• Signaling mutations (eg, JAK2V617F) and mutations in genes involved in epigenetic regulation (eg, TET2) are the most common cooccurring classes of mutations in myeloproliferative neoplasms (MPNs). (westminster.ac.uk)
  • Additional sex combs-like 1 ( ASXL1 ) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations ( ASXL1 -MT) remains poorly understood. (biomedcentral.com)
  • Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal hematopoiesis-related somatic mutations and the development of myeloid malignancies, such as myeloproliferative neoplasms (MPNs). (bvsalud.org)
  • Some patients may need treatment to manage this type of blood cancer - called myeloproliferative neoplasms (MPN) - while others may go through long periods of watchful waiting. (technologynetworks.com)
  • Almost every patient who develops acute leukemia after a history of myeloproliferative neoplasms will die from the disease. (technologynetworks.com)
  • This permitted them to study how TP53 mutations in HSCs affect most cancers development making use of cells donated by sufferers with myeloproliferative neoplasms - a disease that predisposes them to leukemia. (visitfortunecity.com)
  • Even though stem cell source for myeloid malignancies such as myeloproliferative neoplasms myelodysplastic syndromes and acute myeloid leukemia (AML) is definitely well established a link between aberrations in HSPCs and development of mature lymphoid malignancies has been less thoroughly investigated. (academicediting.org)
  • Displaying Mouse Chromosome Paints for Chronic Myelogenous Leukemia and Myeloproliferative Neoplasms(CML/MPN) . (metasystems-probes.com)
  • A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
  • As leukemic transformation of myeloproliferative neoplasms (MPNs) worsens the clinical outcome, reducing the inherent risk of the critical event in MPN cases could be beneficial. (elsevierpure.com)
  • Myeloproliferative neoplasms (MPN) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although actionable mechanisms driving progression remain elusive. (ox.ac.uk)
  • The objective of this project is to decipher mechanisms driving transformation of myeloproliferative neoplasms (MPNs) to secondary acute leukemia (sAML). (lls.org)
  • Myeloproliferative neoplasms (MPNs) are chronic blood disorders that that can cause severe symptoms and early death. (lls.org)
  • This study addressed the role of DEP-1 for regulation of the acute myeloid leukemia (AML)-related mutant FLT3 internal tandem duplication (ITD) protein. (nih.gov)
  • Frameshift and nonsense mutations occur frequently in CMML, acute myeloid leukemia ( 3 ), and myeloproliferative neoplasm (MPN) cases ( 4 ). (aacrjournals.org)
  • TET2 mutations have been associated with reduced patient survival in acute myeloid leukemia. (aacrjournals.org)
  • PMF often progresses to an aggressive acute myeloid leukemia, causing high mortality. (lls.org)
  • Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. (haematologica.org)
  • Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
  • Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)
  • Acute lymphocytic leukemia (ALL), for example, is the most common childhood cancer, but these diseases can occur in individuals of all ages. (cshlpress.com)
  • Patients with acute myeloid leukemia (AML) with minimal differentiation, AML without differentiation, and AML with differentiation usually present with evidence of bone marrow failure (ie, anemia , neutropenia , and/or thrombocytopenia ). (medscape.com)
  • Patients with acute monoblastic and monocytic leukemia may present with bleeding disorders, as well as with extramedullary masses, cutaneous and gingival infiltration, and central nervous system involvement. (medscape.com)
  • Although patients with acute megakaryoblastic leukemia may present with evidence of bone marrow failure associated with pancytopenia, in some cases, thrombocytosis is present. (medscape.com)
  • This section briefly discusses the morphologic features of the subtypes of acute myeloid leukemia (AML) not otherwise categorized (NOS). (medscape.com)
  • But for a small percentage of patients, the slower paced disease can transform into an aggressive cancer, called secondary acute myeloid leukemia, that has few effective treatment options. (technologynetworks.com)
  • Secondary acute myeloid leukemia has a grim prognosis," said senior author Stephen T. Oh, MD, PhD , an associate professor of medicine and co-director of the Division of Hematology at the School of Medicine. (technologynetworks.com)
  • Acute myeloid leukemia, or AML - an intense variety of blood cancer - has been connected to TP53 mutations in hematopoietic stem cells (HSCs). (visitfortunecity.com)
  • Acute leukemia is a group of diseases affecting either the lymphoid or myeloid lineage in hematopoiesis, resulting in acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). (avhandlingar.se)
  • Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood. (frontiersin.org)
