• There were significant positive correlations in AKR/J and C57BL/6J mice, which are highly sensitive to dietary obesity. (nih.gov)
  • In the present study, the ability of IFN-gamma to directly activate peritoneal macrophages from C57BL/6 and Balb/c mice for tumor cytotoxicity and NO production was evaluated. (nih.gov)
  • Taconic's inbred C57BL/6NTac and BALB/cAnNTac mice and outbred Swiss Webster mice are immediately available from our commercial production colonies at the Germ Free (GF) health standard . (taconic.com)
  • In addition the C57BL/6 Germ Free Il10 Knockout (B6) and Il10 Knockout (BALB/c) are available in small quantities for pilot studies. (taconic.com)
  • C57BL/6, also called Black 6 or B6, is the most commonly used inbred strain. (taconic.com)
  • More information and pricing is available on the C57BL/6 Il10 Knockout (B6) and Il10 Knockout (BALB/c) pages. (taconic.com)
  • Using inbred BALB/c and C57BL/6 mice as animal models for American cutaneous leishmaniasis, we evaluated the inhibitory effect of sinefungin on foot-pad infection produced by 5 different Leishmania isolates. (ajtmh.org)
  • Thus, we propose to evaluate the infection by G (TcI) and CL (TcVI) strains of T. cruzi, which have different tropisms and a distinct infection courses, in two lineages of inbred mice (C57BL/6 and BALB/c) that display variable susceptibility degrees for each T. cruzi strain. (fapesp.br)
  • In C57BL/6 mice, which are unable to present the immunodominant epitope, CSP-based vaccines did not confer complete protection, despite the induction of high levels of CSP-specific antibodies. (ox.ac.uk)
  • Therefore, BALB/c and C57BL/6 mice were used to compare colonization ability and gene expression of various inflammatory cytokines, as determined by real-time PCR, after experimental infection with 9 different H. suis strains. (biomedcentral.com)
  • All strains were able to persist in the stomach of mice, but the number of colonizing bacteria at 59 days post inoculation was higher in stomachs of C57BL/6 mice compared to BALB/c mice. (biomedcentral.com)
  • Only in C57BL/6 mice, upregulation of IL-1β was observed. (biomedcentral.com)
  • Therefore, in the present study, BALB/c and C57BL/6 mice were used to compare colonization ability and host responses after inoculation with nine different H. suis strains. (biomedcentral.com)
  • In order to explore a mouse model that is more suitable for simulating the infection of SARS-CoV in the elderly, there are studies adopting BALB/c, C57BL/6, and 129S6 inbred wild-type (WT) mice in 12-14 month age range for experiments. (cyagen.com)
  • BackgroundAdoptively transferring different sources of myeloid-derived suppressor cells (MDSCs) may assist in mice corneal transplant survival.MethodsAllogeneic full thickness corneal transplantation (donor C57BL/6 to recipient Balb/c mice) was performed. (ox.ac.uk)
  • Ten female C3HeB/FeJ, A/J OlaHsd, BALB/cJ, and C57BL/6J mice were intragastrically infected with 5 × 10 9 CFU Lmo-EGD-lux (grey graphs) or Lmo-InlA-mur-lux (black graphs). (biomedcentral.com)
  • The strains chosen (C57Bl/6J, DBA2, BALB/c, C3H/ARC em lps /em em n /em and C3H/HeJ em lps /em em d /em ) differ on at least two genetic loci known to influence innate immune reactions. (gdc-0068.net)
  • From the beginning JAX continued all operations and our inventory of readily available strains (like C57BL/6J, NSG™, and BALB/c) were not impacted. (jax.org)
  • Grafting procedure in brief: donor corneas (C57BL/10 mice) 2 mm in diameter were removed and placed in balanced salt solution. (bmj.com)
  • C57BL/6-Germ-Free Mouse Details. (amuconference.org)
  • Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results. (amuconference.org)
  • Accumulation of antibody-producing cells in the spleen was more active in immunized C57Bl/6 mice treated with cyclophosphamide compared to animals not treated with cyclophosphamide. (amuconference.org)
  • Here, we investigated modifications induced by ZIKV infection in the gut microbiome of immunocompetent C57BL/6J mice. (amuconference.org)
  • Streptozotocin-induced C57BL/6 diabetic mice were implanted with 400 microencapsulated SC- cell clusters in the peritoneum (n = 3 per group). (amuconference.org)
  • In this study, we showed that immunocompetent C57BL/6 mice were susceptible to infection with clinical Dengue virus isolates. (amuconference.org)
  • 0.05) than the figure of uninfected C57BL/6 mice (day 0). (amuconference.org)
  • As we had previously found that the TC-1 HPV11-E6E7 cell line did not grow in fully immunocompetent mice, C57BL/6 mice were immunocompromised by CD3 depletion followed by tumor injection two days after the last depletion. (amuconference.org)
  • B) Changes of GC counts in the small intestine of immunocompetent and immunosuppressed C57BL/6 mice infected with 200 G. seoi metacercariae. (amuconference.org)
  • The membrane-labelling approach was also used to study ExoB16 biodistribution in melanoma-bearing immunocompromised (NSG) mice, to compare with that in the immunocompetent C57Bl/6 mice. (amuconference.org)
  • N -Methyl- N -nitrosourea (MNU) was given in drinking water to C57BL/6 mice and p53 heterozygous knockout mice. (amuconference.org)
  • It is higher in mice housed under non-specific pathogen free (SPF) conditions, and it is generally high on the C57BL/6J and BALB/cByJ backgrounds, low on the C3H/HeSnJSmn background, and very low on the NOD/LtSzJ background (Table 1). (amuconference.org)
  • We have infected BALB/c and C57BL/6 mice with a cloned Leishmania mexicana amazonensis population, obtained from the "Maria" strain. (fiocruz.br)
  • Anti- Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice through the period of infection. (fiocruz.br)
  • For example, in mouse BXD family maps, if the DBA/2J allele produces higher values than the C57BL/6J allele then the additive effect line is colored in green. (genenetwork.org)
