• Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
  • They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)
  • The resemblance to the plasmalemma was obvious, and the microscope pictures served as the first evidence for the cell membrane being a bilayer lipid structure. (wikipedia.org)
  • Only the localized part of the cell membrane brought to the permeabilized state by the external field is competent. (uni-bielefeld.de)
  • The presence of phospholipids on the mammalian cell membrane imparts a net negative charge [ 10 ], restricting anionic entities to bind and subsequent transport into the cell. (biomedcentral.com)
  • The transfer of material from phospholipid-coated microbubbles to cell membranes has been hypothesized to play a role in ultrasound-mediated drug delivery. (ox.ac.uk)
  • We further show that polyethylene-glycol, used in many clinical microbubble formulations, also has a major impact on both membrane lipid ordering and the extent of lipid transfer, and that this occurs even in the absence of ultrasound exposure. (ox.ac.uk)
  • Microbubbles are commonly used as intravascular ultrasound imaging probes and are becoming increasingly popular tools for targeted drug delivery. (hindawi.com)
  • Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations. (plos.org)
  • Fekri F, Delos Santos RC, Karshafian R, Antonescu CN (2016) Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. (plos.org)
  • Our results indicate that transfer of phospholipids alters the organization of molecules in cell membranes, specifically the lipid ordering or packing, which is known to be a key determinant of membrane mechanical properties, protein dynamics, and permeability. (ox.ac.uk)
  • Liposomes are most often composed of phospholipids, especially phosphatidylcholine, and cholesterol, but may also include other lipids, such as those found in egg and phosphatidylethanolamine, as long as they are compatible with lipid bilayer structure. (wikipedia.org)
  • These are composed of natured phospholipids and may contain mixed lipid chains with surfactant properties (e.g. egg phosphatidyl ethanolamine). (ijpsr.com)
  • In this study, we employed quantitative fluorescence microscopy techniques to investigate this phenomenon in both artificial and biological membrane bilayers in an acoustofluidic system. (ox.ac.uk)
  • A major barrier for the efficacy of many clinically relevant anti-cancer drugs (e.g. gemcitabine, 5-flurouracil, cisplatin) is the passage of these molecules across biological membranes, whether in the context of transit across an endothelial monolayer or across the plasma membrane of the cancer cell itself [ 5 ]. (plos.org)
  • These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
  • USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. (plos.org)
  • The word liposome derived from two Greek words Lipo means Fat and Soma means Body, it is named so because of its composition resemblance with phospholipids. (ijpsr.com)
  • Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. (plos.org)
  • Pulsing conditions inducing reversible permeabilization of the cell plasma membrane are not sufficient to induce gene transfer. (uni-bielefeld.de)
  • For example, a subset of astrocytoma cells with ultra-long, thin, and highly dynamic membrane protrusions named tumor microtubes are able to extend in the surrounding tissue for tumor cell invasion, proliferation, and connection between tumor cells ( 11 ). (frontiersin.org)
  • Further generation of drug delivery systems will include true molecular targeting, immunoliposomes and other ligand directed constructs that represent emphasize on biological components capable of tumor recognition with delivery technologies. (ijpsr.com)
  • it is so named because its composition is primarily of phospholipid. (wikipedia.org)
  • Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
  • They were discovered when Bangham and R. W. Horne were testing the institute's new electron microscope by adding negative stain to dry phospholipids. (wikipedia.org)
  • The results of the present study provide strong evidence for the transfer of material from microbubble coatings into cell membranes. (ox.ac.uk)
  • Liposomes are most often composed of phospholipids, especially phosphatidylcholine, and cholesterol, but may also include other lipids, such as those found in egg and phosphatidylethanolamine, as long as they are compatible with lipid bilayer structure. (wikipedia.org)
  • The resemblance to the plasmalemma was obvious, and the microscope pictures served as the first evidence for the cell membrane being a bilayer lipid structure. (wikipedia.org)
  • The phospholipid bilayer provides excellent membrane permeability and protects the encapsulated agents from degradation [ 12 ]. (thno.org)
  • The results of the present study provide strong evidence for the transfer of material from microbubble coatings into cell membranes. (ox.ac.uk)
  • Cell culture contamination occurs when unwanted chemical or biological substances or microorganisms infiltrate a biological mixture and damage cells in some way. (akadeum.com)
  • Chemical substances can rupture cell membranes or affect the cell's typical behavior. (akadeum.com)
  • Dead cells are not necessarily chemical or biological contaminants, but they can have the same effect on a cell population. (akadeum.com)
  • Contrast agents such as microbubbles and nanodroplets have been shown to increase efficacy in a variety of in vitro and in vivo applications including drug delivery, gene transfection, and cancer cell death. (thno.org)
  • Phospholipids are the basic building blocks that make up cell membranes, which separate what s inside a cell from everything else outside. (regenerativemedicine.net)
  • prepared and evaluated pharmacologic and biological properties of a paclitaxel-hyaluronan bioconjugate (ONCOFID™-P, 20% drug content) against human ovarian cancer IGROV-1 and OVCAR-3 xenografts following intraperitoneal administration. (medscape.com)
  • 1. Department of Chemical and Biological Engineering. (thno.org)
  • A major limitation of microbubbles is their inability to leave the bloodstream due to their large size (1-5 µm diameter), which limits their utility to intravascular imaging. (thno.org)
  • 9 - 11 Our group and others have shown that these microbubbles can be further modified for further diagnostic utility in vivo detection for disease targeting and biosensing. (thno.org)
  • The communication process they found requires a group of naturally occurring oxidized phospholipids called OOH-phosphatidylethanolamines (OOH-PEs). (regenerativemedicine.net)
  • As organelles of ~30 to ~200 nm in diameter and 1.08 to 1.22 g/mL in density [ 6 , 7 ], exosomes are budded from the endosome membrane and endowed with a variety of distinctive features, playing a significant role in multiple biological processes [ 8 , 9 ]. (thno.org)