• Abstract -We have investigated the effect of most common oils used in human nutrition on the development of atherosclerosis in apoE-knockout mice. (ahajournals.org)
  • They're an inbred variety of mice raised in laboratories to be used as research specimens for studying behavioral patterns, genetic inheritance, chronic illnesses, and immunology. (giantmicrobes.com)
  • Responses were compared with those in mice deficient in the cold/menthol receptor, TRPM8, expressed in trigeminal sensory neurons innervating the oral cavity. (bmj.com)
  • In a transgenic mouse model of measles virus (MV) infection of neurons, we have previously shown that the host T-cell response was required for resolution of infection in susceptible adult mice. (asm.org)
  • To study the physiological functions of Gbp family members, the most commonly chosen in vivo models are mice harbouring loss-of-function mutations in either individual Gbp genes or the entire Gbp gene cluster on mouse chromosome 3. (crick.ac.uk)
  • Here, we compare findings from two large genetic crosses between mouse strains C3H/HeJ and C57BL/6J to evaluate the reliability of distal eQTL detection, including "hotspots" influencing the expression of multiple genes in trans . (genetics.org)
  • 6 ] have employed gene expression array analysis of the dissected embryonic (16.5d) mouse cerebral cortex to expand the list of genes regionally expressed, and noted that regional differences in expression of genes in the cortical plate should eventually convert into functionally distinct cortical areas with anatomically distinguishable borders after birth. (beds.ac.uk)
  • Genetic engineering of the mouse genome identified many genes that are essential for embryogenesis. (pnas.org)
  • RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. (bioportfolio.com)
  • of these, 11 were expressed in the skin (5 epidermic cytokeratin and 6 hard keratin genes), but none were mutated in hague mice. (genetics.org)
  • One possible approach to the understanding of the molecular events involved in the development and cyclic life of these tiny organs might be to generate knockout mice for the genes that are known to be expressed in the hair follicle ( Y amanishi 1998 ) and then to observe carefully the consequences, if any, of these engineered mutations. (genetics.org)
  • Another approach is to identify at the molecular level, by positional cloning, the genes that are affected in the many mouse hair mutations available. (genetics.org)
  • The positional cloning of mutant alleles, even if it requires the breeding of a large quantity of mice, is more general and results in many instances in the identification of previously unknown genes. (genetics.org)
  • Remarkable advances in molecular genetics have provided powerful tools to investigate the relationships between genes and behaviors in mice. (frontiersin.org)
  • However, the phenotypes of mutant mice are strongly influenced by genetic background, including flanking alleles, as well as the targeted genes. (frontiersin.org)
  • To investigate the roles of the Period genes in photic entrainment, we constructed phase response curves (PRC) to light pulses for C57BL/6J wild-type, Per1 −/− , Per2 −/− , and Per3 −/− mice and tested whether the PRCs accurately predict entrainment to non-24 light-dark cycles (T-cycles) and constant light (LL). (jneurosci.org)
  • To understand the roles of the Per genes in the entrainment mechanism, we obtained complete PRCs to light pulses from C57BL/6J Per mutant mice. (jneurosci.org)
  • Here, we utilized an integrated approach of mRNA-seq and miRNA-seq to investigate the transcriptome expression and regulation of host genes in C57BL/6J and DBA/2J mouse strains during influenza virus infection. (springer.com)
  • With the introduction of temporal expression pattern analysis, we demonstrated that host factors responsible for influenza virus replication and host-virus interaction were significantly enriched in genes exhibiting distinct temporal dynamics between different inbred mouse lines. (springer.com)