  • Methods: Experiment 1: Mice fering from major depression and healthy controls during short from C57BL/6J, AKR/J, and D2 inbred strains were submitted sleewake cycles under constant routine conditions. (pdfdrug.com)
  • Furthermore, macrophages isolated from H99γ-immunized mice on day 7 postchallenge and cultured in vitro were fungistatic against C. neoformans, whereas cryptococcal growth was uncontrolled within macrophages from HKCn-immunized mice. (elsevier.com)
  • Th2-type cytokine production and induction of alternatively activated macrophages were also observed in lungs of HKCn-immunized mice during rechallenge. (elsevier.com)
  • Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction. (ox.ac.uk)
  • Microarray analysis of the transcriptional response of mouse peritoneal macrophages to the T(H)2 cytokine interleukin-4 (IL-4) identified Ym1 and arginase as the most highly up-regulated genes, exhibiting more than 68- and 88-fold induction, respectively. (ox.ac.uk)
  • Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice. (nbrp.jp)
  • This was evident when F1 hybrid macrophages were compared with CBA/H and BALB/c macrophages as targets for both alloreactive and H-2 restricted anti-viral TC cells. (edu.au)
  • Mice belong to the Euarchontoglires clade, which includes humans. (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. (wikipedia.org)
  • Since human endogenous retroviruses also encode Sags, these studies have broad implications for pathogen-induced responses in mice and humans. (utexas.edu)
  • as such, a virus that is able to infect humans may not have the same capacity to infect mice, and vice versa. (ddw-online.com)
  • Though humans and mice share many of the same genes, many challenges exist when attempting to develop a mouse model that mimics the human response to a virus, some of which are related to the unique characteristics of the virus. (ddw-online.com)
  • The mouse model may not possess the same receptor protein as found in humans. (ddw-online.com)
  • The mouse protein may not be expressed on the same cells in the same patterns as seen in humans. (ddw-online.com)
  • It has long been suspected that the dedicated class II chaperone designated HLA-DM in humans or H-2M in mice also makes an important contribution, but due to tight linkage within the MHC, a possible role played by DM peptide editing has not been previously tested by conventional genetic approaches. (ox.ac.uk)
  • In order to study this kind of disease effectively, mouse models need to show similar pathological changes after the initial infection, and may also present severe respiratory diseases, as in humans. (cyagen.com)
  • However, there are certain species differences between mice and humans that influence viral pathology, resulting in some human-infecting viruses being unable to directly infect mice, or that no obvious symptoms are exhibited in mice even after in vivo virus replication. (cyagen.com)
  • Diverse pigmentation phenotypes that vary geographically have been observed in many species, including birds, butterflies, mice, cats, horses, and humans ( 16 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ - 25 ). (opensourcebiology.eu)
  • We observed increased pulmonary Th1-type cytokine production in lung homogenates and classical macrophage activation as evidenced by enhanced expression of inducible NO synthase in the lungs of H99γ-immunized mice compared with mice given a nonprotective immunization with heat-killed C. neoformans (HKCn). (elsevier.com)
  • NP/NCMP PspA4Pro was now used for immunization of mice. (ox.ac.uk)
  • In BALB/c mice, where SYIPSAEKI is efficiently presented in the context of the major histocompatibility complex class I (MHC-I) molecule H-2-Kd, we established that epitope-specific CD8+ T cell responses contribute to parasite killing following sporozoite immunization. (ox.ac.uk)
  • Immunogenicity of the other six proteins (SPELD, ETRAMP10.3, SIAP2, SPATR, HT, RPL3) was analyzed by immunization of inbred BALB/c and outbred CD-1 mice with viral-vectored (ChAd63 or ChAdOx1, MVA) vaccines, followed by challenge with chimeric sporozoites. (jenner.ac.uk)
  • Further, Mtv-null mice were resistant to rapid mortality induced by intragastric inoculation of the Gram-negative bacterium, Vibrio cholerae, but susceptibility to Salmonella typhimurium was not significantly different from BALB/c mice. (utexas.edu)
  • The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice. (ox.ac.uk)
  • Genetic background affects susceptibility to pancreatic ductal adenocarcinoma (PDAC) in the mouse magic size. (lifescienceexec.com)
  • Within this research we have chosen to use five inbred mouse strains, having a spectrum of LPS susceptibility as genetic tools to determine the nature and diversity of innate immune reactions to a single pathogenic stimulus. (gdc-0068.net)
  • Progres¬ sion of infection and histopathological examination confirmed the extreme susceptibility of BALB/c mice and the resistant pattern ofthe C57 BL/6. (fiocruz.br)
  • In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. (jimmunol.org)
  • two strains consumed more calories from carbohydrate than from fat (BALB/cByJ, CAST/Ei). (nih.gov)
  • AKR/J, NZB/B1NJ, and C67BL/6J mice self-selected the highest proportion of dietary fat, whereas the CAST/Ei and BALB/cByJ strains chose the lowest. (nih.gov)
  • BALB/c is widely used for syngeneic tumor model studies as well as in asthma and allergy studies. (taconic.com)
  • Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. (utexas.edu)
  • Subcutaneous administration of SMA-tDodSNO (1 mg/kg) to xenografted mice bearing 4T1 cells showed that SMA-tDodSNO alone caused a twofold decrease in the tumor size compared to the control group. (unict.it)
  • In this study, the global lipidomics and RNA sequencing data show that, in the tumor tissues of CRC-bearing mouse models, HFD not only increases tumor weight, but also the palmitic acid level and TLR4 expression, which are reduced when HFD is replaced by control diet. (edu.hk)
