• In this study spatial reconstructions and electrophysiological measurements of layer II/III pyramidal neurons of the somatosensory cortex from wild-type (WT) and transgenic (TG) human amyloid precursor protein (hAPP) overexpressing Tg2576 mice were used to build faithful segmental cable models of these neurons. (frontiersin.org)
  • Introduced into transgenic mice, vCJD prions assumed an identity "indistinguishable from BSE prions", the researchers write in the PNAS. (bbc.co.uk)
  • The transgenic mice used in this study could be used to check this linkage, the team say. (bbc.co.uk)
  • Unlike some lab models, the mice used in Mayo Clinic's multiple myeloma model have functioning immune systems, making it a transgenic model. (mayo.edu)
  • The international team led by Haim Cohen, PhD, director of the Sagol Healthy Human Longevity Center at Bar-Ilan University, developed transgenic mice that express high levels of the SIRT6 gene and presented data suggesting that their life expectancy can be increased by an average of 30% in both males and females. (genengnews.com)
  • In contrast, the authors noted, "Aged SIRT6-transgenic mice preserve hepatic glucose output and glucose homeostasis through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol. (genengnews.com)
  • The result was 'transgenic mice. (mentalfloss.com)
  • Here we apply 2-dimensional polarization imaging [1] to visualize aggregation of human α-synuclein expressed in brain tissue from transgenic mice. (lu.se)
  • The fact that it can strike one genetically identical twin to the exclusion of the other means that there are more than just genes involved. (scienceblog.com)
  • The scientists conducted experiments with mice genetically-altered to produce the same prions naturally found in cows. (bbc.co.uk)
  • In the early 1980s, researchers began genetically manipulating mice by inserting genes from other species (including humans) during the earliest stages of embryonic cell division. (mentalfloss.com)
  • Recent studies have found differences between almost genetically identical mice that were attributable to differences between their microbiomes. (nih.gov)
  • Thus, the clone would be genetically identical to the nucleus donor only if the egg came from the same donor or from her maternal line. (who.int)
  • Beyond this scientific interest, the commercial concern in animal cloning focuses on replicating large numbers of genetically identical animals, especially those derived from a progenitor that has been modified genetically. (who.int)
  • Causal impact of a full-gene deletion will be investigated in all organ systems by comparing phenotypic characteristics of KO-mice with wild-type control mice of the same genetic C57BL/6N background (Munoz-Fuentes et al. (springer.com)
  • Fixed-frozen retinas from adult C57BL/6N mice were used for immunohistochemistry, laser scanning confocal microscopy, and enzymatic histochemistry. (molvis.org)
  • Recently, two N-acetyltransferase genes, Nat-1 and Nat-2, were cloned from rapid (C57BL/6J) and slow (A/J) acetylator mouse strains. (cdc.gov)
  • So he began to dream of mice strains that were identical and docile, 'like newly minted coins. (mentalfloss.com)
  • In reality, C.C. Little's process for creating inbred mouse strains was neither quick nor exact. (mentalfloss.com)
  • He discovered, for instance, that you can breed strains of mice with bodies that readily accept transplanted cancer tumors. (mentalfloss.com)
  • Researchers quickly realized the value of using standardized mice strains, and the money began pouring in. (mentalfloss.com)
  • The genomic clone encoding NAT-1 is identical in rapid and slow acetylator mouse strains, whereas the clone encoding NAT-2 differs between rapid and slow strains by a single base pair, which changes the encoded amino acid from Asn99 in the rapid acetylator strain to Ile99 in the slow acetylator strain. (cdc.gov)
  • Overall, the ORT is a relatively low-stress, efficient test for memory in mice, and is appropriate for the detection of neuropsychological changes following pharmacological, biological, or genetic manipulations. (jove.com)
  • More than 99.9% of the genetic code is identical among us, and the 0.1% variation is important in health traits such as height, weight and eye color. (cdc.gov)
  • Figure 2 shows two mice with identical genetic codes (as with identical twins). (cdc.gov)
  • Mice have a similar genetic polymorphism in N-acetyltransferase activity and have been used as models of the human polymorphism in many studies of the toxicology and carcinogenicity of arylamines. (cdc.gov)
  • Using tooth Pulp Cells ill SCNT increased the first cleavage rates compared with adult somatic Cells, leading to a higher rate of DNA reprogramming and increased production of an identical embryonic stem cells (ESCs) line. (yildiz.edu.tr)
  • Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. (nih.gov)
  • Brain Res Rev 67, 252-9, 2011, PMID 21356243 Jacquelin C, Strazielle C, Lalonde R. Neurologic function during developmental and adult stages in Dab1(scm) (scrambler) mutant mice. (wikipedia.org)
  • Yet, the mouse shares a similar developmental trajectory to the human heart and a comparable four-chamber morphology that greatly enhances its translational value as a model organism, despite the substantial differences in size (Krishnan et al. (springer.com)
  • Some key developmental genes in the fly can be replaced by the mouse versions without any ill effect, for instance. (newscientist.com)
  • We therefore used optical fluorescence imaging to trace longitudinal calcium FC in the awake, resting-state mouse cortex in the same mice at 5 developmental time points beginning at postnatal day 15 (P15) and ending in early adulthood (P60), resulting in over 500 imaging epochs with both calcium and hemodynamics available as a resource for the field. (biorxiv.org)
  • Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. (lu.se)
  • These findings in mice may help shed light on how schizophrenia, an often severe and debilitating disease, emerges in humans. (scienceblog.com)
  • Many cancer drugs fail clinical trials because a lab model - usually a mouse -- wasn't able to accurately mimic disease processes in humans. (mayo.edu)
  • Drugs that were known to be effective in humans also reduced myeloma tumors in the mice, and drugs that hadn't worked in humans also failed in the mice. (mayo.edu)
  • the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. (cdc.gov)
  • Scientists' inability to replicate research findings using mice and rats has contributed to mounting concern over the reliability of such studies. (eurekalert.org)
  • In research published online April 28 in Nature Methods , the scientists report that the presence of male experimenters produced a stress response in mice and rats equivalent to that caused by restraining the rodents for 15 minutes in a tube or forcing them to swim for three minutes. (eurekalert.org)
  • This stress-induced reaction made mice and rats of both sexes less sensitive to pain. (eurekalert.org)
  • 1-dimensional version of the nasal passages have the same inspira- carcinogen in rats and mice. (cdc.gov)
  • By creating an LS mouse model that reproduced features of the human disorder, the Kontaridis group found that the mutations in PTPN11 that cause LEOPARD syndrome are distinct, and lead to a loss of phosphatase activity and hyperactivation of the AKT/mTOR pathway - which leads to the development of hypertrophic cardiomyopathy. (scienceblog.com)
  • Despite the widespread dendritic degeneration and membrane alterations in mutant mouse neurons, surprisingly little, or no change was detected in steady-state and 50 Hz sinusoidal voltage transfers, current transfers, and local and propagation delays of PSPs traveling along dendrites of TG neurons. (frontiersin.org)
  • Our simulations predict the way how subthreshold dendritic signaling and pattern recognition are preserved in TG neurons: amyloid-related membrane alterations compensate for the pathological effects that dendritic atrophy has on subthreshold dendritic signal transfer and integration in layer II/III somatosensory neurons of this hAPP mouse model for AD. (frontiersin.org)
  • Two weeks post-stroke, mice received intramuscular injections of pseudorabies virus (PRV-152), a trans-synaptic retrograde herpes virus driving expression of green fluorescent protein (GFP), into the affected contralesional forelimb to label neurons in descending tracts to the forelimb musculature. (frontiersin.org)
  • It takes about two years for the mice to develop tumors, which is very slow relative to the mouse life span. (mayo.edu)
  • Two of the most common rodents in North America, deer mice and house mice have many similarities. (crittercontrol.com)
  • Contact between wild mice and pet rodents is the most likely cause of transmission to pet rodent populations. (cdc.gov)
  • Metabolic Remodeling with Hepatosteatosis Induced Vascular Oxidative Stress in Hepatic ERK2 Deficiency Mice with High Fat Diets. (nih.gov)
  • On the other hand, we have in a recent past exposed mice to diets containing fish and mimicking the Wayana Amerindians mercurial contamination or the Western populations' average fish consumption [ 1 , 2 ]. (hindawi.com)
  • After two months of feeding with such diets, we analyzed the mercury accumulation in tissues, the mice body growth kinetics, the possible behavioral impairments, and the concentration of neurotransmitters in various brain structures. (hindawi.com)
