• Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A-converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. (aai.org)
  • IgA are produced from plasmablasts (plasma cell precursors) generated in germinal centers (GC) of Peyer's patches (PP) and mesenteric lymph nodes that constitute major inductive sites of T-dependent IgA antibodies. (biomedcentral.com)
  • The transcription factor nuclear factor (NF)-κB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. (rupress.org)
  • Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
  • Only PSA-treated mice survived, with dramatically reduced brainstem inflammation and altered cytokine and chemokine profiles. (nature.com)
  • Endogenous cytokine levels after immunoselected CD34+ peripheral blood progenitor cell transplantation. (ntu.ac.uk)
  • LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
  • By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
  • Within peripheral tissues iNKT cell recent thymic emigrants exhibit a different TCR repertoire than mature cells, suggesting that the iNKT population is shaped after arrival to the periphery. (elifesciences.org)
  • This Review summarizes the emergent evidence that LECs are important in maintaining peripheral tolerance, limiting and resolving effector T cell responses, and modulating leukocyte function. (jci.org)
  • Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
  • Although the use of GF mice supports a link between the microbiota and adaptive immune responses to MCMV infection, a caveat is that lymphoid organ development and immune responses are impaired in GF animals 21 , 22 . (nature.com)
  • RhG-CSF-mobilized peripheral blood haemopoietic progenitors reside in G0/G1 phase of cell cycle independently of the expression of myeloid antigens. (ntu.ac.uk)
  • In a very interesting review, P. MARRACK & J. KAPPLER focus on naïve, activated, and memory T cells survival separately, and discuss experiments done in vitro and in mice lacking or containing normal populations of lymphocytes. (scielo.br)
  • Separation of chemotherapy plus G-CSF-mobilized peripheral blood mononuclear cells by counterflow centrifugal elutriation: in vitro characterization of two different CD34+ cell populations. (ntu.ac.uk)
  • This review outlines the major mouse-model and human studies leading to characterization of the early life critical window, emphasizing studies analyzing the intestinal and airway microbiotas in asthma and atopic disease. (biomedcentral.com)
  • provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature cellular responses in the periphery and their ultimate demise, with emphasis on mouse NK cells and viral infections. (scielo.br)
  • In a very interesting issue, R.J. NORTH & Y-J. JUNG first argue that mouse tuberculosis and tuberculosis in guinea pig and rabbit are models of tuberculosis in susceptible humans. (scielo.br)
  • Importantly, PSA binding by B cells is essential for induction of regulatory CD4 + and CD8 + T cells secreting IL-10 to control innate inflammatory responses, consistent with the lack of PSA mediated protection in Rag −/− , B cell- and IL-10-deficient mice. (nature.com)
  • Since iNKT cell activation can prevent or promote immunopathology in diverse disease contexts, the strict control of peripheral iNKT cell homeostasis is vital to regulate local immunity. (elifesciences.org)
  • review the heterogeneity of the current models for memory T cells generation and maintenance in humans and mice. (scielo.br)
  • iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
  • particularly studied in mice inoculated with Leishmania major. (123dok.net)
  • rhG-CSF in healthy donors: mobilization of peripheral hemopoietic progenitors and effect on peripheral blood leukocytes. (ntu.ac.uk)
  • This lack of a T-dependent IgA response occurs although germinal centers remained functional with no sign of follicular damage, while a prolonged survival of follicular CD4+ T-cells and normal generation of IgG plasma cells is observed. (biomedcentral.com)
  • Here we assess the immunomodulatory potential of PSA in HSE by infecting PSA or PBS treated 129S6 mice with HSV1, followed by delayed Acyclovir (ACV) treatment as often occurs in the clinical setting. (nature.com)
  • Tuberculosis in mice is also exclusively a lung disease that is progressive and lethal, in spite of the generation of Th1- mediated immunity. (scielo.br)
  • The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. (raf-receptor.com)
  • Lymph node clusters exist throughout the body, some of which are palpable (e.g., cervical lymph nodes ) while others are not (e.g., mediastinal lymph nodes ). (amboss.com)