  • The aim of this mini-review is to discuss emerging epigenetic roles of long non-coding RNAs (lncRNAs) in Acute Myeloid Leukemia (AML). (frontiersin.org)
  • It is a secondary change associated with such disorders as inflammation, bone marrow necrosis, bone marrow injury, and disorders of myeloproliferation (e.g., acute myeloid leukemia) and lymphoproliferation (e.g., lymphoma). (nih.gov)
  • 7 In CML and acute myeloid leukemia (AML), we and others have shown that IL-1 is a positive regulator of LSC, and blocking IL-1 signaling inhibits the LSC. (haematologica.org)
  • Abnormalities in this process lead to a group of diseases known as myeloid malignancies, which include acute myeloid leukaemia-in which the bone marrow produces abnormal white blood cells-and myelodysplastic syndromes, which are caused by too few mature blood cells being produced. (elifesciences.org)
  • Myelodysplastic syndrome (MDS) is a clonal disorder characterized by dyshematopoiesis and high susceptibility to acute myeloid leukemia (AML). (karger.com)
  • We have reported that the expression of BMI1 , a member of PcG, in hematopoietic stem cells or progenitor cells predicts the prognosis of patients with MDS and progression to acute leukemia. (karger.com)
  • Au WY, Fung AT, Ma ES, Liang RH, Kwong YL: Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocytic leukemia and myelodysplastic syndrome. (karger.com)
  • The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias. (lu.se)
  • Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. (lu.se)
  • Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. (lu.se)
  • The Working Group was not aware of any good rodent models that simulate the occurrence of acute myeloid leukemia in humans. (who.int)
  • Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (lu.se)
  • Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. (lu.se)
  • Clonal duplication of a germline PTPN11 mutation due to acquired uniparental disomy in acute lymphoblastic leukemia blasts from a patient with Noonan syndrome. (lu.se)
  • PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (lu.se)
  • The JAK2V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN). (westminster.ac.uk)
  • In this thesis, we have used high-resolution genome-wide methods and murine models to study leukemia as a way to increase our knowledge how leukemia arises and best can be treated.In the first study (Article I) we characterized the genetic alterations in a case presenting with a rare myelodysplatic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U) that later progressed to AML. (avhandlingar.se)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • TET2-knockout mice predominantly develop chronic myelomonocytic leukemia (CMML), but they can also develop other myeloproliferative as well as lymphoproliferative diseases, reflecting the prevalence of TET2 mutations in these varied hematologic malignancies. (aacrjournals.org)
  • The present study demonstrated the biological and functional evidence for the critical role of RUNX1 -MT in ASXL1 -mutated leukemia in the pathogenesis of myeloid malignancies. (biomedcentral.com)
  • Other Malignancies: Pre-malignant and malignant diseases have been reported. (nih.gov)
  • used gene silencing techniques to reduce the expression of MYBL2 in mice and showed that this induced symptoms of myeloid malignancies in the animals. (elifesciences.org)
  • The NCI group has published a recent update of one of their studies, with an additional 10 years of follow-up, and it continues to suggest a possible link between formaldehyde exposure and mortality due to lymphohematopoietic malignancies, particularly myeloid leukemia (Beane Freeman, Blair et al. (who.int)
  • Clinical correlative studies have demonstrated that TET2 mutations are enriched in more advanced phases of MPNs such as myelofibrosis and leukemic transformation, suggesting that they may cooperate with JAK2V617F to promote disease progression. (westminster.ac.uk)
  • We seek to better understand what drives disease development and leukemic progression in MPNs, so that we can develop better therapies for patients with these diseases. (lls.org)
  • This disease is a distinct clonal myeloproliferative disease characterized by a reactive, progressive fibrosis occurring in response to a neoplastic myeloid and/or megakaryocytic proliferation and is accompanied by specific hematologic and clinical findings. (nih.gov)
  • By 6 months post-transplantation, the reconstituted mice had developed a clonal myeloproliferative/myelodysplastic disorder originating from the cells with aberrantly reduced Mybl2 expression. (elifesciences.org)
  • In aggregate, our findings indicate that Tet2 loss drives clonal dominance in HSCs, and Jak2V617F expression causes expansion of downstream precursor cell populations, resulting in disease progression through combinatorial effects. (westminster.ac.uk)
  • Bone marrow scar formation (fibrosis) is a hallmark of myelofibrosis and contributes significantly to the disease progression. (lls.org)
