Mice were strain. Medical search. Frequent questions

Two strains used most often as a genetic background for transgenic or knockout manipulations, C57BL/6 and 129Sv, and the outbred ICR strain were used. (erowid.org)
C57BL/6 mice exhibited lower baseline PPI levels than 129Sv and ICR mice, and 129Sv mice habituated less than C57BL/6 and ICR mice. (erowid.org)
MDMA decreased PPI in C57BL/6 and ICR, but not 129Sv mice, and RU24969 disrupted habituation in C57BL/6 and 129Sv, but not ICR mice. (erowid.org)
Hepatic and renal 5'DI mRNA in a high (C57BL/6J) and low (C3H/HeJ) strain paralleled enzyme activity and concentration, in agreement with a recent report. (jci.org)
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests. (stami.no)
RESULTS We found that the young males of the C57BL/6J strain spent more time moving in the OF. (stami.no)
RNA-seq was used to evaluate the psoriasiform phenotype elicited by 6 days of Aldara (5% IMQ) treatment in both sexes of seven mouse strains (C57BL/6 J (B6), BALB/cJ, CD1, DBA/1 J, FVB/NJ, 129X1/SvJ, and MOLF/EiJ). (altmetric.com)
One of the most common strains in mouse modeling is C57BL/6. (biomedcentral.com)
To determine if the phenotype of rTg4510 mice was similarly affected by the introduction of the C57BL/6 background, we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) background, herein termed rTg4510 B6 . (biomedcentral.com)
Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. (biomedcentral.com)
These studies support the use of the rTg4510 mouse model on a partial C57BL/6 strain background without losing fidelity of the phenotype and suggest that the C57BL/6 background does not inherently protect against tauopathy. (biomedcentral.com)
To test the hypothesis that crossing rTg4510 mice to a C57BL/6 strain background is protective against tauopathy, we have compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 on an F1 FVB/N x C57BL/6NTac background (rTg4510 B6 ) (Figure 1 ). (biomedcentral.com)
Breeding scheme used to produce rTg4510 mice on an F1 FVB/N x C57BL/6 (FVB/B6) strain background (rTg4510 B6 ) (Left) compared to the original rT4510 mice on an F1 FVB/N x 129S6 (FVB/129) strain background (Right). (biomedcentral.com)
Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. (uky.edu)
To model cognitive function after malaria, we created a rodent model of cerebral malaria by infecting C57BL/6 mice with Plasmodium berghei strainANKA.After 7 days, an object-recognition test of working memory revealed a significant impairment in the visual memory of infected mice. (elsevierpure.com)
In this study, the inbred mouse strains A/J and C57BL/6J were used to determine whether their specific strain differences correlate with differences in susceptibility to respiratory depression and constipation. (pacific.edu)
C57BL/6J mice showed a greater degree of change in several respiratory parameters, resulting in more pronounced respiratory depression. (pacific.edu)
This study demonstrates that the strain differences between A/J and C57BL/6J mice have a major effect on opioid-induced constipation and respiratory depression. (pacific.edu)
Our objective was to expose, by inhalation, lung tumor susceptible (A/J) and resistant C57BL/6J (B6) mice to stainless steel (SS) welding fume containing carcinogenic metals and characterize the lung-inflammatory and tumorigenic response. (cdc.gov)

At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice. (jax.org)
We used recombinant congenic mouse strains to map asthma susceptibility genes on mouse chromosome 17. (rug.nl)
We then started to map asthma susceptibility in the Lmr series of recombinant congenic and subcongenic strains. (rug.nl)
For example, researchers tested 371 mice from 66 new strains for their susceptibility to the fungus Aspergillus fumigatus , which can also infect humans. (spectrumnews.org)
FVB is an albino, inbred laboratory mouse strain that is named after its susceptibility to Friend leukemia virus B. This strain was produced from mice established at the National Institutes of Health in 1935. (wikipedia.org)
These mice have greater susceptibility to an asthma-like phenotype than wild-type animals. (wikipedia.org)
Mouse model demonstrates strain differences in susceptibility to opioi" by Andrew L. Young, Archana Viswanath et al. (pacific.edu)
Importantly, this model reproduces the susceptibility of aging, because compared to young mice, old mice display more severe clinical illness and succumb to disease more frequently. (lu.se)

Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment. (nih.gov)

Mice, Mutant Strains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
This graph shows the total number of publications written about "Mice, Mutant Strains" by people in this website by year, and whether "Mice, Mutant Strains" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "Mice, Mutant Strains" by people in Profiles. (ucdenver.edu)

