Mice developed adipose. Medical search. Frequent questions

In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling increases in proinflammatory ART markers and decreases in anti-inflammatory ART markers, and preceding adipose tissue macrophage (ATM) accumulation and proinflammatory M1 polarization. (nih.gov)

Moreover, we hypothesized that these mice would have accumulation of TGs in other tissues, such as the liver or skeletal muscle, resulting in lipotoxicity and metabolic derangements, such as insulin resistance or fatty liver disease. (elifesciences.org)
These mice have reduced glycogen stores in adipose tissue, liver, heart, and skeletal muscle, corresponding with decreased glycogen synthase activity and glycogen synthesis rate. (jci.org)
Mice, because of this ANK2 variation develop decreased insulin secretion when young but it is compensated for by the uptake of glucose into adipose tissue and skeletal muscle. (acsh.org)
For example, lipin-1 is the major PAP in adipose tissue, and cardiac and skeletal muscle since lipin-1-deficient mice had little if any detectable PAP activity [2]. (aocs.org)

We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage-mediated inflammation in obese mice," said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine. (sciencedaily.com)
Treating obese mice with CST inhibited the recruitment of monocyte-derived macrophages to the liver and decreased inflammation, suggesting CST is an anti-inflammatory peptide. (sciencedaily.com)
HFD-fed MHCII(-/-) mice developed less adipose inflammation and insulin resistance than did wild-type mice, despite developing similar adiposity. (nih.gov)
These investigations uncover a mechanism whereby a HFD-induced adipocyte/ART dialog involving MHCII instigates adipose inflammation and, together with ATM MHCII, escalates its progression. (nih.gov)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
Notably, DUAL animals developed lobular inflammation and advanced hepatic fibrosis. (unav.edu)
Conclusion: Our DUAL model is characterized by obesity, glucose intolerance, liver damage, prominent steatohepatitis and fibrosis, as well as inflammation and fibrosis in white adipose tissue. (unav.edu)
analyses, as well as others (8-11), support the hypothesis that adipose tissue-secreted factors may indeed be potent modulators of inflammation-related disorders such as obe- sity, type 2 diabetes, metabolic syndrome, atherosclerosis, inflammatory bowel disease, thyroid-associated (Graves') ophthalmopathy, breast cancer, and nonalcoholic fatty liver disease. (123dok.org)
The interplay between mechanical strain and inflammation in pulmonary fibrosis remain incompletely understood.APPROACH: In this study, we used conditional KO mice to block mechanotransduction by knocking out FAK (Focal Adhesion Kinase) expression in fibroblasts, followed by induction of pulmonary fibrosis using bleomycin. (stanford.edu)
They discovered that processes related to the proliferation of new blood vessels were high in the female mice, whereas the males had a high level of processes associated with inflammation. (nutritioninsight.com)

Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
At the end of the exposure, fasting blood glucose and serum insulin were evaluated before epididymal adipose tissue and liver were collected, flow cytometry, quantitative PCR and Western blot were performed at euthanasia. (deepdyve.com)
We observed that intracerebroventricular administration of IMD-0354 attenuated insulin resistance, inhibited macrophage polarization to M1 phenotype in epididymal adipose tissue in response to PM2.5 exposure. (deepdyve.com)