  • They have shown that blocking a key molecule in the transition pathway prevents this dangerous disease progression in mice with models of the disease and in mice with tumors sampled from human patients. (technologynetworks.com)
  • The researchers also tested a drug compound that inhibits DUSP6 and found that the compound - only available for animal research - stopped progression of the chronic disease to the aggressive disease in two different mouse models of the cancer and in mice with human tumors sampled from patients. (technologynetworks.com)
  • Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. (avhandlingar.se)
  • Thus PcG not only provides a molecular marker for monitoring disease progression of MDS, but also provides a clue for elucidating a molecular mechanism underlying the disease progression, which may help in the development of a new therapeutic strategy against MDS. (karger.com)
  • Surprisingly, loss of just a single Hmga1 allele prevents progression to MF in JAK2V617F mice, decreasing erythrocytosis, thrombocytosis, megakaryocyte hyperplasia, and expansion of stem and progenitors, while preventing splenomegaly and fibrosis within the spleen and bone marrow. (ox.ac.uk)
  • These findings illuminate HMGA1 as a key epigenetic switch involved in MPN transformation and promising therapeutic target to treat or prevent disease progression. (ox.ac.uk)
  • New treatments have become available that help ameliorate symptoms, but they do not reliably slow or halt disease progression. (lls.org)
  • Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome. (lu.se)
  • Akin to the normal hematopoietic system, leukemias are sustained by a small number of leukemia stem-like cells (LSC), which can be distinct from the normal hematopoietic stem cells (HSC) but also exhibit functional characteristics of self-renewal and (abnormal or hindered) differentiation, and are often quiescent ( 2 - 4 ). (frontiersin.org)
  • Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders. (wikipedia.org)
  • We use mouse genetics to model myelofibrosis and understand the cellular and molecular makeup of the diseased microenvironment. (lls.org)
  • This project explores the connection between the niche - the area in the bone marrow where blood cells are formed - and the development of leukemia stem cells (LSCs) that give way to primary myelofibrosis (PMF). (lls.org)
  • The diagnostic term "myelofibrosis" should not be used to describe fibrotic lesions of the bone marrow in mice and rats. (nih.gov)
  • This gain-of-function mutation dysregulates cytokine signaling and is associated with increased accumulation of DNA damage, a process likely to drive disease evolution. (westminster.ac.uk)
  • The presence of an activating mutation affected the leukemias transcriptional profiles by further enhancing transcriptional programs previously associated with KMT2A-Rs. (avhandlingar.se)
  • at 16 weeks after transplantation) competitive advantage of mutation affects the differentiation and function of different committed hematopoietic progenitors which may drive the disease phenotype. (academicediting.org)
  • Characterization of a new disease-causing mutation of SH2D1A in a family with X-linked lymphoproliferative disease. (lu.se)
  • Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. (nature.com)
  • Hairy cell leukemia (HCL) is certainly a chronic lymphoproliferative disorder seen as a somatic recently discovered somatic inhibition in hematopoiesis inside our murine choices aswell as in individuals with in HCL individuals we performed quantitative sequencing of the spot of ITD-1 p. (academicediting.org)
  • A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. (thermofisher.com)
  • Interestingly, the induction of RUNX1-ETO in childhood HSCs largely caused aggressive AML with nearly complete penetrance and a short latency (2-6 months), whereas the induction in adult HSCs predominantly led to smoldering, non-cell autonomous, myeloproliferative disorder with a very long latency and/or incomplete penetrance. (kumamoto-u.ac.jp)
  • A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case. (nih.gov)
  • While the disease latency for leukemia development was not considerably different amongst the leukemia cells, MLL-ENL-IBKD leukemia cells had a marked abundance of LICs in the leukemic BM mononuclear cells compared together with the manage shRNA cells (Figure 6F and Supplemental Figure 10A). (acthreceptor.com)
  • Discussion Within the present study, we supply proof that LICs, but not regular HSPCs or non-LIC fractions inside leukemic BM, exhibit constitutive NF-B pathway activity in unique sorts of myeloid leukemia models. (acthreceptor.com)
  • Latest genomic analyses of leukemias of another lymphoid lineage T cell severe lymphoblastic leukemia (T-ALL) uncovered that a particular subset of T-ALL is normally highly similar on track and myeloid leukemic HSCs in gene appearance and mutational profile (25). (academicediting.org)
