Microenvironment of malignant tumor microenvironment. Medical search. Frequent questions

Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in tumor development and metastasis. (springer.com)
The frequency and polarization of tumor-associated macrophages (TAMs) correlate with disease progression, tumor metastasis, and resistance to various treatments. (springer.com)
Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor−node−metastasis prognosis classification. (nature.com)
In summary, we identify a robust signature, which may enhance prognostic decisions in OSCC and better guide treatment to reduce tumor recurrence or lymph node metastasis. (nature.com)
Standard multimodal management of OSCC is based on the tumor−node−metastasis (TNM) classification 2 , in which the tumor size and location and the presence of metastasis are used to define OSCC prognosis and treatment in the clinical setting 3 . (nature.com)
Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
A large amount of evidence indicates that the generation, malignant transformation and metastasis of many solid tumors can be regulated by ion channels. (jcancer.org)
By contrast, increased CCL5 expression resulting from RUNX3 mutation is associated with more tumor metastasis in the lung. (nature.com)
Furthermore, a recent clinical trial for a CCR5 inhibitor treatment to patients suffering from liver metastasis of colorectal cancer showed its effect on reducing tumor mass with better prognosis, suggesting CCL5-CCR5 axis might also provide a procancer activity 22 . (nature.com)
Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
The majority of deaths from breast cancer are not due to the primary tumor itself, but are the result of metastasis to other organs in the body ( 2 ). (iiarjournals.org)
Currently, detection of breast cancer metastasis relies on clinical manifestations of the spread to distant organs, biopsies of affected organs, radiological evaluations, imaging methods and serum tumor markers ( 3 , 4 ). (iiarjournals.org)
An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
We hypothesize that tumor-derived exosomes endow the fibroblasts in tumor microenvironment with invasive phenotype to the benefit of tumor metastasis. (dovepress.com)
It is confirmed that large variety of miRNAs in exosomes play important roles in tumor metastasis and invasion. (dovepress.com)
Metastasis refers to the spread of malignant cells from a primary tumour to distant sites of the body and the adaptation of these cancer cells to a new and different tissue microenvironment. (units.it)
Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. (biomedcentral.com)
Loss of CREB3L1 inhibited metastasis and tumor growth of ATC xenografts in zebrafish and nude mouse model. (biomedcentral.com)
The researchers used single-cell sequencing technology to perform single-cell transcriptome sequencing on 12 cases of prostate cancer primary tumors and 1 case of prostate cancer lymph node metastasis samples. (medicaltrend.org)
Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
Tumor metastasis: molecular insights and evolving paradigms. (medscape.com)

Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
The goal of this proposal is to investigate whether transcranial histotripsy, a proposed novel and non-invasive treatment of brain tumors, can lead to survival benefit in a murine primary malignant brain tumor model. (umich.edu)
Our studies are focused on but not limited to primary brain tumors, which integrates well with the PI's clinical proficiency as a consultant Neuro-oncologist. (lu.se)
Focus within the network is also on improving treatment of pediatric malignant brain tumors in collaboration with national and international groups. (lu.se)

Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Variation in tumor purity (proportion of cancer cells in a sample) can both confound integrative analysis and enable studies of tumor heterogeneity. (nature.com)
Overall, PUREE is a highly accurate and versatile method for estimating tumor purity and interrogating tumor heterogeneity from bulk tumor gene expression data, which can complement genomics-based approaches or be used in settings where genomic data is unavailable. (nature.com)
Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. (nih.gov)
The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. (spandidos-publications.com)
However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. (spandidos-publications.com)
Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. (spandidos-publications.com)
This paper explores the heterogeneity of glioblastoma and the immune microenvironment, providing a therapeutic basis for individualized treatment. (spandidos-publications.com)
Glioblastoma (GBM) is characterized by significant genetic heterogeneity among tumor cells. (spandidos-publications.com)
This heterogeneity is referred to as 'polymorphism', as tumor cells rapidly undergo mitosis, resulting in the formation of numerous subclones and uncertainty regarding the state of the genome. (spandidos-publications.com)
Furthermore, tumor heterogeneity has a significant impact on both the immune microenvironment and the infiltration of various immune cells within tumors, such as cytotoxic T lymphocytes (CTLs) ( 5 ), myeloid antigen-presenting cells ( 6 ) and cancer-associated fibroblasts (CAFs) ( 7 ). (spandidos-publications.com)
This heterogeneity can vary greatly between different types of immune cells, leading to further complexity in understanding the immune response to tumors. (spandidos-publications.com)
This interaction results in a more complex alteration of both the heterogeneity of tumor cells and the heterogeneity of the tumor microenvironment. (spandidos-publications.com)
Consequently, the heterogeneity of tumor cells is constantly evolving. (spandidos-publications.com)
Thus, tumor heterogeneity has an important role in tumor development. (spandidos-publications.com)
These studies reveal a wide range of genetic tumor heterogeneity in both spatial and temporal dimensions, encompassing diverse single-nucleotide mutations, insertions, deletions and copy number variations ( 9 , 10 ). (spandidos-publications.com)
Treatment failure is ascribed to high infiltrative capacity of tumor cells, marked chemo- and radioresistance, a prounounced immunosuppressive tumor microenvironment and a vast cellular heterogeneity. (lu.se)

The proportion of malignant cancer cells in the tumor mass, herein referred to as tumor purity, also impacts genomic analysis such as the estimation of clonal composition 6 and tumor mutation burden 7 , critical for predicting treatment outcomes and selecting patients for immunotherapy. (nature.com)
Despite advances in surgical techniques and multimodal treatment regimens with radio-, chemo-, and immunotherapy [ 3 - 5 ], the prognosis for malignant glioma patients is very poor with a median survival time of approximately 15 months after diagnosis [ 6 , 7 ]. (hindawi.com)
Immunotherapy drugs such as checkpoint inhibitors, which are commonly used to treat melanomas, work to strengthen a patient's immune system so that it can prevent a tumor from "turning off" the ability of the immune system to fight it. (news-medical.net)
Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
however, it is far from ideal because PD-L1-negative tumors may respond to immunotherapy and positive tumors may not. (medscape.com)
Other factors have been suggested to correlate with response to immunotherapy based on clinical and preclinical studies, including elevated type 1 helper T cell (Th1) tumoral gene signature, [ 11 ] and IFN-γ expression, possibly attributable to its ties to other proteins and cytokines within the tumor microenvironment. (medscape.com)

Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
It is one of the most malignant tumors with high morbidity and poor prognosis [ 2 ]. (hindawi.com)
Prognostic biomarkers can estimate the natural course of the disease and divide the tumor into two groups: good prognosis and poor prognosis [ 3 , 4 ]. (hindawi.com)
Therefore, the elevated levels of SLA and LDH indicate the aggravated tumor burden, tumor angiogenesis, tumor progression, and poor prognosis of patients [ 14 ]. (hindawi.com)
FAP expression is associated with a poor prognosis in a variety of tumors, such as colon ( 5 ), pancreatic ( 6 ), ovarian ( 7 ), and hepatocellular carcinoma ( 8 ). (snmjournals.org)
Many molecular tests for diagnosis and prognosis of melanoma are gradually being introduced but markers of early melanoma development, particularly in the tumor microenvironment, remain lacking. (ascopost.com)
Major Goals: Glioblastoma multiforme (GBM) is a malignant primary brain cancer which carries a dismal prognosis. (umich.edu)
EBV-positive tumors have a higher frequency of Crohn's disease-like lymphoid reaction that correlates with an improved prognosis in patients with gastric cancer. (medscape.com)