We hypothesized that mice lacking TG storage in adipocytes would result in excess TG storage in cell types other than adipocytes and severe lipotoxicity accompanied by metabolic disease. (elifesciences.org)
However, ADGAT DKO mice were unexpectedly otherwise metabolically healthy and did not accumulate TGs ectopically or develop associated metabolic perturbations, even when fed a high-fat diet. (elifesciences.org)
The favorable metabolic phenotype resulted from activation of energy expenditure, in part via BAT activation and beiging of white adipose tissue. (elifesciences.org)
Thus, the ADGAT DKO mice provide a fascinating new model to study the coupling of metabolic energy storage to energy expenditure. (elifesciences.org)
This study introduces a valuable paradigm in the field of adipose tissue biology: blocking triglyceride storage in adipose tissue does not lead to lipodystrophy and impaired glucose homeostasis but instead improves metabolic health. (elifesciences.org)
Because energy sources are not always available from the environment, many metazoan organisms have evolved the ability to store large amounts of metabolic energy as triglycerides (TG) in adipose tissue. (elifesciences.org)
Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. (nih.gov)
And this genetically driven obesity is independent of food consumption or metabolic activity on the part of the mouse. (acsh.org)
In the present study, we aimed to develop a preclinical DUAL (alcohol-associated liver disease plus metabolic-associated fatty liver disease) model in mice. (unav.edu)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Here we discuss the molecular mechanisms through which alimentary cues modulate metabolic, microbial and neuroendocrine circuitries and thus affect the probability of developing premalignant lesions that progress to clinically manifested disease and the response to therapeutic intervention. (nature.com)
Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)
GIH male offspring had increased body weights and developed metabolic syndrome. (ubc.ca)
IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)
Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

Additionally, it has been shown that Noggin depletion in adipose tissue leads to obesity. (wikipedia.org)
A deficiency in the ANK2 gene, which codes for chemical activity on cell membranes, has been shown to cause obesity in mice. (acsh.org)
An unfortunate side effect of this increased absorption of glucose in adipose tissue is that it makes more robust and numerous adipose cells which serve to amplify the insulin resistance over time - which is why the obesity becomes more prominent with age. (acsh.org)
The researchers believe that the discovery might lead to develop new ways to counter obesity and diabetes. (medindia.net)
It could explain why so many people struggle to lose weight and suggests an entirely new direction for developing medical treatments that address the current epidemic of diabetes and obesity. (medindia.net)
We previously hypothesized that apoCIII overexpression would compromise fatty acid delivery to adipose tissues and would thus contribute to resistance to diet-induced obesity, similarly to what was described for overexpression of apoCI [ 15 ]. (biomedcentral.com)
Therefore, the role of apoCIII on adiposity seems to be quite complex because both apoCIII overexpression or disruption results in more severe diet-induced obesity than wild type mice [ 14 ]. (biomedcentral.com)
10 Jan 2023 --- Men are more likely than women to develop conditions associated with obesity, such as cardiovascular disease, insulin resistance and diabetes, according to new research by York University, Canada. (nutritioninsight.com)
Sex is a biological variable that accounts for differences in adipose tissue pathophysiology and clinical manifestations of obesity. (nutritioninsight.com)
People have used rodent models to study obesity and the diseases associated with obesity like diabetes, but they've typically always studied male rodents because females are resistant to developing the same kinds of diseases," says Haas, lead of the study. (nutritioninsight.com)

Increased plasma levels of Noggin have been observed in obese mice and in patients with a body mass index over 27. (wikipedia.org)
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report researchers. (sciencedaily.com)
This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals. (sciencedaily.com)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Characterization of the periprostatic adipose tissue and its effect in the functional activity of the prostate from obese mice treated or not with mirabgron, a beta-3 adrenoceptor agonist. (fapesp.br)
In a recent study published by our group showed thatthe prostate weight and epididimal fat of obese mice are significantly greater when compared to lean mice tissues. (fapesp.br)
Furthermore, obese mice present hypercontractility of the prostate and the bladder. (fapesp.br)
In obese mice, that received the ²3-adrenoceptor, mirabegron for 2 weeks, an approved drug to treating patients with overactive bladder, we observed an improvement in the overactive state of the bladder and a reduction of the epididymal fat mass and LDL levels. (fapesp.br)
Our preliminary results showed the adipocyte area of periprostatic adipose tissue is significantly greater in obese mice than in lean mice. (fapesp.br)

