Mice s natural microbiota. Medical search. Frequent questions

Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that target it. (nature.com)
These data suggest that reduced diversity and/or a change in metabolic function of the gut microbiota may be associated with disease progression in T1D. (biomedcentral.com)

Turnbaugh, P. J., Backhed, F., Fulton, L. & Gordon, J. I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. (nature.com)
https://doi.org/10.1084/jem.20211220 ) cohouse dirty pet store mice and rats with clean laboratory mice to gain insights into infection dynamics, discover new viruses, and identify relationships between viruses and the microbiome. (rupress.org)
Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility. (biomedcentral.com)
In homeostatic conditions, the expression of TRAIL in astrocytes is driven by interferon-γ (IFNγ) produced by meningeal natural killer (NK) cells, in which IFNγ expression is modulated by the gut microbiome. (nature.com)
The mouse microbiome is altered in aging individuals. (squabash.com)
C. mastitidis also has a role in the microbiome of the ocular surface in both mice [2] and humans [3]. (kenyon.edu)
DHM-treated mice showed similar gut microbiota distribution to the control, suggesting a reversal of the ethanol-mediated changes in microbiome shifts. (ocsef.org)
These results emphasize that the microbiome and aging The human gut microbiota. (sonexfinancial.com)
In the same vein, humans don't live in a sterilized box and have a more varied microbiome than lab mice and perhaps the reactions are not comparable. (zmescience.com)
Researchers from the National Institute of Diabetes and Digestive and Kidney Diseases t ested how lab mice with a more natural microbiome would respond to diseases . (zmescience.com)
They took pregnant germ-free mice and they gave some of them a lab mouse microbiome and some a wild mouse microbiome and raised them over several generations. (zmescience.com)

When the team transplanted fecal microbiota from resistant starch-treatment patients to mice fed with a high-fat high-cholesterol diet, the mice saw a significant reduction in liver weight and liver triglyceride levels and improved liver tissue grading compared with mice that received microbiota from the control group. (eurekalert.org)

1 To determine microbiota composition, fecal samples underwent gene sequencing in both vegans/vegetarians (n=23) and omnivores (n=30). (naturalmedicinejournal.com)
Thus, it can modulate the composition and metabolic activity of the intestinal microbiota, which might potentially enhance the health of the host organism[ 5 , 6 ]. (ijpsonline.com)
The microbiota is established in the early part of life, and its composition is shaped by deterministic niche-related factors (host environment), historical factors (pre-exposure to certain microbes), and environmental drivers (e.g., diet) [ 1 ]. (biomedcentral.com)
By analyzing patients' fecal samples, the team found the resistant starch group had a different microbiota composition and functionality compared with the control. (eurekalert.org)
Further analyses of gut microbiota using next-generation sequencing (NGS) of the 16S rRNA gene showed that the pattern of gut microbial composition was clearly altered following 8 weeks of TWK10 administration. (frontiersin.org)

Meanwhile, RSV decreased TMAO levels by inhibiting commensal microbial trimethylamine (TMA) production via gut microbiota remodeling in mice. (nih.gov)
Finally, in mice, it was observed that TMAO production in response to L-carnitine could be induced with microbial colonization in germ-free mice or with chronic dietary L-carnitine intake. (naturalmedicinejournal.com)
Both fish and mice fed TF had significantly lower gut microbial diversity than those fed NF. (deepdyve.com)
Conclusions: Our results reveal that thermal processing of food strongly contributes to the reduction of gut microbial diversity and differentially drives microbial alterations in a host-dependent manner, suggesting specific adaptations of host-gut microbiota in vertebrates responding to thermal processing of food. (deepdyve.com)
Indeed, co-evolution between humans microbial communities are revealing factors that affect and the microbiota in the gastrointestinal tract is a much microbial diversity such as host genotype [6] and a range of environmental factors, particularly diet [7, 8]. (deepdyve.com)
Dietary shifts in humans over time fluence microbial community structure [6, 14], reflecting have presumably occurred in three stages: from an in- the conserved convergence of gut microbiota within a crease in the sharing of plant roots, bulbs, and tubers in host. (deepdyve.com)
Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments. (nature.com)
Microbial exposure during early life has persistent effects on natural killer T cell function. (nature.com)
A role for the microbiota in T1D etiology is suggested by studies that demonstrate changes in the microbial communities prior to clinical disease onset. (biomedcentral.com)
Analysis of microbial populations showed the effects of immune reconstitution, including normalization of gut microbiota and clearance of viral infections. (europeanhealthjournal.com)
We think that by restoring the natural 'microbial identity' of laboratory mice, we will improve the modeling of complex diseases of free-living mammals, which includes humans and their diseases," said Barbara Rehermann, M.D., chief of the Immunology Section, Liver Diseases Branch, of the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (zmescience.com)

