Mice with collagen induced arthritis. Medical search. Frequent questions

Rheumatoid arthritis (RA) is characterized by joint synovitis and bone destruction, the etiology of which remains to be explored. (elifesciences.org)
This study presents an important finding on the role of GLI1 in macrophages and osteoclasts in the pathogenesis of inflammatory arthritis, and suggests a therapeutic potential of GLI1 targeting in rheumatoid arthritis. (elifesciences.org)
Rheumatoid arthritis (RA) is a common chronic inflammatory disease that currently affects approximately 75 million people worldwide. (elifesciences.org)
Together with increasing evidence that worm infection may protect against autoimmune conditions, this raises the possibility that ES-62 may have therapeutic potential in rheumatoid arthritis and hence, it is important to fully understand its mechanism of action. (gla.ac.uk)
Collagen-induced arthritis in mice has been widely used to address questions of disease pathogenesis and to validate therapeutic targets for human rheumatoid arthritis. (ox.ac.uk)
Proinflammatory cytokines, such as tumor necrosis factor-alpha and interleukin--1beta, are abundantly expressed in the arthritic joints of mice with collagen-induced arthritis and, as in human rheumatoid arthritis, blockade of these molecules is effective in reducing the severity of disease. (ox.ac.uk)
This cytokine is suspected to be involved in the development of rheumatoid arthritis (RA) because this cytokine expression is augmented in synovial tissues of RA patients. (aai.org)
Rheumatoid arthritis (RA) 4 is one of the most serious medical problems, affecting ∼1% of all people worldwide, irrespective of race. (aai.org)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and bone destruction at the joints, causing pain and motor disturbance. (biomedcentral.com)
Rheumatoid arthritis (RA) is an autoimmune disease of the joint synovial membranes. (nih.gov)
rheumatoid arthritis. (nih.gov)
Among immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies, particularly in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. (frontiersin.org)
This report contains a description of the cellular localization and kinetics of proinflammatory cytokine expression in murine CIA, a model for rheumatoid arthritis. (ox.ac.uk)
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation. (hindawi.com)
Reduces IL-1β and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. (rndsystems.com)
Objective To assess the safety and efficacy of secukinumab, a fully human monoclonal anti-interleukin-17A antibody, in patients with rheumatoid arthritis (RA). (bmj.com)
Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease of unknown aetiology. (bmj.com)
Low-dose weekly methotrexate (MTX), the most widely used disease-modifying drug for rheumatoid arthritis (RA), reduces disease-associated cardiovascular mortality. (bmj.com)
Premature cardiovascular disease (CVD) is a serious long-term complication of chronic systemic inflammatory diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). (bmj.com)
For the discovery of anti-TNF therapy as an effective treatment for rheumatoid arthritis and other autoimmune diseases. (laskerfoundation.org)
The 2003 Albert Lasker Award for Clinical Medical Research honors two scientists who discovered anti-TNF therapy as an effective treatment for rheumatoid arthritis and other autoimmune diseases. (laskerfoundation.org)
They made their breakthroughs by studying rheumatoid arthritis, a chronic autoimmune disease that afflicts approximately 0.5 to 1.0 percent of the population. (laskerfoundation.org)
He chose rheumatoid arthritis, because it would provide the opportunity to study tissue at the height of inflammation, which was not possible in Graves' disease: Doctors routinely remove diseased tissue from rheumatoid arthritis patients to relieve symptoms. (laskerfoundation.org)
The notion that deranged cytokine behavior fostered rheumatoid arthritis had snagged his attention as well, and the two scientists teamed up, hoping eventually to harness the chaos. (laskerfoundation.org)
The two researchers, as well as others, showed that the joints of people with rheumatoid arthritis teem with proinflammatory cytokines. (laskerfoundation.org)
Combined collagen-induced arthritis and organic dust-induced airway inflammation to model inflammatory lung disease in rheumatoid arthritis. (cdc.gov)
Rheumatoid arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. (cdc.gov)
Our data provide preclinical evidence that TRA-8 is a potential novel biologic agent for rheumatoid arthritis therapy. (nih.gov)
Results: The calibrations revealed high accuracy and reliability of the IR camera for detecting temperature changes in the rheumatoid arthritis animal model. (mendeley.com)
However, immune dysregulation and over activation of inflammatory T cells can induce autoimmune diseases such as Rheumatoid Arthritis (RA). (aiche.org)
Thus, local modulation of PSTPIP2 expression in the joint microenvironment may be a potential strategy for controlling bone erosion in rheumatoid arthritis. (biomedcentral.com)
Green tea has been linked to various health benefits, such as reduced mortality due to cardiovascular disease, lower prevalence of cognitive impairment, improved cholesterol levels, weight management, and alleviation of rheumatoid arthritis symptoms. (nmteaco.com)
Rheumatoid arthritis is also another chronic inflammatory disease where DPPI appears to play a role. (justia.com)
Neutrophils are recruited to the site of joint inflammation and release Cathepsin G, elastase and proteinase 3, proteases which are believed to be responsible for cartilage destruction associated with rheumatoid arthritis. (justia.com)
To explore the correlations between symptom-based principal factors of rheumatoid arthritis (RA) and the effect of traditional Chinese medicine or Western medicine on RA after factor analysis of RA symptoms. (jcimjournal.com)
they have been identified in other arthritides such as rheumatoid arthritis (RA). (medscape.com)
OBJECTIVE: We analyzed NAD+ metabolism in patients with rheumatoid arthritis (RA), its association with disease activity and clinical outcomes of RA, and the therapeutic potential of pharmacologic NAD+ boosting. (bvsalud.org)
Rheumatoid arthritis (RA) is an inflammatory systemic disease that affects the j. (icbcongress.com)
Antibodies against 4 Atypical Post-Translational Protein Modifications in Patients with Rheumatoid Arthritis. (mdbioproducts.com)
Learned immunosuppressive placebo response attenuates disease progression in a rodent model of rheumatoid arthritis. (mdbioproducts.com)
Decreased expression and Activity of the desacetylase Sirtuin-1 contribute to the activated and proangiogenic profile of endothelial cells in rheumatoid arthritis and promote the persistence of experimental arthritis by increasing synovial angiogenesis. (mdbioproducts.com)
Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients. (mdbioproducts.com)
This article examines the use of mesenchymal stem cells as a promising treatment for Rheumatoid Arthritis (RA). (hscn.org)
Stem cell therapy for rheumatoid arthritis (RA) is a promising treatment that has the potential to reduce inflammation and promote tissue repair. (hscn.org)
Rheumatoid Arthritis (RA) is a chronic autoimmune disorder that affects a person's connective tissue, resulting in swollen and painful joints. (hscn.org)
In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively) ( 3 ). (cdc.gov)
This may be facilitated by substituting certain medications (eg, tolmetin instead of naproxen for juvenile rheumatoid arthritis, nonthiazide agents for hypertension, nilotinib or dasatinib for imatinib in the setting of chronic myeloid leukemia) for alternative agents that have not been associated with pseudoporphyria. (medscape.com)