  • Peripheral blood mononuclear cells (PBMCs) ex vivo -stimulated with OVA showed markedly decreased production of IL-10 cytokine after 72 hours relative to animal-matched cells incubated with media alone. (biomedcentral.com)
  • Flow cytometry analysis revealed cleavage of the IgM B cell receptor by recombinant (r) Ide Ssuis _homologue as well as Ide Ssuis derived from culture supernatants of S. suis serotype 2 on porcine PBMCs and mandibular lymph node cells. (bvsalud.org)
  • The groups of 60 male and 60 female Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice were exposed to ATO aerosols by whole body inhalation at chamber concentrations of 0, 3, 10, or 30 mg/m3 for 6 hours/day, 5 days/week for up to 2 years. (nih.gov)
  • The exposure concentrations for the 2-year ATO studies were selected based on the findings of 2-week studies in the Wistar Han rats and B6C3F1/N mice. (nih.gov)
  • In accompanying tissue burden studies, the groups of 25 female rats and 25 female mice were exposed to the same concentrations of ATO for up to 79 weeks. (nih.gov)
  • The virus has been shown to stimulate protective immunity to influenza virus in mice. (nih.gov)
  • [ 21 ] Moreover, depletion of lung resident ILC2 in mice after infection with H1N1 influenza virus A resulted in impaired airway epithelial integrity and lung function, with exaggerated thermodysregulation and higher total protein concentration in the broncho-alveolar lavage (BAL) fluid. (medscape.com)
  • NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. (nih.gov)
  • Unlike NK cells, ILC1 lack granzyme B and perforin but express CD103 [ 11 ] and CXCR3. (medscape.com)
  • [ 1 ] Lack of RORγt expression and IFN-ɣ production differentiate this group of innate cells from LTi cells and ILC1, respectively. (medscape.com)
  • The isolation and culture of an enriched population of cells from rat lymph nodes that have several properties of high endothelial cells are described. (biologists.com)
  • The identity of high endothelial cells was further substantiated using a polyclonal antiserum raised against lymph node cultures, which stained high endothelium in cryostat sections of lymph nodes. (biologists.com)
  • In the mesenteric lymph nodes (MLNs), T regulatory (Treg) cells undergo differentiation and home back to the inductor site to induce and/or maintain antigen-specific oral tolerance [ 8 ]. (biomedcentral.com)
  • After receptor cleavage by rIde Ssuis _homologue, it took at least 20 h for mandibular lymph node cells to restore the IgM B cell receptor to levels comparable to cells previously treated with rIde Ssuis _homologue_C195S. (bvsalud.org)
  • However, the diversity of canine T cells is still poorly understood mainly due to the lack of species-reactive antibodies for use in flow cytometry. (bvsalud.org)
  • The aim of this study was to generate a detailed atlas of peripheral blood TCRαß+ T cells of healthy dogs using single-cell RNA-sequencing (scRNAseq) combined with immune repertoire sequencing. (bvsalud.org)
  • Of particular note, our data provide first evidence for the existence of canine mucosa-associated invariant T cell (MAIT)-like cells, representing one of three newly identified FCER1G+ innate-like CD8A+ T cell populations in the peripheral blood of healthy dogs. (bvsalud.org)
  • The production of key type 2 cytokines, IL-13, IL-4 and IL-5 in response to epithelial cytokines IL-25 and IL-33 in Rag −/− mice led to the discovery of group 2 ILCs. (medscape.com)
  • 2008). Although the A/B tumor incidence in female B6C3F1/N mice generally represents a consistently lower baseline than that in males, greater response above baseline to the effects of lung carcinogens were observed in female B6C3F1/N mice in the NTP studies. (nih.gov)
  • Antimony trioxide (ATO) was nominated by the U.S. Consumer Products Safety Commission due to the substantial human exposure in occupational settings and the lack of adequate 2-year carcinogenicity studies. (nih.gov)
  • The induction of pulmonary neoplasms in exposed female mice failed to exhibit dose dependency, and early mortality from pulmonary neoplasms and pulmonary toxicity was significant in both exposure and chamber controls. (nih.gov)
  • Using IL-4 +/eGFP IL-13 +/Tom dual reporter mice, it was shown that ILC2s were the major source of type 2 cytokines in Ovalbumin induced allergy and after intranasal administration of IL-25 and IL-33. (medscape.com)
  • In ATO-exposed mice, clear evidence of carcinogenic activity, with dose dependent elevations of neoplastic and pre-neoplastic lesions in respiratory tissues in males, and dose dependent elevation of lymphoma incidence in female mice, were observed. (nih.gov)