We establish and characterize the Bckdha ( branched chain keto acid dehydrogenase a ) −/− mouse that exhibits a lethal neonatal phenotype mimicking human MSUD. (nature.com)
Wild-Type (WT) and Tabby (Ta) mice were used to compare effects on a normal phenotype and on a mutant model of ectodermal dysplasia (ED). After 21 days, no effect on bone neoformation was observed in Ta treated lesion (4% neoformation compared to 13% in the control lesion). (hindawi.com)
Right here, we report the phenotype of mice bred to hold two copies of the BAC, which extra utterly recapitulate the phenotypic options of HGPS in pores and skin, adipose, skeletal, and vascular tissues. (eumorphia.org)
These data provide evidence that the lean body phenotype observed in the Cav-1 knockout mice is due, at least in part, to a defect in insulin-regulated lipogenesis. (elsevierpure.com)
Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)

Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)
Thus, apoCIII overexpression resulted in increased NEFA availability to adipose uptake and decreased adipocyte lipolysis, favoring lipid enlargement of adipose depots. (biomedcentral.com)
When activated, PPAR-γ up-regulates the transcription of genes mainly involved in fatty acid metabolism and triglyceride storage, promoting adipogenesis and lipids uptake to the adipose tissue [ 17 , 18 ] improving whole body insulin sensitivity. (biomedcentral.com)

First, an imaging approach called HYBRiD turned mouse tissues transparent and allowed the team to better track the paths of neurons as they snaked into adipose tissue. (lajollalight.com)
Lipogenesis rates were similar, while exogenous lipid retention was increased in perigonadal (2-fold) and brown adipose tissues (40 %) of apoCIII mice. (biomedcentral.com)
These organs and tissues were fixed en block in 10% formalin and cut coronally into four to six slices of 3-mm thickness, depending on the age of the rat, and embedded together in one block for each rat. (shengsci.com)

This study will be of high interest to those in the adipose tissue biology and metabolism fields. (elifesciences.org)
Adipose tissue plays an important role in metabolism through its storage and release of triglycerides, peptide hormones (adipokines) and other proteins, and in the case of brown fat, for its role in thermogenesis ( 1 ). (diabetesjournals.org)
Our metabolism is more complex than that - having developed over millions of years. (acsh.org)

On the behavioral stage, solely restricted and gentle alterations have been reported, with a big a part of analyzed behaviors being unaffected in GAMT KO as in contrast with wild-type mice. (eumorphia.org)
These assays identified an age-dependent decline in glucose homeostasis and hepatic glucose output in wild-type mice. (genengnews.com)

Here, based on significant liver contribution to the catabolism of the branched chain amino acid leucine, we develop a liver-directed adeno-associated virus (AAV8) gene therapy for MSUD. (nature.com)
Viral DNA was isolated from brain, lung, liver, muscle, and adipose tissue of monkeys 7 months after initial infection, long after the active virus has disappeared from blood and feces ( 3 ). (cdc.gov)
Mice lacking lipin-1 ( fld or fatty liver dystrophy) develop fatty livers and hypertriglyceridemia in the pre-weaning period, and are also devoid of mature adipose tissue [reviewed in 1]. (aocs.org)
Another, in the long list of reasons, to breastfeed: suckling at mother's lipid-rich milk triggered the expression of the fgf 21 gene in the liver of infant mice. (org.in)

To generate mice lacking TGs in adipose tissue (ADGAT DKO), we crossed adipose tissue-specific Dgat1 knockout mice (Cre-transgene expressed under control of the mouse adiponectin promoter 3 ) with Dgat2 flox mice 4 . (elifesciences.org)

