• We validated a new reliable and sensitive method to study two features of social behavior (sociability and preference for social novelty) in two strains of male mice, the C57BL/6J inbreed strain and the CD1 (ICR) outbreed strain, using a modified version of the V-shaped maze (Vsoc-maze). (bio-protocol.org)
  • Material and Method]Female mice, 12 weeks old of the inbred strains C3H/HeMs, C57BL/6J, A/J were used through experiments. (go.jp)
  • Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. (duke.edu)
  • The C57BL/6J mouse develops obesity and diabetes in response to a high-fat, high-simple carbohydrate diet. (duke.edu)
  • To determine the dynamics of glucose-induced insulin release in this animal model of NIDDM, we studied the acute insulin response to glucose of perifused islets in C57BL/6J (diabetes-prone) and A/J (diabetes-resistant) mice fed a normal control diet and of others fed a diabetogenic diet. (duke.edu)
  • The defect in C57BL/6J mice was exaggerated in animals fed a diabetogenic diet. (duke.edu)
  • Abstract Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. (helmholtz-hzi.de)
  • More recently large initiatives such as the International Knockout Mouse Consortium (IKMC) are using the C57BL/6N mouse strain to generate null alleles for all mouse genes. (helmholtz-hzi.de)
  • Conclusions Comparison of C57BL/6J and C57BL/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains. (helmholtz-hzi.de)
  • Dams from strains C57BL/6J and NOD/ShiLtJ increased the expected litter size by a mean of 1.66 and 1.79 pups, whereas dams from strains WSB/EiJ, PWK/PhJ, and CAST/EiJ reduced expected litter size by a mean of 1.51, 0.81, and 0.90 pups. (rxivist.org)
  • A review of the literature is presented relating immune factors to agingā€associated cognitive disorders, and parallels are drawn to immune factors and related behavioral impairments in autoimmune New Zealand black and nonautoimmune C57BL/6 mice. (unthsc.edu)
  • Actual Analytics, in collaboration with Challenge Sponsors MRC Harwell, has developed the innovation Home Cage Analyser (HCA) system, which provides 24/7 minimally-invasive, automated recording and analysis of the activity, social interactions and behaviour (eating, drinking and climbing) of individual mice housed socially in their home cage. (nc3rs.org.uk)
  • Analysis based on inferred haplotypes improves power, reduces false discovery, and provides information to identify and prioritize candidate genes that is unique to multifounder crosses like the CC. The number of expression QTLs discovered here exceeds all previous efforts at eQTL mapping in mice, and we map local eQTL at 1-Mb resolution. (epistasisblog.org)
  • Both sets of information were provided by Dr. Michael FW Festing (MRC Toxicology Unit) and were converted for Web presentation by the Mouse Genome Informatics Group at The Jackson Laboratory. (cam.ac.uk)
  • Overall, these results demonstrate that strains vary substantially in their reproductive ability depending on their genetic background and that litter size is largely determined by dam.strain rather than sire.strain effects, as expected. (rxivist.org)
  • In parallel we assess the comparative phenotypes of the two inbred lines utilizing the EMPReSSslim phenotyping pipeline, a broad based assessment encompassing diverse biological systems. (helmholtz-hzi.de)
  • While solid rewards typically in the form of 20 or 40 mg pellets can be used to reinforce rodent behaviour, the use of liquid reinforcement in mice is of particular benefit, as it minimises the impact of potential confounds such as dry mouth or an inability to chew solid reinforcers [ 3 ] which can occur in genetically modified models. (biomedcentral.com)
  • In Flowers for Algernon , Charlie Gordon realizes what his fate will be when he sees the fate of the mouse (Algernon) which underwent the medical procedure that he underwent. (vt.edu)
  • We identified factors that affect the average litter size in a cross by estimating the overall contribution of parent-of-origin, heterosis, inbred, and epistatic effects using a Bayesian zero-truncated overdispersed Poisson mixed model. (rxivist.org)
  • To do this, they were using the mouse as a human model. (vt.edu)
  • Mice came to be a staple model animal because of one researcher, Little, who bred a strain of inbred "oncomice" and because of the American anti-cancer movement. (vt.edu)
