Mice kidney tubules proximal. Medical search. Frequent questions

Glucose reabsorption in the proximal tubule (via Sglt1 and Sglt2) has emerged as an important contributor to the development of diabetes. (nih.gov)
We hypothesized that Olfr1393 may contribute to the progression of type 2 diabetes, particularly the development of hyperfiltration, which has been linked to increased Na + reabsorption in the proximal tubule via the Sglts. (nih.gov)
In the kidney, the first portion of the nephron, called the proximal tubule (PT), performs the majority of solute reabsorption including about two-thirds of calcium. (ku.edu)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a unique class of oral antidiabetic medications that reduce glucose reabsorption in the renal proximal tubules, thereby enhancing urinary glucose excretion 1 . (nature.com)
The kidney proximal tubule is a target of many renal toxicants, including cadmium (Cd), and also a place of reabsorption of essential metals in glomerular filtrate to systemic circulation. (go.jp)
The efficient uptake of Mn 2+ from apical side of S3 cells may suggest an important role of ZIP8 in proximal tubule in reabsorption of Mn, an essential metal. (go.jp)
We therefore investigated the effects of acetazolamide, furosemide, hydrochlorothiazide, and amiloride, known to preferentially inhibit sodium reabsorption at different segments of the nephron, on hypoxia-induced EPO formation in mice. (uni-regensburg.de)
Taken together, SGLT2 inhibitors exhibit renoprotective potential that is partially dependent on the inhibition of glucose reabsorption and subsequent aberrant glycolysis in kidney tubules. (jci.org)
Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)
Reabsorption of glucose predominantly occurs on the brush border membrane of the convoluted segment of the proximal tubule. (medscape.com)
Cystinuria is an inherited defect of the renal tubules in which reabsorption of cystine (the homodimer of the amino acid cysteine ) is impaired, urinary excretion is increased, and cystine stones form in the urinary tract. (msdmanuals.com)
Спадковий синдром Фанконі Fanconi syndrome consists of multiple defects in renal proximal tubular reabsorption, causing glucosuria, phosphaturia, generalized aminoaciduria, and bicarbonate wasting. (msdmanuals.com)
The primary defect results in diminished renal proximal tubular reabsorption of cystine and increased urinary cystine concentration. (msdmanuals.com)

Proximal tubular cells isolated from the knockout mice were more sensitive to cisplatin-induced apoptosis than cells from wild-type mice. (elsevierpure.com)
Using this mouse line, we analyzed cell cycle of proximal tubular cells after DNA damage caused by aristolochic acid and cisplatin nephropathy models. (asn-online.org)
In G0 marker mice, almost all proximal tubular cells remained in the G0 phase under physiological conditions. (asn-online.org)
In the chronic phase of kidney injury, most proximal tubular cells were G0 marker-positive, but some G0 marker-positive cells exhibited nuclear abnormalities, such as nuclear enlargement. (asn-online.org)
We also isolated primary proximal tubular cells from G0 marker mice and induced senescence. (asn-online.org)
Our data suggest that G0 marker mice can be a useful tool for identifying senescent proximal tubular cells both in vivo and in vitro, in combination with cyclin D1 expression. (asn-online.org)
Based on our immunoelectron microscopy, we know that tensin is localized at the cellCmatrix junctions of the tubular cells in kidneys. (ppbhg.org)
Oxidative stress was markedly attenuated by iPS-MSCs both in AN mice and in protein-overloaded tubular cells. (oncotarget.com)
Glucose enters at the luminal side of the proximal tubular cells by an active carrier-mediated transport process that requires energy provided by the sodium gradient between the intra- and extracellular compartments generated by sodium-potassium ATPase. (medscape.com)

To investigate the role of HIF-1 in hypoxia-induced renal epithelial cell death, we generated mice that allow inactivation of HIF-1alpha by tetracycline-inducible Cre-loxP-mediated recombination in primary renal proximal tubule cells (PRPTC), resulting in a suppression of HIF-1-mediated gene transcription during oxygen deprivation. (nih.gov)
Among the different cells that make up these filtration units, the epithelial cells of the proximal tubul e of the nephron are responsible for reabsorbing water and solutes, representing 90% of the total renal mass. (ibecbarcelona.eu)
Moreover, the kidney showed degenerated tubular epithelial cells, congestion with excess of mononuclear cells, necrotic and desquamated epithelial cells of the proximal convoluted tubules. (scirp.org)
The epithelial cells of proximal tubules perform the functions of both copper uptake from the primary urine and release to the blood. (researchgate.net)
HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)