We beforehand reported the era of a transgenic murine mannequin of progeria carrying a human BAC harboring the frequent mutation, G608G, which within the single-copy state develops options of HGPS which might be restricted to the vascular system. (eumorphia.org)
We hypothesized that 1) antioxidant treatment can improve vascular outcomes in mice exposed to CIH and that 2) gestational intermittent hypoxia (GIH) can adversely impact fetoplacental outcomes and lead to cardiometabolic disease in the adult offspring. (ubc.ca)
The first chapter of this thesis examines the effects of CIH on vascular function, oxidative stress and inflammatory markers in CB57BL/6 male mice with or without treatment with the dietary antioxidant, alpha lipoic acid (ALA). CIH impaired aortic relaxation and basal nitric oxide (NO) production. (ubc.ca)
In the second chapter, the impact of 14.5 days of GIH on vascular function of pregnant mice is reported. (ubc.ca)
The study analyzed the transcriptome of adipose tissue EC of male and female in mice to identify molecular signatures that may determine the sex differences in vascular remodeling during HFD-induced expansion of white adipose tissue. (nutritioninsight.com)

Thus, different "adipocyte-specific" Cre lines display different degrees of efficiency and specificity, illustrating important differences that must be taken into account in their use for studying adipose biology. (diabetesjournals.org)
Mouse 3T3-L1 and primary adipocytes activated T cells in an antigen-specific, contact-dependent manner, indicating that adipocyte MHCII is functional. (nih.gov)
In addition, adipocyte basal lipolysis (55 %) and in vivo lipolysis index (30 %) were significantly decreased in apoCIII mice. (biomedcentral.com)

Infection with human adenovirus 36 (Adv 36) has been reported to cause a large accumulation of fat in 4 animals (chickens, mice, rats, and monkeys) ( 1 - 3 ). (cdc.gov)

Mice with a lack of NOG gene are shown to have an outgrowth of the mandible and a cleft palate. (wikipedia.org)
We generated mice that possess a heterozygous deletion of the PTG gene. (jci.org)
Researchers at UT Southwestern Medical Center have discovered a gene, adipose, that controls a person's tendency to pile fat. (medindia.net)
Using several methods, they manipulated adipose in the various animals, turning the gene on and off at different stages in the animals' lives and in various parts of their bodies. (medindia.net)
Although the current study finally identifies the adipose gene's function, the gene was discovered more than 50 years ago when Winifred Doane, now a professor emeritus at Arizona State University, was studying fruit flies and noticed that some contained more fat than others. (medindia.net)
The international team led by Haim Cohen, PhD, director of the Sagol Healthy Human Longevity Center at Bar-Ilan University, developed transgenic mice that express high levels of the SIRT6 gene and presented data suggesting that their life expectancy can be increased by an average of 30% in both males and females. (genengnews.com)
The team then determined that SIRT6 acts to facilitate healthy aging by increasing hepatic gluconeogenic gene expression, de novo NAD + synthesis, and systemically enhances glycerol release from adipose tissue. (genengnews.com)
Gene sequencing software was used to evaluate the tissue differences between male and female mice. (nutritioninsight.com)
This gene is responsible for initiating the production of brown fat-heat generating adipose tissue-in newly born mammals. (org.in)
Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)

In the third chapter, aortic endothelial and perivascular adipose tissue (PVAT) function were evaluated in sixteen-week-old offspring of dams exposed to GIH only in utero. (ubc.ca)
While the researchers analyzed the adipose endothelial cells (EC) of mice, the researchers argue that the findings could apply to humans. (nutritioninsight.com)
In this latest study published in iScience , titled "Transcriptomic profiling reveals sex-specific molecular signatures of adipose endothelial cells (EC) under obesogenic conditions," the researchers focused on differences in the EC that make up the building blocks of these blood vessels in fat tissue. (nutritioninsight.com)

