Microarray gene of drosophila. Medical search. Frequent questions

Here, we investigated, in females of both D. melanogaster and D. nigrosparsa , the gene expression between animals uninfected and infected with w Mel, using RNA sequencing to see if the two Drosophila species respond to the infection in the same or different ways. (nature.com)
Like other animals, Drosophila melanogaster senses and responds to noxious stimuli. (elifesciences.org)
Background: Gene expression measurements during the development of the fly Drosophila melanogaster are routinely used to find functional modules of temporally co-expressed genes. (sciweavers.org)
Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
The Long 3′UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster. (tcd.ie)
Gene expression in the brain of Drosophila melanogaster was measured using GeneChip Drosophila microarrays (Affymetrix) after different durations of sleep and periods of sleep deprivation. (jax.org)
The complete genomic sequence of many organisms such as humans, mice, Drosophila melanogaster and Caenorhabditis elegans are now available. (fraunhofer.de)
The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster. (ncsu.edu)
Association of orthodenticle with Natural Variation for Early Embryonic Patterning in Drosophila melanogaster. (ncsu.edu)
Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster. (ncsu.edu)
Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. (ncsu.edu)
Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. (ncsu.edu)
Over 50 years ago, Susumo Ohno proposed that dosage compensation in mammals would require upregulation of gene expression on the single active X chromosome, a mechanism which to date is best understood in the fruit fly Drosophila melanogaster. (marksteinlab.org)
Kumar S, Jayaraman K, Panchanathan S, Gurunathan R, Marti-Subirana A, Newfeld SJ: BEST: a novel computational approach for comparing gene expression patterns from early stages of Drosophlia melanogaster develeopment. (crossref.org)
Animal models for retinal disease and development: Model organisms including mouse and Drosophila melanogaster are useful tools to understand molecular mechanism of diseases and also identify genetic networks that control retinal development. (gulfcoastconsortia.org)

Comparison of the two scatterplots shows a reduced number of sex-biased differentially expressed genes in the germline-naive samples. (biomedcentral.com)
2) functions of differentially expressed genes in atm mutated flies, regardless of protein-coding genes or non-coding RNAs, are closely related with metabolic process, immune response, DNA damage response or oxidative stress. (biomedcentral.com)

The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
Ye J, Chen J, Li Q, Kumar S: Classification of Drosophila embryonic developmental stage range based on gene expression pattern images. (crossref.org)

Comparisons of genomes demonstrate that gene duplications are common in most species investigated. (wikipedia.org)
These data will provide new insight into how genomes evolve, which types of genes are evolving most rapidly, the relationships between recombination, DNA divergence, and DNA polymorphism, and details about the spatial and organizational evolution of genomes. (unc.edu)
2007). [Review of Evolution of genes and genomes on the Drosophila phylogeny]. (ncsu.edu)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

This implies that the maternal loading of Manf gene goods in larval Manf96 mutants was ample to conquer defects in early cuticle advancement, secretion and layering, but inadequate to finish the initial molt. (mmp-signal.com)
To visualise Manf expression at subcellular level we applied 3rd instar larval salivary gland cells which can be the lar gest ones observed in Drosophila. (mmp-signal.com)
We have used transgenic promoter-GFP constructs to document the detailed pattern of induced Cyp6a2 gene expression in larval and adult Drosophila tissues. (shortscience.org)
A failure to see improvements in constitutive expression of the cellular genes suggests either that increases might come at too great a cost or that patterns of expression in adults are decoupled from the larval phase where increases would be most effective. (biomedcentral.com)

A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
The authors support the claims in the paper through the use of gene knockdown, behavioral experiments, neuroanatomy, and optogenetic activation in the Drosophila fruit fly. (elifesciences.org)
Moreover, since the set of genes varies from study to study and from organ to organ, the researcher faces a daunting problem with every new set of microarray experiments. (biomedcentral.com)
Gene coexpression analysis refers to the en masse discovery of coexpressed genes from a large variety of transcriptomic experiments. (mdpi.com)
Non-amplified RNAs were labeled for microarray experiments and three sets of data were analyzed for significance, hierarchical relationships, and functional clustering. (biomedcentral.com)
Our results are compared to the increasingly diverse reports on P450 induction that can be gleaned from whole genome or from "detox" microarray experiments in Drosophila. (shortscience.org)
Using the singular value decomposition (SVD) technique, we developed a new computational tool, named svdPPCS ( SVD -based P attern P airing and C hart S plitting), to identify conserved and divergent co-expression modules of two sets of microarray experiments. (biomedcentral.com)

