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  • BALB
  • Structural lung damage caused by induced asthma mimics the phenotype found in asthma patients more closely than does the induced damage in BALB/c mice. (jax.org)
  • Phenotype
  • Our preclinical efficacy testing services offer scientific expertise and an array of target-based and phenotype-based outcome measures, both in vivo and at endpoint, for flexible study designs and assay development in mouse models of Lupus. (jax.org)
  • Typing these mice for a particular phenotype and comparing the obtained SDP with polymorphic markers previously mapped by others in the BXD strains may result in a map position for the trait of interest. (nih.gov)
  • genes
  • Importantly, we showed that 6 of 10 genes identified as encoding important virulence factors for mouse and A. thaliana pathogenesis are also required for effective killing of C. elegans ( 2 ). (pnas.org)
  • The variation in aortic lesions found among inbred strains provided the basis for several additional studies that demonstrated the existence of eight genes affecting atherosclerosis. (jax.org)
  • A variety of mutations causing immunodeficiencies, targeted mutations in cytokine genes, as well as transgenes affecting immune functions, have been backcrossed into the NOD/ShiLt inbred strain background. (jax.org)
  • In addition, we find that 7 of the 26 kallikrein genes are differentially expressed between susceptible and resistant mice, including the Klk1b11 gene. (pubmedcentralcanada.ca)
  • AQPCR showed transcriptional changes of fewer genes associated with inflammation and corneal tissue homeostasis in alkali-burned corneas from MRL mice. (arvojournals.org)
  • Loci
  • These advances include (i) a quadrupling of the density of the genetic map of the mouse, (ii) the ease of genotyping large numbers of marker loci distributed across the entire mouse genome by the polymerase chain reaction, (iii) a far more powerful conceptual framework for mapping quantitative trait loci (QTLs) that underlie complex genetic traits, and (iv) significantly more reliable and economical ways to estimate numbers of neurons. (nervenet.org)
  • The role of C5 was further explored in B10.D2 mice, which are identical for all loci other than C5 . (rupress.org)
  • pathogen of mice
  • Interestingly, we showed that a clinical isolate of P. aeruginosa strain PA14 is not only a pathogen of mice but also kills C. elegans ( 1 , 2 ), and we identified two distinct modes of PA14-mediated killing of C. elegans that appear to be mechanistically distinct. (pnas.org)
  • embryo
  • Our results show that Q5k mRNA is present during the whole postimplantational development of the AKR embryo/fetus (gestation day 6 to 15). (vu-wien.ac.at)
  • Using quantitative RT-PCR, we found that Sorbs1 is highly expressed in the mouse uterus during embryo implantation. (g3journal.org)
  • susceptible
  • C5 -deficient B10.D2 mice were protected from CM, whereas C5 -sufficient B10.D2 mice were susceptible. (rupress.org)
  • Antibody blockade of C5a or C5a receptor (C5aR) rescued susceptible mice from CM. In vitro studies showed that C5a-potentiated cytokine secretion induced by the malaria product P. falciparum glycosylphosphatidylinositol and C5aR blockade abrogated these amplified responses. (rupress.org)
  • Murine
  • The importance of these findings for the interpretation of the earlier reported effects of P2X7 in mice is discussed, along with strategies in developing a murine model for testing the therapeutic effects of P2X7 agonists and antagonists upon postmenopausal osteoporosis. (hindawi.com)
  • inflammation
  • Alkali-burned corneas heal faster and more completely in MRL mice than in B6 mice, by means of rapid reepithelialization, reduced inflammation, and reduced fibrosis. (arvojournals.org)
  • viral
  • 12-25 % of MCF induced early lymphomas of AKR mice show MCF viral integration's near c-myc in an opposite transcriptional orientation. (umassmed.edu)
  • variation
  • The interaction between genotype and environment is recognized as an important source of experimental variation when complex traits are measured in the mouse, but the magnitude of that interaction has not often been measured. (genetics.org)
  • In the present study, we analyzed the degree of phenotypic variation in female infertility across 25 inbred mouse strains. (g3journal.org)
  • neoplasms
  • 3-MC injection and the presence of skin tumors had no influence on the development of glomerulonephritis or hematopoietic neoplasms in the NZB mice. (worldwidescience.org)
  • Biology
  • This essay presents some practical advice and suggestions for those who wish to use mice and rats in experiments on the biology of aging. (afar.org)
  • physiological
  • IT is widely recognized that environmental variables, such as who carries out the experiment and when, and physiological variables, such as sex and weight, are confounds that need to be accounted for during the collection of mouse phenotypes. (genetics.org)
  • Although a growing number of aging and Alzheimer's disease (AD) animal models are available, a more comprehensive and physiological mouse model is required. (hindawi.com)
  • rats
  • This article is intended to convey some rules-of-thumb for investigators just starting to think about the design of experiments on aging using mice and rats. (afar.org)
  • In addition the word "mice" will be used throughout to mean "mice and rats," except in those cases where mice are different from rats. (afar.org)
  • receptor
  • Macrophages from mouse strains with the naturally occurring mutation P451L in the purinergic receptor P2X7 have impaired responses to agonists (1). (hindawi.com)
  • bone
  • The concept of immunologic tolerance arose from bone marrow transplantation in neonatal or irradiated mice, in which the predominant mechanism is clonal deletion of donor-specific T cells by donor hemopoietic cells in the recipient thymus. (ox.ac.uk)
  • Rapid reepithelialization and reduced keratitis/iritis were also observed in neutrophil-depleted B6 mice, but not in B6 mice reconstituted with MRL bone marrow. (arvojournals.org)
  • tissue
  • After all, the aging process, which creates decrepit old mice from healthy, fit, young ones, takes many months to do this, and age-dependent changes in many cells, tissue, and organ systems can usually be demonstrated well before the median survival time for the species or stock. (afar.org)
  • early
  • NOD inbred mice originated early on in the inbreeding of the Cataract Shionogi (CTS) strain. (jax.org)
  • Administration of the early acting cytokine flt-3 ligand to these strains resulted in activation of quiescent primitive stem cells exclusively in strains with high endogenous stem cell numbers (DBA and AKR), but was unrelated to strain-specific progenitor cell cycling. (nih.gov)
  • eight
  • Here we report that among eight P. aeruginosa PA14 Tn phoA mutants isolated that exhibited reduced killing of C. elegans , at least five also exhibited reduced virulence in mice. (pnas.org)
  • model
  • remarkably, most of these mutants also were less pathogenic in a mouse burn model ( 9 ). (pnas.org)
  • infiltration
  • Diabetes in NOD mice is characterized by hyperglycemia and insulitis, a leukocytic infiltration of the pancreatic islets. (jax.org)
  • Marked inflammatory cell infiltration and fibrosis were evident in the corneas and anterior chambers of B6 mice. (arvojournals.org)
  • Primary
  • We will study four well-defined and interconnected cell populations in the mouse primary visual system (photoreceptors, horizontal cells, retinal ganglion cells, and neurons in the dorsal lateral geniculate nucleus). (nervenet.org)
  • available
  • A total of 132,285 SNPs for 25 out of the 33 inbred mouse strains with available female infertility data were retrieved. (g3journal.org)
  • Many beginners ask for the oldest available mice for their initial age effect study under the presumption that the old ones will show bigger differences from young controls, and thus produce significant results quicker. (afar.org)