The aim of this study was to evaluate the rate of low-volume metastasis in SLNs detected by OSNA in patients with early-stage cervical cancer. (bmj.com)
OSNA detected micro-metastasis in 6/18 (33.3%) patients. (bmj.com)
The sensitivity and negative predictive value of SLN in detecting lymph node metastasis with OSNA calculated per pelvic sidewall were 85.7% and 96.1%, respectively. (bmj.com)
The strongest predictive factor for patient survival in patients with colon cancer is lymph node metastasis ( 2 ). (turkjsurg.com)
It has been estimated that 20-30% patients with early-stage node-negative disease will develop distant metastasis despite adequate surgical resection ( 3 ). (turkjsurg.com)
Ideally, all harvested lymph nodes should undergo serial sectioning and immunohistochemistry (IHC) routinely to detect these occult metastasis but they are time consuming and expensive ( 5 ). (turkjsurg.com)
Generally, with increasing size of metastasis in the SLN there was an increasing risk of further disease in residual lymph nodes. (ox.ac.uk)
Recommendations for proceeding to cALND can be based on the size of metastasis in the SLN, which relates to the risk of further disease in the residual axillary lymph nodes and subsequent regional recurrence. (ox.ac.uk)
Sentinel lymp5
Introduction Growing evidence in the literature supports the accuracy of sentinel lymph node (SLN) biopsy in early-stage cervical cancer. (bmj.com)
Editor's note This paper will feature in a special issue on sentinel lymph node mapping in 2020. (bmj.com)
Sentinel lymph node (SLN) biopsy technique has been described in colon cancer to detect micrometastasis (MM) ( 6 ). (turkjsurg.com)
When is a completion axillary lymph node dissection necessary in the presence of a positive sentinel lymph node? (ox.ac.uk)
BACKGROUND: The management of the axilla in the presence of positive sentinel lymph node (SLN) remains controversial. (ox.ac.uk)
Recurrence1
One of the reasons for recurrence in pathologically node-negative patients could be missed micrometastasis and occult tumor cells on routine histopathological examination or inadequate lymph node harvesting leading to understaging ( 4 ). (turkjsurg.com)
Biopsy3
Methods After IRB approval, consecutive patients who underwent surgery for International Federation of Gynecology and Obstetrics stage IA1 with lymph-vascular space involvement to IB1 between November 2017 and July 2019 and had SLN biopsy and pelvic lymphadenectomy were included. (bmj.com)
ICG guided SLN biopsy can identify metastatic lymph nodes in colon cancer patients that can be missed on H & E staging with relatively higher sensitivity for early (T1/T2) tumours. (turkjsurg.com)
This study was conducted to evaluate the role of SLN biopsy using NIR-fluorescence in colon cancer patients with respect to detection rate, upstaging rate, frequency of aberrant lymph node drainage, accuracy, and sensitivity of the SLN biopsy procedure. (turkjsurg.com)
Colorectal1
Besides, in 70% of CRC cases, it develops from previous neoplasms, such as colorectal bowel adenomatous polyps [ 3 ] . (encyclopedia.pub)
SLNs5
One-step nucleic acid amplification (OSNA) is a rapid assay able to detect cytokeratin 19-mRNA in SLNs, and it can be used for intra-operative detection of low-volume metastases. (bmj.com)
SLNs were detected with indocyanine-green cervical injection and sent intra-operatively for OSNA. (bmj.com)
OSNA is able to intra-operatively detect low-volume metastases in SLNs. (bmj.com)
The aim of this study was to correlate tumour burden in SLNs with that in the residual lymph node basin to determine the likelihood of residual disease in patients with micro- and macrometastasis in the SLN. (ox.ac.uk)
RESULTS: Of 155 patients, 115 (74%) had macrometastases and 40 (26%) micrometastases in the SLNs. (ox.ac.uk)
Survival4
Further studies are necessary to confirm the accuracy of this technique and to assess survival implications of low-volume metastases detected by OSNA. (bmj.com)
The impact of nodal micrometastases demonstrated by molecular assays and adjuvant therapy on survival of patients with stage I pancreatic cancer has not been adequately assessed. (johnshopkins.edu)
Survival did not differ for patients with molecular micrometastases. (johnshopkins.edu)
Adjuvant chemoradiation improves survival in these patients by treating micrometastases not detected by histology. (johnshopkins.edu)
Sensitivity1
Eighteen patients had node positive disease, and SLN was false negative in four of these patients resulting in a sensitivity of 77.77% with a trend towards higher sensitivity for T1-T2 tumours (90% vs. 62.5%, p= 0.068). (turkjsurg.com)
Conclusion1
CONCLUSION: Patients may be advised to forgo cALND where the SLN contains isolated tumour cells or micrometastasis. (ox.ac.uk)
Evidence2
Seventeen (68%) of 25 patients with stage I disease tested had evidence of mutant Kiras in one or more regional nodes. (johnshopkins.edu)
The majority of patients with stage I pancreatic cancer have PCR/RFLP evidence of lymph node micrometastases. (johnshopkins.edu)
Regional1
Archival tumors and regional nodes from 25 patients with stage I cancers were tested for a Kiras oncogene mutation using polymerase chain reaction and analysis for restriction fragment length polymorphisms (PCR/RFLP). (johnshopkins.edu)
Disease2
Many centres forgo completion axillary lymph node dissection (cALND) in the presence of micrometastatic disease. (ox.ac.uk)
Residual axillary disease was detected in 55/155 (35%) patients with macrometastases and 4/40 (10%) with micrometastases. (ox.ac.uk)
Negative1
Forty-eight patients of clinically staged T1-T3 node negative colon cancer underwent laparoscopic/open resection. (turkjsurg.com)
Metastases5
One-step nucleic acid amplification (OSNA) is a rapid assay able to detect cytokeratin 19-mRNA in SLNs, and it can be used for intra-operative detection of low-volume metastases. (bmj.com)
All micro-metastases were detected in patients with bilateral SLN mapping. (bmj.com)
OSNA is able to intra-operatively detect low-volume metastases in SLNs. (bmj.com)
Further studies are necessary to confirm the accuracy of this technique and to assess survival implications of low-volume metastases detected by OSNA. (bmj.com)
Twenty-nine (58.0%) of 50 patients with micrometastatic SLNs underwent ALND and no further metastases were found in non-sentinel lymph nodes. (elsevierpure.com)
Tumor1
Fas/FasL, PD-ECGF and PCNA were examined by immunohistochemistry and apoptotic tumor cells were detected by in situ TUNEL method. (wjgnet.com)
Patients1
OSNA detected micro-metastasis in 6/18 (33.3%) patients. (bmj.com)