AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentTechnology, Industry, AgricultureHealth CareGeographicals
KeratitisEye Infections, FungalEye Infections, BacterialCorneal UlcerAcanthamoeba KeratitisContact LensesEye InfectionsFusariosisContact Lenses, HydrophilicEye Infections, ParasiticCorneaKeratitis, HerpeticAmebicidesKeratitis, DendriticAcanthamoebaSiliconesPseudomonas InfectionsFungiOphthalmologic Surgical ProceduresPseudomonas aeruginosaAnti-Infective AgentsIndiaBacterial InfectionsNatamycinCorneal StromaKeratoplasty, PenetratingRisk FactorsAnti-Bacterial AgentsTrifluridineRetrospective StudiesContact Lens SolutionsOphthalmic SolutionsFusariumAdministration, TopicalCorneal DiseasesBlepharitisMycoses
FungalOphthalmologyInfectiousConjunctivitisWear and microbial keratitisInfectionsCorneaInfectionFeature of bacterial keratitisUlcerationBlindnessFusariumManagement of microbialMorbidityPseudomonasEpidemiologyIncidencePatientsSevereAntimicrobialDiagnosisMicrobiologyStromal keratitisAcanthamoebaCollagen CrosslinkingInfectiveKeratoconusUlcersBacteriaUlcerativeComplicationsAtypicalVitroMicrobiologicalAbrasionProgressionTreatmentVascularizationCausativeEmergencyOutbreaksOvernightCases
Fungal23
  • Recent findings CXL has been used in cases with bacterial, fungal as well as amoebic keratitis. (medscape.com)
  • Its efficacy in fungal and amoebic keratitis is questionable. (medscape.com)
  • Existing evidence does not support its use in fungal or amoebic keratitis. (medscape.com)
  • Up to 20% of cases of fungal keratitis (particularly candidiasis) are complicated by bacterial coinfection. (medscape.com)
  • Fungal keratitis can occur after a corneal injury involving plant material. (medlineplus.gov)
  • The use of an ocular microbiology lab is a major boost to diagnose fungal keratitis. (ophthalmologytimes.com)
  • Other approaches to help diagnose fungal keratitis have proven to be useful, including molecular analyses, confocal microscopy, and anterior segment optical coherence tomography (OCT). (ophthalmologytimes.com)
  • Dr. Alfonso shared images from an anterior segment OCT in which a patient had fungal keratitis. (ophthalmologytimes.com)
  • Here we see fungal keratitis and the importance of OCT," he said. (ophthalmologytimes.com)
  • Corneal scrapings, crosslinking, and the use of photodynamic therapy are other treatments for fungal keratitis, Dr. Alfonso said. (ophthalmologytimes.com)
  • A study was made of the trend of ophthalmic fungal corneal keratitis in the greater Cairo area of Egypt and its association with climate records during the same period. (who.int)
  • Data on diagnosed cases of fungal keratitis were collected from records of ophthalmic departments of Cairo University hospital and atmospheric temperature and humidity for the greater Cairo area were obtained from online records. (who.int)
  • Reports Of Fungal Keratitis Infections In Contact Lens Wearers. (yourlawyer.com)
  • Thus far, the CDC has received 109 reports of suspected fungal keratitis from 17 different states. (yourlawyer.com)
  • Clinicians are advised to consider the potential for fungal infection in patients presenting with microbial keratitis and to refer them to an ophthalmologist for specimen analysis if warranted. (yourlawyer.com)
  • Additional information regarding the risk for fungal keratitis in contact lens users may be obtained by contacting Nancy Pressly by fax to 1-301-594-2968, email to [email protected] , or by correspondence addressed to the FDA Office of Surveillance and Biometrics (HFZ-510) at 1350 Piccard Drive, Rockville, Maryland, 20850. (yourlawyer.com)
  • Healthcare professionals are encouraged to report cases of fungal keratitis to the FDA's MedWatch reporting program by phone at 1-800-FDA-1088, by fax at 1-800-FDA-0178, online at http://www.fda.gov/medwatch, or by mail to 5600 Fishers Lane, Rockville, MD 20852-9787. (yourlawyer.com)
  • Need Legal Help Regarding Contact Lens Fungal Keratitis Infections? (yourlawyer.com)
  • 18. Comparison Between Polymicrobial and Fungal Keratitis: Clinical Features, Risk Factors, and Outcome. (nih.gov)