In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
We address this question by pharmacologic and genetic blockade of autophagy using mouse models of cisplatin- and ischemia-reperfusion-induced acute kidney injury. (elsevierpure.com)
Chloroquine, a pharmacological inhibitor of autophagy, blocked autophagic flux and enhanced acute kidney injury in both models. (elsevierpure.com)
Rapamycin, however, activated autophagy and protected against cisplatin-induced acute kidney injury. (elsevierpure.com)
Compared with wild-type littermates, these knockout mice were markedly more sensitive to cisplatin-induced acute kidney injury as indicated by renal functional loss, tissue damage, and apoptosis. (elsevierpure.com)
Mechanistically, these knockout mice had heightened activation of p53 and c-Jun N terminal kinase, the signaling pathways contributing to cisplatin acute kidney injury. (elsevierpure.com)
Thus, our results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms. (elsevierpure.com)

First, I examined the patterns of claudin expression in the proximal nephron and found that claudins-2 and -10a are expressed throughout the PT, in both convoluted and straight segments. (ku.edu)
To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
In addition to identifying VHL as a critical regulator of nephron progenitors' metabolic switching, the authors' findings demonstrate that this switch also plays a large role in the differentiation process, and suggest that VHL is required for normal kidney development. (lww.com)
Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)
To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC tg mice with VHL lox/lox mice to generate mice with a conditional deletion of VHL from Six2 + nephron progenitors. (lww.com)
By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
Our findings identify a novel role for VHL in mediating nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required for normal kidney development. (lww.com)
As the rate of glucose entering the nephron rises above 260-350mg/1.73m 2 /min (14.5-19.5mmol/1.73m 2 /min), the excess glucose exceeds the reabsorptive capacity of proximal tubule and is excreted in the urine (i.e. glucosuria). (medscape.com)

These mice enabled us to visualize ATP levels in real time and in a living state by measuring the FRET/GFP ratio and proved ideal for studying drugs that affect energy metabolism. (nature.com)
Using innovative techniques such as single cell RNA-sequencing, the researchers unraveled the crucial role tha t lipid metabolism genes play in protecting against chronic kidney failure. (ibecbarcelona.eu)
Noting these observations, the IBEC researchers went one s tep further and, using human mini-kidneys, demonstrated that these changes were due to a decrease in the expression of some of the genes that regulate lipid metabolism in proximal tubule cells. (ibecbarcelona.eu)
Here, we employed db/db mice and hRECs to find that LSP increases the level of glycolipid metabolism, maintains the morphology of retinal endothelial cells and inhibits acellular capillary neogenesis. (bvsalud.org)
In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. (karger.com)

Those drugs that are considered to act mainly in the loop of Henle, distal tubule, and collecting duct (furosemide, hydrochlorothiazide, and amiloride) did not impair EPO formation. (uni-regensburg.de)
GLUT1 proteins are localized to the basolateral membrane in the distal tubules of the mouse kidney, which lack the labeling of Lotus tetragonolobus lectin (LTL), a proximal tubule marker. (bicellscientific.com)
In the initial proximal tubule, only SGLT-2 and GLUT-2 are expressed, whilst SGLT-1 and GLUT-1 are expressed in the distal part of the tubule. (medscape.com)

Here, we report that p53 in kidney proximal tubules plays a critical role in cold storage/transplantation kidney injury and inhibition of p53 can effectively improve the histology and function of transplanted kidneys. (elsevierpure.com)
Here, we hypothesized that the SGLT2 inhibitor empagliflozin restores normal kidney histology and function in association with the inhibition of aberrant glycolysis in diabetic kidneys. (jci.org)

Acetazolamide on the other hand, which is thought to act predominantly at the proximal tubular site, significantly reduced EPO formation in response to normobaric hypoxia (8 and 14% O2) and functional anemia (0.1% carbon monoxide). (uni-regensburg.de)
Although both were detected at sites that matched cubilin distribution in wildtype animals, the Inhibitors,Modulators,Libraries cellular distributions in heterozygous mice were largely exclusive such that cells appeared to ex press predominantly either EGFP or cubilin. (microrna21.com)
In the kidney, SGLT1 is predominantly localized to the S3 segment of the proximal tubule. (bicellscientific.com)
Secondary active transport occurs in the intestine and the kidney tubules (predominantly proximal tubule) and is mediated by members of the SGLT transporter family. (medscape.com)

