Mice injections intraperitoneal. Medical search. Frequent questions

Abetes was induced by intraperitoneal injection of streptozotocin into 8-week-old C57BL/6 male mice. (achrinhibitor.com)
We, therefore, turned to ovariectomized (OVX) C57BL/6 mice and directly compared a low intensity endurance training on the treadmill to medium and high intensity interval trainings tailored to the individual performance limits. (frontiersin.org)
Previous studies from our group and other labs have demonstrated that oil granulomas represent the major pathology in response to pristane injections in C57BL/6 mice [ 2 , 3 ]. (hindawi.com)
Interleukin-6 (IL-6) seems to regulate both plasmacytoma development in BALB/c mice and oil granuloma formation in C57BL/6 mice during pristane-induced inflammation [ 10 , 12 ]. (hindawi.com)
2022. Comparison of gelatin flavors for oral dosing of C57BL/6J and FVB/N mice. (awionline.org)
We decided to examine the modulating effects of long-term, compulsive treadmill exercise on the hedonic value of MDMA in male C57BL/6J mice. (erowid.org)
This study is designed to investigate FFAR1 function in vivo using a third line of independently generated Ffar1 −/− mice in the C57BL/6 background. (diabetesjournals.org)
To test this hypothesis, C57BL/6 mice were fed 20% alcohol or water ad libitum for 6 weeks and treated with 12.5% HDE by intranasal inhalation method daily during the final three weeks. (cdc.gov)

Cnp −/− mice exhibit early low-grade inflammation of white matter tracts and blood-brain barrier disruption. (nature.com)
Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice. (hindawi.com)
1 µm) in terms of mesothelial damage and peritoneal inflammation, after intraperitoneal (i.p.) injection in mice. (springer.com)
Chronic inflammation was induced by placing polyether-polyurethane sponge discs in the abdominal cavity of anesthetized Swiss mice. (blogspot.com)
Infected mice treated with Pam3CSK4 possessed more hepatic inflammation focus, lower IgG and IgG2a antibody titers, and a lower proportion of spleen CD3+CD4+ T cells. (bvsalud.org)
The research showed inflammation in the lungs of the mice, and fibrosis in their lungs, which persisted following exposure. (cdc.gov)
These preliminary findings, when combined with previous studies by other investigators, which reported inflammation and mesothelioma of the abdominal lining after intraperitoneal instillation (injection into the lining of the abdominal cavity) of MWCNTs in mice, provide additional justification for further research. (cdc.gov)

Mice were received thioacetamide intraperitoneally. (achrinhibitor.com)
Mice received two consecutive intraperitoneal injections of thioacetamide (TAA) at low dosage (300 mg/kg). (wjgnet.com)

Intraperitoneal injections can be similar to oral administration in that hepatic metabolism could occur in both. (wikipedia.org)
The study is to observe the influence of electroacupuncture (EA) stimulation at "Zusanli" (ST36) on the release of nitric oxide (NO) and blood perfusion (BP) in the liver and further explore whether the hepatic blood perfusion (HBP) changes were regulated by EA ST36 induced NO in nitric oxide synthase inhibited mice. (hindawi.com)
However, related studies are absent on which link in the acupuncture will motivate the regulation of the synthesis and release of NO. In this study, we try to observe the influence of electroacupuncture (EA) on the NO concentration and BP in the liver tissue of the mice through inhibiting the activity of eNOS and discuss the relationships between NO levels and hepatic blood perfusion (HBP) regulation by EA. (hindawi.com)
To propose an alternative model of hepatic encephalopathy (HE) in mice, resembling the human features of the disease. (wjgnet.com)
It was previously reported that FFAR1 knockout ( Ffar1 −/− ) mice were resistant to high-fat diet-induced hyperinuslinemia, hyperglycemia, hypertriglyceridemia, and hepatic steatosis. (diabetesjournals.org)
however, Ffar1 −/− mice are not protected from high-fat diet-induced insulin resistance or hepatic steatosis. (diabetesjournals.org)

There are few examples of the use of intraperitoneal injections in humans cited in literature because it is mainly used to study the effects of drugs in mice. (wikipedia.org)
Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples. (nature.com)
We have previously developed a mouse model that exhibits unstable plaques as seen in humans 16 . (nature.com)
However, the kinetics of nitrate secretion in rat saliva appear to have been less well studied than in humans, and even less is known concerning salivary secretion in mice. (inchem.org)
However, the preliminary findings provide the first scientific evidence ever that such migration is possible, given similarities between the body systems of the mouse and those of humans. (cdc.gov)