The analysis of both authentic Dorsal target genes and defined synthetic promoters suggests that the ectopic gradient is sufficient to generate the full repertory of DV patterning responses along the AP axis of the embryo. (sdbonline.org)
In addition to its role in H3K36 tri-methylation, SETD2 is required to maintain high H3K79 di-methylation and MLL-AF9-binding to critical target genes, such as Hoxa9 . (nature.com)
As the SEC can regulate the transcriptional activity of RNA polymerase II, it was hypothesized that these MLL-fusions induce aberrant regulation of transcriptional elongation on MLL-target genes 14 . (nature.com)
Until recently, identifying each gene's enhancers had been challenging because enhancers do not occupy prescribed locations relative to their target genes. (marksteinlab.org)
Microarrays of secondary metabolite biosynthetic genes of Aspergillus nidulans are used to identify target genes of the fungus being up- or downregulated when interacting with the antagonistic Drosophila larvae. (marinefungi.eu)

For a particular gene, find the pattern of expression in different tissues. (gla.ac.uk)
RNA sequencing is a powerful method to study differential gene expression because it can detect a whole gene expression across particular tissues 1 . (nature.com)
The implementation was illustrated on two time series microarray data sets generated from the samples of accessory gland (ACG) and malpighian tubule (MT) tissues of the line W 118 of M. drosophila . (biomedcentral.com)

RNA-seq has been chosen to investigate Drosophila Malpighian (renal) tubules to identify novel genes following a three- way comparison between three popular transcriptome profiling methods. (gla.ac.uk)
RNA-seq has overcome the drawbacks of microarrays and become the leading technology for genome sequencing, transcriptome profiling, novel gene discovery, and novel alternative splicing discovery with wide dynamic range. (gla.ac.uk)
CD genomics provides high-quality services for microarray-based transcriptome studies at a very affordable price. (cd-genomics.com)
To meet multiple research goals, we offer a complete range of arrays for whole-transcriptome-, gene-, exon-, or short noncoding (snc)RNA-level analysis. (cd-genomics.com)
In today's research laboratory, two common ways that gene expression is assessed is by using quantitative polymerase chain reaction techniques (QTPCR) for monitoring expression of smaller numbers of genes, and by employing DNA microarrays for the highly parallel monitoring of thousands of genes (or the whole transcriptome). (ddw-online.com)

Genomic tools such as the availability of the Drosophila genome sequence, the relative ease of stable transformation, and DNA microarrays have made the fruit fly a powerful model in insecticide toxicology research. (shortscience.org)
These suggest that only a third of the genomic repertoire of CYP genes is inducible by xenobiotics, and that there are distinct subsets of inducers/induced genes, suggesting multiple xenobiotic transduction mechanisms. (shortscience.org)
Here, we report that the GA-repeat sequences that recruit the conserved MSL dosage compensation complex to the Drosophila X chromosome are also enriched across mammalian X chromosomes, providing genomic support for the Ohno hypothesis. (marksteinlab.org)
Genetic, genomic, and biochemical approaches to decipher the molecular function of these genes are currently underway. (gulfcoastconsortia.org)

Drosophila is a valuable experimental organism can be used as a reverse genetics model. (gla.ac.uk)
Reverse genetics has been applied to identify novel coding gene function in Drosophila tubules. (gla.ac.uk)
Reverse genetics has been applied to Drosophila to achieve a gene knockdown and overexpression by using the unique Gal4/UAS system to achieve the novel gene knockdown or overexpression in specific tissue and cell types. (gla.ac.uk)
Reverse genetics has been confirmed as particularly important for the functional study of novel genes. (gla.ac.uk)
The tools of modern biology have made dissecting the molecular genetics of adaptation possible, especially in Drosophila. (unc.edu)
Considerable effort has gone into identifying genes involved in olfactory perception however little progress has been made in the genetics of behavior driven by olfactory information. (unc.edu)