  • In this study, we investigated the molecular events following bacterial therapy using an attenuated Salmonella Typhimurium defective in ppGpp synthesis (DeltappGpp), by analyzing those proteins differentially expressed in tumor tissues from treated and untreated mice. (perkinelmer.com)
  • The tumor-bearing mice were treated with the attenuated Salmonella Typhimurium. (perkinelmer.com)
  • Exosomes carrying GKN1 inhibited cell proliferation and induced apoptosis in both AGS and MKN1 cells, and exosomes carrying GKN1-treated nude mice-bearing MKN1 xenograft tumors exhibited significantly reduced tumor volume and tumor weight. (ajou.ac.kr)
  • Naive myeloid cells, inflammation-induced MDSCs (iMDSCs), and tumor-induced MDSCs (tMDSCs) were purified from bone marrow of naive, cecal ligation and puncture, or tumor-bearing Balb/c mice, respectively. (ox.ac.uk)
  • for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in. (citymeuble.com)
  • The Hepa 1-6 tumor model established in immunocompetent mice represents a clinically relevant model for preclinical testing of immunotherapy. (amuconference.org)
  • Both administration of the IL-2 minipellet alone and in combination with LAK cells resulted in complete tumor regression in four of five mice. (elsevier.com)
  • The effect of prolonged antibiotic treatments on tumor development was evaluated in proto- neu transgenic mice, which spontaneously develop mammary carcinomas. (aacrjournals.org)
  • Tumor growth rate in gentamicin-treated mice was significantly faster than in untreated control mice ( P = 0.043). (aacrjournals.org)
  • Taconic offers three key models as off-the-shelf germ-free mice for immediate delivery in typical study sizes, as well as two new constitutive knockout models. (taconic.com)
  • Il10 Knockout mice are useful for studying colitis and immunoregulatory pathways. (taconic.com)
  • Models developed for the study of SARS-CoV after the SARS pandemic and to study the MERS virus (MERS-CoV) sought to overcome limitations like these, and a number of those models appear to have utility in COVID-19 studies: ACE2 models (both knockout and humanised), humanised dipeptidyl peptidase 4 (DPP4) mice and transmembrane serine protease 2 (TMPRSS2) knockout mice. (ddw-online.com)
  • Balb/C, C3H, DBA/2) are also highly susceptible to infection ( 1 , 6 , 7 ). (cdc.gov)
  • We plan to test the effect of topical application of antibacterial peptides, also known as bacteriocins in a mouse model of skin infection. (mattilsynet.no)
  • When treatment was initiated a few days, or even 2 weeks, after infection, an obvious leishmanicidal effect was detected on mice infected with Leishmania mexicana or L. braziliensis isolates, which lasted at least 50 weeks for all isolates studied. (ajtmh.org)
  • A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. (utexas.edu)
  • Infection of Mtv-null mice with an MMTV-related retrovirus, type B leukemogenic virus, also resulted in severely reduced viral loads and failure to induce T-cell lymphomas, indicating that resistance is not dependent on expression of a superantigen (Sag) encoded by exogenous MMTV. (utexas.edu)
  • viral spike protein binds the mouse and rat angiotensin I converting enzyme 2 (ACE2) receptor versions with lower affinity compared to human ACE2, and thus lab animals have limited viral replication and spontaneously clear infection soon after exposure (1-3). (ddw-online.com)
  • Differences between the mouse and human immune system can make modelling the human immune response to infection challenging. (ddw-online.com)
  • Therefore, we compared the virulence and dissemination of Australian clinical isolates collected during October 1989-October 2012 from patients with neurologic and nonneurologic melioidosis after intranasal and subcutaneous infection of mice in an experimental model. (edu.au)
  • Experimental pulmonary Cryptococcus neoformans infection in BALB/c mice is associated with polarized Th2-type cytokine production, alternative macrophage activation, and severe bronchopneumonia. (elsevier.com)
  • Additionally, mice infected with H99γ resolve the acute infection and are subsequently protected against challenge with wild-type C. neoformans. (elsevier.com)
  • Gene expression arrays showed that classical macrophage activation during challenge infection in H99γ-immunized mice was associated with induction of the transcription factor STAT1 and its downstream targets IFN regulatory factor-1, suppressor of cytokine signaling-1, CXCL9, and CXCL10. (elsevier.com)
  • Mouse is a well-established experimental model of Chagas' disease because it reproduces important features of human infection and provides an experimental basis for the study of host lineages and the parasite strain. (fapesp.br)
  • Unlike previous reports on group C adenoviruses, trans-complementation of group B adenoviruses by co-infection with mouse adenovirus 1 did not rescue replication. (ox.ac.uk)
  • Some studies have attempted to characterize the evoked immune response in the mouse, an animal species which has most often been used to model gastric Helicobacter infection. (biomedcentral.com)
  • What are the strategies for mouse models used to evaluate the pathogenicity of SARS-CoV infection? (cyagen.com)
  • The weight loss on the day of infection, day 0, is due to overnight starving of the mice. (biomedcentral.com)
  • After intragastric infection challenge mice had again access to food ad libitum. (biomedcentral.com)
  • ref>Lathem WW, Crosby SD, Miller VL and Goldman WE (2005) Progression of primary pneumonic plague: A mouse model of infection, pathology, and bacterial transcriptional activity. (msu.edu)
  • We now show that 129 mice lacking interferon- (IFN-) develop more severe infection with A. phagocytophilum than IFN- deficient B6 mice. (amuconference.org)
  • Tests of delayed type hypersensitivity reaction with Leishmania antigens were positive in both strains in the beginning ofthe infection, but were negative later on in BALB/c mice. (fiocruz.br)