The use of probiotic strains could be an important landmark in the management of gut dysfunction with a clear impact on the general population. (nature.com)
Thanks to the close relationships established with their hosts, some probiotic strains can provide additional benefits: for example, they can mediate either immune responses or barrier functions 10 . (nature.com)
A blend of four probiotic strains may lead to "widespread improvements" in measures of mood, anxiety, and depression in healthy young men and women, says a new study using Probiotical's multi-strain probiotic, Bifizen. (nutraingredients-usa.com)

Recombinant inbred strains derived from crosses between high and low activity strains exhibit segregation characteristic of a single allele difference. (jci.org)
Southern analyses using a 5'DI probe identified a restriction fragment length variant that segregated with 5'DI activity in 33 of 35 recombinant inbred strains derived from four different pairs of high and low activity parental strains. (jci.org)

Mice bearing mutant genes which are phenotypically expressed in the animals. (ucdenver.edu)
The response of MOLF males was aberrant, however, with decreased expression of differentiation-associated genes (elevated in other strains). (altmetric.com)
Humans share many genes with mice. (wikipedia.org)
Researchers typically use inbred mouse strains, which have identical genes on each chromosome and whose genetics are well established. (spectrumnews.org)

Key aspects of the IMQ response differed between the two most commonly studied strains (BALB/c and B6). (altmetric.com)
Although IMQ-induced expression shifts mirrored psoriasis, responses in BALB/c, 129/SvJ, DBA, and MOLF mice were more consistent with other human skin conditions (e.g., wounds or infections). (altmetric.com)
Therefore we designed a study to assess the phenotypic differences induced by oxaliplatin treatment in six different mice strains (Balb c, AJ, C57Bl6, FVB, DBA, CD1) aiming at identifying the more and less severely affected. (fupress.net)

Recombination frequencies using previously mapped loci allowed assignment of the 5'DI gene to mouse chromosome 4 and identified its approximate chromosomal position. (jci.org)
We propose the symbol Dio1 to denote the mouse 5'DI gene. (jci.org)
In most strains, IMQ altered gene expression in a manner consistent with human psoriasis, partly due to innate immune activation and decreased homeostatic gene expression. (altmetric.com)
Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. (biomedcentral.com)
A knockout mouse , or knock-out mouse , is a genetically modified mouse ( Mus musculus ) in which researchers have inactivated, or " knocked out ", an existing gene by replacing it or disrupting it with an artificial piece of DNA . (wikipedia.org)
By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function. (wikipedia.org)
A laboratory mouse in which a gene affecting hair growth has been knocked out (left) is shown next to a normal lab mouse. (wikipedia.org)
Consequently, observing the characteristics of knockout mice gives researchers information that can be used to better understand how a similar gene may cause or contribute to disease in humans. (wikipedia.org)
[3] Many mouse models are named after the gene that has been inactivated. (wikipedia.org)
For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis. (wikipedia.org)
White heterozygous mice can subsequently be crossed to produce mice that are homozygous for the knocked out gene. (wikipedia.org)
The gene to be knocked out is isolated from a mouse gene library . (wikipedia.org)
Usually, the new sequence is also given a marker gene , a gene that normal mice don't have and that confers resistance to a certain toxic agent (e.g., neomycin) or that produces an observable change (e.g. colour or fluorescence). (wikipedia.org)
Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene. (nih.gov)
Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display. (nih.gov)
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. (nih.gov)
By maximizing the genetic diversity of mouse strains, researchers can identify the gene variants responsible for various phenotypes and behaviors. (spectrumnews.org)
Several mice show remarkable resistance to infection, allowing the researchers to hone in on the gene variants responsible for resistance 3 . (spectrumnews.org)
In addition to albinism and Friend leukemia virus sensitivity, these mice become blind by weaning age due to being homozygous for a retinal deterioration allele on the PDE6B gene. (wikipedia.org)

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. (jci.org)
that reassured us that we had managed to isolate the strains, and this was then confirmed by additional analyses. (pasteur.fr)
Using these analyses in future studies will further help connect in vitro measurements of the sarcomere function to whole heart function.NEW & NOTEWORTHY A detailed study of how perturbations to sarcomere proteins impact whole heart mechanics in mouse models is a major yet challenging step in furthering our understanding of cardiovascular pathophysiology. (bvsalud.org)
1991). FVB/N: an inbred mouse strain preferable for transgenic analyses. (wikipedia.org)

