• In this study, we evaluated the expression of APC and its association with β-catenin signaling pathway, following the induction of an excitotoxic lesion by kainic acid (KA) injection, which cause pyramidal cell degeneration. (springer.com)
  • We found that kainic acid not only induced neurodegeneration but also arouse several caspase 3-mediated molecular and cellular changes including dendritic plasticity, neurogenesis, and gliosis. (biomedcentral.com)
  • Control and implanted mice were injected intraperitoneally with saline or 25 mg/kg kainic acid, and sacrificed at 1, 3, 6, and 12 hours post treatment. (cdc.gov)
  • Sensitive indices of neural injury were used to evaluate the time course of kainic acid (KA)-induced hippocampal damage in adult C57BL/6J mice (4 months), a strain previously reported to be resistant to kainate-induced neurotoxicity. (cdc.gov)
  • 4 5 6 7 Whether phagocytes that remove necrotic tissue after ischemia are of microglial origin or blood-derived macrophages is an open question. (ahajournals.org)
  • Despite these differences in the character of the diseases, in both models neurovirulence is determined by the sequence of the envelope gene encoding the SU protein (10, 17, 31, 32, 39) and also correlates with the capacity of these viruses to infect microglial cells (39), the resident macrophages of the brain. (healthdocbox.com)
  • Among the prostanoid products of arachidonic acid signaling PGE2 effects via its EP1 receptor were identified as another tonality atmosphere in the P-glycoprotein regula- tory signaling pathway (Pekcec et al. (autoportal.ru)
  • This chapter will provide a brief overview of the basic mechanisms of Ca 2+ signaling, describe the available data about microglial [Ca 2+ ] c signals, and discuss current challenges and future directions of this emerging field. (springer.com)
  • The present paper summarizes recent evidences on implication of microglial chemotaxis and phagocytosis in AD pathology and discusses the mechanisms related to chemotaxis toward injured neurons and phagocytosis of unnecessary debris. (hindawi.com)
  • 20 have shown that oxidation products of lipids, nucleic acids, and proteins are abundantly present in the eyes of patients with geographic atrophy, a form of advanced AMD. (arvojournals.org)