Bone Marrow TransplaInduce toleranceRecipientsTherapeuticImmunologyOrganImmunosuppressionAntigensAntibodySuppressor T celAllograft rejectionRegulatory T-celGraftsTransplanted organsTransgenic miceGraft survivalIsletMechanismsAllogeneicLiverRejectionDonor-specificFecalBALBRecipientC57BLClinicalImmune responseTregAutoimmune diseaseMonoclonal antibodiesEngraftmentImmunotherapyGlucose tolerancePeripheral T cellsSelf-toleranceDiabetesSurvivalOutcomeExperimentalInducesNeonatalAbstractVitroAntigen-specificResponsesLymphocyteImmunosuppressiveClonalGeneticGeneInflammatoryLong-term toleranceExpression
Bone Marrow Transpla1
- Bone Marrow Transplantation, 2013. (nih.gov)
Induce tolerance6
- Later developed new tolerogenic strategies have provided strong evidence to re-evaluate the phenomenon of T cell mediated suppression, in particular the use of non-depleting anti-CD4 monoclonal antibodies, demonstrating that neither thymus nor clonal deletion is necessary to induce tolerance. (wikipedia.org)
- Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
- Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus. (rupress.org)
- These data demonstrate that T cells become tolerant to autologous and allogeneic HLA antigens expressed in the thymus via two different mechanisms: hematopoietic cells present in the thymus induce tolerance to "self"-antigens by clonal deletion, whereas thymic epithelial cells induce tolerance by clonal energy and possibly deletion of high affinity clones. (rupress.org)
- Therefore, it is necessary to search for other approaches to induce tolerance to transplants in recipients. (actanaturae.ru)
- The maternal and fetal antigens that are transmitted through the bidirectional transplacental passage during pregnancy may induce tolerance to noninherited maternal antigens (NIMAs) in offspring and to inherited paternal antigens (IPAs) in the mother. (elsevierpure.com)
Recipients10
- C3H/He mice were used as donors and streptozotocin-induced diabetic BALB/c mice were recipients. (tokushima-u.ac.jp)
- It has been shown that transfer of tolerance to other recipients can be made without further manipulation and that this tolerance transfer depends only on CD4+ T-lymphocytes. (wikipedia.org)
- He uses (1) genetically-modified mouse models to study mechanisms underlying immune tolerance and rejection, (2) tissues from human transplant recipients to study immune protection from latent viral infection and tolerance and (3) immune responses to COVID19 in transplant recipients. (stanford.edu)
- The role of host T cells in this model was investigated by using athymic BALB/c nu/nu mice as recipients of normal (C57BL/6 x BALB.Igb)F1 spleen cells. (unige.ch)
- A and B ) Skin from C57BL/6 mice was transplanted to C57BL/6 and BALB/c recipients. (jci.org)
- Generally, insulitis was not seen in the CBA or C57BL/6 recipients, but was found in 56% of BALB/c mice transplanted with an irradiated NOD thymus and in 46% BALB/c mice with a dGua-treated thymus. (diabetesjournals.org)
- Regulatory T cells are critical to tolerance induction in presensitized mouse transplant recipients through targeting memory T cells. (southernbiotech.com)
- To address this issue using a mouse model of CRT, we have derived a panel of ES cell lines that differ from CBA/Ca recipients at defined genetic loci. (ox.ac.uk)
- transplantation of exposed organs can cause invasive mold infections in recipients. (cdc.gov)
- Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. (cdc.gov)
Therapeutic8
- The allogeneic islets transplantation is an ideal therapeutic strategy for patients with diabetes mellitus. (tokushima-u.ac.jp)
- This study suggests that modulation of the gut microbiota as a result of ginger supplementation has a therapeutic effect on obesity in mice. (internationalprobiotics.org)
- These results suggest that CEACAM1-S may be a potential marker of liver quality and that efforts to increase its expression may have therapeutic benefits for transplantation or acute liver injury," the researchers write. (technologynetworks.com)
- Here, we evaluated the safety issues raised by the risk of TAA-TCR gene transfer-associated on/off-target toxicities and the therapeutic potential in relevant transgenic mouse models of adoptive transfer. (unimedizin-mainz.de)