Here, we characterized the whole-genome distribution of methyl-CpG and 5-hydroxymethylcytosine (5hmC) in mouse innate lymphoid cell 3 (ILC3), ILC2 and natural killer (NK) cells. (stanford.edu)
The latter is a tool previously developed by Jacopo, 2020, able to identify tumor antigens similar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T cells in cancer vaccine development. (elifesciences.org)
In mammals, adipose tissue stores energy in the form of fat cells and releases those stores when the body needs energy. (lajollalight.com)
The experiments revealed that when the brain doesn't receive sensory messages from adipose tissue, programs triggered by the sympathetic nervous system - related to the conversion of white fat to brown fat - become overly active in fat cells, resulting in a larger-than-normal fat pad with especially high levels of brown fat, which breaks down other fat and sugar molecules to produce heat. (lajollalight.com)
Different sources of living cells are described, as mesenchymal stem cells (MSCs), adipose-tissue derived stem cells, skin derived multipotent stem cells, or oral cavity MSCs, presenting compatible immunophenotype or morphology [ 2 , 3 ]. (hindawi.com)
The result was that these BMP8B-treated brown fat cells burned more fat and mice given BMP8B in the brain lost weight. (cam.ac.uk)
In the current study, the UT Southwestern researchers examined how adipose works by analyzing fruit flies, tiny worms called C. elegans, cultured cells, and genetically engineered mice, as well as by exploiting sophisticated molecular techniques. (medindia.net)
Recently, the endocrine activity of adipose tissue cells has been intensively studied. (123dok.org)
Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. (biomedcentral.com)
By comparing with previously published data sets, the researchers found that EC from aged male mice showed a more inflammatory profile than female cells. (nutritioninsight.com)
While humans and mice have different genes that may be turned up or down, Haas believes the general findings would likely apply to humans in future research and is interested in studying the same cells in humans. (nutritioninsight.com)
The researchers observed "striking" differences in the cells that build blood vessels in the fatty tissue of male versus female mice. (nutritioninsight.com)

Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
Unlike white fat, which functions primarily to store up fat, brown fat (also known as brown adipose tissue) burns fats to generate heat in a process known as thermogenesis. (cam.ac.uk)
Particularly well developed in humans is white adipose tissue (WAT), a major meta- bolic and secretory organ. (123dok.org)
The mRNA expression levels of peroxisome proliferator-activated receptor (PPAR)-γ and lipocalin-2 in white adipose tissue were, respectively, down- and up-regulated. (biomedcentral.com)
Reduction of PPAR-γ expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. (biomedcentral.com)
This study aims to unveil biological markers that establish the molecular basis of stress-induced glucose intolerance, with a special emphasis on the visceral white adipose tissue (vWAT). (biomedcentral.com)
Yet, the ²3-adrenoceptor activation in adipose tissue is involved with lipolysis, mobilization of fatty acids in white adipose tissue and with brown adipose tissue thermogenesis. (fapesp.br)
Through transcriptome analysis of EC from the white adipose tissue of male and female mice high-fat-fed for seven weeks, the researchers found that adipose EC exhibited pronouncedly sex-distinct transcriptomes. (nutritioninsight.com)

The parent L strain was derived from normal subcutaneous areolar and adipose tissue of a 100-day-old male C3H/An mouse. (bvsalud.org)

A fat tolerance test evidenced delayed plasma triglyceride clearance and greater transient availability of non-esterified fatty acids (NEFA) during the post-prandial state in the apoCIII mice plasma. (biomedcentral.com)

Most investigations have focused on mammals, specifically the mouse and human. (biomedcentral.com)

Within adipose tissue, the expression of lipolytic and lipogenic enzymes was higher, while those related to lipid oxidation were lower in the NDh group compared to the NDo group. (frontiersin.org)

Barrier agains t pathogen s gut bacterial genes in the MetaHIT ation when attempting to extrapolate [10], although Proteobacteria, Ver- catalogue were also well represent- results obtained in mouse models to rucomicrobia, and Fusobacteria are ed in the other metagenomes that the situation in humans. (who.int)

I primi esperimenti volti a provare questa attività sono stati effettuati su topi in crescita, nei quali è stata osservata una riduzione del 50% della massa adiposa totale rispetto ai topi di controllo, somministrando una dieta contenente l'1% di Acido Linoleico Coniugato. (nbflanes.com)

