Mice estrous cycle. Medical search. Frequent questions

The Imitation of the Ovarian Fatty Acid Profile of Superfertile Dummerstorf Mouse Lines during IVM of Control Line Oocytes Could Influence Their Maturation Rates. (fbn-dummerstorf.de)
Nullizygous mice show smaller body size, subfertility, defects in spermatogenesis and ovarian folliculogenesis, irregular estrous cycles, few/no preovulatory follicles and corpora lutea, increased granulosa cell apoptosis, and increased serum progesterone and estradiol levels after superovulation. (jax.org)
This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. (biomedcentral.com)
hPMSC transplantation can significantly improve the serum levels of high gonadotropin and low estrogen of POF mice, promote follicular development, inhibit excessive follicular atresia and granulosa cell apoptosis, and improve the ovarian reserve capacity. (biomedcentral.com)
COS was given to mice through the best route of administration, and the changes in ovarian and immune function were detected using assays of organ index, follicle counting, serum estrogen (E 2 ) and anti-Mullerian hormone (AMH) levels, and the expression of IL-2 and TNF-α in the ovaries. (biomedcentral.com)
In conclusion, COS could significantly improve the ovarian and immune function of chemotherapy model mice, and improve the survival rate of OGSCs, which provided a preliminary blueprint for further exploring the mechanism of COS in protecting ovarian function. (biomedcentral.com)

The numbers of antral follicles and corpus lutea were significantly reduced in PFHxS-treated mice. (researchsquare.com)
After intraventricular administration of kisspeptin-10, the numbers of antral follicles and corpus lutea recovered, along with the levels of GnRH mRNA, FSH, and LH in mice treated with 5 mg/kg/day PFHxS. (researchsquare.com)
Morphological staining showed that the basal follicles and sinus follicles after hPMSC transplantation were higher in POF mice than in those without treatment, and the follicle number was significantly decreased with atresia. (biomedcentral.com)
In 2004, Johnson [ 4 ] and others found that the atresia rate of mouse follicles was significantly higher than the decrease of non-atretic follicles in follicle counting. (biomedcentral.com)

Estrous cycles start after sexual maturity in females and are interrupted by anestrous phases, otherwise known as "rest" phases, or by pregnancies. (wikipedia.org)
The object recognition test (ORT), also known as the novel object recognition test (NOR), is a relatively fast and efficient means for testing different phases of learning and memory in mice. (jove.com)
The extent and time course of the response to SD did not differ between the two phases of the estrous cycle. (uzh.ch)
Changes in hormone levels alter the way the female brain responds to cocaine during different phases of the estrous cycle in mice (equivalent to the menstrual cycle in humans), according to new research reported January 10 in Nature Communications . (bbrfoundation.org)
The rodent estrous cycle lasts 4 days and consists of 4 phases: proestrus, estrus, metestrus (diestrus I), and diestrus (II). (deubiquitinaseinhibitor.com)
The utreri of rats were collected according to estrous cycle phases (menstruation group). (jri.ir)

The gene, scientists explain could be a strong candidate for involvement in premenstrual dysphoric disorder (PMDD) and other maladies linked to natural flux in hormones during the menstrual cycle. (healthjockey.com)
These findings if applied in the clinic could aid in the diagnosis and treatment of cognitive and mood disorders associated with menstrual cycle. (healthjockey.com)
Estrogen and progesterone levels fluctuate naturally for the duration of the primate menstrual cycle plus the rodent estrous cycle. (deubiquitinaseinhibitor.com)

We used the autologous uterine tissue transfer mouse model and studied the mRNA and protein expression of ERα, ERβ, GPER1, and PR in ectopic lesions at 2, 4, and 8 weeks of induction of endometriosis. (springer.com)
GnRH mRNA levels were reduced in Jak2 G −/− mice when compared with controls, while the number of GnRH neurons was equivalent, indicating a reduction in GnRH gene expression. (jneurosci.org)
Moreover, compared with the control group, PFHxS-treated mice showed decreases in serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estrogen (E2), and reduced GnRH mRNA levels, along with the lack of an LH surge. (researchsquare.com)
Furthermore, PFHxS-treated mice had lower levels of kisspeptin immunoreactivity and kiss-1 mRNA in the arcuate nucleus (ARC) and anteroventral periventricular nucleus (AVPV). (researchsquare.com)
Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle. (uams.edu)
C-E) Co-labeling VMHvl neurons for PR (anti--gal) and Cckar (mRNA) in PRPL/PL mice. (cdc.gov)

