• Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. (wikipedia.org)
  • miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. (wikipedia.org)
  • As they reported today in PLOS One , Penso-Dolfin and his colleagues sequenced small RNAs in nine dog tissues as part of an effort to annotate dog miRNAs. (genomeweb.com)
  • The researchers also identified 91 new miRNAs, along with 263 predicted piwi-interacting RNA (piRNA) clusters. (genomeweb.com)
  • They further considered tissue-specific small RNA expression and took a crack at predicting the genes targeted by domestic dog miRNAs. (genomeweb.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (nih.gov)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (nih.gov)
  • MicroRNAs (miRNAs) are noncoding RNAs of approximately 20 nucleotides in length that block gene expression at the posttranscriptional level by partial complementary binding to the 3′-untranslated region (3′-UTR) of mRNA of target genes in animals, resulting in mRNA degradation or translation inhibition [ 3 ]. (hindawi.com)
  • MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • Since recent studies revealed the feasibility to detect blood-based microRNAs (miRNAs, miRs) in breast cancer (BC) patients a new field has been opened for circulating miRNAs as potential biomarkers in BC. (biomedcentral.com)
  • Since the discovery of circulating microRNAs (miRNAs) in body fluids, an increasing number of studies have focused on their potential as non-invasive biomarkers and as therapeutic targets or tools for many dis. (biomedcentral.com)
  • While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. (biomedcentral.com)
  • MicroRNAs (miRNAs) are short (21-24 nucleotides) sequences of RNA that reduce gene expression by promoting the breakdown of messenger RNAs (mRNAs) and by repressing translation of mRNAs into proteins. (freethoughtblogs.com)
  • The miRNAs are small stretches of RNA made by host cells to regulate gene expression. (feedstuffs.com)
  • To see if RNA viruses other than hepatitis C use host miRNA, the researchers developed a screening method that chemically attaches those miRNAs to their targets. (feedstuffs.com)
  • MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)
  • Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
  • miRNAs are a large family of non-coding RNAs which play important roles in translational and post-transcriptional regulation of gene expression and biological processes. (unboundmedicine.com)
  • MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs, which act as key post-transcriptional regulators of target-gene expression. (spandidos-publications.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression at the post-transcriptional level by affecting both the stability and translation of complementary mRNAs. (wjgnet.com)
  • miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
  • MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
  • Our data suggest the physiologic impact of miRNAs on cellular transcription results from a multifaceted network of miRNA and mRNA relationships, working together in an interconnected system and in context of hundreds of RNA species. (rti.org)
  • however, the cell-autonomous roles for endothelial-expressing microRNAs (miRNAs) are poorly understood in this process. (unl.edu)
  • To identify thyroid tumor-associated microRNAs (miRNAs) in the serum with potential for development as unique biomarkers of PTC recurrence. (medscape.com)
  • One of the most promising solutions involves measuring the levels of tumor-derived microRNAs (miRNAs) in the bloodstream. (medscape.com)
  • MicroRNAs (miRNAs) são pequenos RNAs não-codantes, conservados ao longo da evolução, capazes de regular a expressão gênica através da degradação ou repressão da tradução de moléculas-alvo de RNA mensageiro. (bvsalud.org)
  • O presente estudo realiza uma revisão da literatura sobre miRNAs, enfocando aspectos relacionados à biogênese, mecanismos de ação e o papel potencial desses pequenos RNAs na carcinogênese oral. (bvsalud.org)
  • Como os miRNAs podem regular mais de um RNAm-alvo 33 , estima-se que estes pequenos RNAs controlem a expressão de aproximadamente 30% dos genes que codificam proteínas 23 . (bvsalud.org)
  • O presente estudo realiza uma revisão da literatura sobre miRNAs, enfocando aspectos relacionados à biogênese, mecanismos de ação e o papel potencial dessas pequenas moléculas de RNA na carcinogênese oral. (bvsalud.org)