Non-transgenic (NT) littermates of rTg4510 B6 (NT B6 ) mice also had greater amounts of cortical and hippocampal phospho-tau at 10.5 months of age when compared to NT littermates of rTg4510 mice. (biomedcentral.com)
Numerous transgenic mice expressing wild-type or mutant human tau have been created to model the neuropathology of tauopathies-a group of neurodegenerative diseases characterized by the accumulation of tau protein aggregates. (biomedcentral.com)
The strain background of transgenic mice can also alter disease progression and presentation. (biomedcentral.com)

Conserved linkage between this segment of mouse chromosome 4 and human HSA1p predicts this location for human Dio1. (jci.org)

Blue squares indicate phenotypes directly attributed to mutations/alleles in this strain. (jax.org)
The file contains all strain survey measured phenotypes where CBAB6F1 was tested, along with measured means and summary statistics. (jax.org)
We and others have previously reported that this strain background alters the phenotypes of various models, including the JNPL3 model of tauopathy. (biomedcentral.com)
Here we compare the phenotypes of both young and old rTg4510 mice on each strain background. (biomedcentral.com)
In another study, researchers documented the various phenotypes and behaviors visible in Collaborative Cross strains. (spectrumnews.org)
These strains show a much wider variety of phenotypes, such as body length or level of anxiety, than those documented for BXD mice, an existing inbred lab strain 2 . (spectrumnews.org)

Summary Weanling mice were given intraperitoneal inoculations of the neurotropic, JHM strain of mouse hepatitis virus, the virulence of which had been altered by repeated mouse passages. (scienceopen.com)
In mice, the attenuated strains possess a low degree of virulence, due to toxin production. (cdc.gov)
Second, the Sterne strain might regain pXO2 and revert to capsule production, resulting in wild-type virulence. (cdc.gov)
No reversion to virulence has been seen in the Sterne strain since its discovery in 1937. (cdc.gov)
The study objective was to compare the virulence of three strains of C. sakazakii in neonatal CD-1 mice. (iafns.org)

In a previous study, we observed that neonatal CD-1 mice are susceptible to C. sakazakii infection and that the pathogen invades brain, liver, and cecum tissues. (iafns.org)
In 1970, of the sensitive mice from that breeding, some were found to be susceptible to Friend leukaemia virus. (wikipedia.org)
Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice. (cdc.gov)

Of the 120 strains of variola virus in the collection held at VECTOR in the Russian Federation, 55 isolates had been tested for viability and 32 could be propagated. (who.int)

On the basis of pharmacokinetic results obtained in rats and mice exposed to chloroform by inhalation, and of enzymatic studies in human tissues in vitro , in vivo metabolic rate constants (VmaxC = 15.7 mg/hour/kg, Km = 0.448 mg/L) were defined for humans (Corley et al. (cdc.gov)
Behavioural despair" in rats and mice: Strain differences and the effects of imipramine. (bvsalud.org)

These mice were bred into the modern FVB strain at the Jackson Laboratory, with no subsequent selection for histamine sensitivity. (wikipedia.org)

With the whole viral genome of coronavirus 2019-nCoV having recently been sequenced at the Institut Pasteur, the isolation of strains of coronavirus 2019-nCoV detected in France has now been successfully finalized, in a very short space of time, using the samples taken from the first confirmed French cases. (pasteur.fr)

We selected 198 samples for genotyping with the Mouse Diversity array including 36 wild caught mice, 62 wild-derived laboratory strains and 100 classical strains. (jax.org)
The researchers also show that classic lab mouse strains have been selected for domesticity, by documenting wild-like behaviors in those bred from the wild-derived strains. (spectrumnews.org)

C. sakazakii was isolated from all three tissues in mice treated with C. sakazakii, regardless of strain. (iafns.org)
Pantomics Array Description: Normal tissues of 22 major organs duplicated or triplicated from 3 C3H/He strain mice. (delos.info)
Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. (bvsalud.org)

Male mice were exposed to air or gas metal arc (GMA)-SS welding fume at 40 mg/m3 x 3 h/day for 6 and 10 days. (cdc.gov)

Murine NKG2D recognition of MICA/B is an important receptor-ligand interaction used by NK cells in immunodeficient strains to limit engraftment of human tumors. (nih.gov)
By this point, approximately 60% of surviving mice show tumors/lesions. (wikipedia.org)