Female Jak2 G −/− mice exhibited significantly delayed puberty and first estrus, abnormal estrous cyclicity, and impaired fertility. (jneurosci.org)
Following vaginal opening, the mice were checked for estrous cyclicity by vaginal cytology at 9:00-10:00 am daily throughout the study. (biomedcentral.com)

Compared to vehicle exposure, 5 mg/kg/day PFHxS prolonged the estrous cycle, especially the duration of diestrus, after 42 days of treatment. (researchsquare.com)
The present study demonstrated that the animal model for bubaline endometritis can be developed in mice by intravaginal inoculation of E. coli@ 1.5 × 106 CFU/ml at diestrus. (ac.ir)

The estrous cycle (from Latin oestrus 'frenzy', originally from Ancient Greek οἶστρος (oîstros) 'gadfly') is a set of recurring physiological changes induced by reproductive hormones in females of mammalian subclass Theria. (wikipedia.org)
Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the effects of ELA on adult female mice across the estrous cycle. (researchgate.net)
These results demonstrate an essential role for Jak2 signaling in GnRH neurons for normal reproductive development and fertility in female mice. (jneurosci.org)
and report here a role for the Jak2 signaling molecule in the regulation of reproductive development and function in female mice. (jneurosci.org)
These results indicate that chronic exposure of mice to 5 mg/kg/day PFHxS affects reproductive functions by inhibiting kisspeptin expression in the ARC and AVPV regions, leading to the deficit of follicular development and ovulation. (researchsquare.com)
Endocrine and molecular factors of increased female reproductive performance in the Dummerstorf high-fertility mouse line FL1. (fbn-dummerstorf.de)
Reproductive performance primarily depends on the female genotype in a two-factorial breeding experiment using high-fertility mouse lines. (fbn-dummerstorf.de)

Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies. (igbmc.fr)
Secretion of GnRH is also reduced as basal serum luteinizing hormone (LH) levels were significantly lower in female Jak2 G −/− mice while the pituitary responded normally to exogenous GnRH. (jneurosci.org)
This study aims to investigate the effects of PFHxS exposure on female reproduction and the underlying mechanism in mice. (researchsquare.com)
Sleep homeostasis in the female rat during the estrous cycle. (uzh.ch)
To investigate whether sleep homeostasis in the female rat is modulated by the estrous cycle, the vigilance states, EEG power spectra and cortical temperature (TCRT) were assessed on the basis of 4-day continuous recordings. (uzh.ch)
We previously demonstrated that male mice with carcinogen-induced oral SCC exhibit less nociceptive behavior and a higher concentration of neutrophils in the cancer microenvironment compared to female mice with oral SCC. (frontiersin.org)
We found that recombinant G-CSF (rG-CSF, 5 μg/mouse, intraperitoneal) significantly increased circulating Ly6G + neutrophils in the blood of male and female mice within 24 h of administration. (frontiersin.org)
In an oral cancer supernatant mouse model, rG-CSF treatment increased cancer-recruited Ly6G + neutrophil infiltration and abolished orofacial nociceptive behavior evoked in response to oral cancer supernatant in both male and female mice. (frontiersin.org)
Saline-treated male mice with HSC-3 tumors exhibited less oral cancer-induced nociceptive behavior and had more β-endorphin protein in the cancer microenvironment than saline-treated female mice with HSC-3 tumors. (frontiersin.org)
Chronic rG-CSF treatment (2.5 μg/mouse, every 72 h) increased the HSC-3 recruited Ly6G + neutrophils, increased β-endorphin protein content in the tongue and attenuated nociceptive behavior in female mice with HSC-3 tumors. (frontiersin.org)
We hypothesize that neutrophil recruitment could be exploited as a therapeutic approach to alleviate oral cancer pain in female mice. (frontiersin.org)
Ten male and ten female rats and mice from each group were evaluated on day 32. (nih.gov)
Just for contexts, males sing apparently to attract female mice and tell other males that they can beat them up, judging from the responses you get if you play recorded songs in places where wild singing mice live. (metafilter.com)
According to the researchers, at the organism level, genetic ablation of TBX3 significantly delays the puberty onset of animals and disturbs the estrous cycle of female mice. (medicalxpress.com)
The aim of this study was to assess the effects of brief, intense exposure to tobacco smoke on granulosa cell number, oocyte growth, and follicle size during puberty in female Swiss mice. (biomedcentral.com)
Ten female Swiss mice aged 35 days were exposed to tobacco smoke from 3R4F reference research cigarettes. (biomedcentral.com)
Twenty female Swiss mice were obtained after birth. (biomedcentral.com)
This preference for the environment previously paired with the drug was strongest in female mice that had consumed the cocaine when their estrogen levels were high, indicating they had experienced greater reward activation than males, or female mice that consumed the drug while their estrogen levels were low. (bbrfoundation.org)
The primate menstrual and rodent estrous cycles are closely analogous in spite of the fact that female rodents do not have a functional corpus luteum and consequently do not have a phase analogous to the primate luteal phase (Finn, 2020). (deubiquitinaseinhibitor.com)
2005). Hormonal fluctuations in the course of the estrous cycle have the same pattern in younger female rodents starting puberty as they do in older females. (deubiquitinaseinhibitor.com)
Signaling role of prokineticin 2 on the estrous cycle of female mice. (cornell.edu)
Methods: The female adult rats were divided into six groups following estrous cycle determination (n=36). (jri.ir)
When we examined both male and female BTBR mice in comparison to C57BL/6J (C57) controls, we noted that both sexes of BTBR mice showed motor coordination deficits characteristic of cerebellar dysfunction, but only the male mice showed differences in delay eyeblink conditioning, a cerebellum-dependent learning task that is known to be disrupted in ASD patients. (mdpi.com)
Both male and female BTBR mice showed considerable expansion of, and abnormal foliation in, the cerebellum vermis-including a significant expansion of specific lobules in the anterior cerebellum. (mdpi.com)
B-J) PR is expressed in the basal ganglia, cingulate cortex, and dentate gyrus as visualized by - gal activity in PRPL/PL female and male mice. (cdc.gov)
VMHvl neurons in PRCre/+ and PRCre/PL male and female mice. (cdc.gov)