Moreover, RSV increased levels of the genera Lactobacillus and Bifidobacterium, which increased the bile salt hydrolase activity, thereby enhancing bile acid (BA) deconjugation and fecal excretion in C57BL/6J and ApoE(-/-) mice. (nih.gov)
40 C57BL/6J female mice were randomly divided into 4 groups: control group (CON) ,DSS group (DSS) ,DSS + Enterotoxigenic Escherichia coli group (ETEC) ,DSS + ETEC + sitagliptin group (GLP-2). (researchsquare.com)
Herein, we compared the microbiota of non-thermally processed and thermally processedfood (NF andTF) andinvestigatedgut microbiota associated with NF andTFincatfish Silurus meridionalis and C57BL/6 mice to assess effects of thermal processing of food on gut microbiota and to further identify the differences in host responses. (deepdyve.com)
The lab mouse strain C57BL/6 that was used for this study. (zmescience.com)

The researchers also tested the stability and resilience of the wildlings' microbiota and found the microbiota was stable across five generations and resilient to environmental challenges. (sciencedaily.com)

Herein, we studied the dose effects of widely used food supplement, microalgae spirulina ( Arthrospira platensis ), on the colonic microbiota and physiological responses in healthy male Balb/c mice. (frontiersin.org)
16SrRNA was used to detect the changes in gut microbiota in mouse colonic tissue. (researchsquare.com)

Likewise, research on the endogenous circadian timekeeping mechanisms in mice further supports that "circadian resonance" is evolutionarily adaptive. (wikipedia.org)
There are bacteria that have daily timekeepers, and it may be possible that the microbiota have endogenous clocks which communicate with biological clocks of the host. (wikipedia.org)
When using the gut model I primarily using Citrobacter rodentium , a natural mouse pathogen that infects the colon in the presence of the endogenous microbiota and models pathogenic E.coli infection in humans. (imperial.ac.uk)

Our rationale was that the immune responses and microbiota of wild mice and humans are likely shaped in a similar way -- through contact with diverse microbes out in the real world. (sciencedaily.com)
To do so, they drew from two studies where drugs used to target immune responses were successful in treating lab mice in preclinical trials but consequently failed to have therapeutic effects in humans. (sciencedaily.com)
This data confirms that TMAO production from dietary L-carnitine in humans is dependent on intestinal microbiota. (naturalmedicinejournal.com)
Bacterial taxonomy was completed on the mice and it was observed that as in humans, there were genera associated with increased conversion of carnitine to TMAO, but these genera were not shared with those in humans, as mouse flora and human flora do not have much overlap. (naturalmedicinejournal.com)
C. mastitidis is an irregular bacterium within the genus that works as an opportunistic pathogen in immunocompromised animals as well as an important microbe on the ocular surface of mice [2] and humans [3]. (kenyon.edu)
Both fish and humans, she explained, host similar microbiota-communities of useful bacteria that boost the host's immune system. (alaska.edu)

