• It has been suggested that abnormal expression of microRNAs (miRNAs) is associated with carcinogenesis. (spandidos-publications.com)
  • Mature microRNAs (miRNAs) are a class of small, well-conserved, non-coding RNA molecules that silence gene expression usually by interfering with mRNA stability or protein translation ( 6 , 7 ). (spandidos-publications.com)
  • Up to 30% of human protein-coding genes may be regulated by miRNAs ( 8 , 9 ). (spandidos-publications.com)
  • MicroRNAs (miRNAs) are small noncoding RNA molecules that post-transcriptionally regulate gene expression. (oncotarget.com)
  • MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate several gene expressions, pathways, and complex biological networks at the cellular level acting either exclusively or together with other miRNAs. (justia.com)
  • MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)
  • MicroRNAs (miRNAs) são pequenos RNAs não-codantes, conservados ao longo da evolução, capazes de regular a expressão gênica através da degradação ou repressão da tradução de moléculas-alvo de RNA mensageiro. (bvsalud.org)
  • O presente estudo realiza uma revisão da literatura sobre miRNAs, enfocando aspectos relacionados à biogênese, mecanismos de ação e o papel potencial desses pequenos RNAs na carcinogênese oral. (bvsalud.org)
  • Como os miRNAs podem regular mais de um RNAm-alvo 33 , estima-se que estes pequenos RNAs controlem a expressão de aproximadamente 30% dos genes que codificam proteínas 23 . (bvsalud.org)
  • O presente estudo realiza uma revisão da literatura sobre miRNAs, enfocando aspectos relacionados à biogênese, mecanismos de ação e o papel potencial dessas pequenas moléculas de RNA na carcinogênese oral. (bvsalud.org)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNA molecules that repress target mRNAs through complementary binding in the message 3'-UTR. (ukri.org)
  • MiRNAs silence target mRNAs via the RNA-induced silencing complex (RISC), of which Argonaute proteins (Ago) are the major subunit. (ukri.org)
  • In the search for molecular biomarkers that could reveal pre-clinical phases of the disease, scientists have focused much of their attention on microRNAs (miRNAs), the best characterised family of small non-coding RNAs. (biomedcentral.com)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. (mdpi.com)
  • MicroRNAs (miRNA) are small noncoding RNAs, preserved throughout the evolution, able to regulate gene expression through repression of translation or degradation of target molecules of messenger RNA. (bvsalud.org)
  • This study performs a literature review of miRNA, focusing on aspects related to biogenesis, mechanisms of action and potential role of these small RNAs in oral carcinogenesis. (bvsalud.org)
  • Another type of molecule, called micro RNA (miRNA) can bind to mRNA and stop the translation of mRNA into protein. (ukri.org)
  • It was thanks to horses that the researcher came up with the idea to reverse the bone resorption process by using mRNA molecules and/or small non-coding RNA molecules (microRNA/miRNA). (scienceinpoland.pl)
  • miRNA molecules regulate the level of mRNA acting at the post-transcriptional level, having a direct impact on the expected therapeutic effect. (scienceinpoland.pl)
  • Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • The miR-129 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. (wikipedia.org)
  • Micro RNAs are 21- to 24-nucleotide-long, non-coding RNA molecules that regulate gene expression at the post-transcriptional level. (researchsquare.com)
  • Evolutionarily conserved, these 17-22 nucleotide long molecules regulate gene expression at post-transcriptional level generally by repressing translation or increasing degradation of messenger RNAs (mRNAs). (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • An intermediate between DNA and protein is called messenger RNA (mRNA), and neurons can transport mRNA to the parts of the neuron close to synapses and locally control the synthesis of a particular protein that is important for those synapses at a particular time. (ukri.org)
  • The professor proposed to use inorganic technology to protect organic molecules: mRNA is expected to inhibit osteoclasts and promote osteoblasts at the site of a bone defect. (scienceinpoland.pl)
  • They can modulate various biochemical and physiological processes, including plant response and resistance to fungal pathogens, by regulating the expression of numerous genes. (researchsquare.com)
  • Research has long focused on transcription from our genes that uses RNA messengers to code for the formation of proteins, the building blocks of the body. (lu.se)
  • The vast amount of experimental data has enabled the specific microRNA signatures and profiles to be recognised and thus used as potential biomarkers in cancer diagnosis, therapy prediction and prognosis. (wikipedia.org)
  • To achieve the best effectiveness of the defence response, all defence mechanisms must be well regulated. (researchsquare.com)
  • However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
  • Using these cells we will be able to understand more about the mechanisms that regulate the local control of protein synthesis in neurons in response to synaptic activity, and hence further our knowledge of the mechanisms that underlie long-term memory. (ukri.org)
  • As with many other microRNAs, the expression profile of miR-129 changes with the onset of cancer. (wikipedia.org)
  • In experiments where miR-129 levels were returned to normal in cancer cells, SOX4 expression was down regulated. (wikipedia.org)