One difference is that animals that have estrous cycles resorb the endometrium if conception does not occur during that cycle. (wikipedia.org)
Mammals that have menstrual cycles shed the endometrium through menstruation instead. (wikipedia.org)
Ozbilgin K, Boz B, Tuğyan K, Inan S, Vatansever S. RHAMM Expression in the Rat Endometrium during the Estrous Cycle and following Implantation. (jri.ir)

We show that mouse uterine ILC2s have a heightened type-2 gene signature and expand during pregnancy. (elifesciences.org)
The human pregnancy-lactation-involution cycle is a dynamic, multi-step process. (biomedcentral.com)
In estrous cycle and on day 4 of pregnancy, the rat endometrial stroma has two morphologically distinct compartments, denominated supepithelium and deep stroma. (jri.ir)

Humans have menstrual cycles rather than estrous cycles. (wikipedia.org)
PFHxS is persistent and poorly metabolized with estimated half-lives of 1 month, 4 months, and 7.3 years in mice, monkeys, and humans, respectively [6,7]. (researchsquare.com)
To better understand the pathophysiological role of the cerebellum in ASD, it is necessary to have a variety of mouse models that have face validity for cerebellar disruption in humans. (mdpi.com)

Gram-negative bacterial LPS induced poor uterine receptivity and implantation failure in mouse: alterations in IL-1beta expression in the preimplantation embryo and uterine horns. (ac.ir)
The uterus undergoes extensive remodeling during estrous cycle and embryo implantation (10). (jri.ir)
It is known that RHAMM plays an important role in several cellular events, but the role of RHAMM during estrous cycle and embryo implantation has not been investigated much. (jri.ir)

This poster was inspired by the September/October image of our 2014 JAX® Mice, Clinical & Research Services Calendar, representing the C57BL/6J (000664) gold standard mouse strain. (jax.org)

It was discovered that the BDNF Met mice were significantly worse at both tasks. (healthjockey.com)
The results showed that hPMSC transplantation can significantly recover the estrus cycle in the POF group. (biomedcentral.com)

The most commonly used methods for catching and picking up mice are grasping the animal near the tip of the tail, between thumb and forefinger, or by grasping the tail near the base or the neck between the ends of a smooth tipped forceps. (uwm.edu)

Many mammals used in commercial agriculture, such as cattle and sheep, may have their estrous cycles artificially controlled with hormonal medications for optimum productivity. (wikipedia.org)

The finding is claimed to be the first instance that a genotype has been shown to communicate with a hormone cycle, such that it may influence a cognitive behavior. (healthjockey.com)

This poster is a great resource for accurately aging mouse pups of various coat colors. (jax.org)
This double sided laminated poster allows you to quickly and easily identify your mice by visual examination of the external genitalia and accurately age mouse pups of various coat colors. (jax.org)
Young mice ( pups) should be grasped by the cupping the hands around the whole body or by grasping the skin across the shoulder blades with a forceps. (uwm.edu)
6 ] successfully isolated OGSCs from the ovaries of pups and adult mice for the first time, transfected them with GFP virus in an appropriate environment in vitro, and then transplanted them into the ovaries of immunodeficient mice. (biomedcentral.com)

