• METHODS AND RESULTS: We first investigate the metabolism of -shogaol in mouse urine, and then investigate the biotransformation of shogaols in human urine. (biomedsearch.com)
  • Seven C57Bl/6J females were mated with three C57Bl/6J males according to this distribution: one male with two females, another male with two other females, and another male with the remaining three females: the offspring were the subjects of this experiment. (elsevier.es)
  • Twelve male and female DBA/2J mice and 12 male and female C57BL/6J mice were trained to discriminate 10 mg/kg pregnanolone from saline. (aspetjournals.org)
  • The male C57BL/6J mice had to be removed from the study due to increased seizures apparently associated with the chronic intermittent pregnanolone administration used in drug discrimination. (aspetjournals.org)
  • At 3 weeks of age, we weaned male C57Bl/6J mice onto 30% caloric restriction (10% kcal/fat) or normal diet (10% kcal/fat). (nih.gov)
  • Reciprocal F1 hybrids of BALB/c x C57BL/6 matings revealed dominance of the C57BL/6 genotype, no sex linkage, and a significant (but small) maternal effect. (umassmed.edu)
  • Variations of physiological variables (weight, course of infection, stress response) in inbred animals have also been reported ( Gärtner, 2012 ). (elsevier.es)
  • To study the physiological functions of Gbp family members, the most commonly chosen in vivo models are mice harbouring loss-of-function mutations in either individual Gbp genes or the entire Gbp gene cluster on mouse chromosome 3. (crick.ac.uk)
  • C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches. (beds.ac.uk)
  • The present data suggest that many of the previously documented neurosteroid-induced behavioral differences between the DBA/2J and C57BL/6J are acute effects and are not apparent in a drug discrimination procedure. (aspetjournals.org)
  • Conclusions: Our findings demonstrate functional differences between 129 and C57BL/6 Gbp alleles which need to be considered in the design and interpretation of studies utilizing mouse models, particularly for phenotypes influenced by Gbp2 or Gbp2b expression. (crick.ac.uk)
  • Circadian rhythms of locomotion (wheel-running activity) in 12 inbred mouse strains were recorded for interstrain differences in tau DD, the endogenous (free-running) period of the circadian pacemaker measured in constant environmental darkness. (umassmed.edu)
  • Further study of inherited differences in the BALB/c and C57BL/6 strains may be a useful noninvasive experimental approach for investigation of the neurobiological substrates of circadian rhythmicity. (umassmed.edu)
  • Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. (beds.ac.uk)
  • Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. (beds.ac.uk)
  • 6 ] have employed gene expression array analysis of the dissected embryonic (16.5d) mouse cerebral cortex to expand the list of genes regionally expressed, and noted that regional differences in expression of genes in the cortical plate should eventually convert into functionally distinct cortical areas with anatomically distinguishable borders after birth. (beds.ac.uk)
  • The results indicate that 1 or more genetic loci influence the value of tau DD, and a large (50 min) difference in mean tau DD between 2 of the strains, BALB/cByJ and C57BL/6J, allowed further characterization of the origins and inheritance of the polymorphic expression of this circadian pacemaker property. (umassmed.edu)
  • this discrepancy was significantly greater and more variable in BALB/c than in C57BL/6 mice, though the interstrain difference in mean tau DD could not be attributed entirely to this effect. (umassmed.edu)
  • RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. (bioportfolio.com)
  • Here, we showed that serum FGF21 level is increased in mice after a single bout of acute exercise, and that this is accompanied by increased serum levels of free fatty acid, glycerol and ketone body. (mendeley.com)
  • FGF21 gene expression was induced in the liver but not in skeletal muscle and white adipose tissue of mice after acute exercise, and further, the gene expression levels of hepatic peroxisome proliferator-activated receptor α (PPARα) and activating transcription factor 4 (ATF4) were also increased. (mendeley.com)
  • The rise of genetically engineered mouse models of pancreatitis: A review of literature. (bioportfolio.com)
