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  • Rats
  • Changes in hypothalamic monoamine metabolism was investigated in freely moving streptozotocin (STZ)-induced diabetic rats by using in vivo microdialysis technique. (nii.ac.jp)
  • study
  • The microdialysis principle was first employed in the early 1960s, when push-pull canulas and dialysis sacs were implanted into animal tissues, especially into rodent brains, to directly study the tissues' biochemistry. (wikipedia.org)
  • membrane
  • While water-soluble compounds generally diffuse freely across the microdialysis membrane, the situation is not as clear for highly lipophilic analytes, where both successful (e.g. corticosteroids) and unsuccessful microdialysis experiments (e.g. estradiol, fusidic acid) have been reported. (wikipedia.org)
  • The recovery can be determined at steady-state using the constant rate of analyte exchange across the microdialysis membrane. (wikipedia.org)