• 2018). Upregulation of PRKN appearance or RNAi-mediated downregulation UNC0638 of Green1 amounts suppressed TDP43-induced degenerative phenotype in knockout mice exhibited high degrees of TDP43, underscoring an essential function for PRKN Rabbit Polyclonal to GAK in mediating TDP43 clearance and cytosolic localization (Wenqiang et al. (citiesofdata.org)
  • Senp2 knockout mice exhibited a lipodystrophy-like phenotype. (deepdyve.com)
  • The Fmr1, Shank2 and Cntn5 knockout mice exhibited alterations of glutamate receptors, which may become a target for pharmacologic modulation. (nih.gov)
  • Lyset knockout mice exhibited MLII-like phenotypes and human pathogenic LYSET alleles failed to restore lysosomal sorting defects. (stanford.edu)
  • The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. (cdc.gov)
  • β1(-/-) mice exhibit a dramatic neurological phenotype that includes an ataxic gait, spontaneous seizures, and premature death. (jneurosci.org)
  • In Atm-knockout (Atm-KO) mice, complete loss of Atm leads to a very mild neurological phenotype, suggesting that Atm loss is not sufficient to markedly abrogate cerebellar structure and function in this organism. (eur.nl)
  • Expression of inactive ("kinase-dead") Atm (AtmKD) in mice leads to embryonic lethality, raising the question of whether conditional expression of AtmKD in the murine nervous system would lead to a more pronounced neurological phenotype than Atm loss. (eur.nl)
  • However, both strains exhibited normal life span and displayed no gross cerebellar histological abnormalities or significant neurological phenotype. (eur.nl)
  • Greater pressure needs to be exerted on genome stability to obtain a mouse model that recapitulates the severe A-T neurological phenotype. (eur.nl)
  • While the use of a ubiquitous promoter fully and sustainably rescued the disease (long-term survival, normal phenotype and correction of biochemical abnormalities), liver-specific expression of BCKDHA led to partial, though sustained rescue. (nature.com)
  • Most mutations in ATM result in truncation and destabilisation of the protein, but certain missense and splicing errors have been shown to produce a less severe phenotype. (bmj.com)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Mice homozygous for ENU-induced alleles exhibit skin phenotype and alopecia. (jax.org)
  • In the present study, transcriptomic analysis of fracture callus gene expression in three strains of mice was used to identify differe. (researchgate.net)
  • Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)
  • We generated two mouse strains in which AtmKD was conditionally expressed as the sole Atm species: one in the CNS and one specifically in Purkinje cells. (eur.nl)
  • An ENU mutagenesis library was screened for renal phenotypes and mutant mouse strains were established via backcrossing. (asn-online.org)
  • Both patients were 129MM homozygous, olation in the cerebellar peduncle (Figure 2, panels A, B). had never received a blood transfusion or tissue graft, and VM mice showed mild to moderate vacuolation in the me- had lived in the same town within the Castilla-León region dulla, thalamus, and septum, but typically not in the hy- of Spain (Table 1) ( 1 ). (cdc.gov)
  • The majority of the homozygous mutant mice exhibited retinal depigmentation spots in the fundus test. (mmrrc.org)
  • RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (mmrrc.org)
  • While heterozygous mice exhibited a renal-restricted phenotype inherited in an autosomal dominant fashion, homozygous mutants exhibited perinatal lethality due to vascular anomalies and hypoxia. (asn-online.org)
  • On rare occasions, for example when very few F1 mice are obtained from the chimera, F1 heterozygous mice are crossed to 129/SvEvBrd x C57BL/6 hybrid mice to yield additional heterozygous animals for the intercross to generate the F2 mice. (mmrrc.org)
  • Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertility and strong respiratory dysfunction caused by defective mucociliary clearance. (nature.com)
  • In both mouse and Xenopus , miR-34/449-deficient multiciliated cells (MCCs) exhibited a significant decrease in cilia length and number, due to defective basal body maturation and apical docking. (nature.com)
  • Reelin, a glycoprotein secreted by Cajal-Retzius neurons in the marginal zone (MZ), is crucial for this "inside-out" layering, because the layers are inverted in the Reelin-deficient mouse, reeler ( Reln rl ). (jneurosci.org)