  • This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. (lu.se)
  • MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. (wikipedia.org)
  • However, only about 500 human microRNAs represent bona fide miRNA in the manually curated miRNA gene database MirGeneDB. (wikipedia.org)
  • isolated the lin-4 miRNA, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (nih.gov)
  • Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most--if not all--human malignancies. (nih.gov)
  • Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies. (nih.gov)
  • A recently discovered dimension of post-transcriptional gene regulation involves co-regulatory crosstalk between RNA transcripts, which compete for common pools of microRNA (miRNA) molecules. (biomedcentral.com)
  • This non-systematic review article aims to summarise the progress made in understanding the functional consequences of microRNA (miRNA) dysregulation in prostate cancer development, and the identification of p. (biomedcentral.com)
  • Here, we provide a comprehensive global analysis of the evolutionarily distant unicellular green alga Chlamydomonas reinhardtii to quantify the effects of miRNA on protein synthesis and RNA abundance. (freethoughtblogs.com)
  • One way wily viruses can get a leg up is by subverting the micro-RNA (miRNA) of their host. (feedstuffs.com)
  • Last year, Rockefeller scientists were surprised to discover that hepatitis C, a virus that contains RNA rather than DNA, not only sequesters a host miRNA but relies on it. (feedstuffs.com)
  • Now, the same team - including researchers in the laboratories of Charles M. Rice, the Maurice R. & Corinne P. Greenberg professor and head of the Laboratory of Virology & Infectious Disease, and Robert B. Darnell, the Robert & Harriet Heilbrunn professor and head of the Laboratory of Molecular Neuro-oncology - has found evidence that another RNA virus - bovine viral diarrhea (BVD) virus, which infects cows and other livestock - also depends on miRNA for infection. (feedstuffs.com)
  • To find out, he and his colleagues used CLEAR-CLIP to analyze the interactions of 15 RNA viruses with their host miRNA. (feedstuffs.com)
  • Nanowerk News ) Current methods of detecting microRNA (miRNA) - gene-regulating molecules implicated in the onset of various diseases - can be time-consuming and costly: The custom equipment used in such tests costs more than $100,000, and the limited throughput of these systems further hinders progress. (nanowerk.com)
  • RNA 유도 사일런싱 복합체)라고 불리는 단백질 복합체에 합류하고, miRNA는 복합체를 표적 mRNA(target mRNA)의 상보적 영역(complementary region)으로 안내합니다. (jove.com)
  • We report a new second generation sequencing method for identification micro-RNA (miRNA) that can be used to identify body fluids and tissues. (ku.dk)
  • RNA sequencing versus real-time polymerase chain reaction versus microarrays, as well as miRNA profiling versus selected miRNA panels) and other methodological differences ( e.g. , characteristics and size of patient and control groups, sampling time, or use of plasma or serum). (medscape.com)
  • MicroRNAs (miRNA) are small noncoding RNAs, preserved throughout the evolution, able to regulate gene expression through repression of translation or degradation of target molecules of messenger RNA. (bvsalud.org)
  • This study performs a literature review of miRNA, focusing on aspects related to biogenesis, mechanisms of action and potential role of these small RNAs in oral carcinogenesis. (bvsalud.org)
  • MicroRNAs are tiny ribonucleic acid (RNA) molecules (~22 nucleotides long) that recently have been found to play important roles in regulating gene expression in eukaryotic organisms, including plants and animals. (sciencedaily.com)
  • MicroRNA consists of short strings of about 22 nucleotides, the building blocks that make up RNA and DNA. (mit.edu)
  • A-to-I editing can further diversify the microRNA pool by altering individual nucleotides. (lu.se)
  • Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (sciencedaily.com)
  • The mRNA levels in a cell are fine tuned by different mechanisms, one of which is driven by microRNA molecules. (sciencedaily.com)
  • MicroRNAs are ~22 nucleotide long RNA molecules that provide substrate specificity to a protein complex known as the RNA-induced silencing complex. (sciencedaily.com)