Pro-inflammatory M1 macrophages hold the potential to engulf tumor cells. (springer.com)
In contrast, anti-inflammatory M2 macrophages, which are predominantly present in tumors, potentiate tumor progression and immune escape. (springer.com)
Targeting macrophages to modulate the tumor immune microenvironment can ameliorate the tumor-associated immunosuppression and elicit an anti-tumor immune response. (springer.com)
Besides, biomimetic carriers based on macrophages have been extensively explored to prolong circulation, enhance tumor-targeted delivery, and reduce the immunogenicity of therapeutics to augment therapeutic efficacy. (springer.com)
Moreover, the genetic engineering of macrophages with chimeric antigen receptor (CAR) allows them to recognize tumor antigens and perform tumor cell-specific phagocytosis. (springer.com)
Herein, we introduce the role of macrophages in tumor progression, summarize the recent advances in macrophage-centered anticancer therapy, and discuss their challenges as well as future applications. (springer.com)
Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. (springer.com)
Komohara Y, Fujiwara Y, Ohnishi K, Takeya M. Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy. (springer.com)
Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer. (springer.com)
Yang QY, Guo NN, Zhou Y, Chen JJ, Wei QC, Han M. The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy. (springer.com)
We also showed that TGFB1 polarized M2-Tumor Associated Macrophages foster immune evasion and that TGFB1 expression correlates with reduced survival probability. (nih.gov)
Furthermore, imaging of intact lungs revealed that macrophages are required for efficient tumor cell extravasation. (elsevierpure.com)
Conclusion/Significance: These data indicate a direct enhancement of metastatic growth by macrophages through their effects on tumor cell extravasation, survival and subsequent growth and identifies these cells as a new therapeutic target for treatment of metastatic disease. (elsevierpure.com)

We further looked at S100A8 expression in 252 benign and malignant melanocytic tumors, which showed prominent keratinocyte-derived S100A8 expression in melanoma, but not in benign tumors. (ascopost.com)
As these patients mature into adulthood, the risk of developing benign and malignant gonadal tumors increases. (medscape.com)

These strategies will expand the toolkit for treating tumors, especially for solid tumors, drug-resistant tumors, and metastatic tumors. (springer.com)
Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
In dentulous patients, 80% of the metastatic tumors to the oral soft mucosa are found in the attached gingiva, whereas in edentulous patients, metastatic lesions are equally distributed between the tongue and the alveolar mucosa. (medscape.com)

These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
For example, the epithelial−mesenchymal transition phenotype presents more cells with a lower degree of differentiation and greater cell dissociation in the ITF than in other tumor areas 14 , 15 . (nature.com)
Morphological-based isolation separates CTCs according to size discrepancies, using isolation by size of epithelial tumor cells (ISET) or according to density, using density-gradient separation ( 4 ). (iiarjournals.org)
This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. (e-booksdirectory.com)