In the present study, Line1 mouse adenocarcinoma cells were implanted subcutaneously into syngenic BALB/c mice. (nih.gov)
In L. donovani-infected BALB/c mice, one group was treated with Pam3CSK4 after infection and the other group was not treated. (bvsalud.org)

Summary/Conclusion: ESC-NVs effectively restored erectile function via enhanced cavernous angiogenesis and neural regeneration in diabetic mice. (achrinhibitor.com)
These observations show for the first time the effects of propolis modulating intraperitoneal inflammatory angiogenesis in mice and disclose important action mechanisms of the compound (downregulation of angiogenic components and activation of murine macrophage pathways). (blogspot.com)

Infarcted mice were treated with saline or BNP for 10 days. (elifesciences.org)
Trichostatin A (TSA) 2.4 mg/kg in DMSO/Saline solution (1:4) was administered by intraperitoneal injection. (nih.gov)

To address this question, we have generated transgenic mice expressing only the H chain gene or both H and L chain genes of the 6-19 IgG3 anti-IgG2a RF and determined the development of glomerular and vascular lesions. (unige.ch)
H-single and H/L-double transgenic mice displayed comparable high amounts of IgG3 cryoglobulins, but only H/L-double transgenic mice having 10-fold higher levels of IgG3 anti-IgG2a RF progressively developed chronic, lethal glomerulonephritis. (unige.ch)

The NIOSH investigators reported on a scientifically ambitious study of laboratory mice exposed to multi-walled carbon nanotubes by pharyngeal aspiration causing the lab animal to inhale a small drop of liquid with suspended material that closely resembles inhalation of the same material suspended in the air. (cdc.gov)

Understanding when intraperitoneal injections can be utilized and in what applications is beneficial to advance current drug delivery methods and provide avenues for further research. (wikipedia.org)
2022. Refinement of handling and dosing methods for rats and mice. (awionline.org)

In 1964, a study delivered chemical agents such as acetic acid, bradykinin, and kaolin to mice intraperitoneally in order to study a "squirming" response. (wikipedia.org)
A good example of how intraperitoneal injections work is depicted through "The distribution of salicylate in mouse tissues after intraperitoneal injection" because it includes information on how a drug can travel to the blood, liver, brain, kidney, heart, spleen, diaphragm, and skeletal muscle once it has been injected intraperitoneally. (wikipedia.org)

In general, it is preferred when large amounts of blood replacement fluids are needed or when low blood pressure or other problems prevent the use of a suitable blood vessel for intravenous injection. (wikipedia.org)

To elucidate a potential contribution of oligodendroglial NMDAR downregulation to NMDAR1-AB effects, we generated conditional NR1 knockout mice. (nature.com)
Here, we used the σR1-knockout mouse ( Sigmar1 −/− ) to demonstrate unambiguously the role of the σR1 in protecting the retinal ganglion cells against degeneration after acute damage to the optic nerve. (molvis.org)
Ffar1 +/+ (wild-type) and Ffar1 −/− (knockout) mice were placed on two distinct high-fat diets to study their response to diet-induced obesity. (diabetesjournals.org)
Hepatocyte-specific Mettl3 knockin exacerbated NAFLD-HCC formation, while Mettl3 knockout exerted the opposite effect in mice. (bvsalud.org)

The HBP change of the mice was detected by laser speckle perfusion imaging (LSPI) before and after being given interventions, and the NO in liver tissue was detected by nitric acid reductase in each group. (hindawi.com)
Soon after systemic administration of exosome, a substantial accumulation of A-Exo at liver was observed in both the standard and mice model of liver fibrosis. (achrinhibitor.com)
Tumours in the circulatory system, large intestine and liver were reported in mice exposed via the dietary route as well. (gc.ca)
The results showed that the liver and spleen parasite load of infected mice in Pam3CSK4 treated and untreated groups had no statistical difference, indicating Pam3CSK4 might have no therapeutic effect on visceral leishmaniasis. (bvsalud.org)
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. (who.int)
In this study, we investigated the effects of exposure of mice to waterpipe smoke on oxidative stress in lungs and liver and the effects of selenium administration before smoke exposure on the oxidative stress. (who.int)
Malondialdehyde and nitric oxide levels were significantly higher in the lungs and liver, while the activities of superoxide dismutase, glutathione peroxidase-1, and catalase were significantly lower in the waterpipe smoke group when compared to control mice. (who.int)
In conclusion, exposure of mice to waterpipe smoke-induced oxidative stress in lungs and liver. (who.int)