Founding fathers: Using just eight strains of mice, the Collaborative Cross initiative is planning to generate thousands of strains of genetically diverse mice. (spectrumnews.org)
Researchers are creating a population of inbred lab mice, called the Collaborative Cross , with the potential to produce thousands of genetically diverse strains. (spectrumnews.org)
However, available strains are strikingly genetically identical to one another, greatly limiting the amount of genetic variation that researchers are able to study. (spectrumnews.org)
Further breeding among the Collaborative Cross strains has the potential to produce unlimited numbers of genetically diverse mice. (spectrumnews.org)

The control used were tachyzoites maintained in albino mice. (bvsalud.org)

There are six possible calls: homozygous for either allele (A or B), heterozygous (H), VINO (V), deletion (D) and no call (N). There are 117,203 probes with VINOs in at least one of the 198 strains. (jax.org)
Homozygous mice are phenotypically normal. (pkd-rrc.org)
Homozygous mice develop congenital hepatic fibrosis. (pkd-rrc.org)

Recombinant congenic strains are series of strains which have inherited one or more chromosomal fragments from a donor strain and all other DNA from the background strain. (rug.nl)

The eradication of infectious virus from the central nervous system (CNS) following infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV) is thought to be immune-mediated. (scienceopen.com)
Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. (scienceopen.com)
The antibiotics are released in the presence of Salmonella , which is known to produce H 2 S. This approach prevents the quick absorption of antibiotics into the bloodstream, allows localized targeting of the pathogen in the gut, and alleviates disease symptoms in a mouse infection model. (nature.com)
It is probably not possible for humans to acquire a Sterne strain infection by the respiratory or oral route. (cdc.gov)
While it is highly unlikely that the Sterne strain will result in infection, cutaneous anthrax can be successfully treated with antimicrobial agents, making it improbable that a localized infection can become severe or fatal. (cdc.gov)
This paper describes a novel mouse model that recreates the transition of pneumococci from asymptomatic carriage to disease upon viral infection. (lu.se)
In this model, mice are first intranasally inoculated with biofilm-grown pneumococci to establish asymptomatic carriage, followed by IAV infection of both the nasopharynx and lungs. (lu.se)

In all strains we performed a multimodal characterization of its neurotoxicity through morphological and morphometrical assessment in caudal nerve and DRG at light and electron microscopy, intra-epidermal nerve fibers density quantification, evaluation of mechanical and cold allodynia/hypoaesteshesia, caudal and digital nerve conduction velocity, activity of wide dynamic range (WDR) neurons of the spinal dorsal horn. (fupress.net)

Previous studies have shown that secondary metabolites of Bacillus subtilis strain Z15 (BS-Z15) are effective in treating fungal infections in mice. (biomedcentral.com)
What is the Sterne strain (34F2) of Bacillus anthracis ? (cdc.gov)

Natural killer (NK) cell function was examined in each mouse strain using standard (51)Chromium release assays. (nih.gov)

We sought to determine if changing the strain background of a commonly used mouse model of tauopathy (rTg4510) would significantly impact the originally reported phenotype. (biomedcentral.com)
C57BL6J mice also showed significantly more constipation than A/J mice with 40 and 60 mg/kg morphine doses. (pacific.edu)
BAL measures of cytotoxicity and damage were similar between the strains and significantly increased at all time points. (cdc.gov)

Embryonic stem cells are isolated from a mouse blastocyst (a very young embryo ) and grown in vitro . (wikipedia.org)

To do this, they injected sub-lethally irradiated NSG mice with peripheral blood mononuclear cells (PBMCs). (jax.org)

Humanized NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ ( 005557 ) mice were particularly critical to the success of this study. (jax.org)
This study aims to use advanced echocardiography imaging and analysis techniques to identify previously unappreciated mechanical deficiencies in a mouse model of dilated cardiomyopathy (DCM) before the onset of overt systolic heart failure (HF). (bvsalud.org)
This study uses advanced echocardiographic imaging and analysis techniques to reveal previously unappreciated subclinical whole heart mechanical defects in a mouse model of cardiomyopathy . (bvsalud.org)
lactis (Bifal) and arginine (Arg) could have "a major impact on improving human cognition, especially in old adults", according to a recent study in mice. (nutraingredients-usa.com)
Supplementation with Lactobacillus gasseri NK109 may reduce cognitive impairment in aged mice, while also boosting expression of BDNF, says a new study. (nutraingredients-usa.com)
After whole-body autoradiography to study the distribution of inhaled 14C-labeled chloroform in mice, most of the radioactivity was found in fat immediately after exposure, while the concentration of radioactivity in the liver increased during the postanesthetic period, most likely due to covalent binding to lipid and protein in the liver (Cohen and Hood 1969). (cdc.gov)
For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 78 weeks after 6 and 10 days of exposure. (cdc.gov)