In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Malignant ascites is a complex tumor microenvironment (TME) containing various cells, proteins and extracellular vesicles (EVs). (bmj.com)
Methodology We isolated EVs from malignant ascites of eleven patients by two orthogonal methods and analyzed them by tandem mass spectrometry (MS/MS). We also included MS/MS analysis of EVs from related non-malignant control patient fluids and analysis of ascitic cells by spectral flow cytometry (FC). (bmj.com)
EVs in ascites did not come predominantly from tumor cells, but rather from a variety of non-malignant cell types. (bmj.com)
The metabolism of tumor cells has its own characteristics. (hindawi.com)
To cooperate with the rapid development of tumor, the tumor cells produce energy through glycolysis, which is called the Warburg effect [ 10 ]. (hindawi.com)
In hypoxic conditions, LDH can convert pyruvate to lactic acid to support tumor cells [ 12 ]. (hindawi.com)
Hypoxia inducible factor 1 α (HIF-1 α ) can transcriptionally upregulate LDH-A in tumor cells to ensure anaerobic glycolysis and produce enough lactate. (hindawi.com)
Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
Tumors are complex masses composed of malignant and non-malignant cells. (nature.com)
Cancerous tumors are complex mixtures of malignant and non-malignant cells shaping the tumor microenvironment (TME). (nature.com)
In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
In addition, intrinsic differences in subclonal tumor cells that arise from random mutations can create distinct niches within limited lesions. (spandidos-publications.com)
Various subclonal tumor cells have the ability to modify the tumor microenvironment in order to obtain adaptations. (spandidos-publications.com)
However, rather than actively modifying the environment, multiple mechanisms guide the evolution of tumor cells through the selection of subclones with the most adaptive phenotype by environmental factors ( 1 ). (spandidos-publications.com)
Multiregional whole-exome or genome sequencing has revealed that there is significant variation in the genetic makeup of tumor cells across different anatomical locations and within the same tumor over time ( 4 ). (spandidos-publications.com)
It has been discovered that the genetic structure of tumor cells and the components of the immune microenvironment interact with each other. (spandidos-publications.com)
High-throughput sequencing methods are utilized to analyze the mutational spectrum and evolutionary trajectories of tumor cells. (spandidos-publications.com)
Immune microenvironment and immune status analysis exhibited a strong correlation between risk score and infiltrating immune cells. (figshare.com)
The presence of neoplastic islands, classified as large or small according to the number of cells in the ITF, has been described as the most aggressive pattern compared to tumors with a more uniform growth pattern, as tumor invasion occurs in a more widespread manner as cellular islands or single cells 4 . (nature.com)
The studies in this thesis focused on the immediate and late effects of ionizing radiation on neural stem cells and their microenvironment. (gu.se)
My lab's work has pursued how multiple discrete subpopulations of malignant cells within these tumors cooperatively resist therapy via both tumor cell autonomous mechanisms and crosstalk with the stromal microenvironment. (upenn.edu)
My group seeks precise molecular definition of the epigenetic plasticity that promotes homeostasis of tumor cells that retain malignant potential in the face of standard therapy. (upenn.edu)
Cancer-associated fibroblasts modulate the microenvironment of malignant tumors by secreting factors that regulate both malignant cells and nonmalignant cells such as immune and endothelial cells ( 1 ). (snmjournals.org)
First, via its peptidase activity, FAP leads to matrix digestion and remodeling of the tumor microenvironment, enabling invasion and migration of tumor cells ( 9 ). (snmjournals.org)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
Cancerous tumors are made up of many more components than just malignant cells from the tissue of origin. (sciencedaily.com)
Immune cells can be recruited to the tumor site and form what is known as the tumor microenvironment. (sciencedaily.com)
Astrocytes are non-excitable cells in the CNS that can cause life-threatening astrocytoma tumors when they transform to cancerous cells. (mdpi.com)
The tumor microenvironment evolves throughout malignant development with main modifications in non-malignant cells, cytokine networks, and the extracellular matrix (ECM). (aabioetica.org)
We found that melanoma biomarkers are expressed by specific cell types-some by the tumor cells but others by neighboring cells in the so-called tumor microenvironment. (ascopost.com)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
Circulating tumor cells in the blood stream. (iiarjournals.org)
However, solid tumor cells at rest are known to secrete either very low amounts of galectin-9 or, in most of the cases, do not secrete it at all. (bmj.com)
Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein. (bmj.com)
Results We discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. (bmj.com)
2 , 3 Tumor cell-derived exosomes carry particular molecular components originated from donor cells to mediate tumorigenesis and drive tumor progression by regulating tumor microenvironment. (dovepress.com)
So tumor cells-derived exosomes. (dovepress.com)
10 High expression of miR-21 in melanoma cells inhibits mRNA expression of crucial tumor suppressor proteins such as the tissue inhibitor of metalloproteinases 3 (TIMP3). (dovepress.com)
Malignant tumors are complex tissues which arise from normal cells in a protracted multi-step process. (dkfz.de)
As a consequence, such changes disturb cellular signaling pathways and regulatory circuits in affected cells conferring growth advantages, landscaping the micro-environment of the tumor cells, and supporting escape from immunosurveillance. (dkfz.de)
Concomitantly, new blood vessels are formed, inflammatory cells are recruited, and fibroblasts are activated in the surrounding tumor stroma. (dkfz.de)
The complex interactions between tumor cells and vessel, immune, or stroma cells are not yet traceable in an authentic manner in cell cultures in vitro. (dkfz.de)
We recently discovered that Collagen 1A1 is expressed at high levels in perivascular cells and also in tumor cells themselves. (umich.edu)
To do so we will explore whether cell-type specific depletion of Collagen 1A1 from glioma cells will halt tumor progression. (umich.edu)
Recent findings have demonstrated that cooperativity goes beyond cell intrinsic mechanisms as the tumor interacts with the immediate cells of the microenvironment, the immune system and systemic organs to eventually facilitate malignant progression. (nih.gov)
Usually, millions of cells can be released by a tumour into the circulation every day, but only a tiny minority of these cells are able to reach and colonize a distant organs: the utter inefficiency of the metastatic process implies that cells might strongly need biomechanical alterations that allow them to invade and colonize different tissues. (units.it)
However a trend could be observed: lower aggressive tumour cells were more resistant to deformation compared to the higher aggressive tumour cells. (units.it)
Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)
This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
The team also worked to deliver the CAR T cells directly to the tumor site using regional delivery techniques. (aacr.org)
Using an interventional radiology procedure, the investigators injected IcasM28z CAR T cells directly into the pleural cavity in 21 patients with malignant pleural disease (19 with malignant pleural mesothelioma, one with metastatic lung cancer, and one with metastatic breast cancer). (aacr.org)
These results demonstrate that CREB3L1 maintains the CAF - like property of ATC cells by activating the ECM signaling, which remodels the tumor stromal microenvironment and drives the malignancy of ATC. (biomedcentral.com)
The researchers further studied the infiltrating T cells in prostate tumors and subdivided them into 7 cell subgroups. (medicaltrend.org)
Cell subsets (Cluster 3 and 5) are specifically expressed, and the extracellular vesicles and exosomal pathways of the latter are activated, suggesting that tumor-secreted vesicles mediate the transfer of KLK3 to T cells (Figure 1E). (medicaltrend.org)
Published 20 April 2016 Hypoxia modulates global membrane proteome turnover in cancer cells, providing opportunities for tumor specific drug delivery. (lu.se)
Published 15 August 2016 In this study, we provide new insight into how cancer cells adapt to stress factors present within the tumor microenvironment through increased uptake of lipoproteins. (lu.se)
Published 14 June 2019 See here how lipid loading may be involved in the paracrine crosstalk between cancer cells and stromal compartment of the hypoxic tumor microenvironment. (lu.se)
The rich capillary network of chronically inflamed gingiva has been suggested as a mechanism that entraps malignant cells. (medscape.com)
These hematopoietically active sites may attract metastatic tumor cells. (medscape.com)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)
A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)
Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
This process theoretically provides a line of T cells with greater tumor specificity than those obtained from the blood. (msdmanuals.com)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
TAAs) with high specificity to tumor cells. (msdmanuals.com)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)

