• Bone marrow loss and a high proclivity to leukemic progression are the characteristics of myelodysplastic syndrome (MDS). (techscience.com)
  • Cancer biology has significantly benefited from the molecular-level detail provided by these tools, allowing elucidation of many perturbations underlying disease onset and progression. (nih.gov)
  • A better comprehension of cellular hierarchies, epigenetic effects, clonal evolution, and their impact on gene regulation might help to understand disease progression, stratify patient risk, and help to improve the treatment of hematopoietic malignancies in the future. (uni-heidelberg.de)
  • Role of cancer stem cell interactions with their microenvironment in disease progression. (rochester.edu)
  • LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. (hindawi.com)
  • There is a growing body of scientific evidence that suggests the potential implication of periodontitis in the causation and progression of various systemic disease and conditions, such as diabetes, cardiovascular disease, pulmonary disease, adverse pregnancy outcomes and cancer. (intechopen.com)
  • Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)
  • He has served as lecturer for course topics ranging from cancer metastasis and microenvironment to glycosylation in health and disease and biology of neoplasia. (uab.edu)
  • Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
  • Frontiers in Cell and Developmental Biology 5 (2017). (anova-irm.com)
  • Seminars in Cell & Developmental Biology. (anova-irm.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive view of the different members of the TGF-β family, the signaling pathways they control, and how they influence development, normal physiology, and disease. (cshlpress.com)
  • This volume is therefore a comprehensive reference on the biology of the TGF-β family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research. (cshlpress.com)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • During the advanced stages of disease, many breast cancer patients suffer from bone metastasis. (biomedcentral.com)
  • Bone is one of the most common sites for metastasis in human breast cancer. (biomedcentral.com)
  • However, there is no single animal model that ideally replicates the entire metastatic process from primary breast tumor to bone metastasis. (biomedcentral.com)
  • Nevertheless, several models that represent various aspects of bone metastasis have been used successfully to study specific features of the disease. (biomedcentral.com)
  • His laboratory studies immune regulation and its relevance to diseases including cancer. (spotify.com)
  • He became a senior scientist at the O'Neal Comprehensive Cancer Center, the UAB Center for Metabolic Bone Disease and the UAB Comprehensive Arthritis, Musculoskeletal and Autoimmunity Center. (uab.edu)
  • 4:00 PM March 8, 2022 - 'Why Don't We Get More Cancer: The critical role of extracellular matrix and microenvironment in malignancy and dormancy? (stanford.edu)
  • To demonstrate the power of this technology, we will generate a molecular disease fingerprint allowing differentiation between three clinically indistinguishable yet biochemically distinct disease pathways underlying the deadly brain cancer glioblastoma multiforme. (nih.gov)
  • Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
  • The cancer cells that emerge are referred to as blasts and share biological features from these disease-specific alterations and patterns associated with differentiation and the tumor cell of origin. (uni-heidelberg.de)
  • In vivo models that mimic the breast cancer-specific osteolytic bone microenvironment are limited. (biomedcentral.com)
  • Previously, we developed a mouse model of tumor-bone interaction in which three mouse breast cancer cell lines were implanted onto the calvaria. (biomedcentral.com)
  • By comparing the TB signature with gene expression profiles from human breast metastases and an in vitro osteoclast model, we demonstrate that our model mimics both the human breast cancer bone microenvironment and osteoclastogenesis. (biomedcentral.com)
  • Our mouse breast cancer model morphologically and genetically resembles the osteoclastic bone microenvironment observed in human disease. (biomedcentral.com)
  • While a number of strategies exist to treat breast cancer bone metastases (e.g., surgery, radiation and/or chemotherapy), none are curative. (biomedcentral.com)
  • TGF-β signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases. (cshlpress.com)
  • The roles of TGF-β signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered. (cshlpress.com)
  • Most recently, targeting lipid rafts modification has become a unified strategy in immunotherapy of cancer, diabetes, cardiovascular diseases and Regenerative medicine for replacing neuron and human coronary artery smooth muscle cell. (symbiosisonlinepublishing.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Cancer is one of the most emblematic diseases of aging in developed countries. (longlonglife.org)
  • Cancer as a disease of aging: what is it, exactly? (longlonglife.org)
  • We will detail each of these points here and use them to understand why cancer is an age-related disease. (longlonglife.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
  • In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, and adipocyte that are crucial for bone metabolism. (ijbs.com)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
  • Next, an overview of several current models of hematopoietic lineage trees to identify developmental branching points between the lymphoid and myeloid cell compartments is discussed. (scielo.br)
  • Acute myeloid leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
