• Because prohibitin is also expressed in blood vessels of human white fat," the authors conclude, "this work may lead to the development of targeted drugs for treatment of obese patients. (scientificamerican.com)
  • By using leptin-bacterial artificial chromosome (BAC) enhanced green fluorescent protein transgenic mice, a region 4.5 kilobases (kb) upstream of Lep , acts as an adipocyte-specific enhancer, and this region is bound by the transcription factor FOSL2 ( 18 ). (diabetesjournals.org)
  • Our recent report using transgenic mice with cardiac-specific overexpression of mTOR (mTOR-Tg) showed that cardiac mTOR protects the heart against ischemia/reperfusion (I/R) injury. (ahajournals.org)
  • A study performed on transgenic mice overexpressing SIRT6, showed an increased lifespan of about 15% in males. (wikipedia.org)
  • the second (the diabetes model) involved feeding mice a high-fat ketogenic diet for four weeks to induce diabetes, and the a further six weeks of the diet with one of three doses of the potential probiotic (0.1 billion, 1 billion, or 10 billion CFUs). (nutraingredients-usa.com)
  • Also, in collaboration with Walter Pories, that gastric bypass surgery induced a long lasting remission of the disease in about 80% of obese people with diabetes. (wikipedia.org)
  • and produced a statistically significant reduction in glycated hemoglobin and fructosamine in obese patients with type 2 diabetes and nonalcoholic fatty liver disease The chemical itself is an odorless, white to yellowish-white powder. (wikipedia.org)
  • Lachnospiraceae has been found to cause diabetes in germ free mice. (wikipedia.org)
  • When they were re-fed, DIO and ob/ob mice consumed less food intake than normal mice. (nih.gov)
  • Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice. (wikipedia.org)
  • Since the ob/ob mouse cannot produce leptin, its food intake is uncontrolled by this mechanism. (wikipedia.org)
  • In lean and obese mice, selective and combined norepinephrine and dopamine reuptake inhibition reduces food intake and body weight. (wikipedia.org)
  • Yet selective reuptake inhibitors of norepinephrine and dopamine (nisoxetine and a substance codenamed GBR12783, respectively) independently have no effect on food intake in mice. (wikipedia.org)
  • Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells. (rxpgnews.com)
  • In the present study, we found that F-box only protein 2 (FBXO2), a substrate recognition component of SKP1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, were up-regulated in livers of obese mice. (diabetesjournals.org)
  • We have previously demonstrated that leptolide, a member of the furanocembranolides family, promotes pancreatic beta-cell proliferation in mice. (mdpi.com)
  • Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice. (nih.gov)
  • ob/ob mice develop high blood sugar, despite an enlargement of the pancreatic islets and increased levels of insulin. (wikipedia.org)
  • The mice were then sacrificed to obtain liver and serum tissue. (rxpgnews.com)
  • F ) Phosphorylation of STAT5 in liver upon intravenous injection of GH to obese control and βGHRKO mice, as assessed by Western immunoblotting. (jci.org)
  • As shown with mice, obese mice are prone to liver cancer, likely due to two factors. (wikipedia.org)
  • In vivo, acute intraperitoneal administration of leptolide (0.1 mg/kg and 1 mg/kg) improved glucose tolerance and insulin sensitivity in lean mice. (mdpi.com)
  • In insulin-resistant ob/ob mice, renal clearance of RBP4 is reduced compared with lean mice, which likely is due to the elevated serum TTR and increased serum RBP4 binding capacity ( 13 ). (diabetesjournals.org)
  • This is supported by the findings that restoration of SCD1 expression in WAT of aP2-KLF15 Tg mice exhibited increased oxidative stress in WAT, reduced insulin secretion with hyperglycemia. (wikipedia.org)
  • The researchers, led by Zhiping Li of Johns Hopkins University in Baltimore, obtained wild-type mice and fed them commercial diets with different nutritional contents for four to twelve weeks. (rxpgnews.com)
  • Korpela K, Flint HJ, Johnstone AM, Lappi J, Poutanen K, Dewulf E, Delzenne N, de Vos WM, Salonen A (2014) Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals. (springer.com)
  • Therefore, the present study was designed to determine whether PRF administration of opioid, cholinergic, and adenosinergic drugs alters latency of paw withdrawal from a thermal stimulus as a function of mouse genotype and leptin replacement in obese mice. (pubmedcentralcanada.ca)