  • In an attempt to apply deep learning algorithms to help rapidly discriminate between fungal keratitis (FK) and bacterial keratitis (BK), researchers recently found that a convolutional neural network with ensemble learning called DeepKeratitis had the best results compared with single architecture models. (reviewofoptometry.com)
  • Deep learning for discrimination between fungal keratitis and bacterial keratitis: DeepKeratitis. (reviewofoptometry.com)
  • Aspergillus flavus , one of the causative agents of human fungal keratitis, can be phagocytosed by human corneal epithelial (HCE) cells and the conidia containing phagosomes mature into phagolysosomes. (biomedcentral.com)
  • In tropical countries A. flavus is the predominant pathogen causing fungal keratitis of the cornea [ 5 ] along with Fusarium solani . (biomedcentral.com)
Ophthalmology1
  • 14. [Severe bacterial keratitis referred to ophthalmology emergency departments: a retrospective study of 268 cases]. (nih.gov)
Infectious10
  • Chan TC, Li EY, Wong VW, Jhanji V. Orthokeratology-associated infectious keratitis in a tertiary care eye hospital in Hong Kong. (swisscoat.com)
  • Infectious keratitis related to overnight orthokeratology. (cdc.gov)
  • Infectious keratitis after overnight orthokeratology in Canada. (cdc.gov)
  • Keratitis, inflammation of the cornea, can result in partial or total loss of vision and can result from infectious agents (e.g., microbes including bacteria, fungi, amebae, and viruses) or from noninfectious causes (e.g., eye trauma, chemical exposure, and ultraviolet exposure). (cdc.gov)
  • Austin A, Lietman T, Rose-Nussbaumer J. Update on the management of infectious keratitis. (medlineplus.gov)
  • Bacterial keratitis causes most cases of infectious keratitis. (crstodayeurope.com)
  • Many ocular diseases with high morbidity are inherently infectious including blepharitis, bacterial conjunctivitis, microbial keratitis, herpetic keratitis, endophthalmitis, and adenoviral keratoconjunctivitis, while others such as dry eye disease are inflammatory and may have a microbial component. (nih.gov)
  • 13. [Infectious keratitis after penetrating keratoplasty]. (nih.gov)
  • Infectious keratitis is a serious sight-threatening ocular infection and one of the most significant complications of contact lens usage. (biotissue.com)
  • Infectious Diseases of the External Eye: Microbial and Parasitic Infections. (balimedicaljournal.org)
Conjunctivitis2
  • Plus, these deposits can increase the risk for contact lens-related complications, such as papillary conjunctivitis, punctate keratitis, and microbial keratitis. (lens.com)
  • 12. Loss of an eye in a baby from keratitis initially managed as conjunctivitis. (nih.gov)
Wear and microbial keratitis1
  • 16. Contact lens wear and microbial keratitis. (nih.gov)
Infections8
  • Pseudomonas aeruginosa , a versatile Gram-negative pathogen that can cause a wide range of infections, is the most common causative agent in cases of bacterial keratitis associated with contact-lens use. (nih.gov)
  • There is increasing evidence to suggest that keratitis infections are associated with a phylogenetic subgroup of P. aeruginosa isolates carrying the gene encoding the potent cytotoxin exotoxin U, one of two mutually exclusive exotoxins secreted via the type III secretion system. (nih.gov)
  • The mechanisms behind this association are unclear, but understanding the genetic differences that predispose P. aeruginosa to cause corneal infections may allow for the development of targeted and more effective future treatments to reduce the morbidity of P. aeruginosa keratitis. (nih.gov)
  • Incidence of bacterial keratitis varies considerably, with less industrialized countries having a significantly lower number of contact lens users and, therefore, significantly fewer contact lens-related infections. (medscape.com)
  • In this chapter, we will focus on keratitis caused by atypical mycobacterium, since a great number of recent clinical reports of NTM ocular infections are of keratitis. (intechopen.com)
  • These clinical signs are not pathognomonic to a specific microbial ocular infection and hence occur in most bacterial ocular infections. (hindawi.com)