- The introduction of CsA in the early 1970's significantly improved the outcome of organ and bone marrow allograft transplantation and advanced therapeutic options in autoimmune diseases. (ox.ac.uk)
- FK506 appears to have a higher therapeutic index than CsA, and has been used with encouraging results in clinical transplantation trials. (ox.ac.uk)
- Although the natural privileged status of ES cell-derived tissues is, therefore, insufficient to overcome even mH barriers, our findings suggest it may be harnessed effectively for the induction of dominant tolerance with minimal therapeutic intervention. (ox.ac.uk)
- Here, we revisit the use of rodent-adapted and non-adapted Ebola virus (EBOV) in mice to investigate infection tolerance and future utility of these models in pathogenesis and therapeutic intervention studies. (cdc.gov)
Immunology2
- A number of research deal with the development of a strategy utilizing this phenomenon in transplantation immunology. (wikipedia.org)
- Nonetheless, immune tolerance remains the holy grail of transplantation immunology and clinical transplantation. (medscape.com)
Organ8
- Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
- Jonathan Maltzman , MD-PhD studies immune responses relevant to solid organ transplantation. (stanford.edu)
- Blood supply is returned to the organ during transplantation, but that process can cause inflammation and tissue damage called ischemic reperfusion injury, also known as reoxygenation injury. (technologynetworks.com)
- Understanding the factors that lead to organ shortage remains the best option to expand the donor pool available for life-saving transplantation," said Kenneth Dery, an associate project scientist in the UCLA Department of Surgery and the study's lead author. (technologynetworks.com)
- Gut microbes contribute to variation in solid organ transplant outcomes in mice. (uchicago.edu)
- Transplantation is used in terminal organ failures, when other methods of treatment have proved ineffective. (actanaturae.ru)
- Other rare modes of transmission include through breastfeeding, blood transfusion, solid organ transplantation, and slaughtering of viremic animals. (cdc.gov)
- BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. (cdc.gov)
Immunosuppression3
- Transplant tolerance is defined as a state of donor-specific unresponsiveness without a need for ongoing pharmacologic immunosuppression. (medscape.com)
- However, during the study of achieving immune tolerance, ways in which to induce states of "partial tolerance" have been discovered, in which lower-than-conventional amounts of ongoing pharmacologic immunosuppression are needed. (medscape.com)
- Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. (ox.ac.uk)
Antigens5
- This ensures the long duration of once induced tolerance, for as long as the donor antigens are present. (wikipedia.org)
- Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by previous exposure to that antigen or set. (medscape.com)
- The properties of transmembrane and soluble transplantation antigens were compared with respect to the induction of tolerance and the selection of the T-cell repertoire. (uni-muenchen.de)
- However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
- IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. (adipogen.com)
Antibody12
- They were stained with purified MR1 antibody (Panels A and B), followed by biotinylated mouse anti-hamster IgG, Cat. (bdbiosciences.com)
- Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. (ox.ac.uk)
- If antibody therapy is continued for the full 5 weeks, T cell tolerance can still be established, suggesting that antibody therapy does not prevent lymphocytes from registering the presence of antigen. (ox.ac.uk)
- This suggests that a tolerance mechanism whose role is only minor in central tolerance may have a major role in antibody-mediated peripheral tolerance. (ox.ac.uk)
- The 1A8 monoclonal antibody reacts with mouse Ly6G. (bioxcell.com)
- Unlike the RB6-8C5 antibody, the 1A8 antibody reacts specifically with mouse Ly6G with no reported cross reactivity with Ly6C. (bioxcell.com)
- Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice. (uchicago.edu)
- We have recently demonstrated that combined anti-TIM-1 and anti-CD45RB antibody treatment results in tolerance to full MHC-mismatched islet allografts in mice by generating Bregs that are necessary for tolerance. (atcmeetingabstracts.com)
- Collectively, these findings suggest that in this model of antibody-induced transplantation tolerance, Bregs promote graft survival by promoting Treg development via TGF-β production. (atcmeetingabstracts.com)
- Applications Tested: The MAR-1 antibody has been tested by flow cytometric analysis of the MC/9 cell line (a mouse mast cell line). (thermofisher.com)
- Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. (umassmed.edu)
- Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. (umassmed.edu)
Suppressor T cel1
- The generation of suppressor T cells was another important mechanism of tolerance in the late stage. (nih.gov)
Allograft rejection1
- NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. (umassmed.edu)
Regulatory T-cel7
- Immune tolerance Central tolerance Peripheral tolerance regulatory T cells Immune response Immune tolerance in pregnancy Cobbold, S. (wikipedia.org)
- Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. (epa.gov)
- Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. (epa.gov)
- Regulatory T cells in transplantation: transferring mouse studies to the clinic. (ox.ac.uk)
- Regulatory T cells (Treg) can induce and maintain antigen-specific immune tolerance and facilitate allogeneic graft survival successfully in animals. (ox.ac.uk)
- Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance: X.X. Zheng, et al. (adipogen.com)
- They are extremely versatile APCs involved in the initiation of both innate and adaptive immunity ( 1 ), but also in the differentiation of regulatory T cells ( 2 ) required for the maintenance of self-tolerance. (aai.org)
Grafts6
- However, it has been difficult to induce immunological tolerance against islets grafts. (tokushima-u.ac.jp)
- In 1989 was successfully induced classical transplantation tolerance to skin grafts in adult mice using antibodies blocking T cell coreceptors in CD4+ populations. (wikipedia.org)
- One of the first clinically relevant observations pertaining to transplantation was made by Dr. Earl Padgett in the 1920s, when skin grafts were noted to survive longer when skin from close relatives was used. (medscape.com)
- The difference between TNF-α values induced by syngeneic versus allogeneic grafts at day 11 after transplantation reached statistical significance. (jci.org)
- CBA/Ca mice may be made tolerant to minor histoincompatible B10.BR skin grafts by treatment with a short course of non-depleting anti-mouse CD4 and CD8 monoclonal antibodies (mAb), during the transplantation period. (ox.ac.uk)
- Switching the balance from rejection of major histocompatibility-mismatched grafts toward long-term tolerance of donor grafts, with the need for minimal immunosuppressive drugs, is a major transplantation goal. (ox.ac.uk)
Transplanted organs1
- Immune tolerance to transplanted organs is impaired when the innate immune system is activated in response to the tissue necrosis that occurs during harvesting and implantation procedures. (jci.org)
Transgenic mice3
- His laboratory uses medicinal chemistry, kidney cell culture, transgenic mice, and human plasma/urine samples to identify determinants that increase or decrease kidney stone risk. (stanford.edu)
- In contrast, only transgenic mice failed to generate a cytolytic T-cell response to soluble H-2Kk antigen expressed by recombinant vaccinia virus and presented by the H-2Db molecule. (uni-muenchen.de)
- Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)
Graft survival1
- GVHD was observed earlier in Group B than in Group A. In contrast graft survival exceeded 30 days for two mice in Group C (50%, mean POD 28.5±24.0, Plt0.05). (tokushima-u.ac.jp)
Islet2
- The aim of these studies was to determine whether transplantation of NOD thymus into diabetes-resistant mouse strains would generate islet-reactive T-cells. (diabetesjournals.org)