  • In fact, SIRT6 activates a physical response that is identical to diets that increase longevity. (genengnews.com)
  • Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
  • The International Mouse Phenotyping Consortium, IMPC, has set the goal of systematically "knocking out" each protein-coding genes in the mouse and phenotyping these so-called knockout (KO) mice using highly standardized high-throughput tests (Brown and Moore 2012 ). (springer.com)
  • Scientists also began turning off specific genes during early development, creating 'knockout mice. (mentalfloss.com)
  • This suggests that these mice might provide researchers with a good model system for studying schizophrenia and testing new drugs designed to treat people suffering from it. (scienceblog.com)
  • Mayo Clinic researchers have figured out how, with the development of a mouse model of multiple myeloma, the second most common blood cancer in the United States according to the National Cancer Institute. (mayo.edu)
  • In both wild-type and the SIRT6 overexpressing mice, the researchers used a combination of physiological assays, including in vivo multi-omics analyses and 13C lactate tracing. (genengnews.com)
  • Scrambler is a spontaneous mouse mutant lacking a functional DAB1 gene, resulting in a phenotype resembling that seen in the reeler mouse. (wikipedia.org)
  • β1(-/-) mice exhibit a dramatic neurological phenotype that includes an ataxic gait, spontaneous seizures, and premature death. (jneurosci.org)
  • They also have nearly identical droppings. (crittercontrol.com)
  • With the exception of lentigines, Noonan syndrome patients exhibit nearly identical features and pathologies. (scienceblog.com)
  • Sixty-four mice ( Mus musculus ), female, adult, Swiss strain, weighing approximately 20 g, were divided into four groups: G1: control (n = 24), G2: nephropathy group (N) (n = 7), G3, DM (n = 9), and G4: N+DM (n = 24). (scielo.br)
  • In sexual reproduction, clones are created when a fertilized egg splits to produce identical (monozygous) twins with identical genomes. (who.int)
  • Here, we used the Df1 /+ mouse model of 22q11.2DS to investigate the relationship between hearing loss and susceptibility to schizophrenia-relevant brain and behavioral abnormalities. (biorxiv.org)
  • We found that hearing loss in Df1 /+ mice affected schizophrenia-relevant endophenotypes, including electrophysiological measures of central auditory gain and behavioral measures of auditory sensorimotor gating. (biorxiv.org)
  • The object recognition test (ORT) is a commonly used behavioral assay for the investigation of various aspects of learning and memory in mice. (jove.com)
  • Our finding of α-synuclein aggregation in olfactory bulbs of old mice correlates with results from a behavioral study on that mice [2]. (lu.se)
  • A related study in today's on-line issue of the JCI, by a team of scientists at the University Health Network, Toronto, found that in a mouse model of Noonan syndrome, excessive activity of an enzyme called ERK (a downstream target of the RAS pathway) led to the development of hypertrophic cardiomyopathy, and that treatment with an ERK inhibitor currently being tested as an anti-cancer agent, reversed the cardiomyopathy. (scienceblog.com)
  • This study investigated effects of the aqueous extract of its leaves (ATL) on cognitive and emotional deficits using an olfactory bulbectomized mouse (OBX) model. (hindawi.com)
  • This sensor, identical to that found in our top-tier wireless mice, delivers unrivaled precision. (guru3d.com)
  • The prognosis of the therapy of mice with diabetes mellitus using Osmangazi Turk Identical ESC was good. (yildiz.edu.tr)
  • These Outcomes are promising for regenerative medicine ill the therapy of diabetes mellitus, and clarification of the importance of selecting appropriate adult somatic cells in deriving identical ESC lines is also a significant step. (yildiz.edu.tr)
  • Thus, BPA exposure is associated with a higher number of yellow mice predisposed to obesity and diabetes. (cdc.gov)
  • We see a spectrum of differences-some mice develop the multiple myeloma tumor, are resistant to therapy and die rapidly, while some have a more indolent tumor and live longer. (mayo.edu)
  • But until one is found, Mayo's mouse has paved the way for new multiple myeloma clinical trials to improve treatment for patients. (mayo.edu)
  • To test the model's accuracy, Drs. Chesi and Bergsagel gave the mice several multiple myeloma drugs that have already undergone clinical trials. (mayo.edu)
  • One major difference between deer mice and house mice is coloration. (crittercontrol.com)
  • House mice have uniformly gray fur, while deer mice have white feet and undersides with brown upper bodies. (crittercontrol.com)