Revealing the intrinsic program of gene regulation that accompanies mammalian retinal development is a key step for eventual cure of many human retina diseases and blindness. (biomedcentral.com)

Using an integrated approach that combined the power of the Drosophila, Caenorhabditis elegans and mouse model systems with bioinformatics analyses, we established a novel, conserved role for chloride intracellular channels (CLICs) in alcohol-related behavior. (nih.gov)

Rapid evolution and functional divergence have been observed at the level of the transcription of duplicated genes, usually by point mutations in short transcription factor binding motifs. (wikipedia.org)
Furthermore, we found that disruption of the sole Clic Drosophila orthologue significantly blunted sensitivity to alcohol in flies, that mutations in two C. elegans Clic orthologues, exc-4 and exl-1, altered behavioral responses to acute ethanol in worms and that viral-mediated overexpression of Clic4 in mouse brain decreased the sedating properties of ethanol. (nih.gov)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
Al-Qattan MM, Abou Al-Shaar H. Molecular basis of the clinical features of Holt-Oram syndrome resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 intragenic duplications. (medscape.com)
Gene expression profiles obtained without artifacts introduced by isolation procedures or gene mutations provide a valuable overview of retina development under natural developmental conditions. (biomedcentral.com)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Recently, we have cloned SPATA7 as a novel human retinal disease gene, mutations in which lead to LCA and RP. (gulfcoastconsortia.org)

Our gene rank combines a priori knowledge about gene connectivity, say, from the Gene Ontology (GO) database, and the microarray expression data at hand, called the microarray enriched gene rank, or simply gene rank (GR). GR, similarly to Google PageRank, is defined in a recursive fashion and is computed as the left maximum eigenvector of a stochastic matrix derived from microarray expression data. (biomedcentral.com)
Liu Y, Zhang YZ, Imoto S . Microbial Gene Ontology informed deep neural network for microbe functionality discovery in human diseases. (google.com)

There are five distinct thresholds of gene activity in response to the Dorsal nuclear gradient in early embryos. (sdbonline.org)
Expression analysis of several Hox genes in human embryos. (cnr.it)
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
Van Emden B, Ramos H, Panchanathan S, Newfeld S, Kumar S: FlyExpress: An image-matching web-tool for finding genes with overlapping patterns of expression in Drosophila embryos.2006. (crossref.org)
Zhou J, Peng H: Automatic recognition and annotation of gene expression patterns of fly embryos. (crossref.org)

A TopHat and Cufflinks pipeline has been used as an analytical pipeline for novel gene discovery and differential gene expression analysis between Drosophila tubules and whole flies in order to find the tubule-enriched genes. (gla.ac.uk)

Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. (wikipedia.org)
Gene duplications can arise as products of several types of errors in DNA replication and repair machinery as well as through fortuitous capture by selfish genetic elements. (wikipedia.org)
Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)
KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5. (medscape.com)
Li B, Chen S, Sun K, Xu R, Wu Y. Genetic analyses identified a SALL4 gene mutation associated with Holt-Oram syndrome. (medscape.com)
The goal of my research is to identify, clone, and characterize the evolution of genes underlying natural adaptations in order to determine the types of genes involved, how many and what types of genetic changes occurred, and the evolutionary history of these changes. (unc.edu)
Candidate genes with structural changes are identified using population genetic data and positional cloning. (unc.edu)
Subsequently, candidate genes and their regulatory regions are analyzed in order to pinpoint the genetic changes that have occurred and how they have evolved. (unc.edu)
Once these genes are cloned, I can explore the genetic mechanism of attraction behavior and see if homologs of these genes are involved in the olfactory behavior of other species. (unc.edu)
GR reflects the complexity of genetic organization and is illustrated with several existing microarray data sets. (biomedcentral.com)
Two of the most common uses of the DNA microarrays are genetic analysis and the analysis of gene expression. (ddw-online.com)
The genetic basis of the evolved response was examined using microarrays and was characterised by increased expression for many immunity related genes. (biomedcentral.com)
The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis. (silverchair.com)
Currently, we are applying these tools to various research fields, including development, genetic disease gene cloning, and cancer biology. (gulfcoastconsortia.org)