  • First, I characterized changes in the transcriptome and classified developmental stages of leukemic cells carrying MLL-EDC4 fusions along the hematopoietic stem cell to the myeloid trajectory compared to other MLL fusions. (uni-heidelberg.de)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • of graft-versus-host disease, which is observed as a major complication of hematopoietic stem cell transplantation. (karger.com)
  • Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
  • Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • The underlying pathophysiology in AML consists of a maturational arrest of bone marrow cells in the earliest stages of development. (medscape.com)
  • Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. (anova-irm.com)
  • Investigators found microenvironment differences in checkpoint blockade immunotherapy-treated cases involving brain metastases versus recurrent glioblastoma. (genomeweb.com)
  • These metastases are predominantly osteolytic and develop when tumor cells interact with bone. (biomedcentral.com)
  • Within the osteolytic lesions of bone metastases, tumor cells interact with osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells), thereby inhibiting normal bone development and ultimately leading to bone destruction [ 1 - 4 ]. (biomedcentral.com)
  • Here we use fresh patient samples that include treatment-naive primary tumor tissue, matched adjacent normal kidney tissue, as well as tumor samples collected from patients with bone metastases. (pklab.org)
  • Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that leads to cognitive impairment and memory loss. (bvsalud.org)
  • The alteration of the lipid metabolism and cholesterol homeostasis contribute to cardiovascular diseases caused by aging of blood vessels, Alzheimer's disease character by neuron degeneration, and so on. (symbiosisonlinepublishing.com)
  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain and the most common form of dementia among the elderly. (rna-seqblog.com)
  • Researchers at The Ohio State University developed an integrated database named scREAD (single-cell RNA-Seq database for Alzheimer's Disease), which is the first database dedicated to the management of all the existing scRNA-Seq and snRNA-Seq datasets from human postmortem brain tissue with AD and mouse models with AD pathology. (rna-seqblog.com)
  • Jiang J, Wang C, Qi R, Fu H, Ma Q. (2020) scREAD: A single-cell RNA-Seq database for Alzheimer's Disease . (rna-seqblog.com)
  • My lab is focused on Alzheimer's disease. (uams.edu)
  • Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. (stanford.edu)
  • The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated. (elifesciences.org)
  • Genetics of transcription factors and their role in aging and disease. (rochester.edu)
  • Patients with AML present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)
  • However, the inflammation-infection distinction becomes crucial for situations in pathology and medical diagnosis where inflammation is not driven by microbial invasion, such as the cases of atherosclerosis, trauma, ischemia, and autoimmune diseases (including type III hypersensitivity). (wikipedia.org)
  • Our laboratory utilizes pharmacologic approaches and genetic models to examine how the changes in the neuronal microenvironment e.g. inflammation, oxidative stress affects cognitive function. (uams.edu)
  • Periodontitis is a highly prevalent, chronic multifactorial infectious disease, induced by the dysbiotic biofilm that triggers a persistent systemic inflammation and recurrent bacteremia. (intechopen.com)
  • PGRN has been introduced among the secreted growth factors as one related to wound healing, inflammation, and human embryonic development, as well as a wide variety of autoimmune diseases. (biomedcentral.com)
  • Bone marrow transplantation 2022 9 57 (12): 1781-1787. (cdc.gov)
  • I could demonstrate that leukemic cells could be successfully distinguished from the microenvironment based on marker gene annotation from the human cell atlas and ploidy inference. (uni-heidelberg.de)
  • Furthermore, these treatment methods have limited efficacy due in part to the fact that they do not effectively target the interaction between tumor cells and bone [ 5 ]. (biomedcentral.com)
  • Our findings provide biological insights into the interplay between tumor cells and the ccRCC microenvironment. (pklab.org)
  • It's a naturally occuring peptide (small sequence of aminoacids, which comprise proteins) in the human body, which binds to the Natriuretic-Peptide Receptor B (NPR B) existing on the surface of chondrocytes, in the bone, which induces the synthesis of cyclic guanosine-3′,5′-monophosphate (cGMP) molecules, which, in turn, inhibit the MAPK pathway of FGFR3 (by inhibiting certain enzymes in this pathway). (beyondachondroplasia.org)
  • and bone morphogenetic proteins, BMPs) that stimulate tumor growth and bone destruction [ 1 ]. (biomedcentral.com)
  • The transforming growth factor β (TGF-β) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. (cshlpress.com)
  • The contributors describe the various TGF-β family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. (cshlpress.com)
  • Depending on anchored proteins through Glycosylphosphatidylinositol (GPI), or other lipids targeting modification, the microdomains of membrane play very important physiological roles in particular organs, such as bone and blood, cardiovascular, liver, brain etc. through intracellular membrane trafficking, cell signaling transduction and adaptation to microenvironment. (symbiosisonlinepublishing.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • In 2003, surveillance for influenza in hospitalized persons was added to the Centers for Disease Control and Prevention Emerging Infections Program network. (cdc.gov)