Twelve weeks of treadmill running did not alter peripheral metabolism of MDMA 30min following single intraperitoneal injection of MDMA (3mg/kg). (erowid.org)

Final results: Intracavernous injections of ESC-NVs drastically enhanced erectile function in diabetic mice, which reached up to 90 of handle values. (achrinhibitor.com)

Fluorescently labelled A-exo was administered to mice and whole-body fluorescence was observed in order to evaluate the in vivo distribution. (achrinhibitor.com)
HADSCs were intraocularly injected into oxygen-induced retinopathy (OIR) mice to check the movement, fusion, proliferation, and prognosis in vivo. (molvis.org)
RESULTS- Insulin secretion was reduced by ∼50% in Ffar1 −/− mice, confirming that FFAR1 contributes significantly to fatty acid stimulation of insulin secretion in vivo. (diabetesjournals.org)
The present study was performed using unilateral ureteral obstruction mice and HK‑2 cells in vivo and in vitro . (spandidos-publications.com)

Mice deficient for TNF α develop defective oil granulomas with reduced recruitment of macrophages and neutrophils [ 10 ]. (hindawi.com)

Intraperitoneal injection of beta-glucan was shown to greatly delay mortality in mice exposed to whole-body X-ray radiation and tumor growth in tumor-bearing mice. (nih.gov)
Augmented immunological activity as seen in increased NK and LAK activity by beta-glucan seems to play a role in preventing secondary infections associated with irradiation, and probably contributes to the attenuated tumor growth in tumor-bearing mice through enhanced anti-tumor immunity. (nih.gov)
This study demonstrates for the first time that administration of nicotine either by i.p. injection or through over-the-counter dermal patches can promote tumor growth and metastasis in immunocompetent mice. (nih.gov)

Although controversial, intraperitoneal use in ovarian cancer has been recommended as a standard of care. (wikipedia.org)

Here we show that nicotine significantly promotes the progression and metastasis of tumors in mouse models of lung cancer. (nih.gov)
GMA-SS fume significantly promoted lung tumor multiplicity in A/J mice initiated with MCA (16.11 +/- 1.18) compared to MCA/air-exposed mice (7.93 +/- 0.82). (cdc.gov)
Similarly, alcohol-fed mice demonstrated significantly less IL-6 in lung lavage in response to dust than that observed in control mice instilled with HDE. (cdc.gov)
Treating mice with 1.78Â Âµg selenium/kg body weight significantly restored the normal levels of these parameters. (who.int)

Because alcohol blocks airway epithelial cell release of IL-6 in vitro , we hypothesized that alcohol exposure would alter mouse lung inflammatory responses to HDE. (cdc.gov)

The experiments with mice involved a group of two-week-old infants and a group of healthy young adults. (eurekalert.org)

Retinal ganglion cell death was induced by acute optic nerve crush in wild-type and Sigmar1 −/− mice. (molvis.org)
Our data indicated faster retinal ganglion cell death in Sigmar1 −/− than in wild-type mice under the stresses caused by optic nerve crush, providing direct evidence for a role of the σR1 in alleviating retinal degeneration. (molvis.org)

These findings could be advanced by studying how the route of injection affects the organs in the peritoneal cavity. (wikipedia.org)
This study demonstrates how intraperitoneal injections can be used to help diagnose diseases by providing direct access to the peritoneal cavity and affecting the organs in the cavity. (wikipedia.org)

They are one of the few ways drugs can be administered through injection, and have uses in research involving animals, drug administration to treat ovarian cancers, and much more. (wikipedia.org)
Nicotine administration either by intraperitoneal (i.p.) injection or transdermal patches caused a remarkable increase in the size of implanted Line1 tumors. (nih.gov)
2022. A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage. (awionline.org)
2021. Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems. (awionline.org)
An alternative method for oral drug administration by voluntary intake in male and female mice. (awionline.org)

In 1969, errors depending on a variety of techniques of administering IP injections were analyzed, and a 12% error in placement was found when using a one-man procedure versus a 1.2% error when using a two-man procedure. (wikipedia.org)
In this study, a boiling-stable 31-kDa protein (namely GP) was purified from licorice and self-assembled into nanoparticles (206.2 ± 2.0 nm) at pH 5.0, 25 °C. The aconitine-encapsulated GP nanoparticles (238.2 ± 1.2 nm) were prepared following the same procedure and tested for its toxicity by intraperitoneal injection on ICR mouse ( n = 8). (springer.com)