  • A probe designated B6-38 to the pseudoautosomal region of the X and Y chromosome has a characteristic Pst I pattern of fragment sizes which is present only in the C57BL family of strains ( Kalcheva et al, 1995 ). (jax.org)
  • Modification of the adenoviral transfer vector enhances expression of the Hantavirus fusion protein GnS0.7 and induces a strong immune response in C57BL/6 mice. (curehunter.com)
  • Notably, Toxoplasma infections induce robust Gbp2b protein expression in both strains of mice, suggestive of a Toxoplasma-activated mechanism driving Gbp2b protein translation. (crick.ac.uk)
  • Previously, we reported the mercapturic acid pathway as a major metabolic route for -shogaol in mice. (biomedsearch.com)
  • CONCLUSION: Shogaols are metabolized extensively in mouse and human to form thiol-conjugated metabolites and GSH might play an important role in the cancer-preventive activity of ginger. (biomedsearch.com)
  • Lin Z, Edenberg H, Carr L. A novel negative element in the promoter of the mouse alcohol dehydrogenase gene Adh-1. (labome.org)
  • Mouse models of Loa loa. (bioportfolio.com)
  • Recent advances in mouse models for systemic sclerosis. (bioportfolio.com)
  • Mouse models provide powerful research tools for exploring the pathogenesis of the human diseases. (bioportfolio.com)
  • In Vivo Mouse Models to Study Pneumococcal Host Interaction and Invasive Pneumococcal Disease. (bioportfolio.com)
  • To study invasive pneumococcal disease (IPD), many models using mice in particular have be. (bioportfolio.com)
  • Using sickle cell and thalassemia mouse models, researchers will evaluate the possibility of correcting these disorders by inserting healthy genetic material into the diseased blood cells. (bioportfolio.com)
  • We demonstrate that adult Loa loa worms in subcutaneous tissues, circulating microfilariae (mf) and presence of filarial biomarkers in sera occur following experimental infections of lymphopenic mice deficient in interleukin (IL)-2/7 gamma-chain signaling. (bioportfolio.com)
  • Historical data shows that hydrocephaly occurs in the C57BL/6 mouse in 0.05% of the population and may not be evident until the animal is more than two months of age. (taconic.com)
  • C57BL/6 litters were received in 1991 at F151 from the NIH Animal Genetic Resource. (taconic.com)
  • Animal experiments showed that rAd-GnS0.7-pCAG induced a stronger Hantaan virus (HTNV)-specific humoral and cellular immune response in mice, with the cellular immune response to the GnS0.7 being stronger than the HFRS vaccine control. (curehunter.com)
  • Shown is Δ-MFI (corrected for background staining with isotype control mAb) for non-infected (white bars) and infected mice (black bars). (nih.gov)
  • Complete cortical hemispheres from adult mice were dissected and stained for the cytochrome oxidase enzyme in order to measure histochemically defined cortical areas. (beds.ac.uk)
  • To explore this question, we tested the effect of caloric restriction on bone mass and microarchitecture during rapid skeletal growth in young mice. (nih.gov)
  • 05). Thus we conclude that caloric restriction in young, growing mice is associated with impaired skeletal acquisition, low leptin and IGF-1 levels, and high marrow adiposity. (nih.gov)
  • In DBA/2J and C57BL/6J mice, a benzodiazepine, barbiturate, and GABAergic neuroactive steroids all substituted for the stimulus effects of pregnanolone. (aspetjournals.org)
  • Pentobarbital and midazolam were more potent in producing pregnanolone-like discriminative stimulus effects in DBA/2J mice. (aspetjournals.org)
  • Here, we show in the mouse that the paternal promoter region is marked by allelic bivalent chromatin enriched in both H3K4me2 and H3K27me3, from early embryonic stages onwards. (cnrs.fr)
  • The expression of the PIWI family members miwi and mili in mice testis is negatively affected by estrogen. (nextbio.com)
  • This elevated expression persisted on lung-derived migratory DCs (but not lymph node resident macrophages) isolated from the lung-draining mediastinal lymph nodes from infected mice (Fig. 2b and Supplementary Fig. 3b). (nih.gov)
  • Fibroblast growth factor 21 corrects obesity in mice. (labome.org)
  • For example, Fukuchi-Shimogori and Grove [ 4 ] placed an ectopic caudal source of fibroblast growth factor 8 into the developing mouse cortex and caused a caudal duplication of part of the primary somatosensory area. (beds.ac.uk)