Together, our studies demonstrate key roles for Clic genes in behavioral responses to acute alcohol in Drosophila, C. elegans and mice. (nih.gov)
Both experimental and computational approaches are used in combination to identify and model gene functions in both human patients and model organisms, including Drosophila and mice. (gulfcoastconsortia.org)

We initially identified vertebrate Clic4 as a candidate ethanol-responsive gene via bioinformatic analysis of data from published microarray studies of mouse and human ethanol-related genes. (nih.gov)
We also compared various insecticides and xenobiotics for their ability to induce this cytochrome P450 gene, and show that the pattern of Cyp6a2 inducibility is comparable to that of vertebrate CYP2B genes, and different from that of vertebrate CYP1A genes, suggesting a degree of evolutionary conservation for the "phenobarbital-type" induction mechanism. (shortscience.org)
Here we show that these previously described vertebrate stem cell features are conserved in Drosophila intestinal stem cells. (marksteinlab.org)

Different gene expression patterns, shown by tools such as quantitative PCR, microarrays, and high-throughput RNA sequencing, reveal how organisms respond to different environments. (nature.com)
Six individual gene expression clusters were identified based on expression patterns of transcripts through retina development. (biomedcentral.com)
Assume that the data matrix is in the form with genes in rows and arrays in columns, the profiles of the leading right singular vectors of the decomposition (eigengenes) suggest the fundamental gene expression patterns across the arrays, which in turn represent a biological theme if the data is well organized [ 18 ]. (biomedcentral.com)
Gurunathan R, Emden BV, Panchanathan S, Kumar S: Identifying spatially similar gene expression patterns in early stage fruit fly embryo images: binary feature versus invariant moment digital representations. (crossref.org)
Ji S, Sun L, Jin R, Kumar S, Ye J: Automated annotation of Drosophila gene expression patterns using a controlled vocabulary. (crossref.org)
states'' or gene expression patterns. (lu.se)

Recent studies yielded a first direct estimate of the genome-wide rate of gene duplication in C. elegans, the first multicellular eukaryote for which such as estimate became available. (wikipedia.org)
A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
These diverse microarrays are designed based on the most recent genome content for generating genome-wide expression profiles of human, model organisms, plants, and animals. (cd-genomics.com)
This study provides a complementary genome-wide view of common gene dynamics and a broad molecular classification of mouse retina development. (biomedcentral.com)
A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs. (ncsu.edu)
Genome-wide atlas of gene expression in the adult mouse brain. (crossref.org)
A genome-wide, combinatorial approach, including gene expression profiling with both microarray and mRNA-Seq, comparative genomics at both DNA and mRNA level, and downstream target identification using ChIP-Seq, has been adopted. (gulfcoastconsortia.org)

We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of ncc69 -a fly homologue of NKCC1 -results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making Drosophila CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain. (elifesciences.org)

Of all Drosophila homologues acknowledged to become concerned in endocytosis, 47% showed major expression alterations in our microarray experiment. (mmp-signal.com)

Exposure to infection can increase the transcription of these genes substantially, ie from 10-100 fold for some of the genes encoding antimicrobial peptides [ 4 ]. (biomedcentral.com)

Identifying genes that influence behavioral responses to alcohol is critical for understanding the molecular basis of alcoholism and ultimately developing therapeutic interventions for the disease. (nih.gov)
Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
Identification of human retinal disease genes: One of the main focuses in our laboratory is to understand the molecular mechanism underlying human retinal disease. (gulfcoastconsortia.org)
In Drosophila, a major effort in our laboratory is to understand the molecular mechanism of the early retinal cell fate determination process. (gulfcoastconsortia.org)

