Mice tract reproductive. Medical search. Frequent questions

Genital tract outflow is important for the expulsion of normal secretions from the cervix and vagina. (medscape.com)
The exact etiology of such genital tract anomalies is unclear. (medscape.com)
Any defect in the normal organogenesis involving the urogenital sinus or the müllerian duct can result in genital tract anomalies. (medscape.com)
However, in comparison with the male genital tract, the consequences of ZIKV infection on the female genital tract have not been extensively evaluated. (nih.gov)
Rather, most studies evaluated ZIKV infections in the genital tract of pregnant women due to the relationship between ZIKV and congenital abnormalities of the offspring. (nih.gov)
DES studies on the genital tract . (desdaughter.com)

C. felis is closely related to C. pneumoniae (causes pneumonia in humans), C. trachomatis (causes Chlamydia in humans), and C. muridarum (causes pneumonia in mice). (wikipedia.org)
Use of a new nanoparticle delivery system has allowed researchers to generate immunity to Chlamydia trachamotis at mucosal surfaces in mice. (bioquicknews.com)
The scientists immunized mice with a bioengineered version of cellular vaults that enclosed a component of Chlamydia. (bioquicknews.com)
When the immunized mice were exposed to a vaginal challenge with live Chlamydia, their reproductive tracts were protected from severe bacterial infection. (bioquicknews.com)
Outcomes from this innovative research have the potential for discovering therapeutic targets for reproductive tract infections, such as chlamydia, which cause major worldwide health and socioeconomic problems and will put Australia at the forefront of this endeavour. (monash.edu)

Activation of the Notch Signaling Pathway Affects Development of the Reproductive Tract and Fertility in Female Mice. (fiu.edu)
The remaining mice from all groups were allowed to mate with virgin female mice to explore male fertility potential. (degruyter.com)
The fertility index of male mice treated with Orchis anatolica plant was enhanced to a greater value when allowed mating with virgin female mice if compared with male mice fertility index recorded in the other two groups. (degruyter.com)
Sexually mature virgin female mice were exposed to 0.1, 0.5, 1.0, 2.5 or 5.0 MXC via oral gavage for 5 consecutive days for four weeks. (cdc.gov)
This segment of the study clearly demonstrates that a four week exposure of adult female mice to 50% MXC elicits significant estrogenic and toxic effects on the uterine epithelium. (cdc.gov)
The third segment of this study dealt with exposing newborn female mice to MXC and then comparing their reproductive activity upon reaching adulthood with that of the mice exposed as adults in the first two arms of this study. (cdc.gov)
One-day old female mice were exposed to either 0.1, 0.5 or 1.0 mg MXC for fourteen consecutive days. (cdc.gov)

Moderate alcohol consumption doesn't seem to have long-term effects on reproductive health or testosterone levels. (healthline.com)
Epidemiological investigations have shown increasing evidence of altered development and detrimental effects on reproductive health during the past 50 years associated with endocrine disruptors affecting the HPG axis. (intechopen.com)

This study will provide a comprehensive assessment of the toxic effects of the estrogenic pesticide methoxychlor (MXC) on specific segments of the reproductive tract: the ovary, uterus and the oviduct. (cdc.gov)
This study showed ginseng protects folliculogenesis via alteration of hypothalamic- pituitary-gonadal (HPG) axis, induction of proliferation in ovarian somatic cells, reduction of lipid peroxidation, and downregulation of apoptotic markers in the mouse ovary, treated with nicotine. (biomedcentral.com)

In an immunodeficient mouse model, poorer maternal outcomes and higher fetal viral titers were observed when exposure was through sexual transmission rather than subcutaneous or intravaginal infection ( 8 ). (cdc.gov)
The testes of exposed mice exhibited no evidence of gross histological change or elevated stress, irrespective of the RF-EME exposure regimen. (nature.com)
Environmental exposure to contaminants has affected alligators' reproductive and endocrine systems. (eurekalert.org)
Exposure of the non-pregnant and pregnant female will provide the models to evaluate the relative risks of these individuals to impairments of morphological and physiological parameters of the reproductive tract. (cdc.gov)
Thus, unlike exposure of either an adult nonpregnant female or a pregnant female where there is an immediate effect on reproductive activity followed by a complete reversal of this toxicity once exposure ceases, exposure of a newborn female causes a subsequent decrease in reproductive activity which may be permanent. (cdc.gov)
Hence, this chapter summarizes the biological plausibility of EDCs exposure and elucidates the mechanism of action underlying EDCs affecting the regulatory circuits of the mammalian HPG axis and reproductive function. (intechopen.com)
Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring. (bvsalud.org)
Our results indicate that exposure to an attenuated form of WNV protects against severe USUV disease in mice and elicits a neutralizing response to both WNV and USUV. (cdc.gov)
Exposure to estrogens during critical stages of development has been reported to cause irreversible changes in estrogen target tissues such as the reproductive tract. (desdaughter.com)
Recently, concern has been expressed that exposure to soy isoflavones may pose a developmental hazard to infants, particularly to the reproductive system (6- 9). (internetpdfarticles.com)