Major Goals: Approximately 256,000 new patients are diagnosed with primary brain tumor annually worldwide, and many more patients have brain metastases. (umich.edu)

This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
Tumor recurrence almost invariably occurs and poses one of the most difficult treatment challenges in oncology. (lu.se)

Role of tumor-derived exosomal miR-21 in cell invasion was determined by qPCR. (dovepress.com)
8 , 9 The high-invasion and metastatic tendency of melanoma tumors complicates treatment of the malignancy. (dovepress.com)
Major goal: To elucidate the role played by CXCR4-CXCL12 signaling in the GBM microenvironment in mediating the accumulation of IMCs, facilitating tumor invasion and disease progression. (umich.edu)
The hypothesis that cellular biomechanics may play a significant role in tumour genesis and cancer invasion, gains every day more and more support: therefore characterizing these properties in connection with the membrane and cytoskeleton organization could be very important for understanding better the migration mechanisms and to develop new diagnostics and therapeutics tools. (units.it)
In a primary tumor mass, the ECM is strictly modulated in a tumor - permissive way, which in turn facilitates tumor progression and influences cancer cell invasion. (biomedcentral.com)

In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
DeMixT uses probabilistic modeling to infer proportions of stromal and cancer-cell components from a set of input samples, comprising both tumor and normal-tissue samples 8 . (nature.com)
A ) Tumor growth significantly increased in ETP + -tumor tissue allograft into WT mice. (jci.org)
The tissue examined came from patient biopsies from 12 tumors, ranging from benign to malignant, using the NanoString GeoMx® Digital Spatial Profiler . (ascopost.com)
The study authors concluded, "Together, our results establish a framework for high-plex, spatial, and cell type‒specific resolution of gene expression in archival tissue applicable to the development of biomarkers and characterization of tumor microenvironment interactions in tumor evolution. (ascopost.com)