  • It was observed that when cancer cells were subjected to transfection with the precursor of miR-129, GALNT1 was subsequently down regulated by the direct targeting of miR-129. (wikipedia.org)
  • MicroRNAs have given cancer researchers a new perspective to understand and combat cancer. (wikipedia.org)
  • Studies have shown that the expression of miR-126 is downregulated in cancers such as non-small cell lung cancer and colon cancer ( 14 , 15 ), suggesting that the downregulation of miR-126 is significantly related to the occurrence and development of cancer. (spandidos-publications.com)
  • We are interested in microRNAs, which we think have a role in the development of cancer", says Sofi Elmroth. (lu.se)
  • The quantity of microRNAs in different types of cancer varies and each type of cancer appears to display a specific pattern. (lu.se)
  • Around ten years ago, it was discovered that these areas code for a number of small RNA molecules that are now called non-coding RNAs because they don't code for proteins. (lu.se)
  • There are many different types of microRNAs involved in the regulation of different proteins and of other RNA molecules. (lu.se)
  • Provided herein are methods for the prevention and treatment of cardiovascular diseases and disorders in a subject diagnosed as having suffered a cerebrovascular injury by administering agents that contain or induce the expression of microRNA-126. (justia.com)
  • If there is even a slight error in the levels of expression, in the quantity of microRNAs, then there is a very strong correlation to disease. (lu.se)
  • Without limitation, some embodiments comprise methods, systems, and/or compositions relating to microRNAs and/or cell based therapies and the use of the same in the research, diagnosis, or treatment of injury or disease. (justia.com)
  • In the end, we have to know the molecule's chemical composition in order to design drugs that also comprise only one molecule. (lu.se)
  • MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)
  • Our main hypothesis is that PICK1 plays an important role in regulating protein synthesis close to active synapses via its interaction with Argonaute2. (ukri.org)
  • The biological processes they regulate may play an important role in understanding early osteoarthritis pathogenesis. (biomedcentral.com)
  • These molecules probably play a role in the origin of disease, as well as giving us new possibilities for treatments. (lu.se)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • We conducted RNA sequencing (RNA-Seq) of 103 tissues from rapeseed cultivar ZhongShuang11 (ZS11) at seven developmental stages (seed germination, seedling, bolting, initial flowering, full-bloom, podding, and maturation). (preprints.org)
  • Bioinformatic analysis was performed in order to identify putative targets of the differentially expressed microRNAs and to explore potential associations with specific biological processes. (biomedcentral.com)
  • Researchers are finding new RNA all the time because sequencing is now so quick and cheap", says Sofi Elmroth, professor at the Division of Biochemistry and Structural Biology at Lund University. (lu.se)
  • Sofia Elmroth and her research team primarily study microRNAs, which are molecules that influence protein levels in the cells of the body indirectly by binding to messenger RNA. (lu.se)
  • We hope to be able to contribute to the development of a whole new type of drug that, because of its resemblance to the cell's own RNA, can effectively influence cell processes that have not previously been exploited in treatment. (lu.se)
  • Sequencing of DNA gives a direct picture of our genetic make-up, while sequencing of the RNA that is naturally present in cells gives a picture of which parts of our non-coding DNA are used and in what way. (lu.se)
  • An altered level of a superior microRNA is a powerful marker and could be used to diagnose diseases and develop drugs", explains Sofi Elmroth. (lu.se)
  • It has proved difficult to develop drugs that act directly on epigenetic changes in DNA, but now it is possible instead to intervene later in the cell metabolism and regulate the level of specific microRNA molecules. (lu.se)
  • Synovial fluid represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could aid in the understanding of the pathogenesis of osteoarthritis. (biomedcentral.com)
  • If these microRNAs are over or under expressed (increase or decrease in quantity) - for example owing to epigenetic changes to the DNA - this will have an impact on many other regulatory processes. (lu.se)
  • In just a week, Sofi Elmroth and her team can get a new molecule to test on a cell system. (lu.se)
  • Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
  • Over the past decade, non-coding RNAs have become a hot topic in research. (lu.se)
  • We aim to test this hypothesis by analysing the precise mechanism for how PICK1 regulates the function of Argonaute2. (ukri.org)
  • However, there are certain types of microRNAs that have a key function that overrides many others. (lu.se)
  • As chemists, we work on one molecule at a time", says Sofi Elmroth. (lu.se)
  • Our preliminary data show that PICK1, which regulates AMPAR trafficking and dendritic spine morphology during synaptic plasticity, interacts with Ago2 in neurons. (ukri.org)
  • Sequencing is a method used to decide the exact order of the building blocks of DNA or RNA. (lu.se)
  • When a superior microRNA is added or removed, there are knock-on effects that open up new possibilities to develop drugs. (lu.se)