • Moreover, microRNAs found in mammals regulate over a third of the human genome, as shown in a 2005 study by the lab of Whitehead Member and Howard Hughes Medical Institute Investigator David Bartel and colleagues. (bio-medicine.org)
  • angiogenesis
  • Here, we tested whether miR-146a regulates in vitro angiogenic endothelial cell (EC) behaviors, as well as perfusion recovery, arteriogenesis, and angiogenesis in response to femoral arterial ligation (FAL) in vivo . (frontiersin.org)
  • Recently, microRNAs (miRNAs) have been documented as key contributors to the process of angiogenesis. (ahajournals.org)