In addition, the knockout mice were more sensitive to renal ischemia-reperfusion injury than their wild-type littermates. (elsevierpure.com)
METHODS: The kidneys of proximal tubule Dicer (an enzyme for microRNA biogenesis) knockout mice and their wild-type littermates were subjected to CST to determine the function of microRNAs. (bvsalud.org)

The Physiology and Biophysics Department offers three training programs: Research for the PhD in Physiology and Biophysics prepares trainees to study the function and diseases of the brain, heart, and kidneys. (cwru.edu)

Inhibition of Sglt2 is accepted as a viable therapeutic treatment option for patients with type 2 diabetes and has been shown to delay development of diabetic kidney disease. (nih.gov)
Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. (fsu.edu)
We used 9- and 17-wk-old nondiabetic db/m and diabetic db/db mice to examine the role. (fsu.edu)
Vitamin D has to be metabolically activated in the kidney, and patients with CKD including diabetic kidney disease (DKD) are not able to produce enough of the active form of vitamin D (1,25(OH) 2 D). Vice versa, the kidneys are assumed to be a classical 1,25(OH) 2 D target. (karger.com)
Empagliflozin normalized the suppressed Sirt3 levels and aberrant glycolysis that was characterized by HIF-1α accumulation, hexokinase 2 induction, and pyruvate kinase isozyme M2 dimer formation in diabetic kidneys. (jci.org)
Empagliflozin also suppressed the accumulation of glycolysis byproducts in diabetic kidneys. (jci.org)

In addition, male and female WT mice developed diabetes-induced hyperfiltration, which was attenuated in the Olfr1393 KO mice and corresponded with a reduction in luminal expression of Sglt2. (nih.gov)

In a mouse kidney cold storage/transplantation model, we detected p53 accumulation in proximal tubules in a cold storage time-dependent manner, which correlated with tubular injury and cell death. (elsevierpure.com)

Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction. (medscape.com)

In addition, it was previously shown that mice with deletion of claudin-2 have increased urinary calcium excretion. (ku.edu)
Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
Symptoms are colic caused by stones and perhaps urinary infection or the sequela of chronic kidney disease. (msdmanuals.com)

Although decreased citrulline is used as a newborn screening (NBS) marker to identify proximal urea cycle disorders (UCDs), it is also a feature of some mitochondrial diseases, including MT-ATP6 mitochondrial disease. (stanford.edu)

The active endocytic machinery of kidney proximal tubules avidly internalizes filtered proteins, which may also be the case for filtered nanoparticles. (harvard.edu)
Strope S, Rivi R, Metzger T, Manova K, Lacy E. Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules. (ny.gov)

The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world. (asn-online.org)
Human induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) are emerging as attractive options for use in cell replacement therapy, but their effect in kidney diseases remains unknown. (oncotarget.com)

BACKGROUND: Kidney injury due to cold storage-associated transplantation (CST) is a major factor determining the outcome of renal transplant, for which the role and regulation of microRNAs remain largely unclear. (bvsalud.org)
p53 contributes to both ischemic and nephrotoxic kidney injury, but its involvement in kidney cold storage/transplantation is unclear. (elsevierpure.com)

CONCLUSIONS: Thus, the C57BL/6 strain represents the first Ctns(-/-) mouse model to show clear renal defects. (cnrs.fr)

Bone toxicity is closely related to nucleoside analogue effect on renal proximal tubular and phosphaturia. (medscape.com)

In almost all cases of chronic kidney disease, damage occurs in these cells, but until now, it was not known which cellular mechanisms were respon sible for such dysfunction. (ibecbarcelona.eu)

To test this hypothesis, Olfr1393 wild-type (WT) and knockout (KO) mice were challenged with a high-fat diet to induce early-stage type 2 diabetes. (nih.gov)
Collectively, these data indicate that renal Olfr1393 can contribute to the progression of type 2 diabetes, likely as a regulator of Na + -glucose cotransport in the proximal tubule. (nih.gov)
In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
CD-1 mice with streptozotocin-induced diabetes displayed kidney fibrosis that was associated with the EMT at 4 months after diabetes induction. (jci.org)