  • They say that wearers should always seek medical attention sooner rather than later for any discomfort, redness, pain, blurred vision or light sensitivity to avoid infections, such as microbial keratitis, which can lead to blindness. (swbh.nhs.uk)
  • Contact lens usage increases the risk of infections such as microbial keratitis. (medscape.com)
Cornea5
  • Given the limited treatment depth of cross-linking to the anterior third of cornea, future studies can focus on its possible utilization in early keratitis. (medscape.com)
  • Bacterial keratitis is an infection of the cornea (the clear dome covering the colored part of the eye) that is caused by bacteria. (cdc.gov)
  • Keratitis is the clinical diagnosis of inflammation of the cornea, which if left untreated, can lead to blindness of the patient. (ukessays.com)
  • Sutureless amniotic membrane transplantation for severe bacterial keratitis: Cornea. (biotissue.com)
  • Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (biotissue.com)
Infection7
Feature of bacterial keratitis1
  • One feature of bacterial keratitis is rapid progression if left untreated - microbial keratitis is a true ocular emergency that requires immediate and intensive evaluation and treatment. (swbh.nhs.uk)
Ulceration3
  • 6 In keratoconjunctivitis sicca the corneal epithelium develops punctate staining, filamentary keratitis, and ulceration due to partial or total tear deficiency. (bmj.com)
  • The disease affects the corneal epithelium, causing microbial keratitis, ulceration and perforation. (cdc.gov)
  • Microbial keratitis and corneal ulceration associated with therapeutic soft contact lenses. (biotissue.com)
Blindness4
  • If left untreated, bacterial keratitis can result in vision loss or blindness. (cdc.gov)
  • The pair have written an article on 'Contact lens related microbial keratitis - avoidable blindness' which has been published in the International Journal of Ophthalmic Practice). (swbh.nhs.uk)
  • Mohammad said: "Microbial keratitis is one of the main eye traumas for people using contact lenses and can lead to blindness. (swbh.nhs.uk)
  • In severe cases, microbial keratitis can cause blindness or require corneal transplant. (medscape.com)
Fusarium2
  • outbreaks of Fusarium and Acanthamoeba keratitis have been associated with contact lens multipurpose solution use ( 4,5 ), and poor contact lens hygiene is a major risk factor for a spectrum of eye complications, including microbial keratitis and other contact lens-related inflammation ( 3,6,7 ). (cdc.gov)
  • The FDA and CDC are continuing to investigate these case reports and identify specific behaviors that place contact lens wearers at increased risk for Fusarium keratitis . (yourlawyer.com)
Management of microbial2
  • Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of microbial keratitis. (medscape.com)
  • [ 3 ] This review will summarize the most recent findings and future considerations for the use of CXL in management of microbial keratitis. (medscape.com)
Morbidity3
  • Purpose of review Microbial keratitis is one of the leading causes of ocular morbidity. (medscape.com)
  • Microbial keratitis is a common sight-threatening ophthalmic emergency that requires prompt diagnosis and judicious antimicrobial treatment to mitigate ocular morbidity. (crstodayeurope.com)
  • Microbial keratitis can cause significant visual morbidity and is a common reason for presentation to eye casualty clinics. (qxmd.com)
Pseudomonas2
  • This study is a literature review to support future experimental studies which will be conducted to examine the expression of IL-1b and MMP-9 on pseudomonas keratitis after administration of EGCG. (balimedicaljournal.org)
  • Pseudomonas Keratitis, a Review of Where We've Been and What Lies Ahead. (balimedicaljournal.org)
Epidemiology2
  • Epidemiology of contact lens-related inflammation and microbial keratitis: a 20-year perspective. (cdc.gov)
  • However, the overall burden and the epidemiology of keratitis in the United States have not been well described. (cdc.gov)
Incidence9