Major techniques used for this work include monitoring of hormone levels in the blood by radioimmunoassay, quantification of neuronal activity in specific brain regions by neurochemical and molecular biology techniques, identification of specific populations of neurons in the hypothalamus by immunohistochemistry and in situ hybridisation, and use of transgenic mice to study hormone effects on brain function. (otago.ac.nz)
Altered insulin, leptin and ghrelin hormone levels and atypical estrous cycle lengths in two highly fertile mouse lines. (fbn-dummerstorf.de)

The animal cage is available in different dimensions for rats and mice, plus the observational learning version to allow two animals to see each other. (ugobasile.com)

There are over 400 documented inbred strains of mice. (uwm.edu)

Preovulatory LH surge levels were blunted in Jak2 G −/− mice, which was correlated with reduced GnRH neuronal activation as assessed by c-Fos. (jneurosci.org)
By studying neuronal activity in the brains of awake, behaving mice, the researchers discovered that estrogen makes the dopamine transporter more vulnerable to inhibition by cocaine, thus enhancing the drug's pleasurable effects. (bbrfoundation.org)

These cycles are widely variable in duration and frequency depending on the species. (wikipedia.org)

In species with estrous cycles[citation needed], females are generally only sexually active during the estrus phase of their cycle. (wikipedia.org)
In contrast, females of species with menstrual cycles can be sexually active at any time in their cycle, even when they are not about to ovulate. (wikipedia.org)
Male singing mice aren't actually the only ones who sing--there's a minority of females who also sing (maybe 5-15 percent of females? (metafilter.com)
Surprisingly, NMDA-2A subunit synthesis in these cells was found to fluctuate in females in synch with their estrous state. (harvard.edu)
Note that data from WT females shown here are from the same mice shown in Figure 1 C, D. (cdc.gov)

In this study, we focus on the expression of RHAMM in the rat uterus during estrous cycle and implantation period. (jri.ir)

Animals with estrous cycles often have unmistakable outward displays of receptivity, ranging from engorged and colorful genitals to behavioral changes like mating calls. (wikipedia.org)

The purpose of this study was to determine the ontogeny of cellular changes in the expression of estrogen receptors (ERα, ERβ), G protein-coupled estrogen receptor 1 (GPER1), and progesterone receptors (PRs) in endometriosis using a mouse model. (springer.com)
The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. (ac.ir)
Hensch and colleagues recently elucidated a molecular cellular basis for its fast effects on brain activity using mutant mice. (harvard.edu)

Plastic restraint devices can be used to hold mice and other rodents for longer periods of time. (uwm.edu)

Lower Plasmatic Levels of Saturated Fatty Acids and a Characteristic Fatty Acid Composition in the Ovary Could Contribute to the High-Fertility Phenotype in Dummerstorf Superfertile Mice. (fbn-dummerstorf.de)

One naturally occurring genetic defect in mice results in an animal with no hair that is called a nude. (uwm.edu)
Using ovariectomized nude mice, peritonitis carcinomatosa consisting of OVCAR-3 cells with the strongest ERα expression or DISS cells with weaker ERα expression was prepared. (biomedcentral.com)

Mammary glands from mice that underwent abrupt involution exhibited denser stroma, altered collagen composition, higher inflammation and proliferation, increased estrogen receptor α and progesterone receptor expression compared to those that underwent gradual involution. (biomedcentral.com)
The first two compartments (supepithelium and deep stroma) are similar to those of the estrous cycle. (jri.ir)

Eight-week-old ICR mice were divided randomly into four groups: corn oil (vehicle) and PFHxS at doses of 0.5, 5, and 50 mg/kg/day for 42 days by intragastric administration. (researchsquare.com)

A pregnant mouse model for bovine Tri Trichomonas foetus infection. (ac.ir)

In the present study, 30 virgin Swiss Albino mice (5-8 weeks old) were used to evaluate the pathogenic potential of Escherichia coli, isolated from the normally calved postpartum buffalo to induce endometritis. (ac.ir)
Importantly, when aged to 4 months postpartum, mice that were in the abrupt involution cohort developed ductal hyperplasia and squamous metaplasia. (biomedcentral.com)

Learn the highlights of mouse strain nomenclature with this poster. (jax.org)
Here, we add to the literature on the cerebellum in mouse models of autism with the characterization of the cerebellum in the idiopathic BTBR T + Itpr3 tf /J (BTBR) inbred mouse strain, which has behavioral phenotypes that are reminiscent of ASD in patients. (mdpi.com)

