Long non-coding RNA (lncRNA) is a type of RNA that contains over 200 nucleotides and that does not encode protein ( 5 , 6 ). (spandidos-publications.com)
Endogenous4
MicroRNAs (miRNAs) are small noncoding endogenous RNA molecules that repress target mRNAs through complementary binding in the message 3'-UTR. (ukri.org)
Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
Additionally, as competitive endogenous RNAs (ceRNAs), lncRNAs and messenger RNAs (mRNAs) can regulate one other by competing for the shared microRNAs (miRNAs/miRs) ( 14 , 15 ). (spandidos-publications.com)
Hypothesis3
Our main hypothesis is that PICK1 plays an important role in regulating protein synthesis close to active synapses via its interaction with Argonaute2. (ukri.org)
We aim to test this hypothesis by analysing the precise mechanism for how PICK1 regulates the function of Argonaute2. (ukri.org)
Based on the ceRNA hypothesis ( 15 ), the lncRNA-miRNA-mRNA network was constructed and Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis of mRNAs in the network were performed. (spandidos-publications.com)
LncRNAs5
This study investigated the role of long non‑coding RNAs (lncRNAs) in glioblastomagenesis progression. (spandidos-publications.com)
While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
Here, we used RNAseq to identify a novel class of cardiac lncRNAs that are dynamically regulated by exercise. (researchgate.net)
Therapeutic1
Finally, we identified 76 therapeutic agents, 152 miRNAs targets, and 91 TFs regulatory networks. (nature.com)
Genes3
Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)
We have found that a protein (called PICK1), which is known to be involved in synaptic plasticity over the timescale of hours, interacts with another protein (called Argonaute2), which is an important component of the cell machinery that promotes the association of miRNA with mRNA to block protein synthesis. (ukri.org)
Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
Expression6
We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramar. (researchgate.net)
Altered expression of circular RNAs (circRNAs) has previously been investigated in breast cancer. (researchgate.net)
Correlation analysis revealed that mRNA TNF receptor associated factor 4 (TRAF4) was associated with DLEU1 expression. (spandidos-publications.com)
The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
In this study, the gene expression profile in GBM was analyzed using a microarray dataset and RNA-sequencing (RNA-Seq) datasets. (spandidos-publications.com)
Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes pathway analysis of DEmRNAs in the DElncRNA‑miRNA‑DEmRNA network was performed. (spandidos-publications.com)
Critical2
To discover the microRNAs regulating this critical transition, we used 80 biopsies from invasive ductal carcinoma, 8 from ductal carcinoma in situ, and 6 from normal breast. (researchgate.net)
These findings suggest miR-486-5p negatively regulates NEK2, which is a critical prognostic indicator of HCC patient survival after liver transplantation. (oncotarget.com)
Messenger1
An intermediate between DNA and protein is called messenger RNA (mRNA), and neurons can transport mRNA to the parts of the neuron close to synapses and locally control the synthesis of a particular protein that is important for those synapses at a particular time. (ukri.org)
Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
Important1
One important function of miRNAs is controlling the local synthesis of proteins that determine the size or shape of dendritic spines, which is an important factor that correlates with the strength of a synaptic connection. (ukri.org)
Cell1
We have identified a single microRNA that controls glioma cell proliferation, migration, and responsiveness to glucose deprivation. (researchgate.net)
Type1
Another type of molecule, called micro RNA (miRNA) can bind to mRNA and stop the translation of mRNA into protein. (ukri.org)
Data1
Our preliminary data show that PICK1, which regulates AMPAR trafficking and dendritic spine morphology during synaptic plasticity, interacts with Ago2 in neurons. (ukri.org)
Brain1
A large proportion of miRNAs are expressed in the brain, and most of these are found in neuronal dendrites associated with synapses. (ukri.org)
Nucleotides2
MicroRNAs (miRNAs) are short, noncoding RNA molecules of 18-24 nucleotides that regulate gene expression through posttranscriptional modification of target mRNA through binding at the 3′ untranslated region. (diabetesjournals.org)
MicroRNAs (miRNAs) are a class of small non-coding RNAs with a length of 21-24 nucleotides. (biomedcentral.com)
Molecules1
These molecules are involved in the post-transcriptional regulation of mRNAs in plants and animals [ 6 , 7 ]. (biomedcentral.com)
Gene expression1
MicroRNAs are a class of conserved small noncoding RNAs that play regulatory roles in gene expression at the post-transcriptional level. (biomedcentral.com)
Human1
In primary human skeletal muscle cells, inhibition and overexpression strategies demonstrate that miR-29a and miR-29c regulate glucose uptake and insulin-stimulated glucose metabolism. (diabetesjournals.org)
Provide2
We also provide evidence that fatty acid oxidation is negatively regulated by miR-29 overexpression, potentially through the regulation of peroxisome proliferator-activated receptor γ coactivator-1α expression. (diabetesjournals.org)
Our results help to understand the regulation of let-7 by 20-hydroxyecdysone (20E) and will provide a reference for functional analysis studies of microRNAs in ticks. (biomedcentral.com)