  • Within the complex, microRNAs are thought to bind to mRNA molecules containing a complementary stretch of RNA sequence. (sciencedaily.com)
  • In recent years microRNAs have emerged as crucial small non-coding RNA molecules with diverse roles in various diseases including diseases of the liver. (nih.gov)
  • In recent years, a class of small molecules known as microRNAs have been found to play an important role in regulating gene products in most animal and plant species. (nih.gov)
  • MicroRNAs are small RNA molecules that control changes in cell function by selectively regulating the synthesis of proteins. (databasefootball.com)
  • Each sponge can bind up to six microRNA molecules, but they could be engineered to bind more. (mit.edu)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • What we used to call 'junk DNA' has proved to be made up of areas that produce small molecules known as non-coding RNAs. (lu.se)
  • Around ten years ago, it was discovered that these areas code for a number of small RNA molecules that are now called non-coding RNAs because they don't code for proteins. (lu.se)
  • Sofia Elmroth and her research team primarily study microRNAs, which are molecules that influence protein levels in the cells of the body indirectly by binding to messenger RNA. (lu.se)
  • There are many different types of microRNAs involved in the regulation of different proteins and of other RNA molecules. (lu.se)
  • It has proved difficult to develop drugs that act directly on epigenetic changes in DNA, but now it is possible instead to intervene later in the cell metabolism and regulate the level of specific microRNA molecules. (lu.se)
  • Is the Subject Area "Messenger RNA" applicable to this article? (plos.org)
  • MicroRNA binds to messenger RNA (mRNA), preventing it from delivering protein assembly instructions, thereby inhibiting gene expression. (mit.edu)
  • Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (sciencedaily.com)
  • There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (sciencedaily.com)
  • a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
  • Research has long focused on transcription from our genes that uses RNA messengers to code for the formation of proteins, the building blocks of the body. (lu.se)
  • MicroRNAs are ~22-25 nucleotide non-coding RNAs. (ukessays.com)
  • This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles. (hindawi.com)
  • Long non-coding (lnc)RNAs play important roles in the development, differentiation, proliferation and apoptosis of cells ( 6 , 7 ). (spandidos-publications.com)
  • Long pieces of RNA that do not code for protein have diverse and important roles in the cell and may contribute to autism risk, say Nikolaos Mellios and Mriganka Sur. (spectrumnews.org)
  • Dr. Bonnie Bartel at Rice University in Houston, TX together with Drs. David Bartel and Allison Mallory at the Massachusetts Institute of Technology and the Whitehead Institute for Biomedical Research in Cambridge, MA report experiments using transgenic Arabidopsis plants that produce a version of ARF17 mRNA that resists microRNA-mediated cleavage. (sciencedaily.com)
  • Dr. Bellini and her colleagues found that the mutant plants over-accumulate ARF17 mRNA within the hypocotyl, pointing to ARF17 as a major regulator of adventitious rooting and microRNA-mediated regulation as a major regulator of ARF17. (sciencedaily.com)
  • PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding RNAs present throughout the animal kingdom. (biomedcentral.com)
  • lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. (biomedcentral.com)
  • Interestingly, ZNFX1 antisense RNA 1 (ZFAS1) could abolish its tumor suppressor effect by binding microRNA (miR)-150, while miR-150 could inhibit the invasion of hepatic carcinoma cells by inhibiting zinc finger E-box binding homeobox 1 (ZEB1) and matrix metalloproteinases (MMP)14 and MMP16 ( 10 ). (spandidos-publications.com)
  • In this article the researchers describe their identification of important individual microRNAs and relevant genes they regulate to control regulatory T cell development. (rvc.ac.uk)
  • Malfunctions in microRNA have been linked with cancer, but very few direct relationships have been established between specific microRNAs and the genes they regulate. (mit.edu)
  • A second report focuses on the function of the protein ARGONAUTE1 (AGO1), a major component of the RNA-induced silencing complex in Arabidopsis. (sciencedaily.com)