The female internal reproductive structures include the fallopian tubes, the uterus, the cervix, and the upper two thirds of the vagina. (medscape.com)
By blocking access to the uterus and oviducts, the plug is thought to be an adaptation by which males inhibit the passage of sperm from competitor males, thus protecting their reproductive investment. (biomedcentral.com)

In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. (frontiersin.org)
Receptors for ACE2 are plentiful in the lungs, the gastrointestinal tract, the kidney, and the heart, all organs affected by SARS-CoV-2 infection. (nih.gov)
Infections can lead to reproductive dysfunction and severe local infection. (bioquicknews.com)
however, mechanisms behind ZIKV infection and persistence in the male reproductive tract are unknown. (cdc.gov)
Collectively, these data show that oral administration of 4'-ethynyl-2-fluoro-2'-deoxyadenosine protects BLT mice from HIV infection following multiple high-dose vaginal HIV challenges (P = 0.0002) (Figure 2h). (natap.org)

The list of ejaculated proteins remains particularly scant in one of the best-studied mammalian systems, the house mouse ( Mus domesticus ), where artificial ejaculation techniques have proven inadequate. (biomedcentral.com)
Our study attempts to comprehensively identify the proteins transferred from males to females during mating, expanding the application of isotopic labeling to mammalian reproductive genomics. (biomedcentral.com)

1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)

Therefore, it becomes essential to investigate possible effects of emerging viruses on reproductive tissues and cells to better understand potential impacts on fertility that may be sex specific. (nih.gov)
This study will examine functional outcomes such as effects on fertility and pregnancy and correlate these with the observed anatomic and metabolic alterations within the reproductive tract. (cdc.gov)

The toxic effects of these chemicals can alter reproductive behavior and might be reducing population sizes. (eurekalert.org)
This rate of isoflavone intake is much greater than that shown in adult humans to alter reproductive hormones. (internetpdfarticles.com)

A surprisingly wide range of Cre drivers - including six different neuronal promoters as well as the adipose-specific Adipoq Cre promoter - exhibited off-target recombination in the epididymis, with a subset of drivers also exhibiting unexpected activity in other tissues such as the reproductive accessory glands. (elifesciences.org)
This manuscript reports data consistent with a new and unanticipated phenomenon: that Cre or its mRNA may be transmitted between tissues in the mouse and that the male reproductive tract (epididymis) appears to be the most common target of such transported molecules. (elifesciences.org)
The three tested African strains and one European strain from Spain caused 100% mortality in inoculated mice, with similar survival times and histopathology in tissues. (cdc.gov)
Unexpectedly, a European strain from the Netherlands caused only 12% mortality and significantly less histopathology in tissues from mice compared to mice inoculated with the other strains. (cdc.gov)
We also did not detect HIV-DNA in any of the tissues analysed from 4'-ethynyl-2-fluoro-2'-deoxyadenosine-treated mice at necropsy (Table S1, available as Supplementary data at JAC Online). (natap.org)
Longitudinal analysis of CD4+ T cell levels in peripheral blood and in tissues at necropsy revealed that they were preserved in 4'-ethynyl-2-fluoro-2'-deoxyadenosine-treated BLT mice (Figure S1). (natap.org)

For this particular project, the group seeks to recruit a candidate interested in applying interdisciplinary approaches to study the interplay between sperm and somatic cells in male reproductive tracts. (timeshighereducation.com)

The origin and roles of sperm cell dynamics in reproductive tracts remain less than well-understood despite their physiological importance (2022, Semin Cell Dev Biol). (timeshighereducation.com)

2000. The effect of raloxifene on the uterine weight response in immature mice exposed to 17- estradiol, 1,1,1-trichloro-2,2- bis ( p -chlorophenyl)ethane, and methoxychlor. (cdc.gov)
1999. Methoxychlor given in the pre- implantation period blocks sexual arousal in male mice. (cdc.gov)