- Overall, the data suggest that a defect of thymic origin (and correlating with the thymic epithelium) in the NOD mouse can lead to the development of autoreactive T-cells and specific islet cell damage. (diabetesjournals.org)
Mechanisms3
- Multiple mechanisms work in concert to ensure self-tolerance. (epa.gov)
- In the cells-followed-by-CP system, the sequential mechanisms of tolerance were clarified using the specific correlation between superantigens and certain T cell receptor (TCR) V beta segments. (nih.gov)
- We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. (uchicago.edu)
Allogeneic4
- Thus, we evaluated whether Treg can regulate donor-specific T-cell tolerance that received allogeneic islets into the hepatic parenchyma (ITxHP) along with Treg. (tokushima-u.ac.jp)
- C ) 2D-DIGE of lysates obtained from nontransplanted and allogeneic skin transplants (day 7 after transplantation) and labeled with cy2 and cy5 N-Hydroxysuccinimide ester dyes, respectively. (jci.org)
- Thymocytes of SCID-hu mice transplanted with liver and thymus of two different donors (FLDA/FTDB animals) were nonresponsive to Epstein-Barr virus-transformed B cell lines (B-LCL) established from both the FLDA and FTDB, but proliferated vigorously when stimulated with third-party allogeneic B-LCL. (rupress.org)
- The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation, and therefore it would be beneficial to identify less immunogenic HLA mismatches. (elsevierpure.com)
Liver15
- UCLA-led research describes the role that a protein called CEACAM1 plays in protecting the liver from injury during the transplantation process, potentially improving transplant outcomes. (technologynetworks.com)
- Specifically, the researchers found that Hypoxia Inducible Factor 1 (HIF-1α), which regulates oxygen consumption, played a central role in orchestrating the activation of the version of CEACAM1, called CEACAM1-S, that limits cellular injury and improves liver function in mice. (technologynetworks.com)
- They also found that this relationship between CEACAM1-S and HIF-1 in donor livers in humans predicts better overall liver transplantation outcomes and better immune functioning. (technologynetworks.com)
- The researchers showed that as the cell senses low oxygen conditions, HIF-1 α begins regulating the RNA splicing factor, Polypyrimidine tract-binding protein 1 (Ptbp1), that in turn directs the splicing of the CEACAM1 gene, leading to the protective CEACAM1-S version that reduces the liver injury that accompanies transplantation. (technologynetworks.com)
- Forming the 'beneficial' version of CEACAM1-S prior to liver transplantation has the potential to act as a checkpoint regulator of oxygen-related stress and will see a reduction of liver ischemia-reperfusion injury. (technologynetworks.com)
- To study the role of thymic education on the development of the human T cell repertoire, SCID-hu mice were constructed with fetal liver and fetal thymus obtained from the same or two different donors. (rupress.org)
- These animals were studied between 7 and 12 mo after transplantation, at which times all thymocytes and peripheral T cells were derived from stem cells of the fetal liver graft. (rupress.org)
- Being the natural site of FIX synthesis, the liver is expected to provide immune-tolerance & easy circulatory access. (ca.gov)
- After validation for correction, we will then differentiate these iPSCs into liver cells that can be transplanted into our mouse model of hemophilia that is capable of accepting human hepatocytes and allowing their proliferation. (ca.gov)
- These mice exhibit disease symptoms similar to human patients & we propose that by injecting our corrected liver cells they will exhibit normal clotting as measured by various biochemical & physiological assays. (ca.gov)
- We have also generated a new mouse model for the disease that is deficient in 4 genes, making it permissive to the transplantation and expansion of human hepatocytes in its liver. (ca.gov)
- In the present work, we first studied the change in the content of immunoproteasomes and macrophages of the liver at early stages of the development of allospecific portal tolerance in rats by Western blotting and flow cytofluorimetry. (actanaturae.ru)