  • Thus, the objectives of this study were to compare anti-inflammatory effect between Nutrient Enriched Soybean Tempeh (NESTE) aqueous extract and Soybean aqueous extract (SBE) through in vitro regulation of nitric oxide (NO) production in LPS-induced mice macrophage cells (RAW 264.7) and in vivo arachidonic acid induced mice ear edema as well as analgesic effect via in vivo hot plate test. (biomedcentral.com)
  • BALB/c is widely used for immunology studies. (taconic.com)
  • An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. (jefferson.edu)
  • CT26 murine colon cancer cells were implanted in BALB/c mice and allowed to form tumors. (perkinelmer.com)
  • We also use Balb/c immune-competent mice to determine the tumourogenicity and infectivity of transgenic murine cell lines. (ox.ac.uk)
  • 3 Heterotopic keratoplasty in the mouse was first described in the early 1980s 4- 6 while the first reports of orthotopic murine corneal grafts were published a decade later. (bmj.com)
  • Exposure to murine seminal fluid markedly reduced eosinophilic airway inflammation in 2-month-old female mice upon ovalbumin inhalation. (aging-us.com)
  • The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains of mice (e.g. (cdc.gov)
  • Our results are similar to those obtained with mixed parasite populations, and rule out the possibility of selection among different parasite subpopulations as responsible for the diver¬ gent course of the disease exhibited by these two strains of mice. (fiocruz.br)
  • Little and Castle collaborated closely with Abbie Lathrop who was a breeder of fancy mice and rats which she marketed to rodent hobbyists and keepers of exotic pets, and later began selling in large numbers to scientific researchers. (wikipedia.org)
  • Here, we developed a pilot-scale production of PiCoVacc, a purified inactivated SARS-CoV-2 virus vaccine candidate, which induced SARS-CoV-2-specific neutralizing antibodies in mice, rats, and nonhuman primates. (unboundmedicine.com)
  • Recent research with rats and mice has alerted scientists to the possibility of using growth factors21 and stem cells22 to regener-ate cardiac tissue after a heart attack. (citymeuble.com)
  • Rodent lifespans range from a few years in mice and rats to nearly three decades in beavers, porcupines, and squirrels in addition to naked mole-rats. (ucsc.edu)
  • Early studies utilised rabbits and, more recently, sheep 2 but the availability of a large range of reagents for rodents has permitted more mechanistic studies on rats and mice. (bmj.com)
  • Presently this facility housed inbred strains Balb/c, C57/BL6, CBA/J, FVB, NOD SCID, Neo R Tg line, outbred CD1 and Wistar Rats and Rabbits. (niab.res.in)
  • Leishmania parasites In order to avoid hereditary variations and undesired mutations, (MRHO/IR/75/ER) was consistently operate on Balb/c mice on the Section of Parasitology & Mycology, College of Medication, Isfahan School of Medical Sciences, Isfahan, Iran. (naturalistes-st-lupicin.com)
  • By studying germ-free mice that are deficient in immune- or inflammation-related genes and inoculating them with defined flora, his lab can distinguish between the effects of genes and the role of commensals. (citymeuble.com)
  • BALB/c mice exposed to e-cigarette vapor (±nicotine) resulted in a significant increase in peribronchiolar inflammation and influx of immune cells into the airways. (highwire.org)
  • Promastigote lifestyle The subiliac lymph nodes of the Balb/c mice contaminated with were taken out within a sterile Skepinone-L condition previously. (naturalistes-st-lupicin.com)
  • The messages of mouse AIF-1 were abundantly expressed in the testis, moderately in the spleen and lymph nodes and slightly in the liver and thymus of normal BALB/c mice. (lshtm.ac.uk)
  • Here we report that the defective germinal centre reaction in Peyer's patches of aged mice can be rescued by faecal transfers from younger adults into aged mice and by immunisations with cholera toxin, without affecting germinal centre reactions in peripheral lymph nodes. (nature.com)
  • The spontaneous destruction of insulin producing pancreatic beta cells in non-obese diabetic (NOD) mice provides a valuable model of type 1 diabetes. (ox.ac.uk)
  • Spontaneous mouse models are experimental mice that develop tumors due to the abnormal manifestation caused by genetic mutations. (modelorg.com)
  • The present study characterizes macrophage activation during the protective response to wild-type C. neoformans in mice previously immunized with H99γ. (elsevier.com)
  • These studies demonstrate that protective responses to C. neoformans challenge in immunized mice include classical macrophage activation and enhanced macrophage fungistasis of C. neoformans yeasts. (elsevier.com)
  • Allograft inflammatory factor-1 augments production of interleukin-6, -10 and -12 by a mouse macrophage line. (lshtm.ac.uk)
  • To analyse the function of the AIF-1, a macrophage cell line, RAW 264.7, was transfected with mouse AIF-1 cDNA. (lshtm.ac.uk)
  • Seres relies on Taconic's germ-free mice to study the microbiome and our drug candidates. (taconic.com)
  • Federation Bio utilizes Taconic's germ-free mouse models to advance our pre-clinical research programs. (taconic.com)
  • Germ-free mice may be maintained as germ-free long-term or they may be associated with a custom microbiota. (taconic.com)
  • Germ Free Black 6 mice are available for immediate delivery. (taconic.com)
  • Taconic is the only commercial provider of germ-free BALB/c mice. (taconic.com)
  • Germ Free BALB/c mice are available in small cohort quantities. (taconic.com)
  • Germ Free Swiss Webster mice are available for immediate delivery. (taconic.com)
  • 1. What are Germ-free Mice? (cyagen.com)
  • Germ-free mice lack all microorganisms (as determined within the limitations of the detection methods available) and are housed in tightly controlled and monitored isolators to prevent contamination. (cyagen.com)
  • no living organisms can be cultured from germ-free mouse specimens. (cyagen.com)