In two preclinical studies, wildlings mirrored human immune responses, where lab mice failed to do so. (sciencedaily.com)
Microbiota refers to the trillions of tiny microbes, such as bacteria, fungi, and viruses, that live in and on the bodies of people and animals and play a critical role in keeping immune systems healthy. (sciencedaily.com)
In the current study, they transplanted embryos of the most commonly used strain of laboratory mice for immune system research into female wild mice, who then gave birth to and raised wildlings. (sciencedaily.com)
The exact pathogenesis of UC is not completely understood, and it is generally believed to be related to the interaction between environment, immune system, gut microbiota and genetic susceptibility[2]. (researchsquare.com)
The immune cells associated with innate immune responses in the mucosa incorporate monocytes, macrophages, Dendritic Cells (DC), Normal Executioner (NE) and natural lymphoid cells, pole cells, neutrophils and eosinophils. (alliedacademies.org)
Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
These findings demonstrate for the first time that type 1 diabetes-associated genetic variants that restore immune tolerance to islet antigens also result in functional changes in the gut immune system and resultant changes in the microbiota. (biomedcentral.com)
Dysbiosis of the gut microbiota has been described in multiple inflammatory and immune-mediated diseases including rheumatoid arthritis, ulcerative colitis, Crohn's disease ankylosing spondylitis, and type 1 diabetes (T1D). (biomedcentral.com)
As the incidence of autoimmune diseases including T1D has been steadily increasing over the past 50 years [ 2 ], it is speculated that lifestyle changes are causing changes in the gut microbiota leading to alterations in the development of the immune system [ 3 ]. (biomedcentral.com)
The lack of exposure to enough healthy bacteria may leave the immune system of lab mice compromised and not such a good model for human disease. (zmescience.com)

We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut microbiota and the plasma concentration of lipopolysaccharide (LPS), i.e., metabolic endotoxemia. (diabetesjournals.org)
Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. (qascf.com)

characterise several novel Rag1 −/− mouse strains and demonstrate that genetic background strongly influences xenograft development and phenotype. (biologists.com)
Mice that were bred with a genetic mutation that prevented them from producing SIRT2 showed more signs of inflammation at the ripe old age of two than their normal counterparts. (qualitycounts.com)
These approaches represent innovative ways to investigate long-term exposure or colonization by members of the microbiota while still being able to take advantage of genetic mouse models. (rupress.org)
It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. (biomedcentral.com)
Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. (biomedcentral.com)

RESEARCH DESIGN AND METHODS- We changed gut microbiota by means of antibiotic treatment to demonstrate, first, that changes in gut microbiota could be responsible for the control of metabolic endotoxemia, the low-grade inflammation, obesity, and type 2 diabetes and, second, to provide some mechanisms responsible for such effect. (diabetesjournals.org)
CONCLUSIONS- This new finding demonstrates that changes in gut microbiota controls metabolic endotoxemia, inflammation, and associated disorders by a mechanism that could increase intestinal permeability. (diabetesjournals.org)
GLP-2 reduced the degree of inflammation in UC mice, which may be achieved by inhibiting the inflammatory pathways of NF-κB and Janus Kinase (JAK) /STAT3, increasing the dominant bacteria and improving the diversity of gut microbiota. (researchsquare.com)
The gut microbiota plays an important role in maintaining the integrity of the intestinal mucosa, and disruption of the intestinal mucosal barrier and bacterial invasion leads to intestinal inflammation[3]. (researchsquare.com)
While this microorganism is commonly found in the natural environment and in the guts of healthy human beings and animals, its numbers in the gut can increase in response to antibiotic use, potentially resulting in severe inflammation of the gut wall. (integrativepractitioner.com)
[ 5 ] Relatively low concentrations of those same two commonly used emulsifiers, CMC and P80, induced low-grade inflammation and obesity/metabolic syndrome in wild-type hosts and promoted robust colitis in mice predisposed to this disorder. (medscape.com)

Plasma parameters, gut microbiota, bile acid and short-chain fatty acids were analyzed to detect the improved effects and possible mechanisms. (ijpsonline.com)

These findings provide direct evidences of dose-related modulation of gut microbiota and physiological states by spirulina , engendering its future mechanistic investigation of spirulina as potential sources of prebiotics for beneficial health effects via the interaction with gut microbiota. (frontiersin.org)
In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