Collectively, this induction of hyporesponsiveness of effector B-cell responses, in the context of the resetting of the levels of IL-10-producing B cells, is suggestive of a modulation of the balance between effector and regulatory B-cell responses that may contribute to ES-62-mediated suppression of CIA-associated inflammation and inhibition of production of pathogenic collagen-specific IgG2a antibodies. (gla.ac.uk)
In this current study, PEMF decreased paw inflammation in a collagen-induced arthritis (CIA) murine model. (nih.gov)
Oral administration of RGE markedly ameliorated clinical arthritis score and histologically assessed joint inflammation in mice with CIA. (hindawi.com)
Research including animals and humans suggests that ashwagandha could dial down inflammation and stiffness from arthritis . (greatist.com)
Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation. (hindawi.com)
In this context, Lafoensia pacari Jaume St. Hilaire (Lythraceae) extracts and ellagic acid reduced most of the phenotypes of experimental ovalbumin-induced allergic airway inflammation [ 16 ], and Punica granatum (Lythraceae) fruit extract reduced the airway inflammation during LPS-induced ALI in mice [ 17 ]. (hindawi.com)
The interaction of inhalation-induced airway inflammation and arthritis induction resulted in compartmentalized responses with the greatest degree of arthritis and bone loss in male mice with combined exposures. (cdc.gov)
T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. (southernbiotech.com)
Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice. (mdbioproducts.com)
Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation. (mdbioproducts.com)
For example, coxsackievirus B3 (CB3) infection of susceptible mice results in inflammation of the heart (myocarditis) that resembles myocarditis in humans. (cdc.gov)