The effects of Orchis anatolica plant roots on adult male mice testicular structure and function were explored and compared with those of the red Korean Panax ginseng . (degruyter.com)
In order to determine whether this effect was specific to 17$\beta$-E$\sb2,$ associated with chromosomal changes, and relevant to the human, female BALB/c mice were treated neonatally with either 17$\alpha$-estradiol (17$\alpha$-E$\sb2)$ and 5$\beta$-dihydrotestosterone ($5\beta$-DHT), both inactive steroids in adult reproductive tissue, or 17$\beta$-E$\sb2. (tmc.edu)
Forty adult mice were divided into five groups. (biomedcentral.com)

Occasionally, outflow obstruction is found in conjunction with more complicated anomalies (eg, exstrophy or cloacal anomalies) that may also involve the urologic and digestive tracts, making treatment and recovery much more complicated. (medscape.com)
Women who were exposed to diethylstilbestrol in utero may have structural reproductive tract anomalies, an increased infertility rate, and poor pregnancy outcomes. (aafp.org)

In our efforts to explore the biology of the male reproductive tract, we unexpectedly found that expression of Cre in the central nervous system resulted in recombination in the epididymis, a tissue where sperm mature for ~1-2 weeks following the completion of testicular development. (elifesciences.org)
Some of the identified proteins are the mouse orthologues of human sperm proteins known to undergo tyrosine phosphorylation. (umass.edu)
Using an immunological approach we show that the only Src family member present in mouse sperm extract is Src. (umass.edu)
In this project, the group will combine live cell imaging, microfluidic devices, and mathematical modelling to further explore the fundamental mechanisms of how collective sperm dynamics emerge and link to reproductive functions and aging. (timeshighereducation.com)
In mice, the copulatory plug is probably effective at inhibiting sperm from other males, because it remains intact for approximately 24 hours, females are truly fertile for about 4-12 hours during the estrus cycle, and sperm are not stored across estrus cycles [ 40 ]. (biomedcentral.com)
In a different study, when they blocked the protein to treat an eye condition, an unexpected side effect was mouse sperm that weren't able to swim forward. (medicaldiscoverynews.com)
When a male mouse was given a dose of a sAC inhibitor, it immobilized mouse sperm for two and a half hours and remained effective in the female reproductive tract after mating. (medicaldiscoverynews.com)
A compound temporarily disabled mouse and human sperm. (medicaldiscoverynews.com)
It results from new (de novo) changes in the gene that occur during the formation of reproductive cells (eggs or sperm) or in early embryonic development. (medlineplus.gov)

In female rhesus macaques, vaginal inoculation (as a model for sexual transmission) of Zika virus appeared to enhance viral dissemination to the female reproductive tract, compared with subcutaneous inoculation ( 7 ). (cdc.gov)
In this investigation we developed and validated a tool to quantify the severity of pelvic organ prolapse in mice, and we used this tool prospectively to study the role of fibulin 5, aging, and vaginal proteases in the development of pelvic organ prolapse. (elsevierpure.com)
90% of Fbln5 -/- mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and that increased vaginal protease activity precedes the development of prolapse. (elsevierpure.com)
Given the urgent need for novel HIV prevention approaches for women and their infants, we utilized a preclinical BLT humanized mouse model of HIV infection22-28 to evaluate the efficacy of 4'-ethynyl-2-fluoro-2'-deoxyadenosine, a novel NRTI that has the highest potency to date and low toxicity profiles to prevent vaginal and oral HIV transmission. (natap.org)
we did not detect HIV-RNA in any of the 4'-ethynyl-2-fluoro-2'-deoxyadenosine-treated BLT mice exposed to three consecutive high-dose vaginal challenges, once each with HIV-1JR-CSF, HIV-1CH040 and HIV-1RHPA (Figure 2g). (natap.org)

Both ZIKV and SARS-CoV-2 infections may affect male and/or female reproductive systems in addition to other non-reproductive sites. (nih.gov)
Evidence of sexual transmission prompted the investigation of male and female reproductive tracts as ZIKV reservoirs. (nih.gov)
Several groups have demonstrated that ZIKV exhibits tropism for the male reproductive tract. (nih.gov)
We found prolonged ZIKV RNA shedding in semen was associated with male reproductive tract inflammation, indicated by higher leukocyte counts and inflammatory cytokine concentrations in semen of long-term versus short-term shedders. (cdc.gov)
This study of human semen from ZIKV-infected men provides critical insights into impacts of ZIKV on male reproductive tract health. (cdc.gov)

The virus infects Sertoli cells in the testis and causes inflammation leading to structural damage and breakdown of the blood-testis barrier (BTB) in mice. (nih.gov)