For example, when the mice were given antibiotics for seven days, the lab mice's gut microbiota changed and did not recover, while the wildlings' microbiota fully recovered. (sciencedaily.com)
In mice treated with antibiotics, RSV neither decreased TMAO levels nor increased hepatic BA synthesis. (nih.gov)
Furthermore, the absence of CD14 in ob/ob CD14 − / − mutant mice mimicked the metabolic and inflammatory effects of antibiotics. (diabetesjournals.org)
To confirm the potential contribution of gut microbiota in the formation of TMAO from dietary L-carnitine, 5 volunteers were placed on oral broad-spectrum antibiotics for 1 week, and then repeated the L-carnitine challenge described above. (naturalmedicinejournal.com)

TMAO is a product of carnitine metabolism by microbiota in the gut. (naturalmedicinejournal.com)
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. (naturalmedicinejournal.com)
Some studies have demonstrated that early inulin intervention in High Dietary (HD) fed mouse can reduce the glucose metabolism disorders and gut dysbiosis in the offspring[ 7 ]. (ijpsonline.com)

They found that the wildlings acquired the microbes and pathogens of wild mice and closely resembled wild mice in their bacterial microbes present at the gut, skin, and vagina, as well as in the number and kinds of fungi and viruses present. (sciencedaily.com)
They trapped closely related wild mice and sampled their bacterial gut microbiomes. (zmescience.com)

The results of 16SrRNA detection showed that compared with the DSS group, the dominant bacteria such as Lactobacillus and Prevotellaceae were increased and the diversity of gut microbiota was increased in the GLP-2 group. (researchsquare.com)
Increased quantities of the bacterium were found both in participants who had completed the weight loss regimen and in mice which had received post-dieting gut bacteria. (integrativepractitioner.com)
lactis (B. lactis) es un tipo de probiótico (bacteria "buena") que vive en los intestinos. (medlineplus.gov)
Lateral phage transfer in obligate intracellular bacteria (wolbachia): verification from natural populations. (mbl.edu)
They are not exposed to the same bacteria that wild mice would be exposed to. (zmescience.com)
As such, lab mice do not react to medication the same way that mice with a healthy community of gut bacteria would. (zmescience.com)
TWK10-treated mice also experienced an increase in short-chain fatty acid (SCFA)-producing bacteria and higher overall levels of gut SCFA. (frontiersin.org)

The researchers and their collaborators compared the microbiota of the wildlings, wild mice and lab mice. (sciencedaily.com)

Li, Dapeng 2018-05-31 00:00:00 Background: Adoption of thermal processing of the diet drives human evolution and gut microbiota diversity changes in a dietary habit-dependent manner. (deepdyve.com)

These studies indicate that in the steady state, NOD mice harbor a "diabetes-permissive" microbiota, and major perturbations in the microbiota can both reduce and accelerate disease. (biomedcentral.com)

The natural pre-colonization of the mouse digestive track by Helicobacter hepaticus and the modification of the intestinal microbiota appear to prevent the. (pasteur.fr)

Germ-free mice underwent an L-carnitine challenge, which demonstrated no detectable plasma d3-TMAO production after ingestion of d3-carnitine. (naturalmedicinejournal.com)

These results offer new insights into the mechanisms responsible for RSV's anti-AS effects and indicate that the gut microbiota may become an interesting target for pharmacological or dietary interventions to decrease the risk of developing cardiovascular diseases. (nih.gov)
A few of the common natural dietary supplements include herbs like Aloe, Ephedra, Gingko, Ginseng, Saw palmetto, St. John's wort and Echinacea, these herbs with their pure effects enhance up body's capabilities to promote wholesome weight acquire. (wijvallenaf.nl)
Capsaicin and dietary fiber are effective natural food ingredients to control the obesity and metabolic diseases. (ijpsonline.com)

Further, when the mice were fed a 10-week high-fat diet, the microbiota of the lab mice changed significantly and never returned to baseline. (sciencedaily.com)
Dihydromyricetin (DHM), a natural flavonoid, significantly reduces alcoholic liver disease (ALD) outcomes following chronic alcohol (ethanol/EtOH) abuse. (ocsef.org)