  • Unlike house mice, deer mice prefer to live outdoors in forests, grasslands, or farms. (crittercontrol.com)
  • The pests differ in one crucial way in their effect on human health: Hantavirus is a disease carried by deer mice, but not house mice, and can be fatal in some cases. (crittercontrol.com)
  • Efforts should be made to keep house mice out of homes and businesses to reduce the potential for contact. (cdc.gov)
  • Beyond this, they were able to conduct the same level of vigorous activity as young mice, and didn't become frail. (genengnews.com)
  • The aggregation pattern was not found in young mice. (lu.se)
  • If a mouse possessed a trait that Little considered desirable, he'd launch a multi-generational inbreeding process to create a new strain. (mentalfloss.com)
  • These days, when geneticists want to create a new strain of mice, they often take a more hands-on approach. (mentalfloss.com)
  • The abundance of Nat-2 mRNA and Nat-1 mRNA was equivalent in both rapid and slow acetylator mouse strain livers. (cdc.gov)
  • Other mouse diseases, such as salmonellosis and leptospirosis, may come from either species. (crittercontrol.com)
  • They discovered, not unexpectedly, that there was no species barrier between the mice and cows. (bbc.co.uk)
  • Once again there was no apparent sign of a species barrier, but, more significantly, vCJD had virtually the same incubation period in the mice as BSE. (bbc.co.uk)
  • Huge chunks of this information are identical or differ only slightly even between species that appear very different. (newscientist.com)
  • Neuronal position in the developing brain is regulated by mouse disabled-1. (wikipedia.org)
  • To investigate the effects of loss of β1 function in vivo , we have used gene-targeting methods to produce β1(-/-) mice, and we have analyzed their neuronal phenotypes. (jneurosci.org)
  • Diseased brain tissue injected into the mice produced symptoms in 250 days, the same incubation period experienced by cattle with BSE. (bbc.co.uk)
  • J Neurosci 17: 8767-77, 1997, PMID 9348346 Gallagher E, Howell BW, Soriano P, Cooper JA, Hawkes R. Cerebellar abnormalities in the disabled (mdab1-1) mouse. (wikipedia.org)
  • Nature 389, 733-7, 1997, PMID 9338785 Lalonde R, Strazielle C. Sensorimotor learning in Dab1(scm) (scrambler) mutant mice. (wikipedia.org)
  • Df1 /+ mice have a multi-gene deletion analogous to the chromosomal microdeletion that causes human 22q11.2DS, and like human 22q11.2DS patients exhibit high rates of hearing loss arising primarily from susceptibility to middle ear inflammation. (biorxiv.org)
  • In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)
  • Their experiments in lab mice and in human blood and tissue samples further showed that this gene not only is associated with the disease, as predicted computationally, but is also likely to play a major causal role. (stanford.edu)
  • Between 1909 and 1914, C.C. Little toiled in the biology labs of Harvard's Bussey Institute, using mice to learn how mammals inherit traits from their parents. (mentalfloss.com)
  • The mouse MMR protein is synthesized as a 1456 amino acid (aa) precursor that contains a 19 aa signal sequence, a 1369 aa extracellular region, a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (4). (rndsystems.com)
  • In addition to the 10 cysteines there are only 16 identical amino acids in the proteins from human, rhesus monkey, baboon, pig, rat and mouse. (lu.se)
  • Beyond that, we are linking metabolism to the heart and describing phenotypes that emerge in a set of known genes, when knocked out in mice, such as the leptin receptor ( Lepr ), leptin ( Lep ), and Bardet-Biedl syndrome 5 ( Bbs5 ). (springer.com)
  • In this report, the N-acetylation polymorphism in mice was investigated by transiently expressing the cloned N-acetyltransferase genes in COS-1 cells. (cdc.gov)
  • Tmem53 -/- mice recapitulate the human skeletal phenotypes. (nature.com)
  • But the big surprise came when human brain tissue infected with the prions that cause vCJD was injected into the mice. (bbc.co.uk)
  • On the other hand, if a drug works well to eradicate tumor in the mice, there is a 70 percent chance the drug will also work in human patients," Dr. Chesi says. (mayo.edu)
  • In the Df1 /+ mouse model of human 22q11.2 Deletion Syndrome, we find that hearing loss shapes measures that are considered schizophrenia-relevant endophenotypes, such as central auditory gain and auditory sensorimotor gating. (biorxiv.org)
  • Mouse to human, the extracellular region is 82% aa identical. (rndsystems.com)
  • The "self"-protein albumin in mouse airway fluid was uniquely modified by GSH-MDI at position 414K, a preferred site of MDI reactivity on human albumin. (cdc.gov)