I found that HIFα regulates the expression of several retrograde response genes and that modulation of HIFα expression ameliorates some of the phenotypes associated with mitochondrial dysfunction. (kcl.ac.uk)

Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). (cnr.it)
Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer. (cnr.it)
Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg hybridoma library. (tcd.ie)
The method enables the identification of genes required for complex developmental networks and signal transduction pathways. (fraunhofer.de)
Park H, Imoto S , Miyano S. Comprehensive information-based differential gene regulatory networks analysis (CIdrgn): Application to gastric cancer and chemotherapy-responsive gene network identification. (google.com)

This method was used to measure the number of copies of repeated genes such as rRNA genes (2) and to measure whether specific genes were under-replicated during the replication process used in forming polytene chromosomes (3). (ddw-online.com)

In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
Isolation and characterization of alternative messenger RNAs coding class I HLA genes. (cnr.it)
Systemic profiling of ATM regulated genes, including protein-coding genes, miRNAs, and long non-coding RNAs, will greatly improve our understanding of ATM functions and its regulation. (biomedcentral.com)
1) differentially expressed protein-coding genes, miRNAs, and long non-coding RNAs in atm mutated flies were identified at physiological condition and after X-ray irradiation. (biomedcentral.com)
We provide a valuable resource of protein-coding genes, miRNAs, and long non-coding RNAs, for understanding ATM functions and regulations. (biomedcentral.com)

The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
I have also characterised the involvement of the transcription factor hypoxia inducible factor alpha (HIFα) in the mitochondrial retrograde response in Drosophila. (kcl.ac.uk)
1,100 muscle-targeted RNAi interventions to comprehensively assess the function of 447 transcription factors in the developmental growth of body wall skeletal muscles in Drosophila. (sdbonline.org)
Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. (sdbonline.org)
While the transcription of innate immunity genes in response to bacterial infection has been well-characterised in the Drosophila model, we recently demonstrated the capacity for such transcription to evolve in flies selected for improved antibacterial defense. (biomedcentral.com)
Here we use this experimental system to examine how insects invest in constitutive versus infection-induced transcription of immunity genes. (biomedcentral.com)
We also report a restricted ability to improve transcription of immunity genes that is on the order of 2-3 fold regardless of total transcription level of the gene. (biomedcentral.com)
The evolved increases in infection-induced expression of the cellular genes may result from specific cross talk with humoral pathways or from generalised strategies for enhancing immunity gene transcription. (biomedcentral.com)
The similarity in fold change increase across all immunity genes may suggest a shared mechanism for the evolution of increased transcription in small, discrete units such as duplication of cis -regulatory elements. (biomedcentral.com)
We hypothesized that selection for improved defense would lead to further increases in the transcription of these genes upon exposure to infection. (biomedcentral.com)

Within the same functional classes, however, different gene populations were expressed in distinct developmental phases. (biomedcentral.com)
Different genes in the same functional clusters are expressed in the different developmental stages, suggesting that cells might change gene expression profiles from differentiation to maturation stages. (biomedcentral.com)
Ye J, Chen J, Janardan R, Kumar S: Developmental stage annotation of Drosophila gene expression pattern images via an entire solution path for LDA. (crossref.org)

120 different translocations, resulting in the generation of MLL-fusion proteins encompassing more than 75 different partner genes 5 . (nature.com)
The humoral immune response in insects is characterized by cascades of genes whose expression is controlled by a range of recognition proteins that bind pathogen cell wall components and end with the production of a range of secreted host proteins that target bacteria for destruction [ 3 ]. (biomedcentral.com)

Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)
80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)

It is proposed that DEAF-1 is a regulator of Drosophila immunity (Reed, 2008). (sdbonline.org)
These two strategies carry with them different consequences with respect to energetic and pleiotropic costs and may be more or less effective in improving defense depending on whether the genes contribute to humoral or cellular aspects of immunity. (biomedcentral.com)
Contrary to expectation we show that selection preferentially increased the infection-induced expression of both cellular and humoral immunity genes. (biomedcentral.com)
These two avenues for transcriptional change should have different energetic or pleiotropic costs and [ 2 ] may be more or less effective in improving immunity depending on the functional role of the gene. (biomedcentral.com)