The development of collagen-induced arthritis is associated with strong T- and B-cell responses to type II collagen and the chief pathological features of the disease include a proliferative synovitis with infiltration of polymorphonuclear and mononuclear cells, pannus formation, cartilage degradation, erosion of bone and fibrosis. (ox.ac.uk)
The study overexpressed PD-L1 by constructing a recombinant of PD-L1-lentiviral vector, which was subsequently used to transfect mouse bone marrow mesenchymal stem cells (MBMMSCs) and significantly suppressed the development of collagen-induced arthritis (CIA) in DBA/1j mice. (hscn.org)

Arthritis is normally observed about 3 wk after immunization with autologous or heterologous type II collagen in complete Freund's adjuvant and susceptibility to the disease is strongly associated with major histocompatibility complex class II genes. (ox.ac.uk)
Susceptibility for the disease is dependent on MHC class II haplotypes, and only mice with H-2 q and H-2 r haplotypes respond to immunization with IIC and develop arthritis ( 3 ). (aai.org)
METHODS: Arthritis was induced in DBA/1 mice by immunization with type II collagen, and the production of IL-1Ra isoforms was examined in whole joints and in dissected synovial tissues by reverse transcription-polymerase chain reaction (RT-PCR), RNase protection assay, Western blotting, immunostaining, and in situ hybridization. (ox.ac.uk)
Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-Induced Arthritis (CIA) model. (mdbioproducts.com)
Type II Collagen and Adjuvent Susceptibility to CIA is linked to MHC class II molecules and is dependent upon the species of type II collagen used for immunization. (mdbioproducts.com)

In this study, GLI1 expression in the synovial tissue of RA patients was positively correlated with RA-related scores and was highly expressed in collagen-induced arthritis (CIA) mouse articular macrophage-like cells. (elifesciences.org)
A sex-dependent temporal profile in expression of inflammatory factors in the ankle joint was observed in response to intra-articular injection of disulfide HMGB1, with male mice showing a delayed, yet longer lasting increase in mRNA levels for several of the investigated factors. (iasp-pain.org)
Intra-articular HMGB1 did not induce cellular infiltration in the ankle joint suggesting its action on tissue resident cells. (iasp-pain.org)
Compared with male mice, female mice showed less articular and pulmonary disease. (cdc.gov)

Animal models of autoimmune diseases have shown that infections can induce autoimmune disease. (cdc.gov)
To address the question of whether autoimmune diseases can be induced by infections, first autoimmunity needs to be defined. (cdc.gov)

By pharmacological inhibition of GLI1, the proportion of proinflammatory macrophages and the number of osteoclasts were significantly reduced, and the joint inflammatory response and bone destruction in CIA mice were alleviated. (elifesciences.org)
Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor. (ox.ac.uk)
We found that inhibition of resident macrophages attenuated HMGB1-induced pain-like behavior only in male mice. (iasp-pain.org)

The producer cells of IL-17 also express TNF-α, but not Th1 or Th2 cytokines, in mice ( 9 ). (aai.org)
Our findings demonstrated that CXCR4 targeting with CB significantly inhibited the spontaneous and induced-production of key inflammatory cytokines by monocytes isolated from JIA patients. (frontiersin.org)
IL-17 not only induces proinflammatory cytokines, but also directly enhances osteoclastogenesis by upregulating receptor activator nuclear kappa ligand (RANKL) on osteoblasts [ 5 ], contributing to bone erosion in RA. (hindawi.com)
We have found that CB3 triggers autoimmune disease in susceptible mice by stimulating elevated levels of proinflammatory cytokines from mast cells during the innate immune response. (cdc.gov)

