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  • implantable
  • In some embodiments, an implantable microelectrode is provided with a shank comprised of a laterally extending platform whose thickness and/or configuration contributes to reduced tissue encapsulation, with at least one electrode site disposed at least partially on or in the laterally extending platform. (google.com)
  • Novel methods of designing, making, and using an implantable microelectrode or biosensor resulting in reduced tissue encapsulation are also disclosed. (google.com)
  • 2. The implantable microelectrode of claim 1 , wherein the laterally extending platform further comprises at least one longitudinal rib and at least one radially projecting rib projecting from the portion and wherein the configuration of the longitudinal rib, the radially extending rib, and the backbone portion form at least one open space in the laterally extending platform. (google.com)
  • 3. The implantable microelectrode of claim 2 , wherein at least one electrode site is disposed at least partially on or in the longitudinal rib. (google.com)
  • 4. The implantable microelectrode of claim 1 or 2 , wherein the laterally extending platform has a thickness between about 0.5 and 10 microns. (google.com)
  • 5. The implantable microelectrode of claim 1 or 2 , wherein the at least one electrode site includes a plurality of microelectrodes disposed on the laterally extending platform. (google.com)
  • 6. The implantable microelectrode of claim 5 , wherein at least one of the electrode sites is disposed on the most lateral edge of the laterally extending platform or within about 10 microns of the most lateral edge. (google.com)
  • 7. The implantable microelectrode of claim 1 or 2 , wherein the shank further comprises a tip whose shape is chiseled, conical, frusto-conical, or any combination thereof. (google.com)
  • 8. The implantable microelectrode of claim 1 or 2 , wherein the backbone portion and the laterally extending platform further comprise at least one layer of a non-conductive material and a layer of electrically conductive material comprising at least one electrical channel on top of the non-conductive material or between multiple layers of a non-conductive material. (google.com)
  • 10. The implantable microelectrode of claim 9 , wherein the at least one electrode site disposed at least partially on or in the laterally extending platform comprises surface area disposed at least partially on or in the top, bottom, and/or most lateral sides of the laterally extending platform. (google.com)
  • biosensor
  • Here, we developed an interdigitated microelectrode (IME) biosensor coated with an anti-BDNF an anti-BDNF antibody in a polydimethylsiloxane (PDMS)-based microfluidic channel chip. (nih.gov)
  • recordings
  • Multi-unit recordings obtained from current fixed microelectrode technologies typically show deterioration in signal quality with time and almost all of them fail over periods ranging from few weeks to few years. (pubmedcentralcanada.ca)
  • Further, the same microelectrode technology can often yield successful multi-unit recordings for widely varying durations of time before they fail. (pubmedcentralcanada.ca)
  • In this study, we examined the existence of gamma oscillations during polysomnographically defined sleep-wake states using large-scale microelectrode recordings (up to 56 channels), with single-cell and spike-time precision, in epilepsy patients. (jneurosci.org)
  • Recent studies and prior reports indicate changes in enzyme activity and selectivity with certain glutaraldehyde cross-linking procedures that may jeopardize the performance of microelectrode recordings and lead to falsely elevated responses in biological systems. (nih.gov)
  • array
  • The combination of microelectrode array and RTIL, as well as the absence of membrane and volatile solvent, results in an elegant, easy to calibrate gas sensor with potential utility in standard and non-standard conditions. (csic.es)
  • The image on the right is a magnification of a microelectrode array tip with 50 × 150 μm 2 sites. (nih.gov)
  • position
  • Increased influence of convection, obtained by altering the flow rate or by changing the position of the microelectrode in a wall-tube flow cell, at low support ratios in organic solvents was found to result in decreased currents as a consequence of the inability to maintain a sufficient amount of ions at the vicinity of the microelectrode surface. (diva-portal.org)
  • increase
  • The admittance of microelectrodes is well described by a constant phase element model such that both the real and imaginary admittance increase with frequency raised to a power of 0.84-0.96. (rsc.org)
  • Contact between a cell and a microelectrode does not appreciably increase noise. (rsc.org)
  • The increase in the roughness of the microelectrodes surface was imaged using digital holographic microscopy and electron microscopy. (epfl.ch)
  • sites
  • As expected, responses to electroactive amino acids (Cys, Tyr, Trp) were detected at both nonenzyme-coated and enzyme-coated microelectrodes sites, while the remaining amino acids yielded no detectable responses. (nih.gov)