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  • genes
  • Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. (springer.com)
  • differ
  • Strains also have been found to differ in the new LRR test, as well as in the development of acute functional tolerance (AFT) to this response. (springer.com)
  • responses
  • We then focused on the drug-, dose-, and strain-specific responses to β -stimulation and β -blockade of a selection of traits including heart rate, systolic blood pressure, cardiac weight indices, ECG parameters and body weight. (pubmedcentralcanada.ca)
  • chromosome
  • Extensive genetic analyses of chromosome C-banding pattern, biochemical markers and microsatellite DNA (MIT) markers of this strain have demonstrated the characteristics of MUS. (go.jp)
  • commonly
  • Thus, the present findings ratify those reported for these strains, as well as complement the evaluation of worm burden in the other commonly referred inbred mice. (scielo.br)
  • Rats
  • The genetic analysis of a multifactorial disease in experimental animals such as mice and rats is much more revealing than that of a similar disease in human subjects. (diabetesjournals.org)
  • twelve
  • One hundred and twelve mice were tested by this method. (scielo.br)
  • Methods: Twelve genealogically disparate strains of mice were treated with 0 ppm, 25 ppm, and 50 ppm of fluoride in their drinking water. (iupui.edu)
  • variability
  • Behavior was assessed in the home-cage, providing control over environmental factors, to reveal within-strain variability in numerous spontaneous behaviors. (uva.nl)
  • Indeed, despite standardization and in line with previous studies, substantial variability among mice of the same inbred strain was observed. (uva.nl)
  • CPBs mice, which showed a relatively high variability for fraying, appeared to be heterozygous for this character. (brillonline.com)
  • Eppig
  • 1997). A recent summary of mouse guidelines was published in 2006 (Eppig 2006). (jax.org)
  • chronic
  • In a separate test, naive animals of the same strains were tested for HT repeatedly to assess the development of rapid (RTOL) and chronic tolerance (CTOL). (springer.com)
  • Mice were phenotyped either in response to chronic administration of a single dose of the β -adrenergic receptor blocker atenolol or under a low and a high dose of the β -agonist isoproterenol and compared to baseline condition. (pubmedcentralcanada.ca)
  • eight
  • Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the reduction from pre-injection baseline of their body temperature. (springer.com)
  • groups
  • Two hundred and fifty Mus musculus (Linnaeus, 1758) inbred mice from two animal houses in the State of Rio de Janeiro, RJ, Brazil, were divided in two groups (A, B) according to their source. (scielo.br)
  • 2. The mice were then crowded in groups of 8 into enclosures with floor areas of 0.09, 0.2I, or 0.38 m2. (brill.com)
  • model
  • We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. (springer.com)
  • The purpose of this study is to explore inter-individual variance of cardiovascular-related traits induced by sustained pharmacological perturbations of the β -adrenergic system, using inbred mouse strains as a model. (pubmedcentralcanada.ca)
  • unique
  • An inbred strain should be designated by a unique brief symbol made up of uppercase, Roman, letters, or a combination of letters and numbers beginning with a letter. (jax.org)
  • Note: a few historical examples exist of similar mouse and rat strain designations and these are allowed to stand, with their substrain designations identifying them as unique). (jax.org)
  • We started to establish our unique strain, MSM/Ms, from MUS in Japan in 1978. (go.jp)
  • taken
  • Care should be taken that mouse and rat strains do not overlap in strain designations. (jax.org)
  • Digital and 35 mm images were taken of all mouse incisors in order to apply and compare the Dean's Index and the modified Thylstrup and Fejerskov Index (TFI), both indices of dental fluorosis. (iupui.edu)
  • Skeletal radiographs were taken on the euthanized mice and later examined for extra skeletal calcifications and other gross bony deformities. (iupui.edu)
  • show
  • C 57 Black mice were not territorial and did not show a sensitive aggression-flight balance. (brillonline.com)
  • A cross-fostering test between CPBs and C 57 Black did not show any cultural influence on the fraying performance in these mice. (brillonline.com)
  • baseline
  • 0.7) and significant correlations of trait values measured in baseline condition with independent multistrain datasets of the Mouse Phenome Database. (pubmedcentralcanada.ca)
  • Database
  • Mouse strain names should be registered through the Mouse Genome Database (MGD) at http://www.informatics.jax.org/mgihome/submissions/amsp_submission.cgi . (jax.org)
  • Rat strain names should be registered through the Rat Genome Database (RGD) at http://rgd.mcw.edu/tools/strains/strainRegistrationIndex.cgi . (jax.org)
  • least
  • As for the swab anal procedures, the technique of Hall (1937) was modified and the device consists of a plastic rod ( Fig. 1 ), with appropriate dimensions, for the examination of mice weighting at least 18g. (scielo.br)
  • The 129P3/J mouse strain was least affected with negligible dental fluorosis. (iupui.edu)
  • studies
  • These studies and the preparation of this manuscript were supported by NIH grants AA19760, AA12714, AA13519, NSERC grant 45825, the Mouse Phenome Project, and the Department of Veterans Affairs. (springer.com)
  • These studies have used the GK rat ( 7 ), the OLETF rat ( 7 ), the NSY mouse ( 8 ), the NZO mouse ( 9 ), the TSOD mouse ( 10 ), the KK-A y mouse ( 11 , 12 ), and the TH mouse ( 13 ). (diabetesjournals.org)
  • either
  • CBA mice as a rule did not build proper nests at the surface, either because they did not try to make a nest at all or because they treated the nesting material in such a way that they chopped it up to pieces which were too small to shape more than a simple platform at the surface. (brillonline.com)