  • In the past decades, the amount of literature featuring applications of germ-free mice has grown exponentially. (cyagen.com)
  • Germ-free mice are bred in isolators that fully block exposure to other microorganisms, with the intent of keeping their experimental results free from the interference of other biological and environmental factors - such a 'clean slate' is conducive to analyzing host pathology and determining how specific microbiomes influence physiology and disease. (cyagen.com)
  • We can provide customers with germ-free (GF) mouse technical services that meet a wide variety of SPF standards as well as after-sales and training services. (cyagen.com)
  • Thus, Cyagen can produce germ-free mice and provide relevant experimental services. (cyagen.com)
  • This could not be reproduced in the organotypic three dimensional spheroid-brain slice culture model or in the mice xenograft model. (refbase.net)
  • We further validated the functional relevance of exosomal GKN1 in MKN1-injected xenograft mice. (ajou.ac.kr)
  • The tumorigenic role of CHPF was also validated in nude mouse xenograft models. (bvsalud.org)
  • Human T cells are potent effectors against glioma cell lines in vitro and in human/mouse xenograft models of glioblastoma, however, this effect has not been investigated in an immunocompetent mouse model. (amuconference.org)
  • Results obtained in vitro and in vivo were confirmed by immunohistochemical staining of histological sections of spheroids, spheroids in brain slice cultures and tumors in mice brains. (refbase.net)
  • Here, we describe the use of highly sensitive whole body in vivo imaging to assess the efficacy of recombinant viral vector vaccines and benznidazole-cured infections to protect mice from challenge with Trypanosoma cruzi. (ox.ac.uk)
  • The in vivo studies were carried out on cutaneous leishmaniasis in inbred mice to evaluate the effects of topical application of the ointment-based extracts two times daily for 20 days.45 mice were randomised into five groups [placebo group received the ointment base without the extract ,systemic glucantime as a reference group ,Test groups including plants [nine mice]. (florajournal.com)
  • On the other hand, in vivo oral acute toxicity effect of the extract was tested on mice at the dose of 5000 mg/kg body weight. (biomedcentral.com)
  • Hypobetalipoproteinemic mice with a targeted apolipoprotein (Apo) B-27.6-specifying mutation: in vivo evidence for an important role of amino acids 1254-1744 of ApoB in lipid transport and metabolism of the apoB-containing lipoprotein. (mousemine.org)
  • In vitro, these bacteriocins are effective against both antibiotic resistant and sensitive bacteria that will be used in the mouse model against multidrug-resistant bacteria. (mattilsynet.no)
  • Till date, we have overcome several problems in mouse reproductive technology and have efficiently archived mouse resources by sperm and embryo cryopreservation to produce eggs and embryos using the techniques of ultrasuperovulation and in vitro fertilization and to establish the worldwide shipment of cryopreserved or cold-stored embryos and sperm [ 5 ]. (biomedcentral.com)
  • CD45RB(low) CD4(+) T cells from tolerant mice were also immune suppressive in vitro, as coculture of these cells with naive CD45RB(high) CD4(+) T cells inhibited proliferation and Th1 cytokine production in response to donor alloantigens presented via the indirect pathway. (ox.ac.uk)
  • We performed bulk RNA sequencing of hearts at early, mid and late time points from mice with experimental autoimmune myocarditis. (ox.ac.uk)
  • TIGIT expression was upregulated in activated Th2 cells from mice with experimental allergic disease and in Th2 polarization cultures. (ox.ac.uk)
  • Mice are the most widely used experimental mammals, having made important contributions in most areas of biomedical research" ( Festing and Lovell 1981 , p. 42 We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. (citymeuble.com)
  • An experimental model in which the synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas in Balb/c mice was used. (uba.ar)
  • Furthermore, subordinate and isolated mice showed a significant decrease in activity, compatible with depressive behavior described in the literature for experimental models. (peertechzpublications.com)
  • O'Neill, HC & Blanden, RV 1979, ' Variation in H-2 antigen expression in F1 hybrid mice: Analysis using monoclonal antibodies ', Australian Journal of Experimental Biology and Medical Science , vol. 57, no. 6, pp. 627-635. (edu.au)
  • These mice are described in a paper about the health of 'experimental laboratory mice' (2) as having health problems such as aggression in males, heart problems and eye problems - including where the edges of the eyelids become inflamed and where abscesses form around the eyes. (victimsofcharity.org)
  • Here we show that systemic exposure to Toll-like receptor (TLR) ligands causes rapid α(1,2)-fucosylation of small intestine epithelial cells (IECs) in mice, which requires the sensing of TLR agonists, as well as the production of interleukin (IL)-23 by dendritic cells, activation of innate lymphoid cells and expression of fucosyltransferase 2 (Fut2) by IL-22-stimulated IECs. (nature.com)
  • The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. (vanderbilt.edu)
  • A monoclonal antibody (WM1) against the third component of human complement (C3) was produced by fusing P3-X63-Ag8 mouse myeloma cells with spleen cells from BALB/c mice immunized with purified C3. (ox.ac.uk)
  • We present evidence that donor-reactive CD4(+) T cells present in mice tolerant to donor alloantigens are phenotypically and functionally heterogeneous. (ox.ac.uk)
  • CD4(+) T cells contained within the CD45RB(high) fraction remained capable of mediating graft rejection when transferred to donor alloantigen-grafted T cell-depleted mice. (ox.ac.uk)
  • In addition, its high-affinity ligand CD155 was upregulated in mediastinal lymph node dendritic cells from allergic mice. (ox.ac.uk)