- The critical role of the liver in the development of transplant tolerance has been known for a long time. (actanaturae.ru)
- Combined transplantation of the liver and other organs led to better engraftment than when using single allografts [ 4-6 ]. (actanaturae.ru)
- Another key factor involved in the induction of transplant tolerance is the presence of immunocompe tent cells of donor origin within the liver. (actanaturae.ru)
Rejection3
- For all mice in Groups A and B, the fasting blood sugar exceeded 250mg/dl and graft rejection was observed. (tokushima-u.ac.jp)
- Presumably, at this time point a "window of opportunity" appears for subsequent filling of an empty niche with cells of different subpopulations and, depending on this fact, the development of tolerance or rejection. (actanaturae.ru)
- Allogenic transplantation activates the immune response, which leads to transplant rejection. (actanaturae.ru)
Donor-specific1
- Induction of donor specific tolerance (DST) by the introduction of donor cells into a recipient's portal vein is one of the approaches used to solve the problem of transplant engraftment. (actanaturae.ru)
Fecal4
- In the second part , the fecal microbiota of mice fed a HFD or mice fed a HFD along with ginger supplementation were transplanted into microbiota-depleted mice. (internationalprobiotics.org)
- Glucose tolerance and microbiota composition were assessed after an 8-week fecal microbiota transplantation (FMT). (internationalprobiotics.org)
- The researchers performed fecal transplantation to test if gut microbiota mediated NAS-induced glucose intolerance. (hcplive.com)
- After 6 days of fecal transplantation, mice on the commercial saccharin diet received microbiota demonstrated impaired glucose intolerance when compared to the glucose mice. (hcplive.com)
BALB7
- The induction of transplantation tolerance to H-2b alloantigens in BALB/c (H-2d) mice by neonatal injection of (C57BL/6 x BALB/c)F1 spleen cells, produces an autoimmune lupus-like syndrome due to an activation of persisting F1 donor B cells. (unige.ch)
- In these "tolerized" BALB/c nu/nu mice, there was a persistence of F1 donor B cells but none of the autoimmune features were expressed, conversely to tolerized BALB/c nu/+ littermates. (unige.ch)
- The injection of CD4+CD8- T lymphocytes from adult normal BALB/c mice in 3-wk-old tolerized BALB/c nu/nu mice triggered the appearance of all the autoimmune findings observed in euthymic tolerant mice. (unige.ch)
- More strikingly, a similar triggering of the autoimmune syndrome, including high titers of anti-DNA IgG antibodies and circulating immune complexes, was observed after injection of CD4+CD8- T cells from 2-wk-old tolerant BALB/c mice into "tolerized" BALB/c nu/nu mice. (unige.ch)
- Neonatal thymus was pretreated either by irradiation or culture in 2-deoxyguanosine (dGua) and then transplanted into athymic BALB/c, CBA, and C57BL/6 nude mice. (diabetesjournals.org)
- Similar experiments in which a NOD fetal pancreas was transplanted into nude BALB/c mice before NOD thymus transplantation showed a similar frequency and severity of insulitis in both the host pancreas and grafted NOD pancreas. (diabetesjournals.org)
- Autoreactivity appears to be restricted to the H-2K d allele that is shared by NOD and BALB/c mice. (diabetesjournals.org)
Recipient3
- n = 6 recipient mice/time point. (jci.org)
- Recipient mice received 100 ¯o;g anti-mouse CD45RB ip on days 0, 1, 3, 5, and 7 following transplantation. (atcmeetingabstracts.com)
- Recipient mice may also receive 500 ¯o;g anti-mouse TIM-1 (RMT1-10) ip on day -1, and 300 ¯o;g on days 0 and 5 following transplantation. (atcmeetingabstracts.com)
C57BL1
- Here we used a mouse (C57BL/6) model of environmental pollutant exposure by administration of a particulate matter (SRM1649b at 300 μg/day/mouse) suspension intra-nasally beginning 2 months before conception and during gestation, in comparison to saline-exposed controls. (nature.com)
Clinical3
- These have facilitated the translation of strategies for promoting transplantation tolerance towards a new clinical era. (ox.ac.uk)
- My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. (uchicago.edu)