  • Supplementary Fig. S2 showed the differential expression levels (log2-fold change) of 10 interferon-stimulated genes between infected and mock-treated mice at day 3. (springer.com)
  • Supplementary Fig. S3 showed the characteristics of genes differentially expressed between C57BL/6J and DBA/2J over time. (springer.com)
  • A) Heatmap of genes differentially expressed between strains (strain-specific DEGs) showed distinct expression patterns between C57BL/6J and DBA/2J mice. (springer.com)
  • Expression array analysis was performed on endothelial cell RNA isolated from control and hyperlipidemic prelesion mouse aortas, and 797 differentially expressed genes were identified. (ahajournals.org)
  • We further find that the higher expression of Gbp2b mRNA in 129/Sv mice correlates with a gene duplication event at the Gbp2b locus resulting in two copies of the Gbp2b gene on the haploid genome of the 129/Sv strain. (crick.ac.uk)
  • Mouse Genome Database, Group (4 January 2016). (wikipedia.org)
  • Mouse Genome Informatics website, The Jackson Laboratory. (wikipedia.org)
  • The inbred mouse C57BL/6J is the reference strain for genome sequence and for most behavioral and physiological phenotypes. (sciencemag.org)
  • FK506 protects heart function via increasing autophagy after myocardial infarction in mice. (nextbio.com)
  • The present data suggest that many of the previously documented neurosteroid-induced behavioral differences between the DBA/2J and C57BL/6J are acute effects and are not apparent in a drug discrimination procedure. (aspetjournals.org)
  • therefore, one goal of this report was to find out if such differences occurred in mice of the C57Bl/6J inbred strain. (elsevier.es)
  • Conclusions: Our findings demonstrate functional differences between 129 and C57BL/6 Gbp alleles which need to be considered in the design and interpretation of studies utilizing mouse models, particularly for phenotypes influenced by Gbp2 or Gbp2b expression. (crick.ac.uk)
  • Strain differences were also apparent in that the number of worms required by C57BL/6 mice to establish the same level of protection as CBA/J mice was double that needed by CBA/J mice. (ajtmh.org)
  • Circadian rhythms of locomotion (wheel-running activity) in 12 inbred mouse strains were recorded for interstrain differences in tau DD, the endogenous (free-running) period of the circadian pacemaker measured in constant environmental darkness. (umassmed.edu)
  • Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. (beds.ac.uk)
  • Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. (beds.ac.uk)
  • PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. (jax.org)
  • Our results show a divergence of behavioral performance in C57BL/6 substrains, which suggest that small genetic differences may have a great influence on behavioral phenotypes. (frontiersin.org)
  • p. 1508 ) have detected differences in cocaine response between the widely used C57BL/6N and C57BL/6J mouse strains and used quantitative trait locus analysis to identify a mutation in an inducible gene, Cyfip , that interacts with the Fragile X protein (FMRP) to regulate sensitivity and sensitization to cocaine through regulation of neuronal connectivity. (sciencemag.org)
  • Phenotypic differences between mice lacking GIRK1, GIRK2 and GIRK3 correlate well with the known impact of GIRK subunit ablation on neurotransmitter-gated GIRK currents, arguing that most neuronal GIRK channels contain GIRK1 and/or GIRK2. (wiley.com)
  • Genetically engineered mice can be considered a coisogenic strain if the only difference between the engineered mouse and a wild-type mouse is a specific locus. (wikipedia.org)
  • The rise of genetically engineered mouse models of pancreatitis: A review of literature. (bioportfolio.com)
  • Of the many inbred strains, C57BL/6 is the most commonly used background strain for genetically engineered mice. (frontiersin.org)
  • These conclusions were reached on the basis of a series of elegant experiments using mice genetically engineered to lack either major histocompatibility complex (MHC) class I or class II molecules, or mice lacking CD4 + or CD8 + T cells (4-11). (scielo.br)