Interferon / receptor knockout (Ifnar1-/-) mice were inoculated with recent USUV isolates from Africa and Europe, as well as the historic 1959 South African strain. (cdc.gov)

Although testosterone serum titer was observed to be elevated in both treated mice groups a marked elevation was observed only in Orchis anatolica treated mice. (degruyter.com)

The purpose of this Notice is to invite applications proposing cutting-edge research on emerging viral infections that are thought to primarily impact non-reproductive sites, at least at initial presentation, but may also affect the male and/or female reproductive tract. (nih.gov)

After treatment, 5 mice of each group were sacrificed and total mice weights, reproductive organs' weights, spermatogenesis, and androgenic serum markers were investigated. (degruyter.com)

Field and laboratory studies support a mechanism based on endocrine-disrupting chemicals, which interfere with the formation of gonadal steroids such as estrogen and the development of the reproductive tract. (eurekalert.org)

In the second arm of the study, pregnant mice were exposed to 1.25, 2.5, 5.0 or 10.0 mg MXC on Days 5, 6 and 7 of pregnancy. (cdc.gov)
Scientists report a non-hormonal male contraceptive that effectively prevents pregnancy in mice, without obvious side effects. (medicaldiscoverynews.com)
Because of its cause we have not made use of this medium characteristic high abundance in the female before in our department, we aimed to com- reproductive tract, albumin has traditionally pare the IVF implantation and pregnancy served as the main macromolecule in most rate by using hyaluronic acid and albumin culture media used for in vitro growth of as transfer medium. (who.int)

lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)

The males of some other species, including mice, go so far as to seal up the female's reproductive tract with semen that hardens like cement into "a kind of cork. (inverse.com)
Prolonged shedding of Zika virus in human semen is associated with male reproductive tract inflammation. (cdc.gov)

Using transgenic mouse models, cell biology approaches, genomics and proteomic techniques we study the effects of different hormonal stimuli in ontogenesis and function of various organs. (fiu.edu)

Results indicated that body and organs' weights were increased significantly in mice treated with Orchis anatolica where only slight changes were observed in red Korean Panax ginseng treated and control mice. (degruyter.com)

We study maternal factors that promote folliculogenesis, ensure fertilization, and sustain cleavage-stage development in mice. (nih.gov)

Moreover, orexins have been reported to greatly influence gonadotropin-releasing hormone neurons and their secretions to regulate reproductive functions via modulation of the hypothalamic-pituitary-gonadal axis. (researchgate.net)

[ 2 ] The ovaries are derived from endoderm, the internal reproductive structures from mesoderm, and the external reproductive structures from ectoderm. (medscape.com)
By two months of age the ovaries of mice exposed to 0.5 and 1.0 mg MXC were smaller than controls, since there were few, if any, corpora lutea in the MXC-treated mice. (cdc.gov)

The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. (elifesciences.org)
Influence of organochlorine pesticides on development of mouse embryos in vitro . (cdc.gov)
Constitutive Notch signaling causes abnormal development of the oviducts, abnormal angiogenesis, and cyst formation in mouse female reproductive tract. (fiu.edu)
5,6], hyaluronic acid effectively supports dium supplemented with hyaluronic acid) mouse and human embryo development and and a control Group B (whose embryos also their growth [7,8]. (who.int)

Together, our findings should motivate caution when interpreting conditional alleles, and suggest the exciting possibility of inter-tissue RNA or protein trafficking in modulation of reproductive biology. (elifesciences.org)
TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells. (elifesciences.org)
The purpose of this study was to determine the ontogeny of cellular changes in the expression of estrogen receptors (ERα, ERβ), G protein-coupled estrogen receptor 1 (GPER1), and progesterone receptors (PRs) in endometriosis using a mouse model. (springer.com)
We used the autologous uterine tissue transfer mouse model and studied the mRNA and protein expression of ERα, ERβ, GPER1, and PR in ectopic lesions at 2, 4, and 8 weeks of induction of endometriosis. (springer.com)
In one study, genetically engineered mice without this protein were sterile. (medicaldiscoverynews.com)

Compartmentalized secretory leukocyte protease inhibitor expression and hormone responses along the reproductive tract of postmenopausal women. (springer.com)

β1(-/-) mice exhibit a dramatic neurological phenotype that includes an ataxic gait, spontaneous seizures, and premature death. (jneurosci.org)

3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice. (logosbio.com)

To extend these studies, here we exposed unrestrained male mice to RF-EME generated via a dedicated waveguide (905 MHz, 2.2 W/kg) for 12 h per day for a period of 1, 3 or 5 weeks. (nature.com)