  • β1(-/-) mice appear ataxic and display spontaneous generalized seizures. (jneurosci.org)
  • Once Little had his own lab, he employed assistants whose sole job was to check mouse litters for mutants. (mentalfloss.com)
  • In response to the ever-evolving landscape of esports, Razer's approach to mouse design has undergone a profound transformation. (guru3d.com)
  • These mice provided some of the first evidence that susceptibility to cancer can be inherited, just like hair color. (mentalfloss.com)
  • Now a new study showing that the mTOR inhibitor drug rapamycin can reverse cardiac muscle damage in a mouse model of the congenital disease LEOPARD syndrome not only identifies the first possible medical treatment for this rare condition, but also demonstrates the importance of targeted therapies in managing congenital diseases. (scienceblog.com)
  • In this review, we summarize the current advances of the IMPC in cardiac research and describe in detail the diagnostic requirements of high-throughput electrocardiography and transthoracic echocardiography capable of detecting cardiac arrhythmias and cardiomyopathies in mice. (springer.com)
  • The research team also found their altered mice were highly susceptible to infection with the sheep prion disease scrapie, although this produced a different biological pattern. (bbc.co.uk)
  • Sometimes, the traits that Little and his team found most useful were the ones that produced the least healthy mice. (mentalfloss.com)
  • J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Goat Anti-Mouse MMR/CD206 APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB2535A, filled histogram) or isotype control antibody (Catalog # IC108A , open histogram). (rndsystems.com)
  • The mouse Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 175 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells (1). (rndsystems.com)
  • SCOTT: And staying up all night can ease depression - in mice. (wdiy.org)
  • Cell ectopias are identical with targeted disruption of Dab1. (wikipedia.org)
  • Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
  • Detection of MMR/CD206 in J774A.1 Mouse Cell Line by Flow Cytometry. (rndsystems.com)
  • Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
  • We employ Förster Resonance Energy Transfer (FRET) between identical (single color) green fluorescent protein (GFP) tags linked to α-synuclein. (lu.se)
  • Targeted restoration of CREB expression selectively into the LA of CREB-deficient mice is sufficient to fully restore auditory fear conditioning. (nature.com)
  • Moreover, PV+ inhibitory interneurons, another marker for schizophrenia pathology, were significantly reduced in density in auditory cortex but not secondary motor cortex of Df1 /+ mice with hearing loss. (biorxiv.org)
  • Moreover, we report a reduction in density of PV+ inhibitory interneurons in the auditory cortex, but not secondary motor cortex, of Df1 /+ mice with hearing loss. (biorxiv.org)
  • A second group of mice given prions from the first group also became sick in virtually the same period of time. (bbc.co.uk)
  • Mice suffer few outward consequences when infected, because they are the natural reservoir, but hamsters can experience everything from no symptoms to severe illness and death. (cdc.gov)
  • Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene. (nih.gov)
  • The pattern of brain damage was also identical. (bbc.co.uk)
  • STPT automatically generates high-resolution images of coronal sections of the entire mouse brain that can be readily visualized in three dimensions. (frontiersin.org)
  • We also quantified sub-acute neuroinflammation in the post-stroke brain in a separate cohort of mice following a 60 min transient middle cerebral artery occlusion (tMCAo). (frontiersin.org)
  • This protocol is called MICE, the traces are identical). (barco.com)
  • To illustrate our imaging techniques and automated image quantification, we examined long-term post-stroke motor circuit connectivity in mice that received a motor cortex photothrombotic stroke. (frontiersin.org)
  • This house mouse is so widespread that elimination of the mouse and the virus is impractical. (cdc.gov)
  • USE THE MOUSE to search for identical sweets. (games.co.uk)
  • This example uses images which are identical in size. (w3.org)
  • The small size of deer mice allows them easy entry into homes to build nests or store food. (crittercontrol.com)
  • The boxes are identical in size. (mouseprint.org)
  • These assays identified an age-dependent decline in glucose homeostasis and hepatic glucose output in wild-type mice. (genengnews.com)
  • The term "clone", from the Greek word for twig, denotes a group of identical entities. (who.int)
  • I still have the mouse-glueing problem which occurs earlier or later at a session. (sysopt.com)