  • The leukemic mice had severe anemia, hepatosplenomegaly, pulmonary hemorrhage and expansion of dysplastic erythroid progenitors. (elsevierpure.com)
  • MEP)) and erythroid progenitors (CD71 + ) from Jak2 V617F-transduced p53-null leukemic mice had leukemia-initiating capacity, however, myeloid differentiated populations (Mac-1 + ) could not recapitulate the disease. (elsevierpure.com)
  • Interestingly, recipients transplanted with CD71 + cells rapidly developed erythroid leukemia, which was in sharp contrast to leukemic KSL cells to cause lethal leukemia after the polycythemic state. (elsevierpure.com)
  • Holyoake, T.L. A comparison of normal and leukemic stem cell biology in chronic myeloid leukemia. (eurekaselect.com)
  • Genomic characterization of mouse leukemias unveiled de novo signaling mutations in several mice harboring only a KMT2A-R, emphasizing the importance of such mutations in KMT2A-R leukemogenesis. (avhandlingar.se)
  • We use a combination of state-of-the-art genomic methods, including whole genome, RNA and Exome sequencing as well as single-cell DNA and RNA-sequencing and leukemia mouse models in our work. (lu.se)
  • The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome. (nih.gov)
  • Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. (nature.com)
  • To dissect the effects of concomitant Jak2V617F expression and Tet2 loss within distinct hematopoietic compartments in vivo, we generated Jak2V617F/Tet2 compound mutant genetic mice. (westminster.ac.uk)
  • The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice. (shengsci.com)
  • Leukemia 2007(6): 1303-5 [ PubMed abstract ]. (lu.se)
  • Leukemia 2006(6): 1155-8 [ PubMed abstract ]. (lu.se)
  • Chronic myeloid leukemia (CML) is a myeloproliferative disease caused due to translocation between chromosome 9 and 22 leading to a chimeric gene product known as Bcr-Abl. (eurekaselect.com)
  • Previously, we observed that transcription factor RUNX1 mutations ( RUNX1 -MT) coexisted with ASXL1 -MT in CMML and at myeloid blast phase of chronic myeloid leukemia. (biomedcentral.com)
  • Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. (edu.au)
  • What Do We Need To Know About Pregnancy, and Family Planning for Patients Diagnosed With Chronic Myeloid Leukemia? (medscape.com)
  • I'm Dr Michael Mauro, and welcome to the Medscape InDiscussion podcast series on chronic myeloid leukemia (CML). (medscape.com)
  • Therefore, on the basis of the data available at this time, it was not possible to identify a mechanism for the induction of myeloid leukemia in humans. (who.int)
  • We hypothesize that the abnormal bone marrow niche in PMF provides protection to disease-causing LSCs at the cost of the normal blood-forming HSCs. (lls.org)
  • The in vivo effect was investigated using the C57BL/6 mouse bone marrow transplantation (BMT) model. (biomedcentral.com)
  • Mice transduced with both ASXL1 and RUNX1 mutations enhanced inhibitor of DNA binding 1 (ID1) expression in the spleen, liver, and bone marrow cells. (biomedcentral.com)
  • Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
  • Shown is bone marrow from a mouse treated with a compound that blocks DUSP6, a key molecule in the transition from chronic to aggressive disease. (technologynetworks.com)
  • In humans, increased reticulin fibers are associated with many benign and malignant conditions, while increased collagen is prominent in late stages of myeloproliferative diseases or following metastasis to the bone marrow. (nih.gov)
  • The amount of reticulin staining in the bone marrow often has no correlation with disease severity, while increases in collagen staining are associated with more severe disease and a poorer prognosis. (nih.gov)
  • Here we show that retroviral overexpression of Jak2 V617F mutant into wild-type p53 murine bone marrow cells induced polycythemia vera (PV) in the recipient mice, whereas Jak2 V617F-transduced p53-null mice developed lethal leukemia after the preceding PV phase. (elsevierpure.com)
  • Several features of chronic lymphocytic leukemia (CLL) suggest that immune-based strategies may have therapeutic potential. (shengsci.com)
  • In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. (cshlpress.com)
  • We discuss the value of lncRNAs as putative diagnostic, prognostic and therapeutic targets in myeloid leukemias and indicate novel directions in this exciting research field. (frontiersin.org)
  • Therefore, we have proposed a combination of mouse and human studies to determine how DUSP6 and RSK1 contribute to MPN pathogenesis, and to evaluate whether inhibition of DUSP6 and/or RSK1 may have potential therapeutic benefits for MPN patients. (lls.org)
  • The contribution of RUNX1 mutations in the pathogenesis of myeloid transformation in ASXL1 -mutated leukemia, however, remains unclear. (biomedcentral.com)
  • Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 mutations played a critical role in leukemia transformation. (biomedcentral.com)
