Expression of the variant CD23 chain interferes with trimerisation of the receptor and has a dominant-negative effect leading to reduced IgE binding in crosses between NZB and other strains. (ox.ac.uk)
B14-2-14 is a monoclonal cytotoxic IgM antibody which reacts with thymocytes of all mouse strains tested. (jax.org)
One of the first INBRED MOUSE STRAINS to be sequenced. (uchicago.edu)
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
Highly susceptible mouse strains such as SJL/N, A.SW, B10.S (H-2 s ) develop multiple autoimmune manifestations after exposure to inorganic mercury, including lymphoproliferation, elevated levels of autoantibodies, overproduction of IgG and IgE, and circulating immune complexes in kidney and vasculature. (biomedcentral.com)
One of the most common strains in mouse modeling is C57BL/6. (biomedcentral.com)
C57BL10
Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)
C57BL/6 lymph node cells were incubated simultaneously with FITC Mouse Anti-Mouse Vβ 5.1, 5.2 T-Cell Receptor (Cat. (bdbiosciences.com)
Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment. (uni-bielefeld.de)
To determine if the phenotype of rTg4510 mice was similarly affected by the introduction of the C57BL/6 background, we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) background, herein termed rTg4510 B6 . (biomedcentral.com)
Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. (biomedcentral.com)
These studies support the use of the rTg4510 mouse model on a partial C57BL/6 strain background without losing fidelity of the phenotype and suggest that the C57BL/6 background does not inherently protect against tauopathy. (biomedcentral.com)
To test the hypothesis that crossing rTg4510 mice to a C57BL/6 strain background is protective against tauopathy, we have compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 on an F1 FVB/N x C57BL/6NTac background (rTg4510 B6 ) (Figure 1 ). (biomedcentral.com)
Breeding scheme used to produce rTg4510 mice on an F1 FVB/N x C57BL/6 (FVB/B6) strain background (rTg4510 B6 ) (Left) compared to the original rT4510 mice on an F1 FVB/N x 129S6 (FVB/129) strain background (Right). (biomedcentral.com)
Similarly, CD47 −/− C57BL/6 mice were much more sensitive than their wild-type counterparts to experimental passive AIHA induced by anti-RBC monoclonal antibodies. (ashpublications.org)
An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH . (nih.gov)
Phosphorylation1
Despite a small, but significant increase in soluble human tau levels, young rTg4510 B6 mice had equivalent levels of tau phosphorylation, aggregation and cognitive impairments as age-matched rTg4510 mice. (biomedcentral.com)
Receptors1
Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. (ouhsc.edu)
Humans1
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)
Chromosome6
Studies of consomic mice bearing the Y chromosome of the BXSB mouse. (aai.org)
Previous studies have demonstrated that the Y chromosome of the BXSB mouse can lead to accelerated autoimmunity in inbred BXSB mice and in F1 hybrids. (aai.org)
To additionally study the effects of the BXSB-Y, we have studied three sets of Y-consomic mice, NZB.BXSB-Y, NZW.BXSB-Y, and CBA/J.BXSB-Y, each consisting of background genes from the non-BXSB parent and the Y chromosome from the BXSB mouse. (aai.org)
Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11. (uni-bielefeld.de)
Transgenic5
This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. (biomedcentral.com)
Non-transgenic (NT) littermates of rTg4510 B6 (NT B6 ) mice also had greater amounts of cortical and hippocampal phospho-tau at 10.5 months of age when compared to NT littermates of rTg4510 mice. (biomedcentral.com)
Numerous transgenic mice expressing wild-type or mutant human tau have been created to model the neuropathology of tauopathies-a group of neurodegenerative diseases characterized by the accumulation of tau protein aggregates. (biomedcentral.com)
The strain background of transgenic mice can also alter disease progression and presentation. (biomedcentral.com)
Congenic1
Using congenic mice, we have determined that genes on Chrs. (dyslexialab.net)
Spontaneously1
We show here that virtually all CD47-deficient nonobese diabetic (NOD) mice spontaneously develop severe lethal autoimmune hemolytic anemia (AIHA) at 180 to 280 days of age, whereas none of the control CD47 + NOD mice develop lethal AIHA at least during the first year of life. (ashpublications.org)
Susceptible2
Using knock-out and B-cell-conditional knock-out murine models, we identify Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses and makes the mice more susceptible to anti-dsDNA production and renal lupus flare after stimulation with a Toll-like Receptor 9 agonist, CpG-DNA. (cnrs.fr)
Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. (jefferson.edu)
Nude1
In the periphery, the antigen is found on a few percent of lymph node and not on splenic T cells, and it is absent in nude mice. (jax.org)
Additionally1
Additionally, older rTg4510 B6 mice had gross forebrain neurodegeneration that was equivalent to age-matched rTg4510 mice. (biomedcentral.com)
Microbiota3
Gut microbiota modulates bleomycin-induced acute lung injury response in mice. (uchicago.edu)
Previously, using lupus-prone (SWR × NZB)F1 (SNF1) mice, we have shown that the intestinal immune system could play a role in the initiation and progression of disease in SLE, and depletion of gut microbiota produces more pronounced disease protection in females than in males. (bvsalud.org)
Furthermore, we observed that the disease protection achieved in female SNF1 mice upon depletion of gut microbiota correlates with the diminished gut inflammatory protein levels, intestinal permeability and circulating microbial DNA levels. (bvsalud.org)
Model4
Here, we show that Carabin is low in B cells of (NZB × NZW) F1 mice (murine SLE model) long before the disease onset, and is low in B cells of lupus patients during the inactive phases of the disease. (cnrs.fr)
Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. (ouhsc.edu)
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)
We sought to determine if changing the strain background of a commonly used mouse model of tauopathy (rTg4510) would significantly impact the originally reported phenotype. (biomedcentral.com)
Gene4
Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
These gene loci are deleted in mice having the a (e.g. (bdbiosciences.com)
Spinal muscular atrophy gene wobbler of the mouse: evidence from chimeric spinal cord and testis for cell-autonomous function. (uni-bielefeld.de)
Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. (uni-bielefeld.de)
Genes1
Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. (uni-bielefeld.de)
Responses1
The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness. (ox.ac.uk)
Results2
These results suggest that NZB mice or mice carrying the variant allele will be useful models for studying both allergy and quantitative traits associated with atopy. (ox.ac.uk)
Neurotropin happens the disastrous able figures of NZB results. (fleamarketpost.com)
Previously reported1
In contrast, NZW.BXSB-Y males had accelerated renal and cardiac disease and early death, resembling that previously reported for (NZW X BXSB)F1 mice. (aai.org)
Natural1
The exaggerated IgE response provides an explanation for the natural resistance of NZB mice to parasitic infection by Leishmania. (ox.ac.uk)
Black2
Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. (ox.ac.uk)
In this report, we show that New Zealand black (NZB) mice express a variant CD23 allele, with mutations in both the C-lectin-binding domain and stalk region, which fails to bind IgE at high affinity and has reduced expression on the cell surface. (ox.ac.uk)
Levels1
Here, we show that the gut permeability features of lupus-prone female SNF1 mice at juvenile ages directly correlate with the expression levels of pro-inflammatory factors, faecal IgA abundance and nAg reactivity and the eventual systemic autoantibody levels and proteinuria onset. (bvsalud.org)
Effects of Depilatory Cream Formulation and Contact Time on Mouse Skin. (uchicago.edu)
Presence2
The presence of the BXSB-Y in all of the consomic mice was confirmed by crossing the consomic mice with BXSB females and demonstrating accelerated disease in the male offspring. (aai.org)
4 and 8 of the mouse modulate the presence of spontaneous malformations. (dyslexialab.net)
Cells1
Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. (uchicago.edu)
Year1
This graph shows the total number of publications written about "Mice, Inbred DBA" by people in this website by year, and whether "Mice, Inbred DBA" was a major or minor topic of these publications. (ouhsc.edu)
Factor1
Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice. (ouhsc.edu)
Models2
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)
Strain background changes can influence the phenotype of mouse models and can confound crossbreeding studies. (biomedcentral.com)
Original1
On the original F1 FVB/N x 129S6 background, rTg4510 mice present with progressive cognitive decline, increased insoluble tau, robust tau pathology and age-dependent neurodegeneration. (biomedcentral.com)
Control1
We found that the CBA/J.BXSB-Y mice showed few differences from control CBA/J males. (aai.org)
Analysis1
Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)
Background1
Here we compare the phenotypes of both young and old rTg4510 mice on each strain background. (biomedcentral.com)