• In microfluidics, typical laboratory processes can be condensed to a miniature device. (tudelft.nl)
  • This thesis presents the development of several new functions to overcome limitations native to small volumes in centrifugal microfluidics (CM). CM is unique in using centrifugal force to drive liquid flow on a preparative or analytical device. (dissertation.com)
  • Postdoctoral Position Systems and Process Design Engineering Droplet Microfluidics The position requires a strong technical background in the field of systems engineering, with experience in modeling, optimization and graph theory based techniques. (umd.edu)
  • We aim to create the next generation of microfluidic devices using rapid fabrication techniques (3D printing, micro-milling and laser cutting) that would drastically simplify the prototyping and assembly processes of microfluidics systems. (uc.edu)
  • specifically, in the past 3 years, our group has published papers in journals whose primary focus is analytical chemistry, diabetes, pharmacology, and microfluidic devices, to name a few. (msu.edu)
  • In addition, the miniaturization of chemical experiments advances analytical chemistry, biochemistry, medicine and environmental science. (dissertation.com)
  • Details of the work, conducted at the BioPhotonics Laboratory at the UCLA Henry Samueli School of Engineering and Applied Science (Los Angeles, CA), are currently available online in the journal Analytical Chemistry . (laserfocusworld.com)
  • More than a simple ensemble of devices, this is a new research field that combines the properties and characteristics of different materials to find innovative and affordable solutions in applications such as sensing, biotechnology, analytical chemistry. (cnr.it)
  • Here, we introduce a two-plate digital microfluidic (DMF) strategy to interface small-volume samples with NMR microcoils. (rsc.org)
  • In this system, a planar microcoil is surrounded by a copper plane that serves as the counter-electrode for the digital microfluidic device, allowing for precise control of droplet position and shape. (rsc.org)
  • The first is a new programmable digital microfluidic (DMF) platform that allows precise manipulation of hundreds of nano-litre sized aqueous droplets. (bilkent.edu.tr)
  • The device performs all the classical microfluidic operations such as dosing, dispensing and mixing, and provides a platform that supports a range of analytical assays in an automated hands-off system such as immune assays or multiplexed rapid genotypic tests. (bilkent.edu.tr)
  • For commercially available and published LAMP-based assays, the main analytical characteristics of the tests are listed, which are often comparable to those based on the method of reverse transcription polymerase chain reaction (RT-PCR), and in some cases are even superior. (crie.ru)
  • In this field, electrochemical immunosensors have demonstrated to offer interesting alternatives against conventional strategies due to their simplicity, fast response, low cost, high sensitivity and compatibility with multiplexed determination, microfabrication technology and decentralized determinations, features which made them very attractive for integration in point-of-care (POC) devices. (mdpi.com)
  • The MM unit designs microfluidic devices and microfabrication in silicon/glass, PDMS, thermoplastics, and agarose, and structured surface modification. (nih.gov)
  • Experience on microfabrication techniques, will be a plus. (ibecbarcelona.eu)
  • Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
  • Thirdly, DARPA of the US Department of Defense supported a series of microfluidic research programs in the 1990s after realizing there was a need to develop field-deployable microsystems for the detection of chemical and biological agents that were potential military and terrorist threats. (wikipedia.org)
  • Rapid detection of transition metals in welding fumes using paper-based analytical devices. (cdc.gov)
  • Third, we explore the feasibility of extending early warning detection with wearable devices. (bvsalud.org)
  • Pre-symptomatic detection is strong even when features are limited to ECG-derivatives, suggesting that this approach may translate to non-invasive wearable devices. (bvsalud.org)
  • Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detection and personalized therapy and will simplify the diagnosis providing more information in less time. (mdpi.com)
  • Here we introduce a novel integrated analytical technology for photochemistry by microfluidic coupling of a HC-PCF nanoflow reactor to supplementary detection devices. (mpg.de)
  • Paper-based lateral flow devices (LFDs) are regarded as ideal low-cost diagnostic solutions for point-of-care (POC) scenarios that allow rapid detection of a single analyte within a fluidic sample, and have been in common use for a decade. (mdpi.com)