  • Work in knockout mouse models has shown that TET2 loss enhances hematopoietic stem cell (HSC) self-renewal, expanding the HSC pool (reviewed in refs. (aacrjournals.org)
  • Collectively our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease. (edu.au)
  • The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
  • The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
  • The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (lls.org)
  • Leukemia and lymphoma are cancers that affect white blood cells. (cshlpress.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. (cshlpress.com)
  • MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma. (cshlpress.com)
  • Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. (cshlpress.com)
  • Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). (nih.gov)
  • Simultaneous manifestation of fulminant infectious mononucleosis with haemophagocytic syndrome and B-cell lymphoma in X-linked lymphoproliferative disease. (lu.se)
  • Inflammation: This includes inflammatory bowel disease , rheumatoid arthritis , and vasculitis (eg, Kawasaki syndrome ). (medscape.com)
  • The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (lu.se)
  • Loss of Jak2 is lethal by embryonic day 12 in mice. (wikipedia.org)
  • JAK2 gene fusions with the TEL(ETV6) (TEL-JAK2) and PCM1 genes have been found in patients suffering leukemia, particularly clonal eosinophilia forms of the disease. (wikipedia.org)
  • Of note, the JAK2 V617F mutant, found at high frequencies in myeloproliferative diseases, retains the ability to bind Lnk. (jci.org)
  • These patients are commonly treated with JAK2 inhibitors, but their disease progresses despite that therapy, so we're also trying to identify how the disease is able to worsen even in the setting of JAK2 inhibition," said Oh, who treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. (technologynetworks.com)
  • The researchers conducted a deep dive into the genetics of these tumors, both during the slow chronic phase and after the disease had transformed into the aggressive form while patients were taking JAK2 inhibitors. (technologynetworks.com)
  • X-linked lymphoproliferative disease associated with hypogammaglobulinemia and growth-hormone deficiency. (lu.se)
  • Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP. (lu.se)
  • Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members. (lu.se)
  • KMT2A-Rs occur in both ALL and AML but the molecular and/or biological mechanisms determining the lineage affiliation remain largely elusive for this disease. (avhandlingar.se)
  • Phenotypic evaluation of mice with pan-hematopoietic versus B lineage-restricted appearance of transgene led to 100% embryonic lethality (fig. S3A). (academicediting.org)
  • Mice sacrificed at 12 months of age acquired no overt phenotype beyond the B lineage despite apparent activation of mitogen-activated proteins kinase (MAPK) signaling in B lineage cells (Fig. 3 A to fig and D. S3 G and F. = 0.006) upsurge in spleen weight aswell as the quantity and size of GC B cells in = 0.02) in Cd19-cre on HSC self-renewal. (academicediting.org)
  • Mast cell-lineage versus basophil lineage involvement in myeloproliferative and myelodysplastic syndromes: diagnostic role of cell-immunophenotyping. (bdbiosciences.com)
  • We are elucidating the cellular and molecular mechanisms of how LSCs interact with the fibrotic niche in mouse models and how this negatively impacts normal HSCs. (lls.org)
  • We found that HSCs from Lnk-/- mice have an increased quiescent fraction, decelerated cell cycle kinetics, and enhanced resistance to repeat treatments with cytoablative 5-fluorouracil in vivo compared with WT HSCs. (jci.org)
  • We assessed the self-renewal of HSCs from CD45.2 V600E control mice in competitive repopulation assays. (academicediting.org)
  • Taken together, the work included in this thesis highlights the major impact that specific genetic alterations have on leukemogenesis, and how their autonomous and non-autonomous cooperation influence clonal evolution, disease phenotype, and molecular profiles of the leukemia. (avhandlingar.se)
  • This clinically relevant mouse leukemia model serves as a powerful platform for further molecular dissection of t(8;21) leukemogenesis and development of novel therapeutics (Abdallah, Niibori-Nambu, Morii et al. (kumamoto-u.ac.jp)
  • Reactivation of DEP-1 by stable overexpression of Prx-1 extended survival of mice in the 32D cell/C3H/HeJ mouse model of FLT3 ITD-driven myeloproliferative disease. (nih.gov)
  • If you do blood stem cell transplants serially in mice, the blood stem cells poops out when the telomeres are gone. (bethematch.org)
  • Bruggeman SWM, Valk-Lingbeek ME, van der Stoop PPM, Jacobs JJL, Kieboom K, et al: Ink4A and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. (karger.com)
  • Induced pluripotent stem cells (iPSC) can now be generated from skin or blood of mice or humans by overexpressing four key transcription factors. (pas.va)
  • Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