Next, I tested the hypothesis that deletion of the claudin-2 gene Cldn2 in mice causes nephrocalcinosis similar to human kidney stone disease using micro-computed tomography (micro-CT) and histological analyses. (ku.edu)
We also established a renal proximal tubule-specific autophagy-related gene 7-knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys. (elsevierpure.com)
The gene was flanked 3 with a 3-kb mouse tensin fragment and 5 with a 2.2-kb mouse tensin fragment. (ppbhg.org)
Here, we compare gene expression and cellular composition of single-cell suspensions prepared from adult mouse kidney using two tissue dissociation protocols. (biomedcentral.com)
The availability of a mouse carrying a knockin of an EGFP cassette into the cubilin gene has enabled precise histological analysis of cubilin expression. (microrna21.com)
However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)
In the present review, the phenotypes of Met gene‑modified mice are summarized. (spandidos-publications.com)

The biological effects were quantitated by immunocytochemistry, measuring kidney injury markers and performing functional tests. (harvard.edu)

Despite the enormous financial and personal burden that this entails, until now the biological mechanisms behind this condition were unknown, due to the structural and functional complexity of the kidney. (ibecbarcelona.eu)
In healthy adults, each of o ur kidneys contains an average of 1.5 million nephrons, the basic functional units of the kidney that constantly filter waste products from the blood. (ibecbarcelona.eu)
Mosaic mutant mice displaying a functional. (researchgate.net)

GLUT1 proteins are expressed by the villus epithelium in the mouse colon. (bicellscientific.com)
GLUT1 proteins are found in the endothelium making the blood brain barrier in the cerebral cortex of mouse brain. (bicellscientific.com)
These genes encode proteins that together form a heterodimer responsible for cystine and dibasic amino acid transport in the proximal tubule. (msdmanuals.com)

While evaluating cubilin EGFP expression in renal tissue of mice heterozygous for the knockin allele, we observed a striking difference in the distribution of EGFP immunore activity versus cubilin immunoreactivity. (microrna21.com)
Results Monoallelic expression of cubilin Inhibitors,Modulators,Libraries in the renal proximal tubules Kidney sections from wildtype mice and mice heterozy Inhibitors,Modulators,Libraries gous for Cubn exon 1 6 deletion with an EGFP cassette insertion were immunolabeled with antibodies to cubilin and EGFP. (microrna21.com)
In kidneys from wildtype mice, all proximal tubules displayed prominent and relatively uniform brush border immunolabeling with anti cubilin IgG. (microrna21.com)
Conversely, the proximal tubules that showed relatively low EGFP immunofluorescence displayed pronounced cubilin immunolabeling. (microrna21.com)

Blockade of miR-147 and overexpression of NDUFA4 reduce CST injury and improve graft function, unveiling miR-147 and NDUFA4 as new therapeutic targets in kidney transplantation. (bvsalud.org)
Together, these results support a pathogenic role of p53 in cold storage/transplantation kidney injury and demonstrate the therapeutic potential of p53 inhibitors. (elsevierpure.com)

Anti-GLUT1 (SLC2A1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. (bicellscientific.com)
We used histologic, immunofluorescence, RNA sequencing, and metabolic assays to characterize kidneys from these mice and controls during development and up to postnatal day 21. (lww.com)

My findings indicate that this papillary pattern of nephrocalcinosis shares striking similarities to human kidney stone disease. (ku.edu)
Our colleagues subsequently identified multiple SNPs in the CLDN2 locus that associate with human kidney stone disease. (ku.edu)
These kidney organoids contain renal structures including proximal tubules (marked with LTL, in green) and podocytes (expressing PODXL, in red) t hat partly resemble the renal structures of the human kidney. (ibecbarcelona.eu)

Olfactory receptor 1393 (Olfr1393) was recently identified as a novel regulator of Na + -glucose cotransporter 1 (Sglt1) localization in the renal proximal tubule. (nih.gov)

METHODS: As renal phenotype can be influenced by genetic background, we generated congenic C57BL/6 and FVB/N Ctns(-/-) mice and assayed renal lesions and function by histological and biochemical studies. (cnrs.fr)

Empagliflozin treatment significantly increased cytosolic and mitochondrial ATP levels in the hearts of db/db mice. (nature.com)
reported that chronic administration of empagliflozin enhanced ATP production in the heart of db/db mice, although they argued that this was due to an increase in glucose and fatty acid oxidation rather than the utilization of ketone bodies 8 . (nature.com)
In the present study, we crossed cytoATP-Tg or mitoATP-Tg mice with a mouse model of T2D and assessed the effects of empagliflozin on the cardiac energy status of those mice. (nature.com)