  • The GEM Collection's nearly 300 lines provide academic and nonprofit researchers worldwide with unparalleled access to a wide range of genetically engineered mouse models . (taconic.com)
  • Examination of CXB recombinant inbred strains provided no support for the hypothesis of monogenic inheritance. (umassmed.edu)
  • 5,6 Moreover, endothelial responses to OxLDL cosegregate with the size of atherosclerotic lesions, as observed in a set of recombinant inbred strains derived from strains B6 and C3H. (ahajournals.org)
  • Inhibitory receptors specific for MHC class I molecules have been identified in mice and humans. (pnas.org)
  • and the mouse and human CD94/NKG2 receptors are specific for Qa1 b or HLA-E, respectively (reviewed in refs. (pnas.org)
  • In humans and mice alike, GBPs restrict the intracellular replication of invasive microbes and promote inflammation. (crick.ac.uk)
  • Acute exercise induces FGF21 expression in mice and in healthy humans. (mendeley.com)
  • Coisogenic strains are one type of inbred strain that differs by a mutation at a single locus and all of the other loci are identical. (wikipedia.org)
  • Coisogenic strains may also occur through a spontaneous mutation that occurs in an inbred strain. (wikipedia.org)
  • To create a coisogenic strain through breeding, a mouse with the specific mutation on a locus is mated to an inbred strain (e.g. (wikipedia.org)
  • The offspring of the mutated mouse with the inbred strain has a 50% chance of carrying the mutation. (wikipedia.org)
  • However, if the specific mutation cannot be passed on, heterozygous animals should be used to breed with the original inbred strain. (wikipedia.org)
  • A spontaneous mouse hair mutation was identified in a C3H/HeN colony. (genetics.org)
  • In this article we describe a new mutation affecting the fur that was found segregating in the C3H/HeN inbred strain of mouse. (genetics.org)
  • A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. (bioportfolio.com)
  • Mice with a targeted mutation in the pro-opiomelanocortin (Pomc) gene (Pomctm1/tm1 mice) are unable to synthesize desacetyl-α-MSH and α-MSH and they develop obesity when fed chow diet. (auckland.ac.nz)
  • The goal of this RFA is to improve the efficiency of germline transmission of C57BL/6 ES lines to an extent that permits the use of C57BL/6 ES cell for high throughput gene targeting and the efficient production of C57BL/6 mice carrying a null mutation. (nih.gov)
  • One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it's commonly used as the genetic background for transgenic mouse models. (taconic.com)
  • These results provide a comprehensive look at pregnanolone's discriminative stimulus effects in two commonly used strains of mice. (aspetjournals.org)
  • This strain is commonly used as genetic background for transgenic mouse models. (bioportfolio.com)
  • Here, we compared robustness between cohorts of isogenic mice of eight different commonly used strains by analyzing to what extent environmental variation contributed to individuality in each of the eight genotypes, using a previously published dataset. (deepdyve.com)
  • Twelve male and female DBA/2J mice and 12 male and female C57BL/6J mice were trained to discriminate 10 mg/kg pregnanolone from saline. (aspetjournals.org)
  • The male C57BL/6J mice had to be removed from the study due to increased seizures apparently associated with the chronic intermittent pregnanolone administration used in drug discrimination. (aspetjournals.org)
  • Male and female mice of the C57Bl/6J strain were purchased from Harlan Iberica (Barcelona, Spain). (elsevier.es)
  • Seven C57Bl/6J females were mated with three C57Bl/6J males according to this distribution: one male with two females, another male with two other females, and another male with the remaining three females: the offspring were the subjects of this experiment. (elsevier.es)
  • In an ongoing quantitative trait locus (QTL) mapping study designed to reveal genomic loci showing genetic linkage to HP sensitivity, a putative QTL on chromosome 4 (50-80 cM from the centromere) has been identified that appears to account for variability in this trait in male, but not female mice. (elsevier.com)