DEAF-1 recognizes several TTCG motifs within the portion of the Dfd autoregulatory region termed 'module E.' In addition, DEAF-1 binds several similar motifs within a Dfd response element ( DRE ) from the 1.28 gene that enhances maxillary gene expression during embryogenesis (Pederson, 2000). (sdbonline.org)
Tomancak P, Beaton A, Weiszmann R, Kwan E, Shu S, Lewis SE, Richards S, Ashburner M, Hartenstein V, Celniker SE, Rubin GM: Systematic determination of patterns of gene expression during Drosophila embryogenesis. (crossref.org)
Tomancak P, Berman B, Beaton A, Weiszmann R, Kwan E, Hartenstein V, Celniker S, Rubin G: Global analysis of patterns of gene expression during Drosophila embryogenesis. (crossref.org)

After a whole genome duplication, there is a relatively short period of genome instability, extensive gene loss, elevated levels of nucleotide substitution and regulatory network rewiring. (wikipedia.org)
Furthermore, retention of regulatory genes, most notably the Hox genes, has led to adaptive innovation. (wikipedia.org)
The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress Our investigations indicate that Salmonella have leveraged the regulatory activity that Gre factors directly promote gapA gene expression, we visualized the products of the fluorescence vesicle suspension from entering into the metabolite inlet but did not attempt to extract the mean change in the Salmonella enterica. (mister-finch.com)

I have analysed the changes in mitochondrial DNA and mitochondrial gene expression in this model as well as characterising the behavioural and synaptic phenotypes. (kcl.ac.uk)

A correlation coefficient analysis of gene expression during retina development between previous SAGE studies and this study was also carried out. (biomedcentral.com)
Analysis of gene expression can include measuring expression levels of a small set of genes to whole genome expression monitoring. (ddw-online.com)
This report will focus in using DNA microarrays for the analysis of gene expression or expression profiling, and how DNA chips are used for drug discovery and development. (ddw-online.com)
Comparative analysis of gene expression profiling of multiple biological categories, such as different species of organisms or different kinds of tissue, promises to enhance the fundamental understanding of the universality as well as the specialization of mechanisms and related biological themes. (biomedcentral.com)
Grouping genes with a similar expression pattern or exhibiting co-expression together is a starting point in the analysis of gene expression data. (biomedcentral.com)

Significant changes shared by the fly species belong to the expression of genes involved in processes such as oxidation-reduction process, iron-ion binding, and voltage-gated potassium-channel activity. (nature.com)
Efforts are underway to produce whole genome sequences for several other species of Drosophila (see the UC Davis - DPGP project site for details). (unc.edu)

In particular, we apply GR (1) to answer whether bad genes are more connected than good genes in relation with cancer patient survival, (2) to associate gene connectivity with cluster/subtypes in ovarian cancer tumors, and to determine whether gene connectivity changes (3) from organ to organ within the same organism and (4) between organisms. (biomedcentral.com)

GR may be used for hypothesis generation on gene pathways. (biomedcentral.com)

Drosophila expression microarrays and RNA-seq are correlated better than the correlation between Drosophila tiling microarrays and RNA-seq. (gla.ac.uk)
We develop a new concept that reflects how genes are connected based on microarray data using the coefficient of determination (the squared Pearson correlation coefficient). (biomedcentral.com)
The gene rank we suggest is free of these shortcomings: (1) it combines GO library with correlation so that only the connectivity of a small proportion of genes can specified, (2) no thresholding is applied since we use the squared correlation coefficient (coefficient of determination). (biomedcentral.com)
The assumption of the present work is that gene connectivity can be adequately expressed in terms of the gene pairwise squared correlation matrix, therefore the phenotype is not required. (biomedcentral.com)

This analysis revealed that neuronal mitochondrial dysfunction alters the expression of over 300 genes. (kcl.ac.uk)

A total of 2164 orthologous genes were used. (nature.com)
The Drosophila genome contains two genes( CG8422 and CG1237 0) orthologous to Manduca and Acheta DH-Rs. (silverchair.com)

