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  • C57Bl
  • Delivery of hCYP2D6 into wildtype FVB or C57BL/6 mice was by an Adenovirus construct (Ad-2D6) that ensures a direct delivery of the triggering antigen to the liver. (jove.com)
  • strains
  • Mice of the eight inbred strains differing in their susceptibility to radiation-induced pulmonary fibrosis, and in the duration of asymptomatic survival, received 18 Gy whole thorax irradiation and were killed 6 h, 24 h, or 7 days later. (physiology.org)
  • There is no rhyme or reason to the names given to the original inbred strains derived at the beginning of the century. (jax.org)
  • New inbred strains can be named freely by their originators as long as certain rules are followed: the name should be brief, and it should begin with a capital letter followed by other capital letters (preferably) or numbers. (jax.org)
  • The robust genetic system of recombinant congenic strains of mice enabled detection of a novel suggestive locus on chromosome 7. (biomedcentral.com)
  • genetic
  • High resolution genetic maps are often formed through the integration of results obtained in many individual studies, and as each new result is published, it can be swept up into a system of databases (see Appendix B ). Large-scale integration has been possible only because all mouse geneticists speak the same language. (jax.org)
  • For a complete description of the 'Rules and Guidelines for Gene Nomenclature,' one should consult the Lyon and Searle book ( Committee on Standardized Genetic Nomenclature for Mice, 1989 ), and updates published regularly in Mouse Genome . (jax.org)
  • Substrains can arise whenever two or more colonies of an established inbred strain are maintained in isolation from each other for a sufficient period of time to allow detectable genetic differences to become fixed. (jax.org)
  • There are three specific instances where substrain formation can be considered to have occurred: (1) when branches of an inbred strain are separated before the F 40 generation when residual heterozygosity is still likely, (2) when a branch has been maintained separately from other branches for 100 or more generations, and (3) when genetic differences from other branches are uncovered. (jax.org)
  • In humans, existing estimates of these quantities are based on comparisons between consanguineous and nonconsanguineous couples, an approach that confounds socioeconomic and genetic effects of inbreeding. (genetics.org)
  • gene transfer
  • SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice. (biomedsearch.com)
  • We have evaluated GL67A gene transfer to the murine nasal epithelium of wild-type and CF knockout mice to assess this tissue as a test site for gene transfer agents. (ox.ac.uk)
  • We then assessed whether CFTR gene transfer corrected a panel of CFTR-specific endpoint assays in the murine nose, including ion transport, periciliary liquid height, and ex vivo bacterial adherence. (ox.ac.uk)
  • embryonic
  • J:38383 Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL, Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. (jax.org)
  • J:63366 Kadison AS, Maldonado TS, Crisera CA, Longaker MT, Gittes GK, In vitro validation of duct differentiation in developing embryonic mouse pancreas. (jax.org)
  • mutant
  • Alteration of the intracellular fate of mutant CFTR by intervening the protein processing and/or proteolytic pathway has shown promise for treating CF but selective inhibition of proteostatsis demands the controlled release of optimal amounts of drug overtime. (biomedcentral.com)
  • In the first set of rules for distinguishing gene symbols laid down by the Committee on Mouse Genetics Nomenclature in 1940, it was stated that 'the initial letter of the mutant gene symbol shall be the same as the initial letter of the mutant gene, e.g. d for dilution. (jax.org)
  • He cited breeding experiments in nasturtium and Drosophila, in which a distinct, mutant phenotype is lost with successive outcrossings, and recovered with inbreeding of offspring. (wikipedia.org)
  • By outcrossing, he agued, the breeder selects for modifying factors that attenuate the mutant phenotype, and by inbreeding and limiting the gene pool of modifiers, the dominance of the mutation is recovered. (wikipedia.org)
  • murine
  • The efficacy of drug release in CF mice ( Cftr -/- ) lungs was determined by quantifying the changes in proteasomal activity (~2 fold decrease) and ability to rescue the Pseudomonas aeruginosa LPS ( Pa -LPS) induced inflammation, which demonstrates the rescue of CF lung disease in murine model. (biomedcentral.com)
  • linkage
  • These were genotyped in the F 2 hybrid mice and their linkage with survival was tested by binary trait interval mapping. (biomedcentral.com)
  • Okada, B. List of best forex trading platform example, the current human and mouse linkage maps contain more than 20,000 and 10,000 SSRs, respectively, and more than 4 million and 10,000 potential SNPs, respectively. (retzepti.ru)
  • infection
  • In response to C. rodentium infection, 5,123 probe sets were differentially expressed in one or both lines of mice. (biomedcentral.com)
  • Transcripts represented by 1,547 probe sets were differentially expressed between susceptible and resistant mice regardless of infection status, a host effect. (biomedcentral.com)
  • Twelve-week old FVB mice infected with C. rodentium developed a high degree of mortality and severe colitis compared with their outbred SW counterparts, which had more typical subclinical disease in response to infection. (biomedcentral.com)
  • populations
  • Haldane showed that, contrary to Fisher's argument, despite a decreased intensity of selection for dominance in self-fertilized populations, dominance is often more common in inbred than in outbred plant species. (wikipedia.org)
  • locus
  • In fact, the recent explosion in gene and locus identifications in the mouse has brought about a re-evaluation of the entire basis for the naming of chromosomal entities. (jax.org)
  • model
  • Therefore, we have developed a straightforward mouse model that uses the major human autoantigen in type 2 autoimmune hepatitis (AIH-2), namely hCYP2D6, as a trigger 6 . (jove.com)
  • Here we provide a detailed surgical procedure for the BDL model in mice that induce a highly reproducible fibrotic response in accordance to the 3R rule for animal welfare postulated by Russel and Burch in 1959. (jove.com)
  • function
  • Importantly, even with the comparatively large number of animals assessed, the CFTR function studies were only powered to detect changes of more than 50% toward wild-type values. (ox.ac.uk)
  • lung
  • Lung GPx activity, and GPx2 expression, predicted for survival from lethal pneumonitis, and serum GPx for fibrosis, in this panel of mice. (physiology.org)
  • recent
  • More recent research, however, has established that there is also an epigenetic contribution to heterozygote advantage, primarily as determined in plants, though also reported in mice. (wikipedia.org)
  • For one, the estimate relies heavily on accurate assessments of degrees of relatedness, and yet the F values estimated from recent pedigrees do not capture inbreeding among more distant ancestors. (genetics.org)