  • The C57BL/6J was developed by Little in 1921, after crossing the female N.57 with the male N.52, and is the most widely used inbred strain. (frontiersin.org)
  • Male and female mice were 79.9 ± 35.4 d old (mean ± SD) at the beginning of the experiments (the number and sex of mice used for each experiment is provided in the supplemental material, available at www.jneurosci.org ). (jneurosci.org)
  • Male and female Pomcwt/wt and Pomctm1/tm1 mice were fed low-fat (LF) (10 kcal percent fat) or HF (45 kcal percent fat) diets from weaning for 23 weeks. (auckland.ac.nz)
  • Male Pomctm1/tm1 mice develop obesity because they are hyperphagic compared with Pomcwt/wt mice when fed an LF or HF diet. (auckland.ac.nz)
  • A chronic HF diet exacerbates male Pomctm1/tm1 and Pomcwt/wt mouse obesity, and the increased energy intake fully accounts for increased weight gain. (auckland.ac.nz)
  • Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis. (semanticscholar.org)
  • We demonstrate that adult Loa loa worms in subcutaneous tissues, circulating microfilariae (mf) and presence of filarial biomarkers in sera occur following experimental infections of lymphopenic mice deficient in interleukin (IL)-2/7 gamma-chain signaling. (bioportfolio.com)
  • Conserved Bacterial-Binding Peptides of the Scavenger-Like Human Lymphocyte Receptor CD6 Protect From Mouse Experimental Sepsis. (nih.gov)
  • Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease. (plos.org)
  • Thus, resistant C57BL/6 mice infected with L. major develop a TH1 response resulting in gamma interferon (IFN-γ) production, macrophage activation, parasite killing, and resolution of the experimental lesion ( 19 , 36 , 55 ). (asm.org)
  • identified a single genetic locus (Ahl) that could explain the early presbycusis observed in the inbred C57BL/6J mouse strain. (cdc.gov)
  • In the congenic C57BL/6J strain, the Ahl locus has been replaced by the wild-type locus from the inbred CBA/CaJ strain (strain B6.CBA). (cdc.gov)
  • This would be expected based on the fact that the congenic CBA.B6 mice genotypes included the mutant Ahl locus. (cdc.gov)
  • The Mia3 locus from the perspective of both the B6Eve assembly (top) and the GRCm38 mouse reference (bottom). (g3journal.org)
  • Individual Gbp deletion strains differ in their design, as some strains exist on a pure C57BL/6 genetic background, while other strains contain a 129-derived genetic interval encompassing the Gbp gene cluster on an otherwise C57BL/6 genetic background. (crick.ac.uk)
  • These data support the possibility that Oprd1 is a QTL mediating HP sensitivity in mice, and more generally illustrate the important roles of genetic background and gender in the perception of pain. (elsevier.com)
  • The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. (jax.org)
  • The B6- Krt2 SEG strain (lab code IRCS 119), an interspecific recombinant congenic strain homozygous for the chromosomal segment spanning the interval D15Mit41 to D15Mit16 and containing the keratin-2 ( Krt2 ) complex from strain SEG/Pas ( Mus spretus ) in a C57BL/6 genetic background was obtained from Xavier Montagutelli, Institut Pasteur (Paris). (genetics.org)
  • However, an issue of C57BL/6 substrains that is not always appreciated is that behaviors are known to be strongly influenced by genetic background. (frontiersin.org)
  • Lin Z, Edenberg H, Carr L. A novel negative element in the promoter of the mouse alcohol dehydrogenase gene Adh-1. (labome.org)
  • FGF21 gene expression was induced in the liver but not in skeletal muscle and white adipose tissue of mice after acute exercise, and further, the gene expression levels of hepatic peroxisome proliferator-activated receptor α (PPARα) and activating transcription factor 4 (ATF4) were also increased. (mendeley.com)
  • Although no murine MIC molecules have been found, the mouse orthologs of ULBP are likely to be the retinoic acid early inducible-1 gene products (RAE-1) and the related H60 minor histocompatibility antigen ( 22 , 23 ). (pnas.org)
  • We have disrupted the murine Hjv gene and shown that Hjv -/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages. (jci.org)
