• Adult rats (14 stocks and strains) and mice (more than 40 stocks and strains) were euthanized using a 50% volume per minute displacement rate of carbon dioxide for 2 min. (bvsalud.org)
  • However, relatively little information is available on humane aspects of anesthesia and euthanasia in neonatal mice and rats. (bvsalud.org)
  • The study demonstrates that CO may be a potential alternative for preweanling mice and rats at PND6 or older but is not appropriate for neonates at PND5 or younger. (bvsalud.org)
  • The current study was designed based on existing literature regarding minimal exposure times for preweanling rats and mice euthanized with carbon dioxide. (bvsalud.org)
  • The study evaluated the minimal time that adult rats and mice must remain in 100% carbon dioxide for death to be irreversible on removal. (bvsalud.org)
  • These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. (uams.edu)
  • Earlier studies have showed that the ethanolic extract of S. jollyanum increased libido and enhanced sexual behavior in male mice. (scialert.net)
  • The corneal epithelia of SOD-1-deficient mice or wild-type (WT) mice were removed after application of 0.15 N NaOH to establish the animal model of alkali burn. (nih.gov)
  • In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. (duke.edu)
  • A strain of mice widely studied as a model for cystic fibrosis. (uams.edu)
  • Mouse hepatocytes cultured on artificial 3D collagen-chitosan biopolymer matrices retained the expression of hepatocyte markers for 14 days. (sfu-kras.ru)
  • This study was designed to assess the effectiveness of carbon monoxide (CO) as an alternative euthanasia agent for mouse and rat pups on postnatal days (PND) 0 to 12. (bvsalud.org)
  • Changes in gene expression were detected utilizing Clontech Atlas mouse cDNA expression arrays. (wustl.edu)
  • Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from early embryonic tissues between E3.5 and E7.25 and in pluripotent cell lines to evaluate maintenance of imprinted gene expression. (biomedcentral.com)
  • Mouse strains also exhibit considerable variation in their response to ethyl carbamate and other carcinogens - (28), The spontaneous incidence of tumors of particular organs varies with the strain of animal used for the test. (nih.gov)
  • Male mice of many strains fight among themselves, causing skin wounds and deaths. (nih.gov)
  • The many literature references on tumors in various rat or mouse strains should be consulted (5, 7, 16, 21, 27). (nih.gov)
  • Sex There are appreciable differences in the response of male and female animals to some known carcinogens, Examples are the higher incidence of skin tumors in male mice after painting with 7, 12- dimethylbenz[aJanthracene and the greater number of liver tumors in male rats after feeding 2-diacetylaminofluorene. (nih.gov)
  • much larger doses of AFB: administered to weanlings or young adult mice did not induce liver tumors (25). (nih.gov)
  • Does the gender difference in interferon production seen in picornavirus-infected spleen cell cultures from ICR Swiss mice have any in vivo significance? (nih.gov)
  • A high incidence of pulmonary tumors in mice exposed to vinyl chloride has been reported by several investigators (10-15). (cdc.gov)
  • However, tumor incidence in an inbred strain may shift over a period of years. (nih.gov)
  • Although a 31 October 1981 number of studies have demonstrated that pulmo- nary tumors can be induced by vinyl chloride in mice, the significance of such occurrence and the nature of the tumors have not yet been appropri- ately explored (10-17). (cdc.gov)
  • Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice. (nih.gov)
  • Exposure of rats or mice to HCBD led to the formation of renal DNA adducts. (nih.gov)
  • Methods: Surgical injury was induced at E16 and E17 in ICR mouse embryos. (elsevierpure.com)
  • Conclusion: Decorin expression may contribute to scar formation in the late stage of mouse embryos by inhibiting the migration of dermal mesenchymal cells. (elsevierpure.com)
  • In this study, we evaluated the significance of this observation on the innate resistance of ICR Swiss females to EMCV-D-mediated disease. (nih.gov)
  • Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response. (cdc.gov)
  • In this study, we use signature-tagged transposon mutagenesis (STM) to conduct a screen for random insertion mutations that affect colonization in the suckling mouse model for cholera. (nih.gov)
  • Finally, our screen identified several novel genes, disruption of which also caused colonization defects in the mouse model. (nih.gov)
  • Notably, two EpiSC-NT lines show aberrant silencing of Rian and Meg3, two critically imprinted genes in mouse iPSCs. (biomedcentral.com)
  • Splenocyte cultures from female ICR Swiss mice produced greater interferon (IFN) levels, particularly IFN-gamma, than did cultures from males by 12 h post-infection (pi) with the D variant of encephalomyocarditis virus (EMCV-D). This early IFN-gamma is produced by natural killer (NK)-like cells and is dependent on plastic adherent cells and IFN-alpha/beta. (nih.gov)
  • With o-aminoazo- toluene, however, female mice were affected more than males. (nih.gov)
  • Although the genotype of the ESC-PGA cells is different from the female oocyte donor due to meiotic recombination occurring in the oocyte, subsequent matching of the ESC-PGAs based on the major histocompatibility complex antigens allows for engraftment of these cells in mouse recipients [ 10 ]. (biomedcentral.com)
  • Environmental Health Perspectives Vol. 41, pp. 31-52, 1981 Neoplastic and Nonneoplastic Effects of Vinyl Chloride in Mouse Lung by Yasunosuke Suzuki* Neoplastic effects of vinyl chloride were studied in lungs of 27 mice exposed to vinyl chloride monomer at 2500 and 6000 ppm for 5 and 6 months (large doses and long-term exposure). (cdc.gov)
  • The neoplastic effect of vinyl chloride of smaller doses (100, 10, 1 and 0 [control] ppm) and shorter exposure (four weeks) was studied in lungs of 120 mice. (cdc.gov)
  • Treatment of females with rabbit anti-mouse IFN-alpha/beta serum rendered them susceptible to the diabetogenicity of EMCV-D. Although sera from both sexes of ICR Swiss mice exhibited peak IFN levels day 3 pi, IFN-gamma was present in the sera of males at only 1 day pi and in the sera of females at days 1-3 pi. (nih.gov)
  • Antidiabetic effects of Cycas edentata aqueous leaf extract on the blood glucose levels of alloxan-induced diabetic ICR mice (Mus musculus L. (bibliomed.org)
  • An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER . (nih.gov)
  • As mouse ESCs are highly amenable to genetic manipulation and are capable of colonizing the germline of chimaeric mice [ 5 ], they are widely used for the generation of transgenic mice. (biomedcentral.com)
  • Sex hormone modulation of interferon (IFN) alpha/beta and gamma production by mouse spleen cell subsets following picornavirus infection. (nih.gov)
  • Studies performed in mice indicated that the peripheral pathogenicity of LBV had been underestimated in previous studies. (cdc.gov)
  • Dot1L mediated histone H3 lysine79 methylation is essential to meiosis progression in mouse oocytes. (nel.edu)
  • Wang X, Gao W, Ma X, Wang X, Song C, Huang X, Liu H. Dot1L mediated histone H3 lysine79 methylation is essential to meiosis progression in mouse oocytes. (nel.edu)