Each gram of ZOVIRAX Cream, 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum. (rxlist.com)
BALB4
All three PEC vaccines induced J8-specific systemic immunoglobulin G (IgG) antibodies when administered intranasally to female BALB/c mice without the use of additional adjuvants. (bvsalud.org)
Finally, the biodistribution in BALB/c mice bearing lymphoma-tumor and pharmacokinetic study revealed an encouraging profile for T908-probe. (izon.com)
1. 1, 2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamin (DPPE), doxorubicin and folic acid conjugated micelles for cancer management in tumor bearing BALB/c mice. (nih.gov)
Activity of IVE in its free format or incorporated into Pluronic® F127-based polymeric micelles (IVE/Mic) was also evaluated in vivo as a treating drug for L. infantum -infected BALB/c mice. (alecomm.com)
Induce3
In the endogenous hyperlipidemia model, rats were previously treated with GANMO tablets and intraperitoneally injected with poloxamer 407 to induce hyperlipidemia. (hindawi.com)
Our studies demonstrate that DCHP activated PXR to induce hypercholesterolemia and ceramide production in mice. (nih.gov)
Our group utilizes a mouse model of central nervous system infection (NSE-CD46+ mice) to induce inflammation in the brain through a neuron-restricted measles virus infection. (odonnellviruslab.com)
Hydrogels1
Tundisi LL, Yang R, Borelli LPB, Alves T, Mehta M, Chaud MV, Mazzola PG, Kohane DS: Enhancement of the mechanical and drug-releasing properties of poloxamer 407 hydrogels with casein. (harvard.edu)
Anticancer1
14. Synergistic effect of pH-responsive folate-functionalized poloxamer 407-TPGS-mixed micelles on targeted delivery of anticancer drugs. (nih.gov)
Rats1
Carbamazepine has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizures. (nih.gov)
Poly2
A study of nanoparticles formation was performed evaluating two non-ionic surfactants as poloxamer, and poly vinyl alcohol and nanocrystalline cellulose. (doctorhassanpour.ir)
Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts. (amedeo.com)
Diabetic mice1
The diabetic mice model was established. (bvsalud.org)
Sodium1
No evidence of carcinogenicity was observed in female and male mice at doses ranging from 2.4 to 18.8 mg/kg sodium fluoride of body weight (3,4). (nih.gov)
Formulations2
Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. (sigmaaldrich.com)
Hemagglutinin of the H1N1 virus was formulated in Alum and α -tocopherol, and then aged (16-20-month-old) and young (6-8-week-old) mice were immunized subcutaneously two times with 2-week intervals with 5 μ g of different vaccine formulations. (tocotrienolresearch.org)
Concentration2
Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. (sigmaaldrich.com)
The norcantharidin/poloxamer 407 is less toxic than the equivalent dose of norcantharidin, mainly because norcantharidin/poloxamer 407 may release norcantharidin sustainedly, thus reducing norcantharidin concentration in blood. (jcimjournal.com)
Doxorubicin2
4. Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice. (nih.gov)
10. A folate modified pH sensitive targeted polymeric micelle alleviated systemic toxicity of doxorubicin (DOX) in multi-drug resistant tumor bearing mice. (nih.gov)
Hyperlipidemia1
DCHP was then demonstrated to activate intestinal PXR to elicit hyperlipidemia by using tissue-specific PXR-deficient mice. (nih.gov)
Pharmacology1
Given that PXR exhibits considerable species-specific differences in receptor pharmacology, PXR-humanized mice were also used to replicate these findings. (nih.gov)
Biological1
15. Quantification of DOX bioavailability in biological samples of mice by sensitive and precise HPLC assay. (nih.gov)
Significantly3
Notably, sera of mice immunized with Lip-2 and Lip-3 produced significantly higher opsonic activity against clinically isolated GAS strains compared to the positive control, P25-J8 emulsified with the commercial adjuvant, complete Freund's adjuvant (CFA). (bvsalud.org)
Phenotypically, daily urine output in UT-A1-knockout mice was nearly 3-fold that of WT mice and 82% of all-UT-knockout mice, and the UT-A1-knockout mice had significantly lower urine osmolality than WT mice. (emory.edu)
145. The breeding behavior of spiny mice and their ma- turity level at birth are significantly different from other species of mice. (tradingsignalsforex.com)
Vaccine5