The first recorded knockout mouse was created by Mario R. Capecchi , Martin Evans , and Oliver Smithies in 1989, for which they were awarded the 2007 Nobel Prize in Physiology or Medicine . (wikipedia.org)

To evaluate whether it also modulates immune function in mice to exert antifungal effects, we investigated the effect of BS-Z15 secondary metabolites on both the innate and adaptive immune functions of mice, and explored its molecular mechanism through blood transcriptome analysis. (biomedcentral.com)

causing 3-5 million cases of severe illness and 500,000 Alterations in human and mouse lungs have been described reported deaths. (cdc.gov)
Taking advantage of the increased metastatic potential of RhoC-expressing human (A375) melanoma cells, we evaluate four immunodeficient mouse strains: severe combined immunodeficiency (scid), nonobese diabetic (NOD)-scid, NOD-scid beta2m(null), and NOD-scid IL2Rgamma(null) as xenograft tumor recipients. (nih.gov)

Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. (uky.edu)

Millions of knockout mice are used in experiments each year. (wikipedia.org)
Experiments using the first of these mice are published in the August issue of Genomic Research 1 , 2 , 3 . (spectrumnews.org)
Researchers are also conducting experiments on many of the existing 'nearly inbred' strains of mice. (spectrumnews.org)
1972). Experiments in mice, rats, and monkeys indicate that oral doses (up to 60 mg/kg) of 14C-labeled chloroform in olive oil were almost completely absorbed, as indicated by an 80-96% recovery of radioactivity in expired air, urine, and carcass (Brown et al. (cdc.gov)

The present studies were undertaken to evaluate potential murine strain differences in the effects of serotonergic drugs on PPI and habituation. (erowid.org)

Although 3-wk-old MLP-/- mice showed normal LV ejection fraction (LVEF), these mice displayed abnormal torsional and strain mechanics alongside reduced ß- adrenergic reserve. (bvsalud.org)

Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. (altmetric.com)

This knock-in mouse model has a triple HA tag at the C-terminal tail of PKHD1 and produces a fully functional fibrocystin protein. (pkd-rrc.org)
Mice lacking muscle LIM protein expression (MLP-/-) were used to model DCM-linked HF pathogenesis . (bvsalud.org)
Monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), and tumor necrosis factor-alpha (TNF-alpha) were increased in both strains while the B6 also had increased interleukin-6 (IL-6) protein. (cdc.gov)

Wild caught mice, including representatives from M. m. domesticus, M. m. musculus and M. m. castaneus , were used as references to infer the phylogenetic origin of laboratory strains ( http://msub.csbio.unc.edu/ ). (jax.org)

Although both adapted viruses evoked diffuse ditional signs typical of either secondary bacterial pneumo- alveolar damage and showed a similar 50% mouse lethal dose and the same peak lung concentration, each had a nia or acute respiratory distress syndrome (ARDS) occur. (cdc.gov)

Our preliminary data suggest that all the strains show signs of OIPN but not the same modifications in the parameters examined. (fupress.net)

On the basis divided into aliquots for direct use in pathotyping studies, of these mostly retrospective studies, the pathogenesis of and their titers were determined by standard plaque (sub- infl uenza-associated ARDS is widely viewed as being the type H1N1) or median tissue culture infective dose assays same whatever the infecting strain. (cdc.gov)

Three months after introducing its Neuralli psychobiotic, Bened Life remains focused on the science behind its patented PS128 probiotic strain and protecting the specific neurological benefits for the communities it serves. (nutraingredients-usa.com)

Furthermore, microglial activity and morphological changes detected throughout the brains of infected mice were absent from the brains of control mice, and this correlated with the measured cognitive defects. (elsevierpure.com)

To address this issue, in 2004, researchers launched a project called the Collaborative Cross to create 1,000 inbred mouse strains from 5 lab strains and 3 derived from wild populations 4 . (spectrumnews.org)

Routine manipulation of the strain in a microbiology laboratory is not likely to result in exposure. (cdc.gov)

Breeding scheme for producing knockout mice. (wikipedia.org)