The wildlings' microbiota changed only mildly and recovered shortly after the diet ended. (sciencedaily.com)
Topics covered in this episode include types of medicinal mushrooms and their benefits, the effect of gut microbiota on food cravings, high blood sugar as an indicator of cardiovascular disease risk, causes of and solutions to the prevalence of nutrient deficiencies in the modern diet, and how to apply a pleiotropic lens to the root-cause approach of health transformation. (chriskresser.com)
T1D incidence is higher in specific pathogen-free (SPF) or "clean" housing facilities, and many interventions that alter the microbiota (e.g., diet changes) result in disease protection [ 9 ]. (biomedcentral.com)
They have several natural ingredients that have natural appetite suppressant pills in Australia five the a diet pill that actually works most effective ingredients to help suppress appetite. (micromosaictunisia.com)
People with a speedy a diet pill that actually works Instant Knockout capsule, it contains a natural ingredients that create a metabolic rate. (micromosaictunisia.com)

Figure 2: Tools for evaluating microbiota diversity. (nature.com)
Figure 3: Diversity of the human microbiota at different phylogenetic scales. (nature.com)

Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
Fusobacteria was the most abundant phylum in the fish, and Bacteroidetes and Firmicutes dominated in the mice. (deepdyve.com)
For example, our findings are relevant in the context of the hygiene hypothesis, in that early exposure to inflammatory stimuli that are abundant in the natural world, has beneficial effects. (zmescience.com)

Metformin alters the gut get combivir prescription microbiota. (sonexfinancial.com)

a mouse model was generated via inhalation of both particulate matter 10 and diesel particulate matter, and 30% ethanol extracts of either I. japonica (IJ) or P. chinensis (PC) and a mixture of both ethanol extracts (IP) were orally administered to BALB/c mice for 12 days. (bvsalud.org)

There are several reports on the antimicrobial and anti-dysbiosis property of capsaicin by mediating the beneficial alteration of microbiota many studies also found that capsaicin can prevent the onset or development of diseases like obesity, diabetes, or inflammatory bowel diseases[ 7 , 12 ]. (ijpsonline.com)
Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). (biomedcentral.com)

Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases. (diabetesjournals.org)

These mice had a mutation in the casein kinase 1Ɛ gene, which encodes an enzyme that is integral in controlling circadian cycle length. (wikipedia.org)

Laboratory mice are typically maintained in "clean" specific pathogen-free (SPF) facilities that seek to reduce experimental variation and unwanted health effects by excluding a list of known transmissible agents. (rupress.org)
Laboratory mice have been bred to be genetically similar for reproducible results . (zmescience.com)
Indeed, the wild mice had different gut biota than the laboratory mice. (zmescience.com)

The wildlings, but not the lab mice, mimicked the human responses seen in clinical trials. (sciencedaily.com)

The gut microbiota is found to be strongly associated with atherosclerosis (AS). (nih.gov)
This publication pulled together data from several studies, both mouse and human, to assess the role of trimethylamine-N-oxide (TMAO) on atherosclerosis. (naturalmedicinejournal.com)

NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)

Finally, compound 11 suppressed PI3K/AKT/MEK/ERK signaling pathway in lung tissue of mice. (bvsalud.org)

Then, the therapeutic effect of AIPSs on diarrhea in mice caused by lincomycin hydrochloride (LIH), and their regulatory and recovery effects on the intestinal flora, was studied with fructooligosaccharide as the positive control. (qascf.com)
Analysis of mouse intestinal flora showed that AIPSs treated diarrhea caused by LIH and regulated and improved the flora's structure. (qascf.com)
After several weeks in conventional cages, allowing recolonization of intestinal flora, the same mice acquired the ability to produce d3-TMAO. (naturalmedicinejournal.com)