- Use of mice infected with non-adapted virus has been limited due to the absence of overt clinical disease. (cdc.gov)
Immune response2
- Early Tag-specific CTL competence and rare stochastic Tag activation leading to sporadic cancer, which induces an aberrant immune response and CTL tolerance. (mdc-berlin.de)
- The influence of the microbiota on the immune response to transplantation. (uchicago.edu)
Treg1
- This review will focus on the valuable insights experimental mouse models have given us into the effects of currently used immunosuppressive reagents on Treg, the Treg transcription factor forkhead box P3, and strategies to expand or induce alloantigen-reactive Treg in vivo and in vitro. (ox.ac.uk)
Autoimmune disease1
- Further evidence is found in the observation of the immunosuppressant effects of bromocriptine, which has been shown to be an effective adjuvant (immunosuppressant) in patients after transplantation and in patients with autoimmune disease. (medscape.com)
Monoclonal antibodies3
- Because second-generation tolerance arises in the absence of any monoclonal antibodies to CD4 or CD8, it probably represents a natural response of the immune system, which, once initiated, becomes self-sustaining. (wikipedia.org)
- Although hamster immunoglobulin isotypes have not been well defined, BD Biosciences Pharmingen has grouped Armenian and Syrian hamster IgG monoclonal antibodies according to their reactivity with a panel of mouse anti-hamster IgG mAbs. (bdbiosciences.com)
- Nevertheless, despite their immunogenicity in vivo, transplantation tolerance may be readily established by using minimal host conditioning with nondepleting monoclonal antibodies specific for the T cell coreceptors, CD4 and CD8. (ox.ac.uk)
Engraftment1
- NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. (umassmed.edu)
Immunotherapy2
- The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. (epa.gov)
- 2016). "Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses" Nat Med. (bioxcell.com)
Glucose tolerance5
- In addition to microbiota composition, lipid profiles, proinflammatory cytokines, glucose tolerance, and short-chain fatty acid (SCFA) concentrations were analyzed at the end of the experiment. (internationalprobiotics.org)
- The mice that received water, glucose, or sucrose demonstrated comparable glucose tolerance compared to the NAS mice, which showed glucose intolerance. (hcplive.com)
- The team later examined the effects of NAS on glucose tolerance in 7 healthy volunteers for 7 days. (hcplive.com)
- These included increased weight, increased waist-to-hip ratio, higher fasting blood glucose, glycosylated HbA1c and glucose tolerance test, and elevated serum alanine aminotransferase. (hcplive.com)
- In 362 overweight people, they observed gene-dosage effects that link SORLA expression to obesity and glucose tolerance. (medscape.com)
Peripheral T cells1
- For the detection of mouse CD154 on activated peripheral T cells, it is strongly recommended that T cells be purified before activation. (bdbiosciences.com)
Self-tolerance1
- The mechanism by which autoreactive T-cells are generated is not fully understood, but it has been postulated that there is a breakdown in self-tolerance induction during intrathymic T-cell maturation. (diabetesjournals.org)
Diabetes3
- A strategy to develop tolerance would also be of value in autoimmune diseases, such as juvenile-onset diabetes mellitus , rheumatoid arthritis , and multiple sclerosis . (medscape.com)
- The NOD mouse is a model for human insulin-dependent diabetes mellitus. (diabetesjournals.org)
- Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. (southernbiotech.com)
Survival1
- In mice, this three-step therapy induced CD4- and CD8-dependent systemic immune responses that enhanced T-cell infiltration into distant tumors, leading to their eradication and significantly improving survival. (aacrjournals.org)
Outcome1
- In addition, TBE vaccine may be considered for persons who might engage in outdoor activities in areas where ticks are likely to be found, with a decision to vaccinate made on the basis of an assessment of their planned activities and itinerary, risk factors for a poor medical outcome, and personal perception and tolerance of risk. (cdc.gov)