Confocal microscopy image of a kidney organoid generated in vitro from human pluripotent stem cells that have been differentiated for 20 days using three-dimensional cultures. (ibecbarcelona.eu)
in vitro, cold storage followed by rewarming induced cell death in cultured proximal tubule cells, which was accompanied by p53 activation and suppressed by pifithrin-α and dominant-negative p53. (elsevierpure.com)

In addition, claudin-2 expression is an important mediator of calcium transport that is associated with kidney stone disease in humans. (ku.edu)
Chronic kidney disease affects more than 697 million people around the world. (ibecbarcelona.eu)
Specifically, in the kid neys of mice with chronic kidney disease, they detected that a greater proportion of the proximal tubule cells had a different molecular signature than that found in the kidneys of healthy animals. (ibecbarcelona.eu)
however, proximal tubulopathy or end-stage renal disease is not observed. (cnrs.fr)
Impairment of the capability of the kidney to produce and reuptake enough calcitriol and therefore maintain vitamin D, phosphate, and calcium homeostasis is one of the principal pathophysiological components of metabolic bone disease in CKD. (karger.com)
DKD, one of the most common forms of CKD, accounts for almost 50% of end-stage kidney disease in developed countries requiring renal replacement therapy. (karger.com)
Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)
The worldwide prevalence of chronic kidney disease (CKD) has reached epidemic proportions over the last two decades. (oncotarget.com)
In Hong Kong, Renal Registry data from the Central Renal Committee of Hong Kong reported that the incidence of treated end-stage kidney disease (ESRD) has risen from 95 pmp in 1996 to 150 pmp in 2013 [ 1 ]. (oncotarget.com)
Chronic HBV infection per se is known to increase the risk of chronic kidney disease (CKD) such as membranous glomerulonephritis. (medscape.com)
Welcome to Medscape's InDiscussion series on chronic kidney disease . (medscape.com)

Our study demonstrated that S1, S2, and S3 cells provide a useful tool for studying the segment-specific and direction-dependent transport of both toxic and essential metals in the kidney's proximal tubules. (go.jp)
By sequencing the RNA of each of the thousands of cells present in the kidney, the researchers observed for the first time important differences between healthy and diseased cells in the proximal tubule. (ibecbarcelona.eu)
H uman mini-kidneys -also called kidney organoids- are created using bioengineering techniques from human stem cells, and capture some aspects of the complexity of this organ. (ibecbarcelona.eu)
Last April, the researchers demonstrated their effectiveness as a study model by u sing them to decipher in record time how SARS-CoV-2 interacts and infects the cells of these mini-kidneys, in addition to identifying a therapy aimed at reducing viral load. (ibecbarcelona.eu)
Whereas the spleen of mice showed depletion of lymphocytes and mononuclear as well as multinuclear cells. (scirp.org)
During the neonatal period, kidneys play a key role in detoxification and recirculation of iron species released from red blood cells (RBC) and filtered out by glomeruli to the primary urine. (researchgate.net)
Similar effects were shown by the ablation of p53 from proximal tubule cells. (elsevierpure.com)
Evaluation of EGFP immunolabeling in kidney sections from these mice revealed a similar discontinuous distribution, with some cells showing high levels of anti Inhibitors,Modulators,Libraries EGFP immuno fluorescence while adjacent cells had only weak fluores cence. (microrna21.com)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)

The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)

To test whether such interactions affect kidney function, we injected mice with either 5 nm dextran-based nanoparticles (DNP) that are similar in composition to FDA-approved materials or poly(amido amine) dendrimer nanoparticles (PNP) of comparable size. (harvard.edu)
We conclude that there are no major detrimental renal effects of DNP on overall kidney function, but changes in endocytosis-mediating protein expression do occur. (harvard.edu)
Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)
Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
In conclusion the data suggest that the regulation of EPO production is likely to be related to proximal tubular function. (uni-regensburg.de)
In addition to highlighting the influence of genetic background on phenotype, the C57BL/6 Ctns(-/-) mice represent a useful model for further understanding cystinosin function in the kidney and, specifically, in the proximal tubules. (cnrs.fr)
Kidney injury associated with cold storage/transplantation is a primary factor for delayed graft function and poor outcome of renal transplants. (elsevierpure.com)
Notably, pifithrin-α also ameliorated kidney injury and improved the function of transplanted kidneys in 6 days when it became the sole life-supporting kidney in recipient mice. (elsevierpure.com)