Chromatin remodeling of prostaglandin signaling in smooth muscle enables mouse embryo passage through the female reproductive tract. (nih.gov)

Androgens are hormones essential to the formation of the male reproductive tract in vertebrates. (eurekalert.org)

Human Relaxin Family Peptide Receptor 1 (RXFP1) is Activated by Relaxin and Small Molecule Agonist ML290 in Transgenic Mice. (fiu.edu)

Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)
17\beta$-E$\sb2, 17\alpha$-E$\sb2$, and $5\beta$-DHT-induced dramatic developmental and histological changes in the cervicovaginal tract, including hypospadia, hyperplasia, and persistent cornification. (tmc.edu)

Arrow indicates amyloid deposits in a male B6C3F1 mouse from a chronic study. (nih.gov)
One mouse study found that alcohol damage on the male reproductive tract was somewhat reversible after 10 weeks of abstaining from alcohol. (healthline.com)
Researchers at Baylor College say they've found the genetic reason for two common male reproductive tract birth defects in a genome-wide study. (medicaldaily.com)
In addition to gaining insights into possible functions and fates of ejaculated proteins, our study serves as proof of concept that isotopic labeling is a powerful means to study reproductive proteins. (biomedcentral.com)
In the latest study, they found several small molecule inhibitors targeting sAC that blocked mouse and human egg fertilization in a lab dish. (medicaldiscoverynews.com)

To determine what the causative agent was, Baker made a suspension of the infected cat lungs and used the suspension to infect mice via their nasal passage. (wikipedia.org)

Follicular stimulating hormone blood serum titer was also elevated obtained in Orchis anatolica treated mice when compared with the other two groups. (degruyter.com)
The goal of this project is to identify small molecule agonists of Insulin-like3 hormone receptor for treatment of osteoporosis and reproductive abnormalities. (fiu.edu)

they become fertilization-competent after undergoing changes in the female reproductive tract collectively termed capacitation. (umass.edu)

We can conclude that Orchis anatolica plant could be more useful to improve testicular functions and structural parameters in mice when compared with red Korean Panax ginseng . (degruyter.com)

Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)

After autopsy of the deceased specimens, Baker confirmed that they died from the same disease from the condition of the lungs of the mice. (wikipedia.org)
Baker did find the causative agent when he spun the infected mouse lungs in a centrifuge. (wikipedia.org)
He found the elementary bodies (see Characterization sub-heading) of C. felis that had been separated from the mouse lungs, confirming that they were the causative agent of the disease. (wikipedia.org)

Amyloidosis is an age-related change that occurs primarily in mice, with variable mouse strain susceptibility. (nih.gov)
The HPG axis is primarily responsible for governing all the hormonal events related to reproductive activity. (intechopen.com)

CD52 is expressed on lymphocytes, monocytes, macrophages and on epithelial cells of male reproductive tract, shed into seminal plasma and acquired by spermatozoa. (beckman.com)

Without SRY, the mesonephric ducts degenerate, and the paramesonephric ducts develops further into the internal reproductive structures. (medscape.com)
The female external reproductive structures include the lower third of the vagina, the external genitalia, and parts of the bladder. (medscape.com)

FP Cello produces lethal disease in mice, whereas the FP Baker does not. (wikipedia.org)

The first step in evaluating the potential of the phytoestrogens in soy-based infant foods to affect the reproductive system of infants is to determine the isoflavone intake of infants. (internetpdfarticles.com)

In fifty-two matings, none of the females became pregnant compared to thirty percent in untreated mice. (medicaldiscoverynews.com)

Anatomy79

Organisms26

Diseases60

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes34

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science7

Named Groups1

Health Care11

Genital tract6

Chlamydia5

Female Mice7

Effects on reproductive health2

Ovary2

Exposure10

Uterus2

Infection5

Mammalian2

19941

Fertility2

Alter reproductive2

Tissues6

Somatic1

Physiological1

Methoxychlor2

Adult3

Anomalies2

Sperm9

Vaginal5

ZIKV5

Infects1

Interferon1

Testosterone1

Infections1

Spermatogenesis1

Endocrine1

Pregnancy3

Digestive1

Semen2

Genomics1

Organs1

Maternal1

Secretions1

Ovaries2

Development4

Protein5

Leukocyte1

Neurological1

Molecular1

Male mice1

Embryo1

Hormones1

Transgenic1

Developmental2

Study5

Passage1

Hormone2

Fertilization1

Structural1

Actin1

Lungs3

Primarily2

Spermatozoa1

Structures2

Disease1

Infants1

Pregnant1