One study in particular compared the fitness of wild-type mice with mutant mice which had a short free-running circadian cycle. (wikipedia.org)
We wanted to create a mouse model that better resembles a mouse you'd find in the wild," said Barbara Rehermann, M.D., chief of the Immunology Section in NIDDK's Liver Diseases Branch and senior author on the study. (sciencedaily.com)
In the current study, the researchers treated wildlings and lab mice with the same drugs. (sciencedaily.com)
The current study showed that RSV attenuated TMAO-induced AS by decreasing TMAO levels and increasing hepatic BA neosynthesis via gut microbiota remodeling. (nih.gov)
The purpose of this study was to investigate the protective effect of GLP-2 on Dextran sulfate sodium (DSS) -induced UC in mice and its potential mechanism. (researchsquare.com)
In a different study, mice fed a carnitine-supplemented chow increased their carnitine-to-TMAO conversion 10-fold compared to a control group. (naturalmedicinejournal.com)
This study sought to evaluate the efficacy of urolithin A (UroA) in a fructose-induced NAFLD mouse model. (cabi.org)
This study investigated the efficacy of DHM in modifying gut microbiota populations in comparison to ethanol-fed mice. (ocsef.org)
Our study tested the effect of DHM on the gut microbiota at two concentrations. (ocsef.org)
That could be due to the contents of mice guts, a new study reports. (zmescience.com)
A diagram showing the difference between a wild and lab lab mouse, and the hybrid that was created for this study. (zmescience.com)
Although not a goal of the study, it brings up another parallel between mice and men. (zmescience.com)
This study is not saying that all mouse-based studies are now rubbish. (zmescience.com)
In this study, the effect of TWK10 on the progression of age-related impairments was investigated in mice. (frontiersin.org)

However, our current transmission models are often inadequate as they lack a natural reservoir, use single high infectious doses, and nonphysiological routes of inoculation. (rupress.org)

We found that RSV attenuated trimethylamine-N-oxide (TMAO)-induced AS in ApoE(-/-) mice. (nih.gov)
Besides the consistent reduction of Bacteroidetes and the balanced Protebacteria, the response of other dominated gut microbiota in the fish and mice to TF was taxonomically opposite at the phylum level, and those further found at the genus level. (deepdyve.com)
We found that TWK10 not only enhanced muscle strength in young mice, but also prevented the aging-related loss of muscle strength in aged mice, which was accompanied by elevated muscle glycogen levels. (frontiersin.org)

In conclusion, RSV attenuated TMAO-induced AS by decreasing TMAO levels and increasing hepatic BA neosynthesis via gut microbiota remodeling, and the BA neosynthesis was partially mediated through the enterohepatic FXR-FGF15 axis. (nih.gov)
The gut microbiota plays a key role in the pathophysiology of TMAO-induced AS. (nih.gov)

Previous research has suggested that NAFLD is associated with perturbed gut microbiota. (eurekalert.org)

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate. (medlineplus.gov)
Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación. (medlineplus.gov)

In 2017, they led research showing that transferring wild mice gut microbiota into lab mice helped the mice survive an otherwise lethal flu virus infection and fight colorectal cancer. (sciencedaily.com)
We inoculated only the nasopharynx of mice to explore the course of infection in a more natural exposure model. (cdc.gov)
Our infection model revealed that B. pertussis can efficiently colonize the mouse nasopharynx, grow and spread within and between respiratory organs, evade robust host immunity, and persist for months. (cdc.gov)

Figure 6: Compositional transitions in the human gut microbiota. (nature.com)

Mouse studies demonstrate that the diminished gut mucus associated with two emulsifiers (CMC and P80) may permit penetration of gut microbes through the epithelium. (medscape.com)

Thus, there is a tendency to use natural compounds for the management of obesity. (mdpi.com)
There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. (mdpi.com)

The mouse model, which the scientists called 'wildling,' acquired the microbes and pathogens of wild mice, while maintaining the laboratory mice's genetics that make them more useful for research. (sciencedaily.com)
Models that allow for natural transmission of pathogens would complement these approaches and greatly expand our tool kit for studying host-microbe interactions. (rupress.org)

It would thus be useful to develop strategies for changing gut microbiota to control, intestinal permeability, metabolic endotoxemia, and associated disorders. (diabetesjournals.org)
When exposed to the influenza virus, 92% of the mice with wild biomes survived while only 17% of control mice survived. (zmescience.com)