  • Xpc −/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa -deficient or wild-type mice. (aacrjournals.org)
  • Additionally, Xpc -deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa −/− mice, whereas in both models mutant frequency is increased in liver. (aacrjournals.org)
  • Mice deficient for SUN4 exhibited severely disorganized manchette residues and gravely misshapen sperm heads. (uni-wuerzburg.de)
  • Early-passage neural stem cells (NSCs) derived from Dnmt3a-deficient ESCs exhibited a moderate phenotype in precocious glial differentiation compared with wild-type counterparts. (ca.gov)
  • Atm deficient mice exhibit many of the symptoms found in patients with AT and have a high frequency of thymic lymphoma. (bmj.com)
  • The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy. (bmj.com)
  • While control mice recovered from LPS injury without structural abnormalities, ß1-deficient mice had more severe inflammation and developed emphysema. (bvsalud.org)
  • We establish and characterize the Bckdha ( branched chain keto acid dehydrogenase a ) −/− mouse that exhibits a lethal neonatal phenotype mimicking human MSUD. (nature.com)
  • Successful treatment of severe MSUD in Bckdhb-/- mice with neonatal AAV gene therapy. (stanford.edu)
  • We and others have tested AAV gene therapy in mice for two of the three genes involved in MSUD, BCKDHA and DBT. (stanford.edu)
  • We performed the first characterization of a Bckdhb-/- mouse model, which recapitulates the severe human phenotype of MSUD with early-neonatal symptoms leading to death during the first week of life with massive accumulation of MSUD biomarkers. (stanford.edu)
  • Injection in neonatal Bckdhb-/- mice at 1014 vg/kg achieved long-term rescue of the severe MSUD phenotype of Bckdhb-/- mice. (stanford.edu)
  • Researchers from the University of Bonn and the Max Planck Institute for Molecular Genetics used genetic engineering methods to create a mouse that mimics these patients very well. (sciencedaily.com)
  • Using the CRISPR-Cas9 gene scissors, the researchers and their colleagues from the Max-Planck-Institute for Molecular Genetics in Berlin modified the PIGV gene in mice based on a model of the patients. (sciencedaily.com)
  • Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized. (datadryad.org)
  • We found that the OA in STR/Ort mice exhibited a molecular phenotype resembling human OA, and we pinpointed a central role of NF-κB signaling and the emergence of an immune-related signature in OA cartilage over time. (bepress.com)
  • Endocrine and molecular factors of increased female reproductive performance in the Dummerstorf high-fertility mouse line FL1. (fbn-dummerstorf.de)
  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
  • Our lab employs state-of-the-art molecular biology techniques, mouse models, and patient samples to uncover mechanisms that regulate TAM phenotypes. (lu.se)
  • Extensive behavioral tests have shown that this mouse model very closely reflects the disease observed in humans," says Miguel Rodríguez de los Santos from the Institute for Medical Genetics and Human Genetics at the Charité. (sciencedaily.com)
  • The behavioral tests on the genetically modified mice were carried out in cooperation with scientists from the "Animal Outcome Core Facility" of the NeuroCure Cluster of Excellence at the Charité. (sciencedaily.com)
  • Taken together, these findings suggest that a functional deficit in nigrostriatal dopamine transmission may contribute to the behavioral phenotype and the resistance to malonate-induced neurotoxicity characteristic of R6/1 HD mice. (lu.se)
  • Figure 3: miR-34/449 deficiency causes defective basal body docking in mouse airway MCCs. (nature.com)
  • A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. (mpg.de)
  • Here we examined whether deficiency of a de novo DNA methyltransferase, Dnmt3a, affects in vitro differentiation of mouse embryonic stem cells (mESCs) to neuronal and glial cell lineages. (ca.gov)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
  • We used histologic, immunofluorescence, RNA sequencing, and metabolic assays to characterize kidneys from these mice and controls during development and up to postnatal day 21. (lww.com)
  • Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1. (fbn-dummerstorf.de)
  • This is because several of the contaminants in technical grade methoxychlor are directly estrogenic (Kupfer and Bulger 1987b), whereas pure methoxychlor is proestrogenic and requires metabolic activation before exhibiting estrogenic activity (Bulger et al. (cdc.gov)