The book provides a description of noninvasive imaging modalities in diagnosing cancerous tumors of the skin, proffers an analytic framework for assessing the applications of the imaging modalities, and summarizes the state of ongoing research. (e-booksdirectory.com)

Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis, chemotherapy resistance, and immunosuppression. (snmjournals.org)
Because neuropeptide Y is a natural substrate of FAP and the cleavage product has been shown to be proangiogenic, FAP is considered to be involved in tumor angiogenesis, as has been substantiated by studies showing a correlation between FAP expression and microvessel density in tumors ( 10 , 11 ). (snmjournals.org)

It is estimated that there are 53,990 new cases of thyroid cancer in the US in 2018, and thyroid cancer was the fifth most common malignant tumor in American women [ 2 ]. (jcancer.org)
Prostate cancer is the second most common malignant tumor in men worldwide. (medicaltrend.org)

Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. (nature.com)

Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)

In an article published in Annals of Surgery , a team led by physician researchers at Osaka University determined that the number of TILs present in tumors from esophageal cancer (EC) patients could indicate their likelihood of survival. (sciencedaily.com)

However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
The most common, and also the most aggressive, brain tumor in adults is glioblastoma. (lu.se)

Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
Recent evidence demonstrated that galectin-9 is highly expressed in a wide range of human malignancies including the most aggressive tumors, such as high-grade glioblastomas and pancreatic ductal adenocarcinomas, as well as common malignancies such as breast, lung and colorectal cancers. (bmj.com)
Our results suggest that tumor-derived exosomes may facilitate stromal fibroblasts an aggressive phenotype to equip the tumor progression. (dovepress.com)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)

Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
tumor/stroma interactions. (nih.gov)
As the germinal component overgrows the stroma, the benign characteristic histology of gonadoblastoma progresses to a locally infiltrating pattern that predisposes the patient to the malignant spread of the lesion. (medscape.com)

Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
In primary tumors, mutations in driver genes frequently provide a survival advantage and give rise to a dominant clonal population. (spandidos-publications.com)
Researchers determined that the number of tumor-infiltrating lymphocytes (TILs) present in esophageal cancer tumors correlated with patient long-term survival rates. (sciencedaily.com)
tumor model and how it has contributed to our understanding of how these initial simple genetic insults cooperate within the tumor cell to set in motion the malignant transformation program leading to tumor growth through cell growth, cell survival and proliferation, dismantling of cell-cell interactions, degradation of basement membrane and spreading to other organs. (nih.gov)
The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)

13 ]. In addition, high LDH is closely related to increased tumor vascular density and decreased lymphocyte infiltration. (hindawi.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)

Monocarboxylate transporter 4 (MCT4, SLC16A3 ) is elevated under hypoxic conditions in many malignant tumors including gliomas. (hindawi.com)
Furthermore, MCT4 has been shown to be overexpressed in diverse types of neoplasia, among malignant gliomas [ 8 - 14 ]. (hindawi.com)
Major Goals: Gliomas are incurable tumors. (umich.edu)
Machine learning-based identification of glycosyltransferase-related mRNAs for improving outcomes and the anti-tumor therapeutic response of gliomas. (cdc.gov)
Welcome to Belting Lab Projects We develop innovative solutions strongly motivated by the unmet needs of patients with malignant gliomas. (lu.se)

A subset of these are called tumor-infiltrating lymphocytes (TILs). (sciencedaily.com)

FAPI-04 represents a promising tracer for both diagnostic imaging and, possibly, targeted therapy of malignant tumors with a high content of activated fibroblasts, such as breast cancer. (snmjournals.org)

BACKGROUND: Microsatellite instability (MSI) analysis is becoming increasingly important in many types of tumor including colorectal cancer (CRC). (koreamed.org)
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. (news-medical.net)

In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)