  • Thus, targeted disruption of the IFN- g gene in C57BL/6 mice causes these animals, which are otherwise resistant to infection with L. major , to become highly susceptible to these organisms (15,16). (scielo.br)
  • We suggest that the inbred mice model presents an opportunity for researchers to investigate the genetic, and gene-environmental influence on the development of digit ratios. (jove.com)
  • Applicants for this RFA must have a proven track record of producing or developing existing ES lines, preferably from C57BL/6 mice, and have themselves or their collaborators used such lines to create mutant germline competent ES cells by targeted, gene trap or transposon mutagenesis. (nih.gov)
  • Objective- Endothelial cells are central to the initiation of atherosclerosis, yet there has been limited success in studying their gene expression in the mouse aorta. (ahajournals.org)
  • In this study, we report the effect of the most common oils used in human nutrition, provided in diets of low cholesterol content, on the development of atherosclerotic lesions and the regulation of apoA-I gene expression in the apoE-deficient mice. (ahajournals.org)
  • In contrast to 36 other standard inbred strains, it carries a Y chromosome of Asian Mus musculus origin (c.f. (jax.org)
  • Origin: see C57BL/6. (jax.org)
  • 9. The medium according to claim 1, wherein said serum albumin, transferrin and growth factors are each of human, mouse or bovine origin. (google.com)
  • Origin of the inbred strain C57BL/6J. (g3journal.org)
  • Methods: To determine whether the presence of 129 alleles of paralogous Gbps could influence the phenotypes of 129-congenic Gbp-deficient strains, we studied the expression of Gbps in both C57BL/6J and 129/Sv mice following in vivo stimulation with adjuvants and after infection with either Toxoplasma gondii or Shigella flexneri. (crick.ac.uk)
  • Congenic strains of C57BL/10 mice [B10.A, B10.BR, B10.D2, B10.A(2R), B10.A(5R), B110.A(15R), B10.A(1R), B10.A(18R), and B10.OL] have an incidence of clinical microphthalmia ranging from 0.8 to 9.2% (Pierro and Spiggle, 1967). (jax.org)
  • Recently, Johnson has developed two relevant congenic mouse strains. (cdc.gov)
  • This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous inbred C57BL/6J and CBA/CaJ data. (cdc.gov)
  • Most lines are congenic with the C57BL/6NTac inbred background. (taconic.com)
  • Mice (strain C57bl/6J) were kept anesthetized by a spontaneous inhalation of isoflurane. (diva-portal.org)
  • On the C57BL/6J background hippocampal hyperexcitability was observed and cortical and hippocampal spontaneous nonconvulsive seizures. (alzforum.org)
  • Interestingly, naive LAX −/− mice had spontaneous germinal center formation. (jimmunol.org)
  • Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. (nih.gov)
  • The Brodkin laboratory studies the neurobiology and genomics of social behavior development in mouse models relevant to autism. (upenn.edu)
  • Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (upenn.edu)
  • Mice were evaluated with respect to open-field motor activity and habituation, anxiety-related behavior, motor co-ordination and ataxia and operant performance. (wiley.com)
  • GIRK2 −/− mice, and to a lesser extent GIRK1 −/− mice, also displayed reduced anxiety-related behavior in the elevated plus maze. (wiley.com)
  • Within-session progressive ratio scheduling, however, showed elevated lever press behavior in GIRK2 −/− mice and, to a lesser extent, in GIRK1 −/− mice. (wiley.com)
  • C57BL is probably the most widely used of all inbred strains, (substrain C57BL/6 alone accounts for over 14% of occasions on which an inbred strain is used) though in many ways it seems to be atypical of inbred strains of laboratory mice. (jax.org)
  • This substrain is now probably the most widely used of all inbred strains. (jax.org)
  • However, the International Knockout Mouse Consortium uses an embryonic stem cell line derived from a related C57BL/6N substrain. (sciencemag.org)
  • Several strains of inbred black mice, originally derived by W.L. Russell of The Jackson Laboratory in 1921, were designated as C57 Black (C57BL) after approximately the thirty-second generation of inbreeding. (jax.org)