  • Polycythemia vera (PV) and secondary polycythemia (SP) are hematological diseases characterized by erythropoiesis exacerbation. (nature.com)
  • Additionally, in an effort to investigate the frequency of LICs in BM mononuclear cells, we performed limiting dilution analysis by secondary transplantation of leukemia cells. (acthreceptor.com)
  • We focus on understanding the pathogenetic mechanisms underlying leukemogenesis with a special focus on infant leukemia. (lu.se)
  • In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls HSC homeostasis and self-renewal. (jci.org)
  • Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet derived growth factor receptor (PDGF receptor). (thermofisher.com)
  • In the third study (Article III) we demonstrated the that FLT3N676K promote myeloid expansion of KMT2A-R leukemia in primary human cells. (avhandlingar.se)
  • Melphalan is a bifunctional alkylating agent that is active against selected human neoplastic diseases. (nih.gov)
  • Scientists have learned to grow these iPSC in a dish and convert them into mini-versions of mouse and human organs. (pas.va)
  • Such young age-related onset coupled with cellular characteristics recapitulate clinical features in human t(8;21) leukemia, namely predominant AYA onset and association with AML M2 subtype in the FAB classification. (kumamoto-u.ac.jp)
  • MegaCult™-C Collagen and Medium with Lipids kit includes medium and collagen solution for colony-forming unit (CFU) assays of human or mouse megakaryocyte progenitor cells (CFU-Mk). (stemcell.com)
  • Heterophilic antibodies, such as rheumatoid factor (RF) and human anti-mouse antibodies (HAMA), can bind to immune globulins of other species and thus interfere with the immunoassay since the tryptase immunoassay employs mouse-derived anti-tryptase. (medscape.com)
  • Significant work has been performed investigating the effects of TET2 loss in myeloid diseases. (aacrjournals.org)
  • Using genetic techniques to delete the DUSP6 gene prevented the transition to aggressive disease in mice with models of this cancer. (technologynetworks.com)
  • Genetic fine-mapping and CRISPRi screens identify functional variants and their target genes associated with Alzheimer's disease in microglia. (nature.com)
  • Certain genetic alterations are closely tied to specific leukemia types, while others are more promiscuous. (avhandlingar.se)
  • Emergence of LSC is dependent on individual or combined genetic mutations that broadly determine the cellular affiliation of the leukemia, and permit or impose ectopic self-renewal and a restricted differentiation potential into what constitutes the proliferative bulk of the leukemia ( 5 , 6 ). (frontiersin.org)
  • Evaluation of embryos generated from crossing transgenic mice to didn't result in decreased survival or within an overt hematopoietic phenotype. (academicediting.org)
  • This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
  • 1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
  • Bcr-Abl fusion protein has constitutively activated Abl tyrosine kinase activity which is responsible for the uncontrolled proliferation in CML The tyrosine kinase inhibitors (TKIs) such as Imatinib, Dasatinib, and Nilotinib are the current first-line treatments approved by the United States Food and Drug Administration (US FDA) for the treatment of the disease. (eurekaselect.com)
  • We also transduced normal BM cells with shRNAs against IB and transplanted them into lethally irradiated mice to test no matter whether NF-B activation by itself can induce leukemia or myeloproliferative-like disease. (acthreceptor.com)
  • Employing experimental mice, they verified that these mutated cells grew in selection when the animals ended up subjected to inflammatory stimuli. (visitfortunecity.com)
  • Moreover, injection of modified cells from these animals into healthy mice also induced symptoms in the recipients. (elifesciences.org)
  • CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (thermofisher.com)
  • The CD123 antibody, clone 9F5, is derived from the hybridization of NS-1 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with IL-3Rα-transfected COS cells. (bdbiosciences.com)
  • Besides identifying several novel in-frame fusion genes, we also described two new oncogenic leukemia subtypes. (avhandlingar.se)
  • Although a number of attempts have been made to create its mouse model for the past 30 years, no tractable murine models have been generated. (kumamoto-u.ac.jp)
  • The actuarial event-free survival for these 56 patients at 3 years was 37% and was at least as good as that reported for relapsed Hodgkin's disease patients treated with CBV and ABMT. (shengsci.com)
  • CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival. (shengsci.com)
  • Binding mode and structural elements of Bcr-Abl inhibition are discussed with emphasis on pathways involved in this complex disease to determine alternative strategies and combination therapies. (eurekaselect.com)