  • It still needs higher quality clinical trials to find out the incidence rate of microbial keratitis due to ortho-k wear. (swisscoat.com)
  • In 2013, there is a research from America attempting to estimate the incidence rate of microbial keratitis associated with ortho-k lens wear. (swisscoat.com)
  • They surveyed 200 optometrists who practised orthokeratology, and found that the estimated incidence rate of microbial keratitis was 14 in 10000 ortho-k wearing children per year. (swisscoat.com)
  • Such incidence rate is similar to adults who wore daily silicone hydrogel soft contact lenses (A research from Australia found that the incidence rate of microbial keratitis was 12 in 10000 silicone hydrogel soft contact lens wearing adults per year 4 ). (swisscoat.com)
  • The incidence of contact lens-related microbial keratitis in Australia. (swisscoat.com)
  • The incidence of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. (cdc.gov)
  • To estimate the incidence and cost of keratitis, national ambulatory-care and emergency department databases were analyzed. (cdc.gov)
  • Developing effective prevention messages that are disseminated to contact lens users and investigation of additional preventive efforts are important measures to reduce the national incidence of microbial keratitis. (cdc.gov)
  • In fact, most countries with case-reporting systems have documented significant increases over the past few decades in foodborne microbial diseases incidence [ 6 ]. (hindawi.com)
Patients6
  • Episodes of keratitis and contact lens disorders cost an estimated $175 million in direct health care expenditures, including $58 million for Medicare patients and $12 million for Medicaid patients each year. (cdc.gov)
  • Because a specific International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code for microbial keratitis does not exist, a set of keratitis-related codes that could apply to microbial keratitis patients was developed with clinician input. (cdc.gov)
  • 8. Infective keratitis in older patients: a 4 year review, 1998-2002. (nih.gov)
  • Patients with symptoms or evidence of keratitis should be referred to an ophthalmologist. (msdmanuals.com)
  • Their research, over a four month period in 2010, showed that out of 192 patients who attended the Eye Centre's A&E department with contact lens related problems 110 had microbial keratitis. (swbh.nhs.uk)
  • Fifteen patients with CoNV predominantly associated with microbial keratitis wereincluded. (ulster.ac.uk)
Severe3
  • He highlighted the case of a man with severe keratitis last year in whom photodynamic therapy was used. (ophthalmologytimes.com)
  • 9. [Clinical, microbiological and therapeutic features of severe bacterial keratitis]. (nih.gov)
  • Early intervention by PROKERA ® promotes epithelialization and reduces pain, inflammation, and haze in severe bacterial keratitis. (biotissue.com)
Antimicrobial3
  • 76.5% of keratitis visits result in antimicrobial prescriptions. (cdc.gov)
  • Antimicrobial management of presumed microbial keratitis: guidelines for treatment of central and peripheral ulcers. (bmj.com)
  • Culturing microbial pathogens remains the gold standard for identifying the causative organism and determining appropriate antimicrobial therapy. (crstodayeurope.com)
Diagnosis2
Microbiology1
  • The webinar will offer pearls for ophthalmologists from a low-middle-income country (LMIC) to make treatment decisions for microbial keratitis using basic ocular microbiology methods. (cybersight.org.cn)
Stromal keratitis1
Acanthamoeba1
Collagen Crosslinking1
  • Is corneal collagen crosslinking a safe and effective option in the treatment of microbial keratitis? (linkoph.com)
Infective1
  • Virulence factors may initiate microbial invasion, or secondary effector molecules may assist the infective process. (medscape.com)
Keratoconus1
  • The Swiss charity Light for Sight kindly arranged the donation of a refurbished crosslinking device for use in keratoconus and microbial keratitis to the CCBRT, and my wife Marcela Espinosa, MD, and I conducted a rapid training course for local ophthalmologists. (crstodayeurope.com)
Ulcers1