To optimize the pharmacological treatments available for RA, methods are needed that can evaluate not only the symptoms of arthritis but also the pain and unpleasantness associated with experimental animal models of RA. (biomedcentral.com)
Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. (southernbiotech.com)

To this end, we have established to date that ES-62 protection in CIA is associated with suppressed T helper type 1 (Th1)/Th17 responses, reduced collagen-specific IgG2a antibodies and increased interleukin-10 (IL-10) production by splenocytes. (gla.ac.uk)
Indeed, DPPI deficient mice were protected against acute arthritis induced by passive transfer of monoclonal antibodies against type II collagen (Adkison et al. (justia.com)
Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)
Researchers have found that antibodies to type II collagen are present during acute relapsing polychondritis episodes and that the levels correlate with the severity of the episode. (medscape.com)
They are more likely to be found in association with antibodies to type II collagen in patients with relapsing polychondritis. (medscape.com)
however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)

Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. (rndsystems.com)
In human/mouse DR5-transgenic Ubc.Cre mice with CIA, transgenic DR5 was most highly expressed on CD11b+ macrophages, with lower expression on CD4+ T cells. (nih.gov)
In human/mouse DR5-transgenic LysM.Cre mice, transgenic DR5 was restrictively expressed on macrophages. (nih.gov)
Both in vivo near-infrared imaging of caspase activity and TUNEL staining demonstrated that TRA-8 rapidly induced apoptosis of macrophages in inflamed synovium. (nih.gov)
The anti-human DR5 antibody TRA-8 was efficacious in reducing the severity of arthritis via targeted depletion of macrophages and immunomodulation. (nih.gov)

Meanwhile, the inhibitory effect of AK106-001616 was more effective than that of naproxen in the mouse collagen antibody-induced arthritis model with leukotrienes contributing to the pathogenesis. (aspetjournals.org)
Serum levels of TNF-R did not correlate with clinical signs, however, lower anti-collagen antibody levels corresponded with lack of clinical symptoms. (ox.ac.uk)
Formalin-fixed paraffin sections of normal mouse spleen after antigen retrieval were reacted with the anti-CD44 antibody. (bdbiosciences.com)
The IM7 antibody specific for mouse CD44 is recommended to test for immunohistochemical staining of formalin-fixed paraffin and acetone-fixed frozen sections. (bdbiosciences.com)
We found Hmgb1 expression to be elevated in the ankle joints of male and female mice subjected to collagen antibody-induced arthritis (CAIA). (iasp-pain.org)
To determine the therapeutic efficacy and immunomodulatory effect of an anti-human death receptor 5 (DR5) antibody, TRA-8, in eliminating macrophage subsets in a mouse model of type II collagen-induced arthritis (CIA). (nih.gov)
Chicken type II collagen was used to induce CIA in mice, which were then treated with an anti-human DR5 antibody, TRA-8. (nih.gov)
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)

FVB is an albino, inbred laboratory mouse strain that is named after its susceptibility to Friend leukemia virus B. This strain was produced from mice established at the National Institutes of Health in 1935. (wikipedia.org)
These mice have greater susceptibility to an asthma-like phenotype than wild-type animals. (wikipedia.org)

IL-17 was responsible for the priming of collagen-specific T cells and collagen-specific IgG2a production. (aai.org)
Serum levels of total anti-type II collagen IgG and IgG subclasses (IgG1, IgG2a, and IgG2b) remained unchanged. (nih.gov)

Employing IRT in longitudinal preclinical setting to monitor arthritis onset, disease activity and therapeutic efficacies requires a standardized framework to provide reproducible quantitative data as a precondition for clinical studies. (mendeley.com)
Therapeutic effects of anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor treatment in psoriasis and arthritis. (mdbioproducts.com)

Furthermore, MTX protected against glucose deprivation-induced endothelial apoptosis. (bmj.com)