  • Metabolic pathways that regulate TAM phenotypes. (lu.se)
  • 2019). Using the APP/PS1 transgenic mouse model co-expressing the familial Advertisement Swedish mutations (APPstudy, basically the mitochondrial fission flaws had been rescued by co-expression of mitochondrial pro-fusion genes Marf, Opa1, as well as the prominent negative mutant type of Drp1 (Altanbyek et al. (citiesofdata.org)
  • Transgenic mouse models. (nih.gov)
  • To investigate the effects of loss of β1 function in vivo , we have used gene-targeting methods to produce β1(-/-) mice, and we have analyzed their neuronal phenotypes. (jneurosci.org)
  • The pathogenic condition has various phenotypes, including fulminant infectious mononucleosis, dysgammaglobulinemia and malignant B cell lymphomas [Purtilo et al. (lu.se)
  • Thus, LYSET is required for correct functioning of the M6P trafficking machinery, and mutations in LYSET can explain the phenotype of the associated disorder. (stanford.edu)
  • In addition, approximately 3% of patients with true Rubinstein-Taybi syndrome or a phenotype that resembles it show mutations in the EP300 gene, underscoring the genetic heterogeneity of the disorder. (medscape.com)
  • Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs) Inhibits phospholipase A2 in vitro Binds phosphatidylcholine, phosphatidylinositol Binds to fibronectin: The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. (wikipedia.org)
  • However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. (wikipedia.org)
  • ing, and neuropathological and biochemical analysis of the Despite differences in patient age and disease manifesta- tions, we found the same strain properties in these patients mice as previously described ( 3-5 ). (cdc.gov)
  • Each mutant strain exhibited a specific subset of the phenotypes observed with Ikaros null mice. (nih.gov)
  • These defects resulted in a globozoospermia-like phenotype and male mice infertility. (uni-wuerzburg.de)
  • Age-matched 8- to 12-wk-old IRAP wild-type (WT) and knockout (KO) male mice were used for all experiments. (bvsalud.org)
  • Together with colleagues involved in translational epilepsy research at the University Hospital Bonn under Prof. Dr. Albert Becker, the researchers also discovered that the transgenic mice have an increased susceptibility to epilepsy. (sciencedaily.com)
  • To address this key question, we used in vivo time-course analysis of OA development and murine interstrain variability in natural susceptibility to OA to examine changes in non-OA-prone CBA mice versus OA-prone STR/Ort mice, which develop disease that bears significant histologic resemblance to human OA. (bepress.com)
  • In RIII and C57BL/6J mice, we as seen in an MRI brain scan led to a diagnosis of suspected observed moderate to mild vacuolation in the medulla and vCJD. (cdc.gov)
  • C57BL/6J mice also exhibited mild vacu- nosis of vCJD. (cdc.gov)
  • To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa −/− , Xpc −/− and wild-type control female mice in a pure C57BL/6J background were done. (aacrjournals.org)
  • The chimeric mice are bred to C57BL/6J albino mice to generate F1 heterozygous animals. (mmrrc.org)
  • The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
  • Our research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. (lu.se)
  • Moreover, the cancer cells themselves are highly plastic, with some of the cells exhibiting stem-like phenotypes. (lu.se)
  • For example, they showed significantly worse spatial orientation than mice without this mutation and displayed altered social behavior. (sciencedaily.com)
  • Collectively, our data suggest that huRBCs reconstituted NSG mice infected with attenuated P . falciparum is a valuable tool to explore the role of C9 mutation in the growth and survival of parasite mutants and their response to the host's immune responses. (frontiersin.org)
  • Here, we present a cystic kidney phenotype in mice carrying a novel missense mutation in SAMD9L , a gene that has previously been implicated in congenital autoinflammatory disorders and pediatric myelodysplastic syndrome. (asn-online.org)
  • We identified a novel missense mutation in SAMD9L that resulted in a severe cystic kidney phenotype, with associated perturbations in proteostatic stress pathways and metabolism. (asn-online.org)
