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  • BRCA1
  • BRAP2 is known to bind the nuclear localization signal of BRCA1. (nih.gov)
  • In mice carrying a breast cancer-derived mutation in the BRCA1 C-terminal (BRCT) domain, we find that ATM becomes essential for supporting the residual levels of HDR necessary to repair a DNA break. (pnas.org)
  • ATM loss is associated with synthetic lethality of BRCT mutant mice, which provides insight into the therapeutic potential of utilizing ATM kinase inhibitors in combination with PARP-inhibitor therapy for certain BRCA1-deficient tumors. (pnas.org)
  • The ATM kinase is involved in various aspects of DNA damage signaling and repair, but how ATM participates in HDR and genetically interacts with BRCA1 in this process is unclear. (pnas.org)
  • To investigate this question, we used the Brca1 S1598F mouse model carrying a mutation in the BRCA1 C-terminal domain of BRCA1. (pnas.org)
  • Consistent with a critical role for ATM in HDR in this background, loss of ATM leads to synthetic lethality of Brca1 S1598F mice. (pnas.org)
  • Gene
  • This gene encodes a nuclear protein with a JmjC domain. (nih.gov)
  • TEC-specific deletion of Jmjd6 exacerbates development of autoimmune diabetes in a mouse model, which express both ovalbumin (OVA) under the control of the rat insulin gene promoter and OT-I T cell receptor specific for OVA peptide bound to major histocompatibility complex class I K(b) molecules. (nih.gov)
  • Although Jmjd6 deficiency does not affect abundance of Aire transcript, the intron 2 of Aire gene is not effectively spliced out in the absence of Jmjd6, resulting in reduction of mature Aire protein and spontaneous multi-organ autoimmunity in mice. (nih.gov)
  • The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. (jax.org)
  • Also, gene expression changes were analyzed in three feeding-related mouse models: food deprivation, reward and diet-induced increase in body weight. (biomedcentral.com)
  • Using a human glial fibrillary acidic protein (hGFAP) promoter-driven cre transgene, we have achieved efficient inactivation of a floxed connexin43 ( Cx43 ) gene in astrocytes of adult mice. (jneurosci.org)
  • adult
  • p53 inactivation under a constitutive active WAPCre c in prepubertal/pubertal mice, but not under MMTVCre in adult mice, leads to the development of ERα-positive tumors, suggesting that target cells or developmental stages can determine ERα status in mammary tumors. (aacrjournals.org)
  • We examined the postnatal consequences of removing Hedgehog signaling within the adult stem cell niche. (jneurosci.org)
  • Murine
  • Non-secreted forms of IFNγ or its NLS-mutated version were tested in murine and human cells for their ability to induce IFNγ activity, to activate STAT1α and to carry out nuclear translocation of STAT1α. (biologists.org)
  • thus
  • Thus, this tumor system reproduces many important features of human breast cancer and provides tools for the study of the origins of ERα-positive and -negative breast tumors in mice. (aacrjournals.org)
  • Thus, Hh signaling subserves distinct and diverse functions in the sublineages that comprise the stem cell niche. (jneurosci.org)
  • mutant mice
  • In mutant mice, we observed a depletion of both quiescent stem cells and transit-amplifying cells, coupled with massive overproduction of A cells at P8. (jneurosci.org)
  • hippocampal
  • In contrast, we observed an increase in the velocity of hippocampal SD in the stratum radiatum of mice lacking Cx43 in astrocytes. (jneurosci.org)
  • transporter
  • Immunoprecipitation of cellular extracts with antibody to the nuclear transporter NPI-1 showed the formation of a complex with IFNγ-IFNGR1-STAT1α. (biologists.org)
  • conditional
  • made use of a conditional null Smo allele ( Smo c/c ), in conjunction with a Nestin-Cre driver mouse line ( Nestin Cre/+ ). (jneurosci.org)
  • viable
  • Mice lacking Cx43 in astrocytes were viable and showed no evidence of either neurodegeneration or astrogliosis. (jneurosci.org)
  • encode
  • Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. (nih.gov)
  • Description: RNA profiling data sets generated by the Mouse ENCODE project. (nih.gov)
  • leads
  • This leads to Rheb expression and potentiates mTOR signaling to drive the proliferation of TA cells. (nih.gov)
  • Therefore
  • Therefore, mice lacking Cx43 in astrocytes might show impaired propagation of SD. (jneurosci.org)
  • Therefore it is important to explore which neurotransmitter inputs into the DRN determine the escalation of aggression in male mice. (jneurosci.org)
  • loss
  • We now examine how the loss of Hh signaling affects the lineage progression of cells within the SVZ niche. (jneurosci.org)
  • In vitro and in vivo analyses suggest that the failure in migration is a nonautonomous result of the loss of Hedgehog signaling. (jneurosci.org)
  • Plays
  • The data are consistent with previous observations that the NLS of extracellularly added IFNγ plays a role in IFNγ signaling. (biologists.org)
  • activation
  • Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. (uniprot.org)
  • Biological function was associated with activation of STAT1α and nuclear translocation of IFNγ, IFNGR1 and STAT1α. (biologists.org)
  • biological
  • Intracellular human IFNγ possessed biological activity in mouse L cells, which do not recognize extracellularly added human IFNγ. (biologists.org)
  • activity
  • Concomitant with increased velocity of spreading depression, we observed enhanced locomotory activity in mice lacking Cx43 in astrocytes. (jneurosci.org)