IL-10-producing regulatory B cells have been proposed to suppress pathogenic Th1/Th17 responses in CIA: interestingly therefore, although the levels of IL-10-producing B cells were decreased in the spleens of mice with CIA, ES-62 was found to restore these to the levels found in naive mice. (gla.ac.uk)
Therefore, RGE can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA. (hindawi.com)
Furthermore, anti-BP180 autoantibodies from patients affected with BP are capable of inducing dermal-epidermal separation in cryosections of normal human skin, further supporting the pathogenic role of BP180. (medscape.com)

This study was undertaken to investigate the effects of red ginseng extracts (RGE) on autoimmune arthritis in mice and humans and to delineate the underlying mechanism. (hindawi.com)

Additionally, we administered daily intraperitoneal CB treatment to arthritic mice to evaluate its effects on circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, as indicators of disease progression. (frontiersin.org)
Furthermore, CB treatment in a mouse model of collagen-induce arthritis resulted in a significant decrease in circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, leading to a reduction in disease progression. (frontiersin.org)
RESULTS: Production of IL-1Ra increased in the joints during collagen-induced arthritis (CIA). (ox.ac.uk)
RNase protection assays showed that the IL-1beta:IL-1Ra mRNA ratio was increased in inflamed joints through day 14 of arthritis, whereas a reverse pattern was present at later time points (from day 20 to day 60). (ox.ac.uk)
CONCLUSION: Production of IL-1Ra isoforms, particularly icIL-1Ra1, is stimulated in inflamed joints during CIA in mice. (ox.ac.uk)
Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). (ox.ac.uk)
Th17 produces IL-17, which is abundantly expressed in the arthritic joints and neutralization of IL-17 results in attenuation of arthritis [ 4 ]. (hindawi.com)
Furthermore, PD-L1-MBMMSCs decreased the number of dendritic cells and increased the numbers of regulatory T cells and regulatory B cells in joints of CIA mice. (hscn.org)

The immune non-activating metabolite-based MPs modulate DC function and subsequently alter antigen specific T cell immune responses in mice. (aiche.org)

Pre-clinical tests that can evaluate not only the symptoms of arthritis but also the associated pain as sensory-emotional experience are urgently needed. (biomedcentral.com)
We also revealed tofacitinib-resistant significant changes in the voluntary behavior and choice of temperature despite significant mitigation of the symptoms of arthritis. (biomedcentral.com)
Some of these did not parallel with the conventional arthritis scores, particularly during the pharmacotherapy suggesting that mice with CIA show not only the peripheral symptoms but also the central consequences. (biomedcentral.com)
Low back pain (61.7%) and lower-limb arthritis (38.5%) were the most frequent initial symptoms. (bvsalud.org)
The highest prevalence of 'a lot' of arthritis-attributable interference was for those unable to work/disabled or reporting severe arthritis symptoms (pain, stiffness, fatigue), anxiety, depression, or no/low confidence in ability to manage arthritis, across domains. (cdc.gov)

CIA) in male mice. (biomedcentral.com)

Spontaneous Lesions in Aging FVB/N Mice. (wikipedia.org)

Here we show a method where local delivery of an antigen specific therapy can generate antigen-specific Tregs and reduce antigen-specific Th17, Th1 and autoantibodies in a collagen-induced arthritis (CIA) mouse model of RA. (aiche.org)
Arthritis Research & Therapy, 21(1), 1-12. (mdbioproducts.com)