Given their functional roles, infection induced increases in expression were expected for the humoral genes, while increases in constitutive expression were expected for the cellular genes. (biomedcentral.com)

Database of human genes associated with cellular senescence. (senescence.info)

thus, the genes that have evolved in D. sechellia must be those responsible for behavior rather than detection. (unc.edu)
Social communication of predator-induced changes in Drosophila behavior and germline physiology. (tcd.ie)

Drosophila Malpighian (renal) tubules are important epithelial tissue in which to study transport mechanisms. (gla.ac.uk)

Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila. (tcd.ie)

Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)
There are several reasons for the slow adoption of microarray technology to studies of development, especially in mammals, [ 24 ]. (biomedcentral.com)

The temporal gene expression measurements are taken as primary data for which pairwise constraints are computed in an automated fashion from raw in situ images without the need for manual annotation. (sciweavers.org)
Both versions suffer from series limitations: (1) The GO annotation version is difficult to realize in practice because, e.g. with n =50,000 number of genes one has to fill in the connectivity matrix with 2.5×10 9 elements. (biomedcentral.com)

Drosophila expression arrays and Drosophila tiling arrays all suffered from cross-hybridization, miss target detection and hybridization background noise, and also have low dynamic range for detecting lowly and highly expressed genes. (gla.ac.uk)

A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
Using this model I performed microarray analysis to characterise the mitochondrial retrograde response in the Drosophila nervous system. (kcl.ac.uk)
Using transgenesis and microarrays technologies, he developed a drosophila model to elucidate the role of a gene involved in human cardiomyopathies. (rd-alliance.org)
Purified PGNs induce distinct gene expression of PGRP-LC using 5966GS mitigated the lifespan of certain model organisms, such as CcmK of carboxysomes, in local minima corresponding to MD runs were carried out in the PGN layers, we also tested whether BacD affects the response induced by crystallization conditions, which spread considerably by pH (4. (mister-finch.com)

The top category of Deaf1-regulated genes consists of glycolytic enzymes, which are suppressed by Deaf1 and Gsk3 but are upregulated by Deaf1 RNAi. (sdbonline.org)

Drosophila tiling microarrays also have a high false-positive detection rate, which may lead to overestimate the transcriptional activities of the genome. (gla.ac.uk)

Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)

Third, even using currently available comprehensive arrays, tissue-specific genes are still under-represented, including alternatively spliced variants or genes that are only briefly expressed in a tissue-specific pattern. (biomedcentral.com)

Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V. σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila. (tcd.ie)
Gene Dosage in the Dysbindin Schizophrenia Susceptibility Network Differentially Affect Synaptic Function and Plasticity. (tcd.ie)

Seven time groups were used to determine differential gene expression between normal and sleep-deprived flies, whereas three time groups were used to test for differential gene expression due to the effect of mechanical stimulation. (jax.org)

Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

Anatomy48

Organisms7

Diseases6

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology4

Phenomena and Processes95

Disciplines and Occupations4

Technology, Industry, Agriculture1

Humanities1

Information Science19

Health Care10

Melanogaster15

Differentially expressed genes2

Embryonic4

Genomes4

Larval4

Experiments7

Target genes5

Tissues3

Transcriptome5

Genomic4

Genetics6

Mammalian1

Caenorhabditis1

Mutations8

Ontology2

Embryos6

Differential gene expression analysis1

Genetic14

Mice2

Vertebrate3

Expression patterns6

Genome-wide7

Overexpression1

Homologues1

Antimicrobial peptides1

Molecular4

Regulates1

Identification5

Chromosomes1

Somatic1

RNAs5

Transcription10

Developmental3

Proteins2

Receptor2

Immunity4

Embryogenesis3

Regulatory3

Phenotypes1

Analysis of gene expression5

Species2

Organism1

Pathways1

Correlation4

Neuronal1

Orthologous2

Functional1

Cellular1

Behavior2

Mechanisms1

Adult1

Mammals2

Annotation2

Hybridization1

Model4

RNAi1

Transcriptional1

Homeobox1

Arrays1

Synaptic2

Flies1

Induce1