  • Several studies support this notion, including reports on decreased production of inhibitory T helper type 2 (Th2) cells and inhibitory cytokines in the NOD mouse ( 18 - 20 ), hyporesponsiveness of T cells to T cell receptor (TCR) ligation ( 21 ), and impaired expression of CTLA4 upon TCR ligation ( 22 ). (diabetesjournals.org)
  • Noncytolytic viral clearance is not restricted to the CNS: in a transgenic mouse model of hepatitis B virus infection of the liver, cytokines were also shown to be crucial for reduction of viral load ( 14 , 15 ). (asm.org)
  • Taconic Biosciences has recently added an additional 75 mouse models to the GEM Collection Repository. (taconic.com)
  • Mouse models of chronic heart failure (HF) have been widely used in HF research. (bioportfolio.com)
  • C57BL/6 inbred strains of mice are widely used in knockout and transgenic research. (frontiersin.org)
  • C57BL/6J is a widely-used inbred strain of mouse. (jax.org)
  • Out of over 3,000 varieties of lab mice, the breed of black mice known as C57BL/6 is the most well-known and widely used animal models in research. (giantmicrobes.com)
  • The nonobese diabetic (NOD) mouse is a widely used murine model for the autoimmune disorder underlying human type 1 diabetes. (diabetesjournals.org)
  • A probe designated B6-38 to the pseudoautosomal region of the X and Y chromosome has a characteristic Pst I pattern of fragment sizes which is present only in the C57BL family of strains ( Kalcheva et al, 1995 ). (jax.org)
  • 3 ApoE-deficient mice develop severe hypercholesterolemia and atherosclerosis on a regular low-fat/low-cholesterol diet. (ahajournals.org)
  • Due to the above described properties, apoE-knockout mice are excellent animal models for evaluating the influence of pharmacological and nutritional agents on atherosclerosis development. (ahajournals.org)
  • Variations of physiological variables (weight, course of infection, stress response) in inbred animals have also been reported ( Gärtner, 2012 ). (elsevier.es)
  • Genetics of resistance to infection with Salmonella typhimurium in mice. (semanticscholar.org)
  • Those C57BL/6 mice which lived until a chronic state of infection were rarely well protected and harbored few female worms. (ajtmh.org)
  • infection model is also achievable, utilizing immune-competent or -deficient mice infused with purified Loa mf. (bioportfolio.com)
  • Mice were culled on day 7 after infection and blood and spleen cell phenotype and activation were evaluated. (hindawi.com)
  • Studying differential responses of inbred mouse lines with distinct genetic backgrounds to influenza virus infection could substantially increase our understanding of the contributory roles of host genetic factors to disease severity. (springer.com)
  • Overall, a comprehensive framework for analyzing host susceptibilities to influenza infection was established by integrating mRNA-seq and miRNA-seq data of inbred mouse lines. (springer.com)
  • Previous studies have demonstrated that the immune response plays an important role in protection against infection with Trypanosoma cruzi in mice 6 10 15 . (scielo.br)
  • C57BL/6, CBA/J, C3H, B10D2) are resistant to infection with Leishmania major . (scielo.br)
  • These mice fail to control the infection and develop extensive lesions. (scielo.br)
  • Upon infection with L. major , mice of the resistant phenotype clearly develop a dominant Th1 phenotype of immune response to the parasite's antigens. (scielo.br)
  • Moreover, IL-4 transgenic resistant mice expressing low levels of this cytokine fail to clear the infection (17,18). (scielo.br)
  • When susceptible mice were intercrossed with specific immune knockout mice, a critical role for gamma interferon (IFN-γ) was identified in protection against MV infection and CNS disease. (asm.org)
  • However, in each of these model systems, either the immune response must be adoptively transferred into persistently infected or otherwise tolerant mice, or the infection occurs in multiple cell types in which different clearance mechanisms may be operative ( 5 , 12 , 27 ). (asm.org)