  • In recent years, there has been an increasing need for rapid and simultaneous detection of multiple analytes present within a single sample and to facilitate this, we report here a novel solution-detection using a multi-path LFD created via the precise partitioning of the single flow-path of a standard LFD using our previously reported laser direct-write (LDW) technique. (mdpi.com)
  • In addition, video post-processing and contour-detection and tracking algorithms are used to count and label the cells or particles passing through the microfluidic chip. (laserfocusworld.com)
  • Therefore, this study aims to develop a portable on-site/on-chip analysis system by evaluating combinations of microfluidic extraction and detection systems for target toxic radionuclides such as selenium, lanthanide, and actinides. (titech.ac.jp)
  • Two types of microfluidic devices consisting of parallel phase microchip and plug flow microtube were investigated, and optimal conditions for the extraction and detection performance for the target elements were identified. (titech.ac.jp)
  • Detection techniques for target elements included fluorescence microscopy and thermal lens spectrometry, and were also compared to conventional detection methods. (titech.ac.jp)
  • These results provided ample evidence for deploying microfluidic extraction and detection systems for use in elemental screening at Fukushima, achieving acceptable separation efficiencies above 90% for all cases in less than 30 seconds. (titech.ac.jp)
  • The technique using this hybrid microfluidic chip, dubbed microfluidic codes, allows for the automatic detection of cancer cells, bacteria, and viruses and has proven to exhibit an accuracy of more than 90 percent. (futurism.com)
  • the devices are usually straightforward, in one piece and most of the devices use colorimetric detection [2] which is easy to read and requires no equipment. (blackholelab-soft-lithography.com)
  • Advances in microfluidic technology towards flexibility, transparency, functionality, wearability, scale reduction or complexity enhancement are currently limited by choices in materials and assembly methods. (nature.com)
  • Inevitably, the process of creating a complex channel, and then sealing its open surface against another material to create an enclosed channel, is a significant practical obstacle to advances in microfluidic devices. (nature.com)
  • Despite significant advances, few roadblocks has hindered microfluidic systems from replacing convectional bench-top analytical tools and widely penetrate the point of care in low resource settings where they are needed most. (uc.edu)
  • Advances in platforms that drift away from legacy products in terms of both the solid supports and in device architecture are trending in the literature. (chromatographyonline.com)
  • Abstract: Microfluidic technologies developed over the past decades have underpinned the success of the Lab on Chip. (bilkent.edu.tr)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • Various microfluidic approaches have been devised to mimic traversal in vitro by measuring the time required for cells to pass through a constriction. (nih.gov)
  • Microfluidic evaluation of red cells collected and stored in modified processing solutions used in blood banking? (msu.edu)
  • The use of dielectrophoresis in microfluidic devices as a separation or concentration method for particles or cells is becoming an important option for many different applications where short analysis time and quick results are required, such as food safety, environmental monitoring, and clinical analysis. (confex.com)
  • We use computational tools (Computational Fluid Dynamics) and novel experimental setups (automated microfluidic systems) to study these flow states and evaluate the conditions under which they can be harnessed to actuate biomolecular transport and assembly, accelerate DNA replication and separate cells (based on their shape and size). (uc.edu)
  • The SPM unit specializes in complex microscopy and spectroscopy techniques, mathematical models, and image analysis of cells, tissues, and molecular complexes. (nih.gov)
  • In order to demonstrate proof-of-concept for the new platform, the team used the device to measure the density of white blood cells in human whole-blood samples, as white blood cell density is routinely tested to diagnosis various diseases and infections, including leukemia, HIV and bone marrow deficiencies. (laserfocusworld.com)
  • Fatih Sarioglu, an assistant professor in Georgia Tech's School of Electrical and Computer Engineering has added an extra feature to microfluidic chips that would enable them to assign codes onto cells and trace them as they pass through the chips' channels. (futurism.com)
  • These devices find it tough to distinguish particles or cells close in size as the spatial resolution is determined by the size of the laser beam and the optics used to detect scattered light. (e-consystems.com)