We measured body energy balance, tissue capacity to store exogenous lipids, lipogenesis and lipolysis rates in non-transgenic and apoCIII overexpressing mice fed a HFD during two months. (biomedcentral.com)

However many more pro and anti-inflammatory mediators produced by the adipose tissue have been described since then. (springer.com)

Transgenic mice overexpressing human apoCIII have marked elevated TG and non-esterified fatty acid (NEFA) levels [ 21 ]. (biomedcentral.com)
In contrast, the authors noted, "Aged SIRT6-transgenic mice preserve hepatic glucose output and glucose homeostasis through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol. (genengnews.com)
Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)

There are obvious differences between mice and humans, and from a therapeutic perspective this work is preliminary. (cam.ac.uk)
In adult humans, brown adipose tissue is very scarce and probably not functional. (123dok.org)

Furthermore, when BMP8B was administered to specific parts of the brain it increased the amount of nervous activation of brown adipose tissue. (cam.ac.uk)
But our findings showed that treating mice with Bmp8b did not have this effect, it simply made them lose weight by burning more fat in their brown adipose tissue. (cam.ac.uk)
Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
Researchers at Dana-Farber Cancer Institute have identified a long-sought 'master switch' in mice for the production of brown fat. (medindia.net)
Another major adipose tissue subtype, brown adipose tissue, is present around kidneys, adrenals, and aorta, as well as within the mediastinum and neck. (123dok.org)

Male C57BL/6 mice were fed with a normal diet (ND) or ND supplemented with HN (NDh) or HO (NDo). (frontiersin.org)
C57BL/6 mice received 10% vol/vol alcohol in sweetened drinking water in combination with a Western diet for 10, 23, and 52 weeks (DUAL model). (unav.edu)

To test this hypothesis, we selectively deleted both TG-synthesis enzymes, DGAT1 and DGAT2, in adipocytes (ADGAT DKO mice). (elifesciences.org)
We generated mice lacking both known TG synthesis enzymes, DGAT1 and DGAT2 1 , 2 , in adipocytes. (elifesciences.org)

Experiments in mice have shown that noggin also plays a role in learning, cognition, bone development, and neural tube fusion. (wikipedia.org)
In vivo implantation of polycaprolactone (PCL) biomembrane functionalized with BMP-2/Ibuprofen in mouse maxillary defects was followed by bone neoformation kinetics evaluation using microcomputed tomography. (hindawi.com)
Several therapeutic applications are developed in the field of bone and cartilage defect treatments, based on the osteoinductive and osteoconductive properties of these materials but also on the intrinsic physiological regenerative properties of bone [ 3 ]. (hindawi.com)
Hahm and colleagues started with mice that were unable to make uPAR and irradiated them to destroy their bone marrow. (medscape.com)
Some of these mice were transplanted with bone marrow from other mice that couldn't make uPAR, and some were transplanted with normal mouse bone marrow. (medscape.com)
In response to the LPS challenge, the mice that got the deficient bone marrow didn't develop proteinuria, whereas the mice that got the "uPAR-capable" bone marrow did. (medscape.com)

Using mice lacking the DNA hydroxymethylase TET2, we showed the requirement for TET2 in optimal production of hallmark cytokines by ILC3s and interleukin-17A (IL-17A) by inflammatory ILC2s. (stanford.edu)
The overactivation of the sympathetic system and the promotion of a pro-inflammatory state in the adipose tissue [ 8 ] are common features of insulin resistance [ 9 - 12 ]. (biomedcentral.com)
Adipose tissue is an important source of pro-inflammatory, pro-contractile and pro-proliferative substances. (fapesp.br)
However, based on our previous findings we don't know whether the improvement in the bladder reactivity after Mirabegron treatment could be due to a direct effect on the smooth muscle and/or a lower release of pro-contractile, pro-proliferative and pro-inflammatory substances originates from periprostatic adipose tissue. (fapesp.br)

