An operationally simple and entirely green protocol for heteropoly acid catalyst conjugate addition of indoles and pyrrole to unsaturated carbonyl compounds and nitro-alkene in water was investigated. (sharif.edu)
Alkaloid2
The first indole alkaloid, strychnine, was isolated by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818 from the plants of the genus Strychnos. (wikipedia.org)
Camalexin is a simple indole alkaloid produced by the plant Arabidopsis thaliana, often used as a model for plant biology. (wikipedia.org)
Derivatives6
The latter include terpenoid structural elements, synthesized by living organisms from dimethylallyl pyrophosphate (DMAPP) and/or isopentenyl pyrophosphate (IPP): Non-isoprenoid: Simple derivatives of indole Simple derivatives of β-carboline Pyrroloindole alkaloids Indole-3-carbinol Indole-3-acetic acid Tryptamines Carbazoles Isoprenoid: hemiterpenoids: ergot alkaloids monoterpenoids. (wikipedia.org)
One of the simplest and yet widespread indole derivatives are the biogenic amines tryptamine and 5-hydroxytryptamine (serotonin). (wikipedia.org)
Pyrolo-indole alkaloids form a relatively small group of tryptamine derivatives. (wikipedia.org)
These polymaleimide derivatives can be active catalysts for the selective oxidation of heterocyclic compounds to quinoline and indole via the recycling of -C=O and -C-OH groups, which was confirmed by tracing the reaction with GC-MS using maleimide as the catalyst and by FT-IR analysis with polymaleimide as the catalyst. (nature.com)
Catalytic performance exploration showed that these polymaleimide (PMI) derivatives can be active catalysts for the selective oxidation of heterocyclic compounds to quinoline and indole via the recycling of -C=O and -C-OH groups. (nature.com)
Indole and many of its derivatives are present in many substances commonly found in nature. (sharif.edu)
Conjugate addition1
Specifically, visible-light-induced PAGs were used to facilitate the 1,4-conjugate addition between indoles and vinyl ketones. (shu.edu)
Synthesis4
The work disclosed in this dissertation outlines novel reactions involving indoles and their applications towards the total synthesis of natural products, tronocarpine and dippinine B. (uwo.ca)
The research in this thesis outlines two new methods for the synthesis of further functionalized indole products. (uwo.ca)
This work describes the use of photoacid generators (PAGs) as tools for organic synthesis, generating strong acids upon light absorption catalyzing Michael addition reactions. (shu.edu)
Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis. (escholarship.org)
Infections positive test results for oxidase, catalase, arginine dihydro- lase, and o -nitrophenyl--D-galactopyranoside and nega- tive reactions for urease, nitrates, and indole. (cdc.gov)
This minireview showcases the role indole diterpenoids have played in inspiring the recent development of clever synthetic strategies, and new chemical reactions. (escholarship.org)
Chemical modifications in the N1 position are among the most frequently performed changes in the ergoline system, as the Indole nitrogen is easily accessible for alkylations, acylations, Mannich reactions and Michael additions. (innovatechems.com)
Some simple indole alkaloids do not contain tryptamine, such as gramine and glycozoline (the latter is a derivative of carbazole). (wikipedia.org)
Isoprenoid indole alkaloids include residues of tryptophan or tryptamine and isoprenoid building blocks derived from the dimethylallyl pyrophosphate and isopentenyl pyrophosphate. (wikipedia.org)
Moiety2
This firstly involved building a rather complex indole unit, using typical aromatic chemistry for the majority of the functionality, saving a rather neat Stille coupling to attach a methyl acrylate moiety. (chemistryworld.com)
The enamine undergoes Michael addition to the acrylate moiety, followed by a Mannich reaction of the indole with the newly formed iminium ion to give the product as a single isomer. (chemistryworld.com)
Ketones1
The Highly Stereoselective Michael Reaction of α,β-Unsaturated Ketones with Silyl Enol Ethers of Thioesters Catalyzed by Trityl Salts. (u-tokyo.ac.jp)
Reaction4
This study investigates microparticles formed by a thiol-Michael addition step-growth polymerization reaction with tunable physiochemical properties and their uptake by macrophages. (bvsalud.org)
Pyrroles also readily underwent Michael addition at Α-positions under the same reaction conditions. (sharif.edu)
Trityl Perchlorate Catalyzed Tandem Michael-aldol Reaction. (u-tokyo.ac.jp)
An intramolecular oxy-Michael reaction under basic conditions was used to construct the [6,6]-spiroketal in a stereocontrolled manner. (acs.org)
Molecule1
Important as a component of many pharmaceuticals, indole is a biological molecule found throughout the natural world. (uwo.ca)
Nitrogen1
Noting that DEET and indole exhibit overlapping chemical features, including the presence of an aromatic ring and a neighboring nitrogen atom (Fig. 1a), we hypothesized that indole might interfere with OR8 function. (vimsensorshop.com)
Biological1
Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. (escholarship.org)
Inhibition1
In our arm-in-a-cage assay, 1 M of DEET reduced mosquito visits on average by 69.3% while the same indole concentration achieved 97.8% inhibition. (vimsensorshop.com)
Acid1
A series of hybrid compounds that incorporated anthranilic acid with activated 1H-indoles through a glyoxylamide linker were designed to target bacterial RNA polymerase holoenzyme formation using computational docking. (edu.au)
Addition2
They are produced by methylation of indole nucleus at position 3 and the subsequent nucleophilic addition at the carbon atom in positions 2 with the closure of the ethylamino group into a ring. (wikipedia.org)
The Michael addition between indole and methyl vinyl ketone in the presence of. (sharif.edu)
Complex1
Inhibitors of bacterial RNA polymerase transcription complex" by Daniel S. Wenholz, Michael Miller et al. (edu.au)
Presence1
The correct structural formula of strychnine was determined only in 1947, although the presence of the indole nucleus in the structure of strychnine was established somewhat earlier. (wikipedia.org)
Role1
Role of indole curcumin in the epigenetic activation of apoptosis and cell cycle regulating genes. (cdc.gov)
High2
Hydrogen bond activation of donor-acceptor cyclopropanes was successful in generating a multitude of functional indole products in high yields. (uwo.ca)
High indole dosages have been demonstrated to repel the oviposition of mosquitoes such as Toxorhynchites spp. (vimsensorshop.com)
Search1
In our search for potential long-range inhibitors of attractants to human hosts, we have hypothesized that the shared chemical similarities between indole and DEET may confer the former with the ability to block odorant receptor function and inhibit human host attraction in a similar way as DEET. (vimsensorshop.com)
On the other hand, the designer responsible for the idea of FORM is Michael Sontag , who is famous for working without drawing sketches, but draping the textiles around the bodies of the mannequins. (theplumgirl.com)
Whenever I get a wet pet fur in a fragrance, I am almost sure Jasmine sambac is used in a concentrated form, which frees the animalic vapors hidden in the indoles of the innocent white petals. (theplumgirl.com)
Range2
Indole significantly inhibits OR8 activation by (R)-1-octen-3-ol, mosquito visits to a human hand and long-range human host-seeking. (vimsensorshop.com)
A range of substituted 1H-indole-2,3-diones (isatins) was synthesized to assess their capability to inhibit caspases and prevent apoptosis in Jurkat T cells. (wright.edu)
Method1
Method two functionalizes indoles by reacting them with strained three-membered ring molecules called cyclopropanes. (uwo.ca)
Final1
Michael T. Osterholm, PhD, MPH tion with final consensus recommendations supported by all working group members. (cdc.gov)