  • The core component of a REA test device is a PET chip coated with aluminum and SiO 2 thin layers, onto which biorecognitive molecules are immobilized. (hindawi.com)
  • Upon addition of a sample containing the analyte of interest, a NP-protein-analyte complex is formed in the test device that is captured on the REA chip, for example, via streptavidin-biotin interaction. (hindawi.com)
  • Microfluidic devices also called μ TAS (micro total analysis systems) or lab-on-a-chip systems belong to the most promising technologies studied in this context. (hindawi.com)
  • On the other hand, lab-on-a-chip is concerned with miniaturization and integration of laboratory processes and experiments into single (often microfluidic) chips. (wikipedia.org)
  • In this definition, lab-on-a-chip devices do not strictly have biological applications, although most do or are amenable to be adapted for biological purposes. (wikipedia.org)
  • Lab on a Chip devices are becoming increasingly important for many bio-analytical applications. (confex.com)
  • A lab-on-a-chip (LOC) is a device that facilitates the incorporation of a concatenation of various laboratory functions on a unique integrated circuit. (adejournal.com)
  • The Biosensors for Bioengineering Group is looking for an Early Stage Researcher to work on the development of 3D skeletal muscle tissue integrated within microfluidic organ-on-chip devices. (ibecbarcelona.eu)
  • The contract will be within the framework of the MORFEO project (Muscle-on-a-chip approach to reproduce fibrotic processes in engineered 3D co-culture organoids for Muscular Dystrophy): whose main objective is the development of Muscle-on-chip devices to model Col6-related myopathy. (ibecbarcelona.eu)
  • The microfluidic assembly is placed just above a separate, inexpensive lens that is put in contact with the cell phone's existing camera unit, allowing the entire cross-section of the microfluidic device to be mapped onto the phone's CMOS sensor-chip. (laserfocusworld.com)
  • We are creating the equivalent of a cellphone network on a microfluidic chip. (futurism.com)
  • The analyser uses a submersible microfluidic lab-on-chip device, with low power (~ 1.5 W) and reagent consumption (63 µL per sample). (nature.com)
  • He moved to Southampton in 2004 after 10 years at the University of Glasgow In 2012 he was awarded a Royal Society Industry Fellowship with Sharp Labs to develop microfluidic diagnostic technologies using consumer electronics. (bilkent.edu.tr)
  • A team at Georgia Institute of Technology has found a way to digitize data obtained through microfluidic chips, which could make remote diagnostic testing faster, cheaper, and more accurate. (crsociety.org)
  • The silver enhancement reagents may be integrated into the microfluidic assay platform to be released upon sample addition. (hindawi.com)
  • Shorter diffusion times, the potential for parallelism and the conservation of reagents and samples all contribute to the motivations of microfluidic development. (dissertation.com)
  • 1) a synchronized spectrometer for the measurement of visible light spectra while the device is in motion, (2) a configuration for the generation of small aliquots, (3) a modified passive valve for restricting liquid flow, (4) a liquid deposition method for reagents to a single outlet, (5) two designs for modular development of CM experiments. (dissertation.com)
  • Once the liquid is introduced into the device, it can interact with various reagents that are preloaded onto the paper. (daitime.com)
  • These include the cost and complexity of the fabrication technique, the qualitative or semi-quantitative nature of their readability, and problems with the stability and storage of reagents on paper. (daitime.com)
  • The device miniaturization not only means lower costs through mass production, but also improvement in terms of analysis time, simplicity of use and decrease in consumption of materials (reagents and analytes)(Chandrasekaran et al. (cnr.it)
  • Compared to conventional immunoassays microfluidic systems offer efficient mass transport and a reduced surface to volume ratio. (hindawi.com)
  • a Conventional lithographic techniques for microfluidic devices require a sealing step, as shown by the schematic. (nature.com)
  • As a result, the overlap of the dissolved specimen and the intense light field in the micronsized core is increased manyfold compared to conventional bioanalytical techniques, facilitating highly-efficient photoactivation processes. (mpg.de)
  • for this reason, their technology is based both on the techniques used in integrated circuit manufacturing and on "soft" fabrication methods (Xia & Whitesides, 1998). (cnr.it)
  • develops analytical and computational solution methods. (washington.edu)