Depending on the genetic background of the model, pristane injection can trigger a local inflammatory response (lipogranuloma), erosive arthritis that resembles rheumatoid arthritis, and systemic lupus erythematosus, followed by autoantibody formation and many clinical manifestations [ 3 - 5 ]. (hindawi.com)
Recent studies have shown that LIFUS inhibits social avoidance behavior in mice by reducing activation of the microglial inflammatory response, increasing neuronal excitation, and protecting the integrity of the neuronal structure [ 5 ]. (aging-us.com)

This mouse model was instrumental for the description of NIRAF as a potential indicator of an atherosclerotic plaque's risk in causing future cardiovascular events. (nature.com)
To circumvent the slow progress of human osteoporosis and the manifold confounding factors associated with human studies, we here turned to a mouse model in order to compare various treadmill training regimens for their propensity to prevent osteoporosis-associated bone loss. (frontiersin.org)
These studies on transplanted tumors were extended to a mouse model where the tumors were induced by the tobacco carcinogen, NNK. (nih.gov)
A transgenic mouse model of autoi. (unige.ch)
Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)
To test this hypothesis, the regenerative capability of OPCs in young [(10 weeks ±2 (SD)] and aged [(62 weeks ±10 (SD)] mice was studied in mice subjected to central fluid percussion injury (cFPI), a TBI model causing widespread white matter injury. (lu.se)

2022. A Comparison of blood collection techniques in mice and their effects on welfare. (awionline.org)
Injection of GP-AC nanoparticles and the mixed licorice-aconite decoction, respectively, caused mild recoverable toxic effects and no death, while the aconitine, particle-free GP-AC mixture and aconite decoction induced sever toxic effects and 100 % death. (springer.com)
In this study, the effects of walnut on gut microbiota were tested in a mouse tumor bioassay using the colonotropic carcinogen, azoxymethane (AOM) added to the total Western diet (TWD). (aacrjournals.org)

Statistically significant weight reductions and 20% mortality were also observed in the mice co-exposed to HDE and alcohol. (cdc.gov)

TNFα levels were also inhibited in the alcohol and HDE-exposed mouse lung tissue as compared to the HDE only exposed group. (cdc.gov)

and (iv) mice received intraperitoneal injection of 1.78Â Âµg selenium/kg body weight as sodium selenite 15Â min before the exposure to waterpipe smoke. (who.int)

We therefore immunized young female Cnp −/− mice lacking the structural myelin protein 2′-3′-cyclic nucleotide 3′-phosphodiesterase (Cnp) with a "cocktail" of NMDAR1 peptides. (nature.com)
Mice primed with M2-DNA channel protein. (cdc.gov)

Specifically, mice undergoing a 12-week treadmill running exercise did not exhibit any approaching bias toward the MDMA-associated compartment in this CPP paradigm. (erowid.org)

Inhalation of gas metal arc-stainless steel welding fume promotes lung tumorigenesis in A/J mice. (cdc.gov)
Takashima K, Ito Y, Gonzalez FJ, Nakajima T. Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. (who.int)

One study utilized IP injections to study pain in the abdomen after a hysterectomy when administering anesthetic continuously vs patient-controlled. (wikipedia.org)
Our objective in this study was to determine whether inhalation of freshly generated GMA-SS welding fume also acts as a lung tumor promoter in lung tumor-susceptible mice. (cdc.gov)

This paper aims to explore the therapeutic effect of TLR-2 agonist Pam3CSK4 on Leishmania-infected mice and the underlying immune molecular mechanisms. (bvsalud.org)

Forty healthy male Kunming mice weighing 20-22 g, average age of 3 months, were randomly allocated into EA, L-NAME, L-NAME EA, and control groups, 10 mice in each group. (hindawi.com)

The preliminary findings are the first to demonstrate that carbon nanotubes aspirated by laboratory mice can actually migrate from the alveoli in the lungs (the tiny structures in the lung that are critical for gas exchange), through the lungs, to the pleura. (cdc.gov)
HDE stimulated a 2-4 fold increase in lung and tracheal PKCε (epsilon) activity in mice, but no such increase in PKCε activity was observed in dust-exposed mice fed alcohol. (cdc.gov)