Therefore, we aimed at identifying a glycolysis-related prognostic model for HNSCC and to analyze its relationship with tumor immune cell infiltrations. (figshare.com)
Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis, and which plays a critical role in tumor progression in various malignancies. (researchsquare.com)

The biomarkers of early melanoma evolution and their origin within the tumor and its microenvironment are a potential key to early diagnosis of melanoma," said corresponding author of the study Maija Kiuru, MD, PhD , Associate Professor of Clinical Dermatology and Pathology at UC Davis Health. (ascopost.com)

This change in tumor cell metabolism is considered as a major change in tumor transformation. (hindawi.com)
Once the diagnosis of gonadoblastoma is made, the potential risk of malignant transformation warrants surgical removal of the abnormal gonad. (medscape.com)
[ 1 , 2 ] Gonadoblastoma is a rare benign tumor that has the potential for malignant transformation and affects a subset of patients with an intersex disorder or disorder of sex development (DSD). (medscape.com)

provide an excellent local environment for interactions and collaboration between research groups and clinicians working on brain, spinal cord and pituitary tumors. (lu.se)

The ensuing intracellular and extracellular pH disturbances affect multiple aspects of tumour biology, ranging from proliferation to immune surveillance, and can even facilitate further mutagenesis. (bvsalud.org)
The extracellular matrix (ECM) is a fundamental part of the tumor microenvironment. (biomedcentral.com)

Collectively, our results suggest that RUNX3-mediated CCL5 repression is critical for modulating anti-tumor immunity. (nature.com)
Uncover the role of H3.3-G343R mutation in shaping the DNA damage response, anti-tumor immunity and mechanisms of resistance in glioma. (umich.edu)

Our goal is to assess the molecular mechanisms by which mATRX and mIDH1 impact the biology of the tumors and influence the tumor immune microenvironment. (umich.edu)
Almost two decades after the landmark discovery of cooperative oncogenesis between oncogenic Ras V12 and the loss of the tumor suppressor scribble in flies, this and other tumor models have provided new concepts and findings in cancer biology that has remarkable parallels and relevance to human cancer. (nih.gov)
Students We have thesis projects for Masters students in tumor biology. (lu.se)

Lin X, Wu JF, Wang DM, Zhang J, Zhang WJ, Xue G. The correlation and role analysis of KCNK2/4/5/15 in Human Papillary Thyroid Carcinoma microenvironment. (jcancer.org)

Evidence from many studies indicates that KCNKs is abnormally expressed in many solid tumors and plays a regulatory role in the development and malignant progression of cancer. (jcancer.org)

abstract = "Background: The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. (elsevierpure.com)

To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)

However, how metabolism reprogramming promotes tumor progression and immune escape remains unclear. (researchsquare.com)
However, how PKM2 promotes tumor progression and its mechanism remain obscure. (researchsquare.com)

In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity. (nii.ac.jp)

PUREE was trained on gene expression data and genomic consensus purity estimates from 7864 solid tumor samples. (nature.com)
PUREE predicted purity with high accuracy across distinct solid tumor types and generalized to tumor samples from unseen tumor types and cohorts. (nature.com)

Anatomy36

Organisms7

Diseases61

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes43

Disciplines and Occupations2

Information Science3

Health Care6

Metastasis23

Brain tumors4

Heterogeneity17

Immunotherapy7

Prognosis8

Macrophages13

Benign and malignant2

Metastatic tumors3

Epithelial5

Cells80

Metastases1

Recurrence2

Invasion5

Tissue6

Cancerous1

Angiogenesis3

Common malignant tumor2

Proteins2

Immunosuppression1

Present in tumors1

Glioblastoma2

Aggressive4

Stroma3

Survival5

Infiltration2

Gliomas5

Lymphocytes1

Fibroblasts1

Colorectal2

Hypoxic conditions1

Glycolysis2

Biomarkers1

Transformation3

Interactions1

Extracellular2

Anti-tumor immunity2

Biology3

Papillary1

Progression of cancer1

Abstract1

Hypoxia1

Promotes2

Immunity1

Solid tumor2