  • Arabidopsis ago1 mutants lacking the AGO1 protein have numerous severe developmental defects, supporting the notion that regulation by microRNAs is critical for normal plant growth. (sciencedaily.com)
  • Only recently, biochemical and structural studies made it possible to close the gaps in our knowledge on how cardiovirus 2A is able to act in diverse translation-related processes as a novel RNA-binding protein. (portlandpress.com)
  • MicroRNAs, as their name implies, are small RNAs that provide an essential regulation of gene expression by controlling translation of protein expressing messenger RNAs. (rvc.ac.uk)
  • A total 3 short hairpin RNA (sh)‑lncRNA XIST sequences, overexpression vector (oe)‑lncRNA XIST, microRNA (miR)‑320a mimic, miR‑320a inhibitor, PIK3CA inhibitor, and their corresponding controls were transfected in hepatic carcinoma cells. (spandidos-publications.com)
  • Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. (biorxiv.org)
  • The let-7 RNA was found to be conserved in many species, leading to the suggestion that let-7 RNA and additional "small temporal RNAs" might regulate the timing of development in diverse animals, including humans. (wikipedia.org)
  • The tissue-specific expression patterns of these RNA species and their high stability in biological fluids are well established. (medscape.com)
  • Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development. (nih.gov)
  • For example, we have shown that microRNA biogenesis pathways play a crucial role in dopamine neuron maintenance and its pharmacological stimulation promotes survival of dopamine neurons. (helsinki.fi)
  • A small fragment of RNA may regulate the expression of RORA, a gene implicated in many autism-related pathways, according to a study published 6 February in Scientific Reports. (spectrumnews.org)
  • In this review, we highlight the latest advances in the field of microRNA biology and their potential as emerging therapeutic targets in liver disease. (nih.gov)
  • Sagnelli E, Potenza N, Onorato L, Sagnelli C, Coppola N, Russo A. Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma. (wjgnet.com)
  • In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
  • Research conducted by three independent groups and reported in The Plant Cell shows that fundamental developmental processes controlled by the plant hormone auxin are regulated by microRNAs in the model plant Arabidopsis thaliana. (sciencedaily.com)
  • Having one too many copies of MeCP2, the Rett syndrome gene, may block the growth of neuronal branches by interfering with the production of small pieces of RNA, according to a study published 10 March in Developmental Cell. (spectrumnews.org)
  • Here, we describe a protocol to quantify microRNA editing isoforms using two-tailed RT-qPCR, with either SYBR Green or hydrolysis probes. (lu.se)
  • The user will perform reverse transcription of RNA samples, generate standard curves, and quantify the resulting cDNA in the following qPCR step. (lu.se)
  • To get a more robust view of regulatory features in the dog genome, the researchers used the Illumina HiSeq 2000 to sequence small RNA libraries representing domestic dog blood and tissues from the brain, heart, kidney, lung, ovary, skin, testes, and smooth muscle. (genomeweb.com)
  • Our results represent a clear improvement in our knowledge of the dog genome, paving the way for further research on the evolution of gene regulation, and the contribution of microRNAs to pathological conditions," first author Luca Penso-Dolfin, a vertebrate and health genomics researcher at The Genome Analysis Centre in Norwich, said in a statement. (genomeweb.com)
  • We have only known that microRNAs even existed since the early 1990's, and their importance in gene regulation and development wasn't appreciated until the 2000's. (freethoughtblogs.com)
  • MicroRNAs are short non-coding RNAs with important functions in the regulation of gene expression in healthy and diseased tissues. (lu.se)
  • Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. (biomedcentral.com)
  • If these microRNAs are over or under expressed (increase or decrease in quantity) - for example owing to epigenetic changes to the DNA - this will have an impact on many other regulatory processes. (lu.se)
  • We hope to be able to contribute to the development of a whole new type of drug that, because of its resemblance to the cell's own RNA, can effectively influence cell processes that have not previously been exploited in treatment. (lu.se)