  • In this chapter, we describe the fabrication and the characterization of integrated photonic devices based on nanostructured silicon for biochemical optical sensing. (cnr.it)
  • This design could be easily adapted by other microfluidic systems due to its simple design, ease of fabrication, and portability. (nih.gov)
  • Microfluidic systems used in LOC devices allow the manufacture of millions of microchannels, each measuring mere micrometers. (adejournal.com)
  • To resolve the highly variable DMn concentrations in marine systems, both in space and time, the traditional approach needs to be replaced by in situ techniques. (nature.com)
  • knowledge on: general properties of microfluidic systems, physics involved in gas and liquid flow in microchannels, surface forces dominating in the microscale, two-phase flow in microchannels, heat transfer in microchannels in the presence of boiling and condensation, bubbles and droplets manipulation in microfluidic applications. (ntnu.edu)
  • The objective of this research was to evaluate a relatively new technology, microfluidic paper-based analytical devices (uPADs), for measuring the metals content in welding fumes. (cdc.gov)
  • This μFISH implementation makes use of a non-contact scanning probe technology, namely, a microfluidic probe (MFP) that hydrodynamically shapes nanoliter volumes of liquid on a surface with micrometer resolution. (springer.com)
  • Therefore, it is not uncommon for students in the Spence group to be experts in cell culture and cell preparation, but also understand the basics behind laser-induced flow cytometry, chemiluminescence techniques, or how to prepare microfluidic devices from 3D-printing technology. (msu.edu)
  • Nanowerk Highlights ) Microfluidic paper-based analytical device (µPAD) is a type of technology used for fluid analysis that takes advantage of the properties of paper and microfluidic channels. (daitime.com)
  • A team at Georgia Institute of Technology has found a way to digitize information observed on microfluidic chips, resulting in an inexpensive, sophisticated pocket medical testing device that would make testing accurate and convenient outside of hospitals. (futurism.com)
  • The selected candidate will: work in an industry and university collaborative project, perform research and development of lab-scale prototypes for applications, devise new algorithms to model microfluidic devices, perform simulation, modeling or analytical evaluation using tools such as COMSOL, ANSYS, Matlab or other equivalent software packages The candidate should have a Ph.D. degree in engineering, applied physics or some equivalent discipline. (umd.edu)
  • Combined with PDMS (Polydimethylsiloxane) hydrophilic surface treatment and vacuum filling, a microfluidic perifusion system equipped with the bubble trap was successfully applied for long-term culture of mouse pancreatic islets with no bubble formation and no flow interruption. (nih.gov)
  • Electrochemical techniques, for example differential pulse voltammetry, linear sweep voltammetry, Square Wave Voltammetry, and Electrochemical Impedance Spectroscopy cyclic voltammetry, are notable for several factors, including generating no waste due to the usage of electrons for signal acquisition. (mdpi.com)
  • Concern for the economic and environmental impact of chemical analysis has been a driving force behind the miniaturization of analytical analysis. (dissertation.com)
  • For this purpose we employ the combination of experimental techniques in real and reciprocal spaces, including grazing incidence X-ray scattering and fluorescence, off-specular neutron scattering, flicker spectroscopy, etc. (lu.se)
  • Resonance enhanced absorption (REA) nanocolor microfluidic devices are new promising bioassay platforms, which employ nanoparticle- (NP-) protein conjugates for the immunodetection of medically relevant markers in biologic samples such as blood, urine, and saliva. (hindawi.com)
  • From the interaction of these nanomaterials within the near field of electromagnetic fields generated from metallic nanostructures, their emission could be developed and enhanced by the correctly overlapping of spectroscopical properties of both parts of the nano- or micro-luminescent device. (eurekaselect.com)
  • A key milestone in ISH-based techniques was fluorescence in situ hybridization (FISH) (Bauman et al. (springer.com)
  • Illuminating Samples Fluorescence microscopy is a powerful imaging technique widely used in various fields, especially in biomedical research, to visualize and study fluorescently. (laserfocusworld.com)
  • In the last few years, great efforts have been spent in the development of integrated microsystems, devices of few square centimeters in size including microsensors, microfluidic components, reaction chambers, detectors, and so on. (cnr.it)