Mice are currently the laboratory animal species most closely related to humans for which the knockout technique can easily be applied. (wikipedia.org)
1990). Interspecies differences in the rate of chloroform conversion were observed in mice, rats, and squirrel monkeys, with species differences in metabolism being highly dose-dependant. (cdc.gov)

A behavioural characterisation of the FVB/N mouse strain. (wikipedia.org)

IMQ responses in B6 mice were most consistent with human psoriasis and best replicated expression patterns specific to psoriasis lesions. (altmetric.com)
Spontaneous Lesions in Aging FVB/N Mice. (wikipedia.org)

Previously, we found that Lactobacillus rhamnosus CNCM I-3690 can protect intestinal barrier functions in mice inflammation model. (nature.com)
This mouse model has a deletion of PKHD1 exons 3 through 4. (pkd-rrc.org)
This mouse model lacks PKHD1 exon 67. (pkd-rrc.org)
Torsional and strain dysfunction precede overt heart failure in a mouse model of dilated cardiomyopathy pathogenesis. (bvsalud.org)

Nonetheless, our findings suggest that B6 mice provide a better background than other strains for modeling psoriasis disease mechanisms. (altmetric.com)
No human disease due to anthrax caused by the Sterne strain has been reported. (cdc.gov)
The degree of disease is dependent on the bacterial strain and host factors. (lu.se)
This recommendation followed approval by the FDA in May 2013 to extend use of the SA 14 -14-2 strain Japanese encephalitis vaccine (Ixiaro), the only vaccine against the disease available in the United States, to children aged 2 months to 16 years. (medscape.com)

Neonates were orally gavaged with C. sakazakii strains MNW2, SK81, or 3290 at doses ranging from 102.8 to 1010.5 CFU on postnatal day 3.5. (iafns.org)

Melanoma metastases growth is delayed and variable in scid and NOD-scid mice. (nih.gov)
In contrast, NOD-scid beta2m(null) and NOD-scid IL2Rgamma(null) mice show rapid tumor engraftment, although tumor growth is variable in NOD-scid beta2m(null) mice. (nih.gov)
NK cells were detected in all strains except NOD-scid IL2Rgamma(null), and in vitro activated scid, NOD-scid, and NOD-scid beta2m(null) NK cells kill human melanoma lines and primary melanoma cells. (nih.gov)
The absolute NK deficiency in NOD-scid IL2Rgamma(null) animals makes this strain an excellent recipient of melanoma and potentially other human malignancies. (nih.gov)
In cell cultures and in "humanized" NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG, 005557 ) mice, they interfered with the immune system's ability to recruit the synovium-attacking T cells. (jax.org)

FVB mice show elevated aggressive behavior towards newly intruding FVB mice shortly after the new mouse's introduction, potentially due to chronically disrupted circadian rhythms. (wikipedia.org)

The Sterne strain is currently the predominant strain used for immunization of domesticated animals against anthrax worldwide, and has been used for this purpose for many decades. (cdc.gov)

It also shows that genetic research in mice can generate data relevant to human. (rug.nl)
A delegation of more than 2,000 conference participants descending on Adelaide late in September provided a significant boost to the city's RevPAR, helping the City of Churches to a double-digit boost in the official hotel statistics, new data from STR reveals. (hotelmanagement.com.au)
According to the STR data, both Brisbane and Hobart witnessed strong months. (hotelmanagement.com.au)
CARD R-BASE strains data has been updated. (nig.ac.jp)
KYOTO RAT strains data has been updated. (nig.ac.jp)
Description: RNA profiling data sets generated by the Mouse ENCODE project. (nih.gov)

Anatomy8

Organisms67

Diseases12

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes73

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Health Care13

Geographicals3

C57BL19

Susceptibility8

Documenting differences1

Mutant Strains3

Probiotic strains3

Recombinant inbred2

Genes4

BALB3

Gene19

Analyses4

Transgenic3

Chromosome1

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Virulence5

Susceptible3

Isolates1

Rats and mice2

Jackson Laboratory1

20191

Wild derived2

Tissues3

Male mice1

Tumors2

Genetically4

Albino1

Homozygous3

Chromosomal1

Infection7

Characterization1

Bacillus2

Chromium1

Significantly3

Embryo1

Mononuclear cells1

Study7

Physiology1

Transcriptome analysis1

Severe2

Cortical1

Experiments4

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Protein3

REFERENCES1

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Model4

Disease4

Doses1

SCID5

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Animals1

Data6