  • C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo. (crick.ac.uk)
  • When using the C57BL/6By mouse strain in a publication, please include JAX stock #000663 in your Materials and Methods section. (jax.org)
  • For example, Krubitzer and Kahn [ 1 ] review that the mouse, ghost bat, and short-tailed opossum have approximately the same size cortical sheet, but differ substantially in the size of one of three primary sensory cortical areas. (beds.ac.uk)
  • Three inbred strains (C57BL/1O, DBA/1, and Bulb/c) differ with regard to this asymmetry. (sciencemag.org)
  • Together, these show that genetically inbred mouse strains consistently differ in phenotypic robustness against environmental variation, suggesting that genetic factors contribute to variation in robustness. (deepdyve.com)
  • thus, in the present study, we performed aorta transplantation to determine atherosclerotic lesion formation of aortic grafts from B6 and C3H mice in their F1 hybrids. (ahajournals.org)
  • Homozygous apoE-knockout mice, hybrids of C57BL/6J and 129 Ola strains, were progeny of those described by Piedrahita et al 15 and bred in The Unidad Mixta de Investigación, Zaragoza, Spain. (ahajournals.org)
  • Notably, Toxoplasma infections induce robust Gbp2b protein expression in both strains of mice, suggestive of a Toxoplasma-activated mechanism driving Gbp2b protein translation. (crick.ac.uk)
  • The evidence presented shows that LT kills mice through a TNF-α-independent, FasL-independent, noninflammatory mechanism that involves hypoxic tissue injury but does not require macrophage sensitivity to toxin. (jci.org)
  • The data revealed that although the pattern by which C57BL/6 mice developed maximum granuloma formation and subsequent modulation was identical to that observed in CBA/J mice, C57BL/6 granulomas were consistently half the volume of their counterpart lesions in CBA/J mice. (ajtmh.org)
  • Eye lesions in C57BL/6J mouse. (jax.org)
  • Although the aorta transplantation procedure is used primarily to study long-term graft rejection, it also is used to investigate the progression or regression of atherosclerotic lesions in apoE −/− mice. (ahajournals.org)
  • The investigator must recognize that the described ophthalmic abnormalities represent a background feature of inbred black mice in order to avoid incorrect interpretation of experiments that involve the eyes in these mice. (jax.org)
  • Various defects in the immune system of the NOD mouse have been reported, giving rise to the prevailing view that the predisposition of NOD mice to type 1 diabetes reflects abnormalities in peripheral tolerance mechanisms ( 3 , 17 ). (diabetesjournals.org)
  • The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY. (bioportfolio.com)
  • Behaviour differs from C57BL/10J. (jax.org)
  • In the Eμ-myc transgenic mouse model, single therapeutic vaccination of irradiated, α-GalCer-loaded autologous tumor cells was sufficient to significantly inhibit growth of established tumors and prolong survival. (bloodjournal.org)
  • In this study, we evaluated the reproducibility of eQTL detection of two large genetic crosses of mouse strains C3H/HeJ and C57BL/6J. (genetics.org)
  • Two key features of recombinant inbred panels are well-characterized genomes and reproducibility. (g3journal.org)
  • Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model. (nextbio.com)
  • Therapeutic vaccination strategies that incorporate immune adjuvants are likely to enhance immune recognition and targeting of hematologic cancers, an example being in mice vaccinated against mouse lymphomas with whole tumor cells loaded with CpG adjuvant. (bloodjournal.org)
  • Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. (biomedsearch.com)
  • Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • The sequencing of these six CC strains updates the efforts toward inbreeding undertaken by the UNC Systems Genetics Core. (g3journal.org)
  • He was the first to establish the use of inbred mice in studying genetics. (giantmicrobes.com)
  • In mice, a strain produced from brother-sister matings for at least 20 sequential generations. (jax.org)
