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  • regulation
  • The functional diversification of microRNAs may require breaking the genomic linkage between paralogs, probably to avoid the co-regulation of multiple products by the same regulatory sequences. (wikipedia.org)
  • In particular, we experimentally validate common regulation of Mtpn by miR-375 , miR-124 and let-7b and thus provide evidence for coordinate microRNA control in mammals. (nature.com)
  • genome
  • Using genome-wide transcriptome analysis, a transcriptional signature of UVB-induced senescence was identified, and bioinformatics tools were applied to identify microRNA-mRNA functional interactions that direct the process of UVB-induced senescence. (uibk.ac.at)
  • apoptosis
  • Propofol induces apoptosis of epithelial ovarian cancer cells by upregulation of microRNA let-7i expression. (cancerindex.org)
  • MicroRNAs have been shown to be involved in a wide range of biological processes such as cell cycle control, apoptosis and several developmental and physiological processes including stem cell differentiation, hematopoiesis, hypoxia, cardiac and skeletal muscle development, neurogenesis, insulin secretion, cholesterol metabolism, aging, immune responses and viral replication. (exiqon.com)
  • mRNAs
  • Since most target sites on the mRNA have only partial base complementarity with their corresponding microRNA, individual microRNAs may target as many as 100 different mRNAs. (exiqon.com)
  • Moreover, individual mRNAs may contain multiple binding sites for different microRNAs, resulting in a complex regulatory network. (exiqon.com)
  • regulators
  • Moore's introductory editorial, titled "MicroRNAs: small regulators with a big impact on lipid metabolism," and four reviews from experts in the field make up the series. (asbmb.org)
  • inhibitors
  • Atherosclerosis in humans should also be susceptible to treatment with inhibitors of microRNAs," Schober suggests. (uni-muenchen.de)
  • Synthetic inhibitors are available for each and every microRNA, and could be used for therapeutic purposes as soon as their efficacy and safety has been demonstrated in clinical tests. (uni-muenchen.de)
  • Identification
  • Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. (uibk.ac.at)
  • http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+microRNA-mRNA+functional+interactions+in+UVB-induced+senescence+of+human+diploid+fibroblasts. (uibk.ac.at)
  • loci
  • MicroRNAs are sometimes encoded by multiple loci, some of which are organized in tandemly co-transcribed clusters. (exiqon.com)
  • eukaryotic
  • While they were first discovered only in the early 1990s, microRNAs have since been found in all standard laboratory eukaryotic systems, mammals, plants and fungi. (asbmb.org)
  • expression
  • MicroRNA expression profiles classify human cancers. (springer.com)
  • The new study shows that microRNA expression profiles can even distinguish cancerous cells that cannot otherwise be identified on the basis of their outward appearance. (innovations-report.com)
  • MicroRNAs are important sections of genetic material that play a major role in gene expression. (asbmb.org)
  • In addition, highly tissue-specific expression and distinct temporal expression patterns during embryogenesis suggest that microRNAs play a key role in the differentiation and maintenance of tissue identity. (exiqon.com)
  • Roles
  • In addition to their important roles in healthy individuals, microRNAs have also been implicated in a number of diseases including a broad range of cancers, heart disease and neurological diseases. (exiqon.com)
  • cancers
  • A third paper in Nature from Joshua Mendell and colleagues at The Johns Hopkins University School of Medicine reported that some microRNAs cooperate with a gene already known to cause human cancers. (innovations-report.com)
  • In humans, this microRNA is involved in the mechanisms of immunity, and in many different cancers (see below) it was found to be expressed at a particularly low level. (wikipedia.org)
  • mice
  • In a second paper published in Nature, Gregory Hannon, Scott Lowe and their colleagues showed that a specific cluster of microRNAs can cause lymphomas in mice. (innovations-report.com)
  • Development
  • Exiqon has pioneered the development of microRNA research and diagnostics tools with leading-edge products and services based on the proprietary Locked Nucleic Acid (LNA™) technology. (exiqon.com)
  • function
  • Since most paralogous microRNAs conserve their function, it has been suggested that mir-2 evolution is dominated by a birth-and-death dynamics driven by random drift. (wikipedia.org)
  • This is likely to affect the function of that particular microRNA. (wikipedia.org)