Provides precise information on the optimum day for mating during estrous cycle in the rats. (ugobasile.com)

At the end of 15 days, five mice in each group were euthanized and the ovaries were analyzed for follicular morphometry and granulosa cell count. (biomedcentral.com)

It is now well-established that the hippocampal CA2 region plays an important role in social recognition memory in adult mice. (researchgate.net)

Those in the high-estrogen period of their cycle were revealed to have produced still more BDNF. (healthjockey.com)

The phase on the estrous cycle can be experimentally determined by measuring serum estradiol and progesterone levels or by evaluating adjustments in vaginal cytology (Becker et al. (deubiquitinaseinhibitor.com)

Gene set enrichment analysis was used to analyze gene expression data from mouse mammary luminal progenitor cells. (biomedcentral.com)
E, F) Cre expression mirrors that of PR in the VMHvl of adult PRCre/+ mice in adjacent sections. (cdc.gov)

A four-phase terminology is used in reference to animals with estrous cycles. (wikipedia.org)
Only animals in the estrous phase were euthanized. (biomedcentral.com)

Shank3B knockout mice also exhibit social memory deficits. (researchgate.net)

To determine its biological function in reproduction, we used Cre (cAMP response element)/LoxP technology to generate GnRH neuron-specific Jak2 conditional knock-out (Jak2 G −/− ) mice. (jneurosci.org)

F) The vast majority of -gal+ (PR+) cells in various regions in PRPL mice are neurons, as evidenced by co-labeling with NeuroTrace (fluorescent Nissl) in the arcuate and NeuN for the remaining regions. (cdc.gov)

These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)

Altered testicular cell type composition in males of two outbred mouse lines selected for high fertility. (fbn-dummerstorf.de)

Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1. (fbn-dummerstorf.de)
Higher quality rather than superior quantity of oocytes determine the amount of fertilizable oocytes in two outbred Dummerstorf high-fertility mouse lines. (fbn-dummerstorf.de)

More laboratory mice are used in research every year than any other animal species. (uwm.edu)

Sex differences in somatotrope response to fasting: biphasic responses in male mice. (uams.edu)
A) Sex differences in density of -gal+ (PR+) cells in adult PRPL/PL mice. (cdc.gov)

Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. (igbmc.fr)

As per the researchers, detail experiments in mice appeared to have demonstrated the workings of a common variant of the particular gene. (healthjockey.com)
The scientists demonstrated that the performance of memory tasks by mice that possessed both the variant and the regular gene depended on their location in their estrous cycles. (healthjockey.com)
In addition to this, the researchers also exhibited that mice that had the variant gene were more skittish. (healthjockey.com)
For the research, the scientists compared the performance of mice that had the regular BDNF gene and those with BDNF Met. (healthjockey.com)

Overall, the ORT is a relatively low-stress, efficient test for memory in mice, and is appropriate for the detection of neuropsychological changes following pharmacological, biological, or genetic manipulations. (jove.com)

The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)

Aptitude for the object-placement test was apparently based on the stage of each mouse's estrous cycle. (healthjockey.com)

In these mice, the luciferase coding sequence is inserted before the endogenous Per2 stop codon. (molvis.org)

Mating-induced prolactin surge is not required for subsequent neurogenesis in male mice. (otago.ac.nz)

Do mice with better body condition sing more because they physically can or because they want to? (metafilter.com)

Anatomy25

Organisms18

Diseases6

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Psychiatry and Psychology2

Phenomena and Processes50

Disciplines and Occupations1

Information Science2

Health Care4

Ovarian6

Follicles4

Phases6

Menstrual cycle3

MRNA6

Cyclicity2

Diestrus2

Reproductive7

Female26

Endometrium3

Pregnancy3

Humans3

Embryo3

C57BL1

Significantly2

Methods1

Hormonal1

Behavior1

Pups4

Hormone2

Rats and mice1

Inbred strains1

Neuronal2

Duration1

Females5

Implantation1

Receptivity1

Cellular3

Rodents1

Ovary1

Nude2

Stroma2

Randomly1

Pregnant1

Postpartum2

Strain2

Optimum1

Ovaries1

Adult mice1

Estrogen1

Serum1

Expression2

Animals2

Deficits1

GnRH1

Neurons1

Immune1

Males1

Fertility2

Species1

Differences2

Conditional1

Gene4

Detection1

Responses1

Apparently1

Endogenous1

Surge1

Body1