• We hypothesized that interaction with the Ets family factor PU.1, whose expression is limited to hematopoietic cells, might be nec- essary for activation of target genes like tartrate-resistant acid phosphatase (TRAP) in osteoclasts. (edu.au)
  • Taken in total, the results afford an example of how lineage-specific gene regulation can be achieved by the combinatorial action of two broadly expressed transcription factors. (edu.au)
  • This activation was dependent on intact binding sites for both factors in the TRAP promoter. (edu.au)
  • RANK, similar to other TNF receptor family members, interacts with TNF receptor-associated factors (TRAFs), which in turn act as adaptors to downstream signaling pathways ( 11 ). (jimmunol.org)
  • Osteoclasts are responsible for bone resorption, a process which is regulated by various factors and is delicately balanced with bone formation ( 1 , 2 ). (jimmunol.org)
  • SOX10 can influence the generation of myelin protein transcription through its interactions proteins such as OLIG1 and EGR2, which is important for the functionality of neurons. (wikipedia.org)
  • It directly binds to several transcription factors and either blocks or enhances their activity. (wikipedia.org)
  • The protein encoded by this gene contains an AT-hook DNA binding motif, which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. (wikipedia.org)
  • citation needed] Microphthalmia in newborns is sometimes associated with fetal alcohol syndrome or infections during pregnancy, particularly herpes simplex virus, rubella and cytomegalovirus (CMV), but the evidence is inconclusive. (wikipedia.org)
  • SWI/SNF chromatin remodeling enzymes are multiprotein complexes composed of one of two related ATPases, BRG1 or BRM, and 9-12-associated factors (BAFs). (semanticscholar.org)
  • This evolutionarily conserved domain is found in proteins ranging from yeast to human and is shared by other chromatin-binding proteins, such as scaffold attachment factor A and B. The SAP domain can recognize and bind to AT-rich DNA sequences present in scaffold-attachment regions/matrix-attachment regions. (wikipedia.org)
  • Cells of the osteoclastic and osteoblastic lineages communicate through cell-to-cell contact and paracrine factors in a bidirectional fashion. (jimmunol.org)
  • We set out to identify the promoter(s) of SMAD4 , evaluate their activity in cell lines and define possible transcription factor binding sites (TFBS). (pubmedcentralcanada.ca)
  • Solar UV exposure is a major causative factor for age-related changes such as skin cancer development. (mdpi.com)