Collagen-induced arthritis can be transferred into severe combined immunodeficiency (SCID) mice by spleen cells from diseased DBA/1 mice. (ox.ac.uk)
In parallel, interferon-gamma (IFN-gamma) production by lymph node cells, stimulated in vitro with type II collagen, was assessed as a marker of T cell activity. (ox.ac.uk)
There was a progressive increase in the number of TNF-alpha-, IL-1beta- and IL-6-positive cells from day 1 to day 10 of arthritis, during which time IFN-gamma production by CD4+ T cells from draining lymph nodes declined sharply. (ox.ac.uk)
A further finding of potential significance was that TNF-alpha was consistently detected at day 1 of arthritis, whereas IL- 1beta-positive cells were not found until day 3, suggesting that the expression of TNF-alpha precedes that of IL-1beta. (ox.ac.uk)
The inhibitory effect of RGE on Th17 differentiation and osteoclastogenesis observed in mice was also confirmed in the subsequent experiments performed using human peripheral blood mononuclear cells. (hindawi.com)
Studies of human umbilical vein endothelial cells (HUVEC) and arterial endothelial cells (HAEC) showed that therapeutically relevant concentrations of MTX phosphorylate AMPKα Thr172 , and induce cytoprotective genes including manganese superoxide dismutase (MnSOD) and haem oxygenase-1 (HO-1). (bmj.com)
To further explore possible sex differences in cellular involvement, we used the macrophage inhibitor, minocycline, and mice with specific TLR4 depletion in myeloid cells or nociceptors. (iasp-pain.org)
Interestingly, while the contribution of TLR4 on myeloid cells to nociception was minimal in females compared to males, TLR4 on nociceptors are important for HMGB1-induced pain in both sexes. (iasp-pain.org)
These mice were then sacrificed on day 30, and the blood, spleen and lymph nodes (LNs) were harvested to analyze the presence of antigen specific autoantibodies, T cells, and antigen specific T cells. (aiche.org)
Regulatory T cells are critical to tolerance induction in presensitized mouse transplant recipients through targeting memory T cells. (southernbiotech.com)
The specific cause and pathophysiology of heterotopic ossification (HO) remain uncertain, but the condition appears to involve the inappropriate differentiation of mesenchymal cells into osteoblastic stem cells in response to still-unidentified inducing agents. (medscape.com)

CIA can be induced in susceptible rodents by intradermal injections of homologous or heterologous native type II collagen (IIC), a major component of cartilage Ags. (aai.org)

Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis. (ox.ac.uk)

In 1970, of the sensitive mice from that breeding, some were found to be susceptible to Friend leukaemia virus. (wikipedia.org)
They are susceptible to induced squamous cell carcinoma. (wikipedia.org)

A mutual acquaintance recommended that Feldmann meet Maini, a leading rheumatologist and researcher at the Arthritis Research Campaign's Kennedy Institute of Rheumatology at Imperial College in London. (laskerfoundation.org)
Arthritis & Rheumatology. (mdbioproducts.com)

Autoantibodies to minor cartilage-specific collagens (ie, types IX and XI) have been described. (medscape.com)
Type II collagen (CII) is a fibrillar collagen that is primarily located in cartilage tissue. (mdbioproducts.com)
The major molecular form of collagen in cartilage is type II collagen. (mdbioproducts.com)
The function of type II collagen is to provide tensile strength and give cartilage the ability to resist shearing forces. (mdbioproducts.com)

Recently, Th17 was reported to express RANKL itself as well as directly inducing mature osteoclasts via cell-to-cell contact, substantiating its role in inflammatory bone destruction [ 6 ]. (hindawi.com)
The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes. (cdc.gov)
OB release bone matrix rich in collagen type I and participate in the hydroxyapatite crystal formation in collagen fiber deposition process, namely bone mineralization process, eventually forming new bone. (frontiersin.org)
OC destroys the mineral and collagen matrix by secreting matrix metalloproteinases (MMPs), cathepsin K (CtsK), H + and Cl − , and eventually forming bone lacunae. (frontiersin.org)

The evidence supporting the claims of the authors is solid, although inclusion of the analysis of cell type-specific GLI1-deficient mice would have strengthened the study. (elifesciences.org)
Tissue cryostat sections of undecalcified paws from type II collagen-immunized DBA/1 mice, taken 1-10 days after the onset of clinical arthritis, were examined for the presence of tumour necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 using an indirect immunoperoxidase technique. (ox.ac.uk)
Two years is a common life expectancy in wild-type house mice. (wikipedia.org)
Type II collagen is also located in the vitreous humor of the eye, the inner ear, the nose, and the intervertebral discs of the spine. (mdbioproducts.com)
Mutations of the COL2A1 gene affect the synthesis of type II collagen and cause chondrodysplasias. (mdbioproducts.com)
The degradation of collagen type II is an early indicator of osteoarthritis. (mdbioproducts.com)
Various species of highly purified Type II Collagen are supplied lyophilized and in solution for use in the induction of arthritis in vivo. (mdbioproducts.com)