  • Here, we introduce a device that enables the precise measurement of (i) the size of a single cell, given by its buoyant mass, (ii) the velocity of the cell entering a constricted microchannel (entry velocity), and (iii) the velocity of the cell as it transits through the constriction (transit velocity). (nih.gov)
  • Overview of numerical techniques for the simulation of micro flows. (ntnu.edu)
  • However, there are some drawbacks to using silicon-based devices in biomedical applications such as their high cost and bioincompatibility. (wikipedia.org)
  • Next steps for the device include other potential applications such as counting potential waterborne parasites for water-quality monitoring, says Hongying Zhu, a UCLA Engineering postdoctoral scholar at the BioPhotonics Lab and co-author of the research. (laserfocusworld.com)
  • The course is intended to give an insight into the physics involved in fluid flow in microchannels, including different micro flow devices and their applications. (ntnu.edu)
  • There is growing interest in the development of analytical and separation techniques that can be applied at the microscale level. (confex.com)
  • To streamline analysis processes for waste characterization, simple and portable analytical devices in and around the decommissioning site have been required. (titech.ac.jp)
  • The most recent advancement in the µPAD field is the integration of electronic components into these devices. (daitime.com)
  • The seamless integration of electronic components into paper-based microfluids allows the application of advanced measurement techniques in a simple and cost-effective platform," commented Bezinge. (daitime.com)
  • Since the system fluid dynamics are dependent on the internal pore size, capillary flow is shown to become characterized by structural colour, while independent of channel dimension, irrespective of whether devices are printed at the centimetre or micrometre scale. (nature.com)
  • The fluid flow in paper is driven by capillary forces and controlled by the porosity and geometry of the device. (blackholelab-soft-lithography.com)
  • skills on: solving simple problems of gas and liquid flows in microchannels, designing a microchannel system, evaluation of the appropriate experimental technique for the study of a given flow problem. (ntnu.edu)
  • The device is illuminated from the side by the LEDs using a simple butt-coupling technique. (laserfocusworld.com)
  • Here we demonstrate this method to create self-enclosed microfluidic devices with a few simple steps, in a number of flexible and transparent formats. (nature.com)
  • A. Guillermo Bracamonte , " Frontiers in Nano and Micro-Device Design for Applied Nanophotonics, Biophotonics and Nanomedicine ", Bentham Science Publishers (2021). (eurekaselect.com)
  • Design and fabricate microfluidic devices. (ibecbarcelona.eu)
  • An emerging concept utilizes origami design for physically and functionally flexible electromagnetic devices. (researchgate.net)
  • The idea was to design microfluidic devices with a simpler and less expensive method, the resulting device being portable, easy to use and to dispose. (blackholelab-soft-lithography.com)
  • The development of low-cost, accurate, and easy to operate point-of-need (PON) devices to be used for cancer diagnosis and treatment follow-up is a worldwide need, especially in developing countries. (hokudai.ac.jp)
  • Herein, we demonstrate that adsorptive immobilization via a cationic polymeric interlayer is a competitive and fast technique for the binding of the capture protein streptavidin onto planar SiO 2 surfaces such as REA biochips. (hindawi.com)
  • The manufacture of the device out of PET films by hot embossing or laser micromachining and the physical basics of REA were discussed in detail by Assadollahi et al. (hindawi.com)
  • The traditional bonding techniques used to manufacture silica-particle-based HPLC stationary phases provide many benefits, but can emerging technologies tackle unmet needs? (chromatographyonline.com)
  • The main advantages of these devices are their low cost, portability, and ease of use, which make them well suited for field testing, particularly in resource-constrained settings. (daitime.com)
  • In 1985, Unipath Inc. commercialized ClearBlue, a pregnancy test still used today that can be considered the first microfluidic device containing paper and the first microfluidic product to market. (wikipedia.org)
  • Paper-based analytical devices (PADs) are considered a key solution, as they provide a low-cost platform for developing PON biosensors for cancer biomarker detections. (hokudai.ac.jp)
  • The main properties of paper that are exploited in hybrid devices is the ability of paper to contain and immobilize biosensors. (blackholelab-soft-lithography.com)
  • With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)
  • 8 ]. Current research focuses on the optimization of this system as versatile, fast, and sensitive microfluidic POC one-step-immunoassay platform. (hindawi.com)