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  • diabetes
  • The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions. (nih.gov)
  • In the NOD mouse, the incidence of type-1 diabetes is thought to be influenced by the degree of cleanliness of the mouse colony. (nih.gov)
  • A widely accepted extrapolation from this data has been the notion that NOD mice maintained under germ-free conditions have an increased incidence of diabetes. (nih.gov)
  • In this study, we demonstrate that the incidence of diabetes in female NOD mice remained unchanged under germ-free conditions. (nih.gov)
  • These findings challenge the view that germ-free NOD mice have increased diabetes incidence and demonstrate that modulation of intestinal microbiota can prevent the development of type-1 diabetes. (nih.gov)
  • We sought to determine the influence of intestinal microbiota on the incidence of type-1 diabetes in NOD mice. (nih.gov)
  • spontaneous
  • In one cohort of NOD mice (n = 22) housed in a separate isolator, a spontaneous contamination with a gram-positive aerobic spore-forming rod (that was subsequently typed as Bacillus cereus) was detected at week 16. (nih.gov)
  • xenograft model
  • We demonstrated that our MDA-MB-231 xenograft model shed CTCs into mouse circulation using a new technology that enabled viable human CTC capture from mouse blood (Talasaz et al, 2009). (nih.gov)
  • Here, we describe a novel human lung xenograft model in mice to study the pathogenesis of NiV. (nih.gov)
  • We also found that inhibition of AATBC resulted in cell proliferation arrest through G1 cell cycle mediated by cyclin D1, CDK4, p18 and phosphorylated Rb.Furthermore, JNK inhibitor SP600125 could attenuate the apoptotic effect achieved by AATBC knockdown, confirming the involvement of JNK signaling in the induced apoptosis.Moreover, mouse xenograft model revealed that knockdown of AATBC led to suppress tumorigenesis in vivo. (nih.gov)
  • Moreover, mouse xenograft model revealed that knockdown of AATBC led to suppress tumorigenesis in vivo. (nih.gov)
  • Major Histoco
  • A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. (nih.gov)
  • cohort
  • The infarcted ventricular wall was significantly thicker in the cohort receiving MSCs compared with control mice. (biomedsearch.com)
  • Assays
  • Purified splenocytes were analyzed using cytokine ELISpot assays or adoptively transferred into NOD-RAG−/− recipients. (nih.gov)
  • mutation
  • Prkdcscid is a loss-of-function mutation in the mouse homologue of the human PRKDC gene, which encodes a protein that resolves DNA strand breaks that occur during V(D)J recombination in developing T and B lymphocytes. (wikipedia.org)
  • The phenotypic penetrance of Prkdcscid varies among inbred strain backgrounds, but the mutation is most effective at eliminating adaptive immunity on the NOD genetic background. (wikipedia.org)
  • biomedical research
  • Mice have been used in biomedical research since the 16th Century when William Harvey used them for his studies on reproduction and blood circulation and Robert Hooke used them to investigate the biological consequences of an increase in air pressure. (wikipedia.org)
  • tend
  • Tail length varies according to the environmental temperature of the mouse during postnatal development, so mice living in colder regions tend to have shorter tails. (wikipedia.org)
  • Female
  • Anti-CD20 or control antibody treatment was initiated in 10-week-old NOD female mice typed to be IAA negative, with a subset also injected at 2-week intervals with a CD25-specific antibody to deplete Tregs. (nih.gov)
  • Citation
  • not in citation given] House mice have an adult body length (nose to base of tail) of 7.5-10 cm (3.0-3.9 in) and a tail length of 5-10 cm (2.0-3.9 in). (wikipedia.org)
  • citation needed] House mice primarily feed on plant matter, but are omnivorous. (wikipedia.org)
  • functional
  • While numerically increased, on a per cell basis, Treg functional activity in anti-CD20-treated NOD mice was equivalent to that in controls (Supplementary Fig. 4). (nih.gov)
  • In addition to the regular pea-sized thymus organ in the chest, house mice have a second functional pinhead-sized thymus organ in the neck next to the trachea. (wikipedia.org)
  • human
  • In addition, we offer manual annotation of a number of haplotype regions in mouse and human and regions of comparative interest in pig and dog that are unique to Vega. (zfin.org)
  • 90% of the human and mouse genomes are syntenic. (wikipedia.org)
  • 40% of both human and mouse genomes can be aligned at the nucleotide level. (wikipedia.org)
  • Male
  • Mice are territorial, and one dominant male usually lives together with several females and young. (wikipedia.org)
  • glucose
  • Urine glucose was measured every one or two weeks as shown and mice that had reached 4+ (55 mmol/L) were considered diabetic. (nih.gov)