Passive transfer experiments have demonstrated that purified autoantibodies from patients with the pemphigus group of diseases can induce blister formation when delivered to newborn mice. (medscape.com)

An easy to use protocol incorporating contactless image acquisition and computer-assisted data analysis was developed to detect disease-related temperature changes in a collagen-induced arthritis (CIA) mouse model and validated by comparison with two conventional methods, clinical arthritis scoring and paw thickness measurement. (mendeley.com)

In the current study, peripheral blood and surgically excised synovial tissue from RA patients, DBA/1 mice, Pstpip2 Cre R26- ZsGreen reporter mice, and Esr2 fl/fl / Adgre -Cre tool mice were used for in vivo studies. (biomedcentral.com)

We described for the first time significant alterations of the voluntary behavior of the mice with CIA during the clinical periods, indicating that the overall physical/motivational states and its circadian variation, as well as the specific preference to a certain environmental temperature, are modified in the mice with CIA, as observed in human patients. (biomedcentral.com)
FVB mice show elevated aggressive behavior towards newly intruding FVB mice shortly after the new mouse's introduction, potentially due to chronically disrupted circadian rhythms. (wikipedia.org)

Various disease models for RA have been developed, and collagen-induced arthritis (CIA) is one of the well-established models ( 2 ). (aai.org)
Data also support suppression of the lung inflammatory response, but increases in extracellular matrix protein deposition/interstitial disease in the setting of arthritis. (cdc.gov)
Quantitative in vivo micro-computed tomography for monitoring disease activity and treatment response in a collagen-induced arthritis mouse model. (mdbioproducts.com)
The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. (cdc.gov)
Genetic factors are important in the development of autoimmune disease, since such diseases develop in certain strains of mice (e.g., systemic lupus erythematosus or lupus in MRL mice) without any apparent infectious environmental trigger. (cdc.gov)
More often, many different microorganisms have been associated with a single autoimmune disease, which indicates that more than one infectious agent can induce the same disease through similar mechanisms ( Table ) ( 9 ). (cdc.gov)
Objective: Arthritis patients experience the impact of disease beyond routinely assessed clinical measures. (cdc.gov)

A human/mouse-chimeric DR5-transgenic mouse, under the regulation of a mouse 3-kb promoter and a loxP-flanked STOP cassette, was generated and crossed with an ubiquitous Cre (Ubc.Cre) mouse and a lysozyme M-Cre (LysM.Cre)-transgenic mouse to achieve inducible or macrophage-specific expression. (nih.gov)

OBJECTIVE: To examine the patterns of production of interleukin-1 receptor antagonist (IL-1Ra) isoforms and of IL-1beta during arthritis in vivo. (ox.ac.uk)
Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis. (rndsystems.com)

Acute trauma patients should have no history of arthritis. (biomedcentral.com)
In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. (bvsalud.org)

Likewise, treatment of (NZW×BXSB)F 1 mice with MTX enhanced AMPKα Thr172 phosphorylation and MnSOD, and reduced aortic intercellular adhesion molecule-1 expression. (bmj.com)

A retroviral vector expressing the HSVtk gene alone had no effect on this arthritis transfer model with or without ganciclovir. (ox.ac.uk)
In addition to albinism and Friend leukemia virus sensitivity, these mice become blind by weaning age due to being homozygous for a retinal deterioration allele on the PDE6B gene. (wikipedia.org)

IRT was found to be superior over the conventional techniques specially at early arthritis onset, when it is difficult to observe subclinical signs and measure structural changes. (mendeley.com)

Anatomy40

Organisms11

Diseases38

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology2

Phenomena and Processes31

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

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Rheumatoid47

Inflammation11

Development of collagen-induced arthritis2

Immunization5

Articular4

Autoimmune diseases2

Inhibition3

Cytokines4

Experimental2

Antibodies6

Macrophages5

Antibody8

Susceptibility2

IgG2a2

Therapeutic2

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Humans1

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Male mice1

Spontaneous1

Therapy2

Cells11

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Susceptible2

Rheumatology2

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Disease7

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