• But over the past five years, we found this huge, hidden family of microRNAs that we didn't know about that are now showing up in almost every area of biology. (wired.com)
  • The scientists have demonstrated for the first time in an animal model that small ribonucleic acid molecules, so-called microRNAs, also fulfil an important function in organ development. (redorbit.com)
  • According to the researcher's model, the microRNA molecules appear to control the production of a protein called MMP-9. (redorbit.com)
  • miRIDIAN microRNA mimics are chemically synthesized synthetic double-stranded RNA molecules which are intended to mimic the endogenous duplex resulting from Dicer processing. (horizondiscovery.com)
  • If the microRNAs are missing, more MMP-9 proteins are produced and they accumulate near the milk ducts. (redorbit.com)
  • This is because in contrast to early identified ubiquitous and abundant ncRNA, such as the snRNA of the spliceosome, most of the newly identified microRNA for example have low, spatial and temporal expression patterns in accordance to their main function. (cepheid.com)
  • Today it is a major challenge to identify those microRNA and better understand their regulatory functions in normal and pathological cells. (cepheid.com)
  • It is well known that microRNAs perform very important regulatory functions inside living cells. (redorbit.com)
  • This thematic series, published in Journal of Biomedical Science , highlights recent advances in the research field of microRNA. (biomedcentral.com)
  • Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. (biomedcentral.com)
  • Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside. (springer.com)
  • miRIDIAN microRNA mimics require delivery into cells using methods similar to those for siRNA (transfection reagents, electroporation, etc. (horizondiscovery.com)
  • The new study shows that microRNA expression profiles can even distinguish cancerous cells that cannot otherwise be identified on the basis of their outward appearance. (innovations-report.com)
  • Since most paralogous microRNAs conserve their function, it has been suggested that mir-2 evolution is dominated by a birth-and-death dynamics driven by random drift. (wikipedia.org)
  • This is likely to affect the function of that particular microRNA. (wikipedia.org)
  • At the moment, the scientists can only speculate about what happens when the microRNAs do not function correctly. (redorbit.com)
  • We find that vertebrate microRNAs target, on average, roughly 200 transcripts each. (nature.com)
  • Kertesz M, Iovino N, Unnerstall U et al (2007) The role of site accessibility in microRNA target recognition. (springer.com)
  • Brennecke J, Stark A, Russell RB et al (2005) Principles of microRNA-target recognition. (springer.com)
  • Cepheid works on improving microRNA identification and analysis by combining different powerful bioinformatic approaches and regularly updates its proprietary database to detect all microRNA sequence and antisense target with its in-house developed methodology to establish the corresponding regulating antisense interaction network for microRNA. (cepheid.com)
  • Referring to this difficulty and the growing interest of life science industries in microRNA, we combined our expertise in ncRNA and bioinformatics, creating the first annotated database of the non-coding part of the human genome. (cepheid.com)
  • Furthermore, our results suggest widespread coordinate control executed by microRNAs. (nature.com)
  • Selbach M, Schwanhausser B, Thierfelder N et al (2008) Widespread changes in protein synthesis induced by microRNAs. (springer.com)