  • Among emergency department visits, 19,000 visits for corneal disorders involving contact lenses and 41,000 visits for keratitis occurred in 2010, including 25,000 visits for corneal ulcers. (cdc.gov)
Bacteria2
  • A total of ninety-six samples were collected and the microbial conditions were based on total aerobic bacteria (TEB), coliforms, yeasts, and moulds counts as well as the identification of coliforms and yeasts using identification kits. (hindawi.com)
  • Most cases of microbial keratitis are caused by bacteria and respond to empiric treatment with topical antibiotics. (crstodayeurope.com)
Ulcerative1
  • The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses: a case-control study. (cdc.gov)
Complications3
  • If the wearers can follow strictly the instructions given by the optometrists, and had regular aftercare visits (3-4 monthly for ortho-k wearers), risk of having microbial keratitis and other contact lens related complications must be able to keep to a minimum. (swisscoat.com)
  • Bacterial keratitis remains one of the most important potential complications of contact lens use. (medscape.com)
  • This is one of the most feared complications of bacterial keratitis that may result in secondary endophthalmitis and possible loss of the eye. (medscape.com)
Atypical2
Vitro1
  • Tuft SJ , Matheson M. In vitro resistance in bacterial keratitis in London. (bmj.com)
Microbiological2
  • Young AL, Leung KS, Tsim N, Hui M, Jhanji V. Risk factors, microbiological profile, and treatment outcomes of pediatric microbial keratitis in a tertiary care hospital in Hong Kong. (swisscoat.com)
  • Bacterial keratitis: a prospective clinical and microbiological study. (bmj.com)
Abrasion1
  • Patching can increase corneal temperature and therefore increase the risk of secondary microbial keratitis after abrasion. (medscape.com)
Progression1
Treatment8
  • Summary CXL appears to be a promising adjunctive treatment in selective cases of mild to moderate bacterial keratitis. (medscape.com)
  • Treatment protocols in microbial keratitis need to be individualized. (medscape.com)
  • Corneal collagen cross-linking is a potentially useful adjunctive treatment for management of selective cases of bacterial keratitis. (medscape.com)
  • Further research is mandatory to customize the treatment protocols of cross-linking in cases with microbial keratitis. (medscape.com)
  • When keratitis fails to respond as expected, investigations and treatment can be escalated in a stepwise fashion. (crstodayeurope.com)
  • 1,2 In an eye with keratitis that is responding to antibiotics, inflammation often increases for the first 1 to 2 days of treatment. (crstodayeurope.com)
  • This paper will use the Darwinian Medical approach and the Adaptationist Program to discuss the implications of the suppressed immune response in development and treatment of keratitis and the various microbial and mechanical causes thereof. (ukessays.com)
  • Microbial keratitis is an urgent condition that requires prompt treatment. (reviewofoptometry.com)
Vascularization1
  • Scar tissue formation with the presence of corneal vascularization may be the end result of a bacterial keratitis. (medscape.com)
Causative1
  • 1-4 Few clinical features of keratitis are specific enough to reliably diagnose the causative organism on clinical appearance alone. (crstodayeurope.com)
Emergency1
  • The Marketscan Commercial, Medicare, and Medicaid databases also were used to estimate costs per visit for office, outpatient, or emergency department visits that did not result in hospital admission for keratitis, by insurance source. (cdc.gov)
Outbreaks1
  • Microbial contamination can lead to food poisoning outbreaks and unsatisfactory products [ 3 ] and this is an enormous economic problem worldwide. (hindawi.com)
Overnight2
  • Bullimore MA, Sinnott LT, Jones-Jordan LA. The risk of microbial keratitis with overnight corneal reshaping lenses. (swisscoat.com)
  • Overnight orthokeratology-associated microbial keratitis. (cdc.gov)
Cases1
  • So, we'll start with a couple of cases just to give a perspective of how microbial keratitis presents in our part of the world. (cybersight.org.cn)