Animal Use AlternativesDisease Models, AnimalModels, AnimalMutationMice, Mutant StrainsPoint MutationMutation, MissenseMice, Neurologic MutantsPolydactylyEthylnitrosoureaPhenotypeChromosome MappingSyndactylyEye AbnormalitiesCrosses, GeneticHomozygoteGenes, LethalMolecular Sequence DataHeterozygoteFrameshift MutationBase SequenceMice, Inbred C57BLGenes, RecessiveNeural Tube DefectsAllelesAmino Acid SequenceAbnormalities, MultipleGerm-Line MutationMice, TransgenicPedigreeMice, Inbred C3HEmbryonic and Fetal DevelopmentGene Expression Regulation, DevelopmentalTranscription FactorsMutation RateExonsMice, Inbred BALB CProteinsAmino Acid SubstitutionPolymerase Chain ReactionDNA Mutational AnalysisGenotypePolymorphism, Single-Stranded ConformationalMutagenesisMutagenesis, Site-DirectedSequence Analysis, DNAModels, GeneticCodon, NonsenseCell LineDNA PrimersGenetic Predisposition to DiseaseGenetic LinkageSequence DeletionGene DeletionGenes, DominantGenetic TestingProtein Structure, TertiaryDNA-Binding ProteinsEscherichia coliSuppression, GeneticMice, KnockoutGenetic Diseases, InbornHuntington DiseaseModels, MolecularProtein BindingCodonSignal TransductionCells, CulturedBinding SitesMembrane ProteinsModels, BiologicalSequence Homology, Amino AcidNeurodegenerative DiseasesGenetic Complementation TestRNA, MessengerNuclear ProteinsFounder EffectGenes, p53TransfectionSyndromeCloning, MolecularPolymorphism, Single NucleotideSequence AlignmentDNAMutant ProteinsParkinson DiseaseGenetic VariationGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionSaccharomyces cerevisiaeConsanguinityBacterial ProteinsAnimals, Genetically ModifiedEpistasis, GeneticPlasmidsRecombinant ProteinsNerve Tissue ProteinsGenetic MarkersGene ExpressionDrosophila melanogaster