Experimental1
- Mouse microbiomes: overlooked culprits of experimental variability. (uchicago.edu)
Induces1
- After transplantation, MyD88 induces DC maturation as well as the production of inflammatory mediators, such as IL-6 and TNF-α. (jci.org)
Neonatal2
- Autoimmune syndrome after induction of neonatal tolerance to alloantigens. (unige.ch)
- 2. Cre/LoxP recombinase-mediated hepatocellular carcinoma (HCC) development in neonatal Tag-tolerant mice. (mdc-berlin.de)
Abstract1
- Kim J, Liu W, Liu L, Lee K, Stott R, Yeh H, Markmann J. TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction [abstract]. (atcmeetingabstracts.com)
Vitro3
- Mainly analyzed by in vitro assays in tumor transplantation models, little is known about their function in autochthonous tumor models in vivo. (mdc-berlin.de)
- We are currently optimizing our differentiation protocol and conducting preliminary studies where these in vitro differentiated cells will be transplanted in our mouse model. (ca.gov)
- Reporter cells were serially interrogated in vitro before and after irradiation as monolayer and multicellular spheroid cultures and as subcutaneous xenografts in nu/nu mice. (lincoln.ac.uk)
Antigen-specific1
- Bregs are antigen-specific, IL-10-dependent, and are capable of transferring tolerance to untreated, transplanted animals. (atcmeetingabstracts.com)
Responses4
- Mixed lymphocyte reaction showed that T-cells from tolerant mice had very weak responses against spleen cells from C3H mice. (tokushima-u.ac.jp)
- Results: MICCop cells were able to inhibit the harmful autoreactive T-cell response and prevented mice from further relapses without affecting general immune responses. (uni-koeln.de)
- Necrotic lysates from transplanted skin elicited higher inflammatory responses in DCs than did nontransplanted lysates, suggesting DC-mediated responses are triggered by factors released during transplantation. (jci.org)
- Haptoglobin is released after skin transplantation and positively correlates with inflammatory responses of DCs. (jci.org)
Lymphocyte3
- The term "infectious tolerance" was originally used by Gershon and Kondo in 1970 for suppression of naive lymphocyte populations by cells with regulatory function and for the ability to transfer a state of unresponsiveness from one animal to another. (wikipedia.org)
- Once the tolerant state is established, it is difficult to break that tolerance by lymphocyte infusions from normal donors. (ox.ac.uk)
- [ 9 ] In research using a mouse model, inhibition of prolactin release impaired lymphocyte function and depressed macrophage activation. (medscape.com)
Immunosuppressive1
- Transplantation tolerance could eliminate many of the adverse events associated with immunosuppressive agents. (medscape.com)
Clonal1
- Special care was taken to overcome the " hard" barriers of allo- or xeno-combinations by reducing the "split tolerance" produced through the clonal destruction mechanism. (nih.gov)
Genetic1
- [ 3 ] Seemingly impossible without genetic identity, the field of transplantation was left silent for another 20 years. (medscape.com)
Gene3
- Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. (antibodies-online.com)
- For this purpose, transgenic (H-2b x H-2d)F1 mice were constructed that carry integrated copies of a modified H-2Kk gene resulting in the secretion from various cell types including thymocytes of soluble H-2Kk molecules. (uni-muenchen.de)
- Sorl1 gene knockout in mice accelerated the breakdown of triacylglycerides in adipocytes and protected the animals from diet-induced obesity. (medscape.com)
Inflammatory2
- Here, we show that haptoglobin, an acute phase protein, is an initiator of this MyD88-dependent inflammatory process in a mouse model of skin transplantation. (jci.org)
- A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. (uchicago.edu)
Long-term tolerance1
- The goal is to achieve long-term tolerance of the transplant through short-term therapy. (wikipedia.org)
Expression1
- This propensity for tolerance could be attributed to the paucity of professional antigen-presenting cells and the expression of transforming growth factor (TGF)-?2. (ox.ac.uk)