To create a hydrogel for sustainable vaccine release, we dispersed the pDNA nanoparticles in poloxamer 407 gel which is liquid at 4 °C and turns into soft gels at 37 °C, providing ease of administration and preventing burst release of pDNA. (nih.gov)
In addition, vaccine efficacy was determined by intranasal viral challenge of mice using mouse-adapted H1N1 virus. (tocotrienolresearch.org)
Our results showed that the new vaccine formulation improved IFN- γ and IL-4 responses in the experimental mice. (tocotrienolresearch.org)
Results from the HI assay showed that α -tocopherol in the vaccine formulation could increase HI activity in both young and aged mice. (tocotrienolresearch.org)
Furthermore, α -tocopherol, as an adjuvant, increased the protectivity of the influenza vaccine in both aged and young groups through the decreased lung viral load and increased survival rate of the experimental mice. (tocotrienolresearch.org)
Model4
Catalase loaded PACkET protects endothelial cells from killing by H2O2 and alleviated the pulmonary edema and leukocyte infiltration in mouse model of endotoxin-induced lung injury, whereas SOD-loaded PACkET mitigated cytokine-induced endothelial pro-inflammatory activation and endotoxin-induced lung inflammation. (nih.gov)
The objective of this study was to test the effects of FDA-approved L-type calcium channel antagonist nimodipine on amyloid accumulation and dystrophic neurite formation in 5XFAD mice, a mouse model of amyloid pathology. (nih.gov)
Here, we sought to determine the role of UT-A1 in the urine-concentrating mechanism in a newly developed UTA1-knockout mouse model. (emory.edu)
R. Iyer, J. L. Croucher, M. Chorny, J. L. Mangino, I. S. Alferiev, R. J. Levy, V. Kolla, G. M. Brodeur, Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. (chop.edu)
Properties1
The in vivo transfection properties were investigated by injection of tibialis muscles and intratracheal administration of female Swiss mice. (scirp.org)
Viral1
Given their small size (10C100 nm), simple preparation, and extended circulation period [76] confirmed that P85 could facilitate antiretroviral medication efficacy within a serious mixed immunodeficiency (SCID) mouse style of viral encephalitis. (insulin-receptor.info)
Injection3
Intra-peritoneal administration (5 days/week for two weeks) of N-JQ1 in nude mice hosting a xenograft TNBC after flank injection of MDA-MB-231 cells determined a great reduction in the growth and vascularity of the neoplasm. (unical.it)
To compare the acute toxicity of common injection and sustained-release preparation of norcantharidin for mice so as to identify the attenuation of the sustained-release preparation of norcantharidin. (jcimjournal.com)
The poloxamer 407 was used as a sustained-release vehicle for topical administration of norcantharidin, and the acute toxicity of mice treated with common injection and sustained-release preparation of norcantharidin was observed. (jcimjournal.com)
Survival1
Metronomic cordycepin therapy prolongs survival of oral cancer-bearing mice and inhibits epithelial-mesenchymal transition. (visualprotein.com)
Group1
The symptoms of mice were similar between the two groups, but the appearance of symptoms in norcantharidin/poloxamer 407 group was 4 hours later than that in norcantharidin group. (jcimjournal.com)
Solid1
Fuller teamed up with Jayakumar Rajadas, PhD, director of the Stanford Biomaterials and Advanced Drug Delivery Laboratory, to modify the poloxamer so that it would become solid and elastic when heated above body temperature but dissolve harmlessly into the bloodstream when cooled. (sciencedaily.com)
Solution1
N-JQ1, prepared using the nanoprecipitation method of preformedpoly-lactid-co-glycolic acid in an aqueous solution containing JQ1 and poloxamer-188 as a stabilizer, presented a high physico-chemical stability. (unical.it)
Vehicle1
5XFAD transgenic mice and non-transgenic littermates were treated with vehicle or nimodipine-containing chow from two to eight months of age, then brains were harvested and amyloid pathology assessed by immunoblot and immunofluorescence microscopy analyses. (nih.gov)
Administration1
Fuller immediately suggested a Food and Drug Administration-approved thermoreversible poloxamer called Poloxamer 407. (sciencedaily.com)
Common1
It acts by binding to and activating FLT3 (CD135) which is found on what (in mice) are called multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells. (wikipedia.org)