  • At this point, researchers started using the term "microRNA" to refer to this class of small regulatory RNAs. (wikipedia.org)
  • mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (sciencedaily.com)
  • Dr. Treistman adds that the microRNA process observed in this study may represent a general mechanism of neuronal adaptation to alcohol, with miR-9 playing a pivotal role in a complex regulatory network. (nih.gov)
  • In future studies, it will be interesting to determine if similar microRNA-based regulatory mechanisms influence alcohol problems in human populations. (nih.gov)
  • Previously it was known that microRNAs were important for the development of a subset of helper T cells called regulatory T cells, which are required to regulate the immune response and prevent attacks against host tissue that lead to autoimmunity. (rvc.ac.uk)
  • MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. (rvc.ac.uk)
  • Sharp, who is affiliated with MIT's Biology Department and Center for Cancer Research, said microRNA exists in every cell and controls a wide range of cell regulatory activities. (mit.edu)
  • Mechanistically, bulk RNA-seq and gene set enrichment analysis of ECs enriched from the aortic arch intima, as well as single cell RNA-seq from atherosclerotic lesions, revealed that endothelial miR-181a2b2 serves as a critical regulatory hub in controlling endothelial inflammation, cell adhesion, cell cycle, and immune response during atherosclerosis. (unl.edu)
  • While the standard method, qPCR, allows for quick and cheap microRNA quantification, specificity is limited due to the short lengths of microRNAs and the high similarity between closely related microRNA family members. (lu.se)
  • NEW YORK (GenomeWeb) - A team from the UK, the US, and Sweden has expanded the collection of microRNAs previously documented in the genome of the domestic dog, Canis familiaris . (genomeweb.com)
  • Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
  • MIT post-doc Joel Neilson, left, graduate student Margaret Ebert and Institute Professor Phillip Sharp have developed a new technique to study the function of microRNA that could shed light on the genetic material's hypothesized role in cancer. (mit.edu)
  • The new technique could shed more light on microRNA's role in tumor development: Earlier studies have shown that a type of microRNA known as let-7 inhibits a cancer-inducing gene called RAS. (mit.edu)
  • We are interested in microRNAs, which we think have a role in the development of cancer", says Sofi Elmroth. (lu.se)
  • The quantity of microRNAs in different types of cancer varies and each type of cancer appears to display a specific pattern. (lu.se)
  • Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379 (miR-379) in prostate cancer bone metastasis. (lu.se)
  • The many RNAs of this class resembled the lin-4 and let-7 RNAs, except their expression patterns were usually inconsistent with a role in regulating the timing of development. (wikipedia.org)
  • MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems. (hindawi.com)
  • Although they are structurally similar, plant and animal microRNAs repress gene expression through very different mechanisms. (freethoughtblogs.com)
  • This study demonstrates for the first time that alcohol exposure can cause rapid changes in microRNA levels, altering gene expression, and perhaps behavior," added Antonio Noronha, Ph.D., director of NIAAA's Division of Neuroscience and Behavior. (nih.gov)
  • Take control of microRNA expression for powerful functional screening of hundreds or thousands of microRNAs. (horizondiscovery.com)
  • Selectable promoters on optimized microRNA constructs with the Tet-On 3G tetracycline-inducible expression system for unsurpassed control of mature microRNA expression. (horizondiscovery.com)
  • A novel construct for inducible expression of a mature microRNA, shMIMIC Inducible Lentiviral microRNA pooled libraries are available to target every human and mouse microRNA within in the miRBase database ( www.mirbase.org ). (horizondiscovery.com)
  • Choose shMIMIC Lentiviral microRNA Pooled Libraries for constitutive expression of mature microRNAs. (horizondiscovery.com)
  • The expression patterns of microRNAs vary less by brain region and age in people with autism than in controls. (spectrumnews.org)