Although the mechanisms of metal transport in the convoluted proximal tubule (S1 and S2 segments) and the straight proximal tubule (S3 segment) may differ, little is known about the segment-specific modes of metal transport. (go.jp)
Here, we utilized immortalized cell lines derived from the S1, S2, and S3 segments of mouse kidney proximal tubules, and examined the segment-specific and direction-dependent transport of Cd and manganese (Mn) using a trans-well culture system. (go.jp)

And management is poorly described drug that is supposed fluctuating cholesterol Kidney damage Liver problems Heart problems. (wahoowebsite.com)

Hence, the vitamin D receptor (VDR) is highly expressed in kidney tissue [ 3-5 ]. (karger.com)

As such, it is maintained within a narrow range through the actions of gastrointestinal, bone, kidney, and endocrine tissues. (ku.edu)

This study aims to investigate the effects of PFHxS exposure on female reproduction and the underlying mechanism in mice. (researchsquare.com)
NCTR has published several papers illustrating the mechanism of mitochondrial toxicity in response to different drugs in the mouse and rat. (fda.gov)
In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)

Kidney Blood Press Res (2021) 46 (2): 152-161. (karger.com)

RESULTS: C57BL/6 Ctns(-/-) mice showed significantly higher renal cystine levels than the FVB/N strain. (cnrs.fr)

They concluded that the extract failed to show spermatotoxic effects and no significant acute or chronic mortality were observed in mice given F. vulgare fruits and aerial parts orally. (scirp.org)

Dr. Lacy's research on mouse development has identified a previously unrecognized player in the regulation of stem/progenitor cell differentiation-nuclear pore complex (NPC) composition. (ny.gov)
Lupu F, Alves A, Anderson K, Doye V, Lacy E. Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. (ny.gov)
Combining single cell RNA-sequencing, and the use of bioengineering to produce mini-kidneys, they were able to identify the key cellular level differences between healthy and diseased kidneys. (ibecbarcelona.eu)
In this study, single cell RNA-sequencing of the mini-kidney samples was carried o ut in the laboratory of Dr. Felipe Prósper at the Clínica Universidad de Navarra and CIMA Universidad de Navarra. (ibecbarcelona.eu)
The lung of mice showed congestion, emphysema with variable degrees of mononuclear cell infiltrations and peribronchial congested blood capillaries and mononuclear cell infiltration. (scirp.org)
T317088 TAg Stable Y-LIZ DNA Polymerase-β Knockout Mouse Embryonic Fibroblast Cell Line carries the. (topsan.org)
T316992 TAg Stable Y-LIZ Wildtype Mouse Embryonic Fibroblast Cell Line carry the lambda-LIZ transgene (Y-LIZ), a shuttle. (topsan.org)
Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)

Specifically, microRNA-147 (miR-147) is consistently elevated during CST injury in mice and in dysfunctional renal grafts in humans. (bvsalud.org)

PFHxS is persistent and poorly metabolized with estimated half-lives of 1 month, 4 months, and 7.3 years in mice, monkeys, and humans, respectively [6,7]. (researchsquare.com)

Kidneys play an especial role in copper redistribution in the organism. (researchgate.net)
While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)
The kidneys play an important role in glucose homeostasis. (medscape.com)

The numbers of antral follicles and corpus lutea were significantly reduced in PFHxS-treated mice. (researchsquare.com)

Anatomy19

Organisms7

Diseases12

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes9

Disciplines and Occupations1

Information Science3

Reabsorption13

Tubular cells9

Epithelial5

Acute Kidney7

Nephron8

Metabolism5

Distal3

Histology and function2

Predominantly4

Wild-type littermates2

Physiology1

Diabetic6

Sglt21

Accumulation1

Renal tubular1

Urinary3

Marker1

Endocytic2

Diseases3

Unclear2

Defects1

Phosphaturia1

Dysfunction1

Diabetes4

Gene7

Measuring kidney injury1

Functional3

Proteins3

Cubilin4

Therapeutic2

Immunofluorescence2

Human kidney3

Localization1

METHODS1

Empagliflozin3

Vitro2

Disease11

Cells9

Transporters1

Function11

Segment2

Liver1

Tissue1

Tissues1

Mechanism3

20211

Cystine1

Orally1

Cell8

Specifically1

Humans1

Role3

Significantly reduced1