  • Effects of Adoptive Transferring Different Sources of Myeloid-Derived Suppressor Cells in Mice Corneal Transplant Survival. (ox.ac.uk)
  • Using gene therapy, Harvard scientists have restored vision to mice suffering glaucoma by rewinding the aging process in their cells. (citymeuble.com)
  • The mutations most commonly seen in PDAC substitution of either valine or aspartate in place of glycine at codon 12 mimic the GTP-bound form or active conformation of (13 14 15 A transgenic mouse model directing oncogenic KRAS activity to the pancreas promoter sequence directs expression of human specifically to the acinar cells of the exocrine pancreas. (lifescienceexec.com)
  • The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. (amuconference.org)
  • Cells of (CBA/H X BALB/c)F1 hybrid mice express CBA/H-derived H-2k antigens more weakly than do CBA/H cells, but H-2d antigens are similarly expressed by F1 and BALB/c cells. (edu.au)
  • Quantitative absorption of anti-H-2Kk serum by spleen cells of F1 or CBA/H mice also suggested about 3-fold less H-2Kk antigen on F1 cells. (edu.au)
  • The male mice received prostate cancer cells and the female mice received breast cancer cells. (victimsofcharity.org)
  • Three weeks after the cancer cells were injected, 80% of the young male mice had bone tumours as did 20% of the older animals. (victimsofcharity.org)
  • Three weeks after the cancer cells were injected, 80% of the young female mice had bone tumours as did 50% of the older animals. (victimsofcharity.org)
  • Endometriosis with varying severity was developed in mice by peritoneal implantation of uterine fragments. (who.int)
  • The results of such studies using ACE2 humanized mouse models indicate that the level of hACE2 expression is directly related to the severity of the disease. (cyagen.com)
  • Given that the genetic background of inbred mice is consistent, editing the mouse genes can overcome the shortcomings of wild-type mice to a certain extent. (cyagen.com)
  • The follow is a list of mouse genetic background strains that have been successfully cryopreserved by our facility. (northwestern.edu)
  • Mouse allograft inflammatory factor-1 (AIF-1) cDNA was cloned and the AIF-1-specific monoclonal antibodies were established to examine its tissue distribution. (lshtm.ac.uk)
  • It is the preferred background strain for most genetically engineered mouse models. (taconic.com)
  • A review of the challenges associated with virus research and the effective use of mouse models in SARS-CoV research following the 2003 SARS pandemic, reveals the potential utility of both genetically-engineered mouse models as well as standard laboratory mice in COVID-19 studies. (ddw-online.com)
  • Mice given the drug produced fewer myofibroblasts, and their heart function was similar to that of mice … Recent years have seen a rise in the use of genetically engineered mice (often known as 'genetically engineered mouse models' or 'GEMMs') in research and preclinical studies. (citymeuble.com)
  • Despite advances in the field, nude mice remain an essential player in various studies. (citymeuble.com)
  • Here's a little background on nude mice and how to handle them. (citymeuble.com)
  • Among the various mouse models, nude mice were the first immunocompromised strain to be used in research. (citymeuble.com)
  • Cancer Research UK support for horrific experiment in 'nude' mice. (victimsofcharity.org)
  • Researchers who thanked Cancer Research UK (CRUK) for their 'generous financial support' conducted cruel and outdated experiments on a number of nude mice, in order to give them bone cancer. (victimsofcharity.org)
  • In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
  • Compared to other research model animals, the mouse has the advantages of lower cost, easy breeding, faster reproduction, and more litters - providing several generations on a reduced timespan, ideal for such time-sensitive studies. (cyagen.com)
  • MATERIALS AND METHODS Animals Inbred male BALB/c mice, age 3C5 weeks, were obtained from the animal facility of Centro de Pesquisas Gon?alo Moniz, Funda? (solventcentral.com)
  • Mouse research has also highlighted a … Animals are necessary to reproduce the complex network involved in atherosclerosis and aneurysm formation. (citymeuble.com)
  • Can mouse models help researchers cross the finish line? (ddw-online.com)
  • Among several commercial services who have claimed to be specialized to generate mouse models with genetic modifications, I recognize that Cyagen is one of the best. (cyagen.com)
  • Therefore, it is important to enhance the availability and accessibility of mouse resources to conduct research projects efficiently using valuable mouse models. (biomedcentral.com)
  • Furthermore, the AMMRA participates in the Global Mouse Models for COVID-19 Consortium to support research fighting the coronavirus pandemic. (biomedcentral.com)
  • Another study published in June shows that MPEP also lessens repetitive behaviors and seizures in mouse models of fragile X syndrome 3 . (spectrumnews.org)
  • What are the advantages of using mouse models to study human-infecting coronavirus diseases? (cyagen.com)
  • Although these mouse models all showed respiratory epithelial cell infections from exposure to SARS-CoV, mice were found to die with encephalitis. (cyagen.com)
  • The creation of mouse models to investigate the multistep progression model has greatly expanded our knowledge (9 10 The diverse genetically engineered models which use a variety of promoters to target multiple exocrine cell types cause a spectrum of pathologic changes that mimic various aspects of the human disease (11). (lifescienceexec.com)
  • JAX plays a special role in maintaining and distributing genetically defined mouse models to the worldwide scientific community. (jax.org)
  • Now you can generate new mouse models from a selection of common inbred strains without the need for MTAs or special permission. (jax.org)
