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  • tumor
  • However, recent studies in mouse models of pancreatic neuroendocrine tumors, glioblastoma, and breast cancer showed an unwanted side effect of SO and related antiangiogenic substances: After initial antitumor activity, enhanced tumor progression and increased metastasis occurred ( 18 , 19 ). (aacrjournals.org)
  • This was associated with a ∼60% reduction in tumor-derived blood vessels by quantitative morphometry of CD31-stained tumor areas, and appearance of endothelial cell apoptosis by internucleosomal DNA fragmentation in vivo . (aacrjournals.org)
  • Vandetanib in combination with cisplatin and radiation inhibited both tumor growth and the incidence of cervical lymph node metastases, and prolonged survival in an orthotopic nude mouse model of HNSCC. (aacrjournals.org)
  • In tumor-bearing mice, infusion of this HBDt.TFt results in rapid occlusive thrombosis selective only for tumor microvasculature with resultant infarctive destruction of tumors. (aacrjournals.org)
  • We previously showed that the rather novel vascular endothelial growth factor (VEGF) heparin-binding domain substructure (HBDt), when expressed on the surface of a modified M13 phage, selectively enabled accumulation in vivo on the vascular surface of the CD31-positive endothelium of tumor vasculature ( 1 ). (aacrjournals.org)
  • The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence. (fishersci.com)
  • In the Ishikawa orthoptopic murine model, treatment with GSK2256098 resulted in lower tumor weights and fewer metastases than mice inoculated with Hec1A cells. (aacrjournals.org)
  • Finally, a role for the α6β4 integrin in tumor initiation has been shown in a Ras-induced squamous cell carcinoma mouse model ( 22 ). (aacrjournals.org)
  • To test this hypothesis, we allografted either murine B16 melanoma or Lewis lung carcinoma cells into WT and CIB1-KO mice, and monitored tumor growth, morphology, histology, and intra-tumoral microvessel density. (pubmedcentralcanada.ca)
  • US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. (nih.gov)
  • US imaging with contrast microbubbles targeted to VEGFR2 allows noninvasive visualization of VEGFR2 expression in tumor vessels in mice. (nih.gov)
  • knockout
  • More importantly, we established successfully a HCC metastatic mouse model implanted s.c. with retrovirus packaging cells expressing RhoC siRNA and proved that knockout RhoC expression might inhibit metastasis of HCC in vivo for the first time. (aacrjournals.org)
  • Cell death induced by survivin targeting exhibited the hallmarks of mitochondrial-dependent apoptosis with release of cytochrome c and loss of mitochondrial transmembrane potential and was suppressed in Apaf-1 or caspase-9 knockout mouse embryonic fibroblasts. (aacrjournals.org)
  • After exposure to 75% oxygen for 5 days (postnatal day [P] 7-P12) and subsequently to room air for the next 9 days (P13-P21), we evaluated retinal vascular morphology by ADPase staining in retinal whole mounts, retinal neovascularization response by histochemistry in serial retinal sections, and retinal VEGF gene expression by real-time PCR analysis in A 2A R knockout (KO) mice and their wild-type (WT) littermates. (arvojournals.org)
  • Diabetes was induced with streptozotocin in Tnfa knockout (KO) mice, to provide a chemical model of diabetes, and Tnfa (KO) mice were crossed with Ins2 Akita mice to generate a genetic model, with both models being devoid of TNFα. (arvojournals.org)
  • C57BL
  • Co-MSCs were extracted from human cadaver, and wild-type (C57BL/6J) and SERPINF1 −/− mice corneas. (arvojournals.org)
  • OIR was induced in C57BL/6J mice by continual aeration with 75% oxygen from postnatal day (P) 7 to P12 that afterward returned to normal room air. (arvojournals.org)
  • Eight- to 10-week-old female wild-type C57BL/6J mice were used (Jackson Laboratories, Bar Harbor, Me, and Department of Comparative Medicine, Stanford, Calif). The mice weighed 20 to 25 g and were maintained as described previously. (ahajournals.org)
  • vascular
  • We and others have previously reported that the TIMP3/ADAM17 pathway is involved in the control of glucose homeostasis and adipose, hepatic, and vascular inflammation in both genetic and nutritional models of obesity in mice, as well as in patients with obesity-related T2DM and atherosclerosis ( 13 - 18 ). (diabetesjournals.org)
  • Human
  • The Apc Min/+ mouse was derived by chemical mutagenesis with ethylnitrosourea ( 5 ) and is heterozygous for a germ-line mutation in the Apc gene similar to that found in patients with human familial adenomatous polyposis. (aacrjournals.org)
  • Recent studies support an association between the Apc Min/+ mouse model and human colorectal cancer ( 6 - 8 ). (aacrjournals.org)
  • bone
  • CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. (fishersci.com)
  • skeletal
  • VEGFR2-targeted microbubbles (MB(V)), control microbubbles (MB(C)), and nonlabeled microbubbles (MB(N)) were tested for binding specificity on cells expressing VEGFR2 (mouse angiosarcoma SVR cells) and control cells (mouse skeletal myoblast C2C12 cells). (nih.gov)
  • VEGFR2
  • Expression of mouse VEGFR2 in culture cells was tested with immunocytochemical and Western blot analysis. (nih.gov)
  • shown
  • Previous work in the Apc Min/+ mouse has shown that therapeutic approaches targeting either VEGFR or EGFR signaling affect predominantly the size or number of adenomas, respectively. (aacrjournals.org)
  • effects
  • In obese syngeneic mice, metformin treatment mimicked the effects observed with GM-CSF neutralization and MMP9 inhibition, suggesting these proteins as new targets for metformin. (aacrjournals.org)
  • We overexpressed Timp3 in mouse macrophages (MacT3) to analyze its potential antidiabetic and antiatherosclerotic effects. (diabetesjournals.org)
  • To assess the effects of ZD6474 on early- and later-stage disease, treatment was initiated in 6- and 10-week-old Apc Min/+ mice for 28 days. (aacrjournals.org)
  • recent
  • Interestingly, a recent study using RhoC-deficient mice showed that loss of RhoC does not affect the development of palpable mammary adenocarcinoma but leads to a drastic inhibition of metastasis. (aacrjournals.org)