  • The tests, which compared behaviours between two inbred strains of mice, were repeated in four different model laboratories that varied in details such as background noise, the age of the mice, environmental enrichment, familiarity with handler, lighting levels and cage size. (drugdiscoveryopinion.com)
  • We also facilitate the informed selection and use of mouse models by highlighting the impact that genetic background has on key cancer characteristics, including cancer susceptibility, the spectrum of tumor types and frequencies observed in a model, age of tumor onset/detection, and metastatic potential. (jax.org)
  • Through selective inbreeding they created the first rat to serve as a model organism used in biological and medical research. (criver.com)
  • It has also provided new data on the effects of genetic background on individual and group behaviour which could influence the further interpretation of studies using these mice. (nc3rs.org.uk)
  • It is fundamental to making mouse models of human cancer and their associated data Findable, Accessible, Interoperable, and Reusable (FAIR). (jax.org)
  • This analysis adds to our understanding of factors that influence litter size in mammals, and also helps to explain breeding successes and failures in the extinct lines and surviving CC strains. (rxivist.org)
  • Image: Flickr - Andresmoschini A year ago, when researchers at Purdue University argued that environmental standardisation in laboratory experiments involving mice was likely to lead to more, rather than less, variation between different laboratories, they met with some resistance since it was not clear what factors should be varied to improve reproducibility. (drugdiscoveryopinion.com)
  • Mice of the same strain would have been expected to show the same behaviours in each laboratory but, in 33 out of 36 behavioural characteristics such as fear and curiosity, the standardised group showed as much as five times more variation between laboratories compared with the heterogenised group. (drugdiscoveryopinion.com)
  • Purpose]To clarify the mechanism the heterogeneity in the response to ionizing irradiation arising from a genetic variation between individual humans, we here investigated the irradiated skin reaction of mice fractionated irradiation with comparison of the results after single dose irradiation setting. (go.jp)
  • The researchers believe that tests in mice using a heterogeneous test design more closely resemble human clinical trials and should reduce both the number of animals needed for preclinical studies and the number of false positives. (drugdiscoveryopinion.com)
  • In this study, mice on a high-fat, high-sugar diet were treated with aerobic exercise or returned to a normal diet. (vanderbilt.edu)
  • Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice. (ac.ir)
  • Mechanisms of rapid adaptation to hypnotic effects of ethanol in mice : a pharmacogene. (ohsu.edu)
  • Within the parental effects, the effect of the dam's strain explained more than the sire's strain (13.2% vs. 1.8%), and the dam's strain effects account for 74.2% of total variation explained. (rxivist.org)
  • Apparently this puts a strain on the local working girls, so they jet in a substantial contingent from Reno and the Bay Area. (rapeutation.com)
  • Sociability is defined as the tendency of the experimental mouse to spend more time exploring an unfamiliar mouse than exploring an object or an empty chamber. (bio-protocol.org)
  • 3. Peak skin reaction score was exhibited dose dependency, although fractionated irradiation groups was low compared with single dose groups, the strain difference was not observed in each irradiation group. (go.jp)
  • Whilst theyll both deter wasp issues, underfloor entrances have access benefits in not restricting traffic flow(and easy flight access for all those alnost made it home foragers), mouse defence and where in the hive the bee enters( close to the center of activity, so nearer to where forage is most needed). (beekeepingforum.co.uk)
  • Restoration of GDF11 reverses cardiovascular aging in old mice and leads to muscle and brain rejuvenation, a discovery that was listed as one of the top 10 breakthroughs in science in 2014. (usg.edu)
  • In particular, peak skin reaction score in latent periods and low dose observed strain difference. (go.jp)