  • Accordingly, researchers using the rat and mouse orthotopic keratoplasty models have developed grading systems for corneal graft rejection which incorporate each of these features-cellular infiltration, oedema, opacity, and new vessel ingrowth-and produce an aggregate score. (bmj.com)
  • Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes. (mousemine.org)
  • The cryopreservation of sperm and embryos is useful to efficiently archive valuable resources of genetically engineered mice. (biomedcentral.com)
  • Researchers can obtain live mice, cryopreserved embryos, or the sperm of choice from those mouse banks. (biomedcentral.com)
  • Valuable, well-characterized mouse lines that are no longer routinely used can be safely stored as frozen embryos. (northwestern.edu)
  • The mutants exhibit severe forebrain truncation in homozygous mouse embryos and various craniofacial defects in heterozygotes. (silverchair.com)
  • Intranasal delivery in BALB/c mice demonstrated enhanced brain distribution with increasing time after administration. (omeka.net)
  • The interaction of a mouse monoclonal antibody (4A6) and birch profilin, a structurally well conserved actin- and phosphoinositide-binding protein and cross-reactive allergen, was characterized. (ox.ac.uk)
  • Inbred female Balb/c-mice were exposed to silica (7631869) dust over a period of 39 weeks to study alterations of B-lymphocyte immunocompetence. (cdc.gov)
  • For these experiments we will use a well established inbred mouse strain - BALB/c female mice between 6 and 8 weeks, where the pathogenic bacteria are inoculated onto wounds made by scraping the skin with a scalpel blade. (mattilsynet.no)
  • Territorialim, sexual selection and social interaction was intrinsic characteristic of the mouse lab and dominant behavior can be observed in both male and female mice. (peertechzpublications.com)
  • The researchers state the young female mice had a 'burden' of tumours in their bones that was about 56 times higher than that of older mice. (victimsofcharity.org)
  • Our data demonstrate that age-related seminal fluid exerts opposing effects in asthmatic male and female mice. (aging-us.com)
  • however, in female mice it was only significant in the nicotine-exposed group. (highwire.org)
  • Lung ACE-2 expression was increased in male mice in a nicotine-dependent manner as compared with female mice. (highwire.org)
  • In a standard F2 intercross between two inbred parental lines there are two alleles at every polymorphic locus that are often referred to as the little "a" allele and big "A" allele. (genenetwork.org)
  • Till date, the international collaboration of mouse banks (International Mouse Strain Resource: IMSR) has successfully collected more than 60,000 strains of genetically engineered mice (Table 1 ). (biomedcentral.com)
  • The archived mouse strains can be browsed through the IMSR website ( http://www.findmice.org/ ) [ 6 ]. (biomedcentral.com)
  • The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. (wikipedia.org)
  • Laboratory mice are usually of the species Mus musculus. (wikipedia.org)
  • The laboratory mouse genome has been sequenced and many mouse genes have human homologues. (wikipedia.org)
  • Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (Peromyscus leucopus) and the North American deer mouse (Peromyscus maniculatus). (wikipedia.org)
  • In the early part of the 20th century, Harvard undergraduate Clarence Cook Little was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)
  • The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. (wikipedia.org)
  • The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. (wikipedia.org)
  • The Jackson Laboratory (JAX) deliberately breeds mice to be genetically predisposed to have debilitating ailments-including cancerous tumors, obesity, paralysis, a depressed immune system, and high levels of anxiety and depression. (citymeuble.com)
  • All mice were found in compliance using the NIH Information for the utilization and Care of Laboratory Pets. (lifescienceexec.com)
  • Hence, the perceived necessity for the study of mice behavior in the laboratory in order to promote knowledge that could be used in the development of new equipment, procedures and techniques, improving the welfare of laboratory mice. (peertechzpublications.com)
  • To find out the function of some of these highly conserved non-protein-coding regions in mammals, Edward Rubin's team at the Lawrence Berkeley National Laboratory in California deleted two huge regions of junk DNA from mice containing nearly 1000 highly conserved sequences shared between human and mice. (uncommondescent.com)
  • J:259852 Mouse Genome Informatics and the WTSI Mouse Genomes Project, MGI Strain Genome Feature and Gene Model Load. (jax.org)
  • Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. (vanderbilt.edu)
  • Regarding the construction strategy of a hACE2 humanized mouse model, researchers are currently using different (tissue-specific or widely expressed) promoters and expression vectors constructed by the hACE2 gene, to obtain a randomly inserted transgenic mouse model by prokaryotic injection. (cyagen.com)
  • We have immunized mice with various DNA constructs encoding APR/8/34 influenza virus hemagglutinin (HA), either fused to or separate from, IL-23 or RANTES using a gene gun. (ox.ac.uk)
  • For preclinical evaluation of immunogenicity of these proteins in mice, chimeric P. berghei sporozoites were created that express the P. falciparum proteins in sporozoites as an additional copy gene under control of the uis4 gene promoter. (jenner.ac.uk)
  • Being a model for individual deviation, inbred mouse strains have already been central to your knowledge of the function of obtained Rabbit polyclonal to Caldesmon.This gene encodes a calmodulin-and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction.The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomy and innate immune system systems. (gdc-0068.net)