  • The combination of deep learning with whole-brain computational models reveals the low-dimensional representation of neurodegenerative diseases, which emerges from a highly multidimensional brain, providing valuable insight into pathological states' diagnostic, prognosis, and treatment response. (elifesciences.org)
  • Bone remodeling - It's a dynamic physiological event and active process throughout the skeleton, essential for calcium homeostasis and preserving the integrity of the skeleton, through the coupled activity of osteoclasts and osteoblasts [ 7 ]. (beyondachondroplasia.org)
  • Although neural in origin, their name is slightly misleading: They mature just as readily into bone, muscle or connective tissue as they do into a neuron. (stowers.org)
  • Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
  • Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors. (rochester.edu)
  • In these cases, the release of neutrophil granules and engagement of antitumor immunity may play an important role in eliminating residual disease. (bioxcell.com)
  • The TGF-β family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. (cshlpress.com)
  • Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). (biomedcentral.com)
  • A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
  • When the achondroplasia mutation is present, these cells are deregulated, which affects bone growth [ 10 ]. (beyondachondroplasia.org)
  • In vertebrates, bands of mobile cells fan out from the embryonic brain and spinal cord and then resettle in far-flung locales to form structures as diverse as bone or nerves. (stowers.org)
  • But this paper demonstrated that cells that harbor a disease-causing mutation can be rescued. (stowers.org)
  • Analysis of 22 tumor samples, including multiple myeloma, gastric, breast and thyroid cancers, shows that Numbat can reconstruct the tumor copy number profile and precisely identify malignant cells in the tumor microenvironment. (pklab.org)
  • The molecular basis of human diseases, including but not limited to the most common single-gene cause of intellectual disability and autism, Fragile X Syndrome, and the development of therapeutics. (rochester.edu)
  • Most AML subtypes are distinguished from other related blood disorders by the presence of more than 20% blasts in the bone marrow. (medscape.com)
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
  • Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies. (rochester.edu)
  • Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation. (cdc.gov)
  • I established and adjusted the experimental and bioinformatic procedures to generate reproducible and scalable data by scRNA/ATAC-seq of peripheral blood and bone marrow biopsies from AML patients. (uni-heidelberg.de)
  • Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
  • Sequencing methods that analyze the transcriptome (scRNA-seq) and epigenome (scATAC-seq) are ideally suited to resolve tumor cell heterogeneity as well as non-malignant cell types in the microenvironment. (uni-heidelberg.de)
  • Of interest, we have observed in a rodent transgenerational model of intrauterine growth restriction (IUGR) that a diet supplemented with essential nutrients, yet unaltered in its caloric content, prevents adult metabolic disease and is associated with abrogation of reprogrammed gene expression. (nih.gov)
  • In this study, we identified and used a TB microenvironment-specific gene expression signature from this model to extend our understanding of the metastatic bone microenvironment in human disease and to predict potential therapeutic targets. (biomedcentral.com)
  • Our receptor-ligand interaction analysis reveals a highly complex interactive network of the NB microenvironment from which we highlight several interactions that we suggest for future therapeutic studies. (pklab.org)
  • This developmental arrest results in 2 disease processes. (medscape.com)
  • Biomarkers are indicators used in medical research to measure biological processes, disease processes, and responses to treatment. (beyondachondroplasia.org)
  • Even though the bisphosphonate class of drugs (which target the tumor-bone interface) have been shown to improve the quality of life and disease-free survival in some patients, more therapeutic targets and agents are desirable [ 6 ]. (biomedcentral.com)
  • Animal models are considered useful tools for investigating the pathogenic mechanisms and therapeutic strategies of diseases. (bvsalud.org)
  • Since most hematological malignancies are very heterogeneous diseases, robust patient-specific prognostic signatures are required for clinical applications. (nature.com)
  • MDS is a bone marrow disease of unknown etiology that occurs most often in older patients and manifests as progressive cytopenias that occur over months to years. (medscape.com)
  • [ 4 ] Particularly increased risk exists for AML that occurs after chemotherapy for another disease or for de novo AML with an abnormality of chromosomes 5, 7, or both. (medscape.com)
  • In adults, bone turnover occurs mainly through bone remodeling [ 8 ]. (beyondachondroplasia.org)
  • Welfare in Europe and Japan, for immuno- ods for developmental neurotoxicity and System toxicity testing in adult rodents. (cdc.gov)
  • Sanderson was promoted to professor of pathology, neurobiology and developmental sciences in 2000 before being named the Drs. Mae and Anderson Nettleship Endowed Chair in Oncologic Pathology in 2002. (uab.edu)
  • Second, the rapid proliferation of the abnormal myeloblasts, along with a reduction in their ability to undergo programmed cell death (apoptosis), results in their accumulation in the bone marrow, the blood, and, frequently, the spleen and liver. (medscape.com)
  • Previous studies have reported the anti-inflammatory effects of wogonoside in several diseases. (oncotarget.com)