  • The classic examples of necessarily be processed by the cel replication fidelity can confer strong chemical agents that require met- into a mutation (see Chapter 12, by mutator phenotypes that result in ge- abolic activation to become carci- DeMarini). (who.int)
  • Characterization of endo-phenotypes in relation to the physiological function of the insulin signaling pathway in liver tissue may contribute to a better understanding of the overall regulation of growth and body composition. (usda.gov)
  • Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
  • How similar is the mouse to human patients? (sciencedaily.com)
  • The targeted mouse gene is Pdgfc (platelet-derived growth factor, C polypeptide), the ortholog of human PDGFC. (mmrrc.org)
  • Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
  • Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)
  • A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
  • This NSG mouse, depleted with γ-chain of the IL-2 receptor, has been shown to better tolerate a variety of human transplanted cells ( 17 - 24 ). (frontiersin.org)
  • Based on our previous experience in Bckdha-/- mice, we designed a transgene carrying the human BCKDHB gene under the control of a ubiquitous EF1α promoter, encapsidated in an AAV8 capsid. (stanford.edu)
  • We report here that mutant mice lacking Gli2 function exhibit foregut defects, including stenosis of the oesophagus and trachea, as well as hypoplasia and lobulation defects of the lung. (nih.gov)
  • A reduction of 50% in the gene dosage of Gli3 in a Gli2-/- background resulted in oesophageal atresia with tracheo-oesophageal fistula and a severe lung phenotype. (nih.gov)
  • Mutant mice lacking both Gli2 and Gli3 function did not form oesophagus, trachea and lung. (nih.gov)
  • Airway IFN-γ + CD8 + T-cells were decreased and lung germination was eliminated in mice that aspirated A. fumigatus conidia that were formaldehyde-fixed or heat-inactivated. (cdc.gov)
  • Strikingly, Xpa −/− and Xpc −/− mice also showed a phenotypical difference in terms of tumor spectrum. (aacrjournals.org)
  • Previously I have determined that Rpl22 functions as a haploinsufficient tumor suppressor in a mouse T-cell lymphoma model by activating NFB and its target Lin28B 3. (dtic.mil)
  • In particular, compound 21 (SNS-314) is a potent and selective Aurora kinase inhibitor that exhibits significant activity in pre-clinical in vivo tumor models. (rcsb.org)
  • We recently demonstrated that abrogating Sprouty2 function strongly inhibits intracranial tumor growth and leads to significantly prolonged survival of glioblastoma bearing mice by induction of ERK-dependent DNA replication stress. (springer.com)
  • Silencing of Mnks in TAMs reprograms them into an anti-tumor phenotype, entailing activation of TILs and induction of vessel normalization, which hampers distant metastasis. (lu.se)
  • TAMs are plastic cells that exhibit a spectrum of states spanning from an anti-tumor/immunoactivating (sometimes referred to as M1-like) to a pro-tumor/immunosuppressive (sometimes referred to as M2-like) phenotype. (lu.se)
  • We proposed already in 2011 that TAMs of an anti-tumoral phenotype located in the vicinity of tumor vessels (perivascular TAMs) promote vessel normalization that hampers metastatic dissemination. (lu.se)
  • Lower Plasmatic Levels of Saturated Fatty Acids and a Characteristic Fatty Acid Composition in the Ovary Could Contribute to the High-Fertility Phenotype in Dummerstorf Superfertile Mice. (fbn-dummerstorf.de)
  • mir-34/449 TKO mice exhibit defective mucociliary airway clearance and infertility. (nature.com)
  • Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)
  • In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
  • Enzymatic assays for ATP and lactate production confirmed that dispersed pneumococci exhibited increased metabolism compared to those in biofilms. (lu.se)
  • Researchers now used genetic engineering methods to create a mouse that mimics these patients very well. (sciencedaily.com)
  • We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
  • 1998]. XLP patients exhibit immune defects such as abnormal natural killer and T cell mediated cytotoxicity. (lu.se)
  • Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. (ca.gov)
  • Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. (mpg.de)
  • We found that SET domain bifurcated 1 Since no difference in food intake was observed between adqcKO f/f (Setdb1) was a SUMOylated protein and that Senp2 de-SUMOylated Senp2 and Senp2 mice fedeitherwithNCD or HFD and regulated Setdb1 action in trimethylation at histone 3 lysine 9 (Supplementary Figure S2A). (deepdyve.com)