  • The figure above -- derived from exhaustive opsin gene family annotation in all available genome projects -- shows that the immediate rodent ancestor of naked mole-rat (NMR) had eight phylogenetically expected opsins, as mouse does today. (ucsc.edu)
  • Homozygous inactivation of this gene causes embryonic lethality and extensive developmental defects in inbred strains. (jax.org)
  • Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. (mousemine.org)
  • Three mammalian species are reservoir competent: the white-footed mouse ( Peromyscus leucopus ), raccoon ( Procyon lotor ), and gray squirrel ( Sciurus carolinensis ), although serologic and molecular evidence has suggested that numerous other small, medium, and large mammals may also be reservoirs ( 1 , 3 ). (cdc.gov)
  • This was then further explored in species that can generate their own body heat (endotherms) and usually maintain a relatively constant body temperature ( T b ), also known as homeotherms, like mice whereby marijuana derivatives were used to induce hypothermia. (springer.com)
  • Here, we look at a species familiar to most: Mus musculus, or the mouse. (citymeuble.com)
  • The mouse AIF-1 was highly conserved among all reported AIF-1 from a variety of species, from invertebrates to mammals, and the cloned cDNA was in good accordance with putative expressed regions of genomic sequences in the mouse major histocompatibility complex (MHC) class III region. (lshtm.ac.uk)
  • Male BALB/c mice were exposed head/nose-only during three consecutive days for 45, 90, 180, or 360 min/day to et al. (cdc.gov)
  • Potentially, more than 2000 pups can be produced from the cryopreserved sperm collected from a male mouse. (biomedcentral.com)
  • METHODS: Skeletally mature C57Bl6 male mice underwent DMM surgery in the right leg. (ox.ac.uk)
  • Desk 3 B6-Chr YFVB-and BALB-Chr YFVB-consomic mice create a considerably larger amount of lesions than FVB-mice on pancreatic lesion multiplicity FVB-male transgenic mice had been crossed with C3 SW B6 D2 and BALB inbred stress females to create F1 progeny. (lifescienceexec.com)
  • METHODS: Male balb/c mice underwent 30% total body surface area full-thickness steam burn. (mcw.edu)
  • Observing their daily routine, the presence of aggressive behavior patterns of individual mice, mainly male adult mouse. (peertechzpublications.com)
  • In the adult male mice, the aggressive behavior, there is high prevalence of behavior between adult individuals. (peertechzpublications.com)
  • In 2-month-old male mice, however, human seminal fluid failed to decrease asthmatic features and even enhanced osteopontin and IL-17A transcription. (aging-us.com)
  • We further show that vaping increases ACE-2 expression in the lung, which is further enhanced by nicotine exposure in male mice. (highwire.org)
  • Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. (vanderbilt.edu)
  • ref>Rogers JV, Choi YW, Giannunzio LF, Sabourin PJ, Bornman DM, Blosser EG and Sabourin CLK (2007) Transcriptional responses in spleens from mice exposed to Yersinia pestis CO92. (msu.edu)
  • Material/Methods: Mice were subjected to whole-body exposure with 60Co gamma rays with a dose range of 0-8 Gy at a dose rate of 0.80 Gy/min. (medscimonit.com)
  • Methods A syngeneic model system for invasive breast cancer with (4T1.2) or without (67NR) the tendency to form lung metastasis was established in BALB/c mice. (icr.ac.uk)
  • We used two ethological methods: i) Open-field and ii) Elevated plus-maze test in the three categories of behavior observed, dominant, subordinate and isolated mice. (peertechzpublications.com)
  • Ovalbumin treatment induced a high incidence (approximately 50%) of mast cell degranulation compared to control phosphated-buffered saline-treated mice. (ox.ac.uk)
  • GF Swiss Webster mice are excellent embryo recipients or foster mothers. (taconic.com)
  • In the new study, researchers looked at the effect of MPEP treatment on BALB/c mice, an inbred strain that is less social than typical Swiss Webster mice. (spectrumnews.org)
  • By contrast, Swiss Webster mice treated with MPEP spend less time sniffing a novel mouse than those treated with placebo. (spectrumnews.org)
  • Still, confirming results from previous studies, MPEP significantly decreases the amount of time that Swiss Webster mice engage in repetitive behaviors when placed in a cage with a freely roaming mouse, such as rearing up, climbing the walls of the cage and self-grooming. (spectrumnews.org)
  • Compared with Swiss Webster mice, BALB/c mice have low levels of each of these repetitive behaviors in the presence of another mouse, and these behaviors are not significantly affected by MPEP treatment. (spectrumnews.org)
  • Desk 2 Linkage to pancreatic lesion multiplicity in F2 N2 and intercross backcross mice. (lifescienceexec.com)
  • However, additional adoptive transfer of MDSCs did not further ameliorate corneal survival in these allogeneic corneal transplantation mice.ConclusionsInflammation-induced MDSC transfer could reduce corneal neovascularization and prolong corneal allograft survival. (ox.ac.uk)
  • At all time points following the aerosol stimulation of the mice with whole Escherichia-coli-055:B5, the thymus independent anti Escherichia-coli lipopolysaccharide (LPS) response was significantly suppressed in the spleen. (cdc.gov)
  • Post-hoc analysis mice could partly explain the larger increase in mPer expression revealed that women with major depression had significantly in this strain, a higher stress response seems not to underlie the more slow wave sleep in naps which occurred in the evening lower EEG delta power rebound after SD in this strain. (pdfdrug.com)
  • The variation in dietary fat selection across inbred strains provides a tool for dissecting the complex genetics of this trait. (nih.gov)
  • In Kumamoto University, the Center for Animal Resources and Development (CARD) was established as a research center for genetics and biomedical science using genetically engineered mice and as a quality center of mouse resources as a mouse bank in 1998 [ 4 , 5 ]. (biomedcentral.com)