In fact, the mutant genotype was strongly selected against, thereby suggesting natural selection towards those genotypes that are resonant with the natural LD cycle. (wikipedia.org)

In the inbred non-obese diabetic (NOD) mouse model of T1D, susceptible NOD mice were shown to harbor a distinct gut microbiota to a variety of T1D-protected inbred strains [ 8 ]. (biomedcentral.com)

Pharmacological vitamin C (VC) is a potential natural compound for cancer treatment. (cabi.org)

Unlike squeaky clean lab mice raised in artificial settings, wild mice have developed symbiotic relationships with microbes they have encountered in the outside world -- just as people have done. (sciencedaily.com)

A mixed group of wild-type and mutant mice were then released in an outdoor experimental enclosure and, following a fourteen month timespan, the mice were monitored. (wikipedia.org)
The wild-type mice both survived longer and reproduced at a greater rate than the mutant mice. (wikipedia.org)

al investigated if combinations of natural polyphenols, known for their antioxidant potential, could protect against ionizing radiations. (polyphenols-site.com)
1) Plant-derived polyphenols were screened for their potential ability to confer radioprotection to mice given a lethal whole-body γ radiation (137Cs) dose expected to kill 50% of the animals in 30 days. (polyphenols-site.com)

It is possible that circadian clocks play a role in the gut microbiota behavior. (wikipedia.org)

Researchers developed a new mouse model that could improve the translation of research in mice into advances in human health. (sciencedaily.com)
Supercharge your health, performance, and longevity with the Adapt Naturals Core Plus supplement bundle, launching in July. (chriskresser.com)
The manufacturers stategy attractive the scientific research at the mice that their health care microbiota are not recommended. (micromosaictunisia.com)
In conclusion, TWK10 could be viewed as a potential therapeutic agent that attenuates aging-related disorders and provides health benefits by modulating the imbalance of gut microbiota. (frontiersin.org)

1987. Apparent induction of microsomal carboxylesterase activities in tissues of clofibrate-fed mice and rats. (cdc.gov)

Numerous studies have confirmed that the supplementation with natural functional food may help reduce the risk of obesityrelated complications[ 2 , 3 ]. (ijpsonline.com)
Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. (cancerindex.org)
Animal models are based either on studies of human viruses in animals, often requiring the use of immunocompromised hosts and/or host-adapted viruses, or the use of related viruses in their natural hosts. (basicmedicalkey.com)
We do not intend to propose a general switch to natural microbiota in all types of studies. (zmescience.com)

Administering DHM at 10 mg/kg better preserved gut microbiota after alcohol feeding compared to 5 mg/kg in the family analysis, suggesting potential dose-dependent effects. (ocsef.org)
Perhaps most importantly, it get combivir prescription will be critical to avoid multiplying the hype in the human body (the microbiota) offer tremendous potential in understanding aging. (sonexfinancial.com)

Anatomy26

Organisms56

Diseases25

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology1

Phenomena and Processes46

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture11

Humanities2

Information Science5

Named Groups2

Health Care10

Function of the gut microbiota2

Microbiome11

Fecal microbiota1

Composition5

Microbial11

C57BL4

Stability and resilience1

Colonic2

Endogenous3

Humans6

Immune10

Modulates2

Genetic5

Inflammation6

Bile acid1

Interaction2

Antibiotics4

Metabolism3

Bacterial2

Bacteria7

Collaborators1

20181

Perturbations1

Colonization1

Germ-free mice1

Dietary3

Significantly2

Diet5

Diversity2

Abundant3

Alters1

Balb1

Dysbiosis2

Metabolic diseases1

Gene1

Laboratory mice3

Responses1

Atherosclerosis2

Lymphoid cells1

Tissue1

Intestinal flora3

Study14

Inoculation1

Found3

TMAO2

NAFLD1

Medicines Comprehensive Database2

Infection3

Transitions1

Demonstrate1

Obesity2

Pathogens2

Control2

Strongly1

Strains1

Pharmacological1

Wild mice1

Mutant mice2

Polyphenols2

Role1

Health4

Rats1

Studies4

Potential2