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  • mutation
  • Nevertheless, they differ in pathogenesis of manifestation of the particular mutation and also in the strain background. (frontiersin.org)
  • On the other hand, the identification and understanding of specific impairments related to a particular mutation should be of interest regarding the variability of human hereditary cerebellar degenerations ( Manto, 2005 ) and the use of mouse models for the development of disease-targeted therapeutic approaches. (frontiersin.org)
  • neuronal
  • Cerebellar mutants are variable relative to the feature and extent of the cerebellar and extra-cerebellar neuronal degeneration. (frontiersin.org)
  • behavior
  • The mice were tested in the open field for exploration behavior, in the Morris water maze with visible as well as reversal hidden platform tasks and in the forced swimming test for motivation assessment. (frontiersin.org)