  • The discovery of microRNAs that regulate gene expression has changed our view of cellular biochemistry. (spectrumnews.org)
  • Chromosomal duplications or deletions may influence autism-linked genes indirectly, by altering fragments of RNA that regulate gene expression, according to a study published 25 February in PLoS One. (spectrumnews.org)
  • To optimally utilize the biological and clinical information that is contained in microRNA expression levels, tools for their accurate and cost-effective quantification are needed. (lu.se)
  • If there is even a slight error in the levels of expression, in the quantity of microRNAs, then there is a very strong correlation to disease. (lu.se)
  • Over the past decade, non-coding RNAs have become a hot topic in research. (lu.se)
  • 8 Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, New York, USA. (jci.org)
  • Sharp and MIT biology graduate student Margaret Ebert, lead author of the paper, decided to block microRNA activity by creating a gene that produces microRNA sponges and inserting it into their target cells. (mit.edu)
  • Researchers are finding new RNA all the time because sequencing is now so quick and cheap", says Sofi Elmroth, professor at the Division of Biochemistry and Structural Biology at Lund University. (lu.se)
  • The assays can detect as few as five copies of microRNAs, and can detect microRNAs with high A-T sequence content due to the inclusion of the company's Locked Nucleic Acid, or LNA, technology in the PCR primers. (genomeweb.com)
  • Today there are many companies that can quickly produce exact copies of the microRNAs that occur naturally in the body. (lu.se)
  • We are now looking at additional data for dog and a variety of farm animals," Penso-Dolfin said, "combining microRNA discovery to the investigation of their possible role in domestication. (genomeweb.com)
  • Functional profiling reveals critical role for microRNA in differentiation of human mesenchymal stem cells. (horizondiscovery.com)
  • We have investigated the role of microRNAs in the context of bone function and dysfunction and have found that concentrations of certain microRNAs differ between fractured and non-fractured patients of osteoporosis (Kocijan et al. (databasefootball.com)
  • We also studied the role of A-to-I RNA editing in regulating miR-379 function. (lu.se)
  • In the current study, researchers led by Dr. Treistman, Professor of Psychiatry and Director of the Brudnick Neuropsychiatric Research Institute at the University of Massachusetts Medical School in Worcester , MA, examined whether microRNA might be involved in the alcohol tolerance observed in the BK channel. (nih.gov)
  • In this work, RVC researchers set about to understand microRNA regulation of helper T cells development. (rvc.ac.uk)
  • MIT researchers have developed a new way to study the function of microRNA, tiny strands of genetic material that help regulate at least 25 percent of a cell's genes. (mit.edu)
  • By de-activating microRNA, researchers can observe the resulting effects and determine which genes the microRNA is targeting. (mit.edu)
  • The sponge gene also includes a "reporter" gene that causes the cell to become fluorescent if it has taken up the gene, so the researchers can know for sure whether the microRNA sponge is being produced in a particular cell. (mit.edu)
  • More importantly, the sponge technique could be used to create transgenic animals that express the sponge in all of their cells, allowing researchers to study microRNA function at the organismal level. (mit.edu)
  • A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)
  • That could change, however, now that MIT Institute Professor Phillip Sharp and his colleagues have found a way to inhibit the activity of microRNA by genetically altering cells. (mit.edu)
  • The MIT team has found a way to block microRNA activity by tricking cells into producing a microRNA "sponge," which soaks up microRNA and renders it ineffective. (mit.edu)
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • People with autism show differences from controls in the levels of microRNAs, small noncoding bits of RNA, in the social and sound-processing parts of the brain. (spectrumnews.org)
  • The aim of the present study was to reveal the new molecular mechanism of long non‑coding (lnc)RNA XIST in the development of hepatic carcinoma. (spandidos-publications.com)