The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
05) in the white matter of brain-injured aged mice, without difference in proliferating Olig2+/PDGFRα+ cells, indicating a diminished proliferation of progenitors with different spatial origin. (lu.se)

We found that acute MDMA-stimulated dopamine release in nucleus accumbens was abolished in the exercised mice, whereas an obvious elevation of accumbal dopamine release was observed in sedentary control mice. (erowid.org)

We observed that sedentary control mice all demonstrated reliable MDMA-induced CPP with our conditioning protocol. (erowid.org)
Experiments were performed in 3 month old animals and in all cases the mice used as control were littermates of the treated mice. (nih.gov)

In contrast, comparing wild-type and Cnp −/− mice without/with NMDAR1-AB regarding hippocampal learning/memory and motor balance/coordination revealed distinct stair patterns of behavioral pathology. (nature.com)

These early uses of Intraperitoneal injections provide good examples of how the delivery method can be used, and provides a base for future studies on how to properly inject mice for research. (wikipedia.org)

Since the leukocyte and lymphocyte numbers were increased by a single dose of beta-glucan, the radioprotective effect of beta-glucan is probably mediated, at least in part, by a hemopoietic action in irradiated mice. (nih.gov)
Immunohistochemistry confirmed neuroinflammation/neurodegeneration in Cnp −/− mice, yet without add-on effect of NMDAR1-AB. (nature.com)
This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches. (nih.gov)

The superior therapeutic efficacy was displayed in A-exo treated mouse group.PT12.HucMSC exosome confer protection against ultraviolet radiation induced acute photodamage through modulation of SIRT1 pathway Peipei. (achrinhibitor.com)
Mice implanted with hybridoma secreting 6-19 IgG3 anti-IgG2a rheumatoid factor (RF) with cryoglobulin activity develop acute glomerulonephritis and cutaneous leukocytoclastic vasculitis. (unige.ch)

The therapeutic efficacy of A-exo was determined by measuring the level of ALT, ALP, TBIL and TP in blood of mice. (achrinhibitor.com)

Five days after the hADSC intravitreal injection, the area of neovascularization was reduced by 94.83% compared with that of the OIR group. (molvis.org)
Mice were group-housed in single-sex cages on a light:dark cycle (12/12 h) with food and water available ad limitum. (nih.gov)

However, Ffar1 +/+ and Ffar1 −/− mice had similar weight, adiposity, and hyperinsulinemia on high-fat diets, and Ffar1 −/− mice showed no improvement in glucose or insulin tolerance tests. (diabetesjournals.org)

In mice lacking one copy of the BDNF gene ( BDNF +/− ), CB 1 R (GABA) responses were potentiated and were preserved from the action of haloperidol, a DA D 2 receptor (D 2 R) antagonist able to fully abolish CB 1 R (GABA) function in rewarded animals. (jneurosci.org)

Here, we examined the relationship between SE-induced MAPK pathway activation and neuronal survival in the dentate gyrus of the mouse. (jneurosci.org)

Despite the virulence and rapid kinetics of candidate, we vaccinated mice with M2 peptide of a widely shared consensus sequence. (cdc.gov)

A disadvantage of using intraperitoneal injections is that they can have a large variability in effectiveness and misinjection. (wikipedia.org)

The few examples that do exist pertain to the treatment of pancreatic/ovarian cancers and injections of other drugs in clinical trials. (wikipedia.org)

Anatomy25

Organisms27

Diseases34

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Psychiatry and Psychology4

Phenomena and Processes36

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Health Care6

C57BL8

Inflammation7

Thioacetamide2

Hepatic6

Humans5

BALB2

Angiogenesis2

Saline2

Transgenic mice2

Multi-walled carbon nanotubes1

Methods2

Intraperitoneally2

Intravenous1

Knockout4

Liver8

Metabolism1

Diabetic mice1

Vivo4

Deficient1

Tumor growth3

Controversial1

Significantly4

Vitro1

Infants1

Ganglion2

Peritoneal cavity2

Administration5

Procedure2

Inflammatory response2

Model6

Effects3

Mortality1

Tissue1

Exposure1

Protein2

Treadmill1

Tumorigenesis2

Study2

Mechanisms1

Male1

Lung2

Cells2

Dopamine1

Control2

Wild-type1

Provide1

Effect3

Acute2

Efficacy1

Group2

Similar1

Lacking one copy1

Neuronal1

Widely1

Large1

Treatment1