  • Inbred strains are produced from at least 20 generations of mating from the same litter to obtain the highest possible level of genetic uniformity. (giantmicrobes.com)
  • Inbred laboratory mouse strains are maintained by brother x sister mating. (g3journal.org)
  • GIRK3 knockout ( −/− ) mice behaved indistinguishably from wild-type mice in this panel of tests. (wiley.com)
  • We next analyzed miRNA from the LN cells and found that 100 out of 609 miRNA species were differentially regulated in AEA-treated mice when compared to controls. (nih.gov)
  • In order to determine if this could stem from an impaired survival signal, we introduced Bcl-2 into RAG2 deficient Dµ transgenic mice. (diva-portal.org)
  • To address the role of E2-2 in B cell development, we have reconstituted mice, using E2-2 deficient fetal liver cells, and analysed the B cell compartments. (diva-portal.org)
  • E2-2 deficient mouse embryos were shown to display a partial block at the DN3 stage, which was not due to proliferation or apoptosis defects. (diva-portal.org)
  • This notion has been supported by classical experiments which established that T cell-deficient mice rapidly succumb after inoculation with any one of several species of Leishmania , and that transfer of normal T cells confers resistance to the animals (1-3). (scielo.br)
  • To study LAX function in vivo, we generated LAX-deficient mice by homologous recombination. (jimmunol.org)
  • Methods and Results- Thoracic aortic segments from 8-week-old female B6 and C3H apolipoprotein E-deficient mice were transplanted into the infrarenal aorta of 10-week-old female F1 mice. (ahajournals.org)
  • Indeed, B6 mice exhibit a significant increase in apoB-containing lipoproteins in the arterial wall compared with C3H mice when fed an atherogenic diet or when deficient in apoE. (ahajournals.org)
  • Asymmetric microphthalmia and "anophthalmia" were found in affected mice. (jax.org)
  • While the individual strains of C57BL mice are genetically identical within the strain, they all show the same propensity to develop sporadic microphthalmia or anophthalmia. (jax.org)
  • Figure 1 shows a C57BL/6J mouse with moderate microphthalmia. (jax.org)
  • C57BL/6J mouse with moderate microphthalmia. (jax.org)
  • The cataracts found in inbred C57 black mice with microphthalmia may be characterized by minor cortical degeneration, by major involvement of the cortex and nucleus, or by extrusion of lens cortex through a dehiscence in the lens capsule. (jax.org)
  • C57BL/6J mouse with severe microphthalmia. (jax.org)
  • In Vivo Mouse Models to Study Pneumococcal Host Interaction and Invasive Pneumococcal Disease. (bioportfolio.com)
  • When performing in vivo experiments in isoflurane-anesthetized mice, it is recommended to supplement with a Na 2 CO 3 infusion to maintain a normal acid-base balance. (diva-portal.org)
  • Aorta transplantation in the mouse provides a direct means for studying the role of the vascular wall in a biological process in vivo. (ahajournals.org)
  • Approach and Results- We characterized a method for the isolation of endothelial cell RNA with high purity directly from mouse aortas and adapted this method to allow for the treatment of aortas ex vivo before RNA collection. (ahajournals.org)
  • Conclusions- We demonstrated that RNA can be isolated from mouse aortic endothelial cells after in vivo and ex vivo treatments of the murine vessel wall. (ahajournals.org)
  • Timed histopathological analysis identified bone marrow, spleen, and liver as major affected organs in both mouse strains. (jci.org)
  • RESULTS Mice exhibited pronounced heterogeneity in liver histological scoring, leading to classification into four subgroups: low-fat low (LFL) responders displaying normal liver morphology, low-fat high (LFH) responders showing benign hepatic steatosis, high-fat low (HFL) responders displaying pre-NASH with macrovesicular lipid droplets, and high fat high (HFH) responders exhibiting overt NASH characterized by ballooning of hepatocytes, presence of Mallory bodies, and activated inflammatory cells. (diabetesjournals.org)