  • 2004). Using individual TDP43 knock-in flies, UNC0638 TDP43-contaminated mouse principal neurons, TDP43-transfected HEK293T cells, and TDP43transgenic mice, Sunlight et al. (citiesofdata.org)
  • Loss of the Y chromosome does not occur in male reproductive cells, so it is not inherited by the children of men who exhibit Y chromosome loss. (neurosciencenews.com)
  • To test if ß1-containing integrins are required during repair following acute injury, we administered E. coli lipopolysaccharide (LPS) by intratracheal injection to mice with a postdevelopmental deletion of ß1 integrin in AT2 cells. (bvsalud.org)
  • We observed a significant increase in IFN-γ-producing CD8 + T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor , a species that is not typically associated with invasive, disseminated disease. (cdc.gov)
  • Although the number of tyrosine hydroxylase-positive neurons was not reduced and nigrostriatal connectivity remained intact in 16-week-old R6/1 mice, the size of tyrosine hydroxylase-positive neurons in the substantia nigra was reduced by 15%, and approximately 30% of these cells exhibited aggregated huntingtin. (lu.se)
  • Dispersed pneumococci also upregulated genes associated with production of bacteriocins and downregulated colonization-associated genes related to competence, fratricide, and the transparent colony phenotype. (lu.se)
  • results in the overall inversion of the layers seen in the reeler ( Reln rl ) mutant mouse ( Caviness and Sidman, 1973 ). (jneurosci.org)
  • huRBC-reconstituted immunodeficient mice received infectious challenge with attenuated P. falciparum C9 parasite mutants (C9-M), complemented (C9-C), and wild type (NF54) progenitors to study the role of immune effectors in the clearance of the parasite from mouse circulation. (frontiersin.org)
  • adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
  • No other genes in this area are thought to contribute to the phenotype. (medscape.com)
  • The present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. (lu.se)
  • The disease phenotype is characterized by an impaired response to IFN-γ, leading to severe viral disease and mycobacteriosis [Dupuis et al. (lu.se)
  • To address these issues, we expressed Reelin ectopically in the developing mouse cortex, and the results showed that Reelin caused the leading processes of migrating neurons to assemble in the Reelin-rich region, which in turn induced their cell bodies to form cellular aggregates around Reelin. (jneurosci.org)
  • Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. (datadryad.org)
  • This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
  • Gene expression endo-phenotypes were analyzed in QTL Express with multiple normalization methods. (usda.gov)
  • The median survival of Xpc −/− mice showed a significant decrease, whereas the median survival of Xpa −/− mice did not. (aacrjournals.org)
  • Altered testicular cell type composition in males of two outbred mouse lines selected for high fertility. (fbn-dummerstorf.de)
  • For this work, we used genetically engineered mouse models of glioma, primary stromal and glioma cell lines, classical glioblastoma cell lines, and organotypic slice cultures. (lu.se)
  • β1(-/-) mice appear ataxic and display spontaneous generalized seizures. (jneurosci.org)
  • Recently we also found that Rpl22 knockout mice exhibit an MDS-like phenotype associated with anemia and abnormal bone marrow BM hematopoiesis. (dtic.mil)
  • Sodium currents in dissociated hippocampal neurons are normal, but Na v 1.1 expression is reduced and Na v 1.3 expression is increased in a subset of pyramidal neurons in the CA2/CA3 region, suggesting a basis for the epileptic phenotype. (jneurosci.org)
  • Intrastriatal perfusion with malonate in R6/1 mice resulted in a short-lasting, attenuated increase in local dopamine release compared to wild-type mice. (lu.se)
  • By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
  • Instead, the mice suffered a complex series of responses in the immune system, leading to a process referred to as fibrosis throughout the body. (neurosciencenews.com)
  • The objective of this study was to understand the response of mice lacking insulin-regulated aminopeptidase (IRAP) to an acute water load. (bvsalud.org)
  • Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis Nature Genetics. (mpg.de)