The experiments showed that when mice lacked the protein BMP8B they found it more difficult to maintain their normal body temperature. (cam.ac.uk)
In support of this notion, we demonstrate that recombinant expression of caveolin-1 in Cav-1 null mouse embryo fibroblasts rescues insulin receptor protein expression. (elsevierpure.com)
Researchers at the Salk Institute have identified the protein Mitf as a key mediator in the repair processes of the peripheral nervous system in mice, suggesting a promising new therapeutic target. (innovationtoronto.com)

In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
In contrast, animals with reduced adipose activity were fatter, less healthy and had diabetes. (medindia.net)
KKAy mice, a genetically susceptible model of type II diabetes mellitus, were administered intra-cerebroventricularly with IKK2 inhibitor (IMD-0354) and were exposed to either concentrated PM2.5 or filtered air (FA) for 4 weeks simultaneously via a versatile aerosol concentration exposure system. (deepdyve.com)

All transplanted mice received a dose of lipopolysaccharide (LPS), which induces proteinuria in mice. (medscape.com)

They also became much more obese than normal mice, particularly when fed a high-fat diet. (cam.ac.uk)
Next, they took normal mice and irradiated them before giving them the LPS challenge. (medscape.com)

All of 42 BUF, 2 of 55 BUF-Rnu/+ and 28 of 33 ACI-Tsr1/Tsr1 rats survived more than 52 weeks, and developed thoracic thymoma, but no cervical thymomas did. (shengsci.com)
The results of a 90 day subchronic feeding study of HCB in rats, mice, and hamsters were presented. (cdc.gov)
The percentage of inhaled benzene that was absorbed and retained during a 6-hour exposure period decreased from 33 to 15% in rats and from 50 to 10% in mice when the exposure concentration was increased from about 10 to 1,000 ppm (Sabourin et al. (cdc.gov)
1987). Mice and rats have different absorption characteristics in that the cumulative inhaled dose in mice was greater than that in rats (Eutermoser et al. (cdc.gov)
97% in rats and mice when the animals were treated with benzene by gavage at doses 0.5-150 mg/kg (Sabourin et al. (cdc.gov)

We additional present that genetic discount of the mechanistic goal of rapamycin (mTOR) considerably extends lifespan in these mice, offering a rationale for pharmacologic inhibition of the mTOR pathway within the therapy of HGPS. (eumorphia.org)

Researchers have long known that nerves extend into adipose tissue but suspected they weren't sensory neurons that carry data to the brain. (lajollalight.com)
methods used to study neurons closer to the surface of the body or in the brain don't work well deep in adipose tissue, where nerves are hard to see or stimulate. (lajollalight.com)

Today, Cohen's lab is developing methods for extending healthy life based on these findings. (genengnews.com)

Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)

Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)
In effect, a wide range of exported secretory proteins, dubbed adipokines, have been identified as constituents of the adipose proteome (adipokinome). (123dok.org)

Dr. Graff said the next step is to understand better the exact mechanisms by which adipose exerts its control. (medindia.net)
Here, we examined the potential mechanisms involved in this exacerbated response of apoCIII mice to the HFD. (biomedcentral.com)

An insulin tolerance test (ITT) revealed that young Cav-1 null mice on a normal chow diet are significantly unresponsive to insulin, compared with their wild-type counterparts. (elsevierpure.com)
However, the adipose tissue mass (45 %) and leptin plasma levels (2-fold) were significantly greater in apoCIII mice. (biomedcentral.com)

We expected to generate a mouse model similar to those of classic lipodystrophy due to defects of TG storage in adipose tissue. (elifesciences.org)

Anatomy31

Organisms12

Diseases27

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology2

Phenomena and Processes51

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science2

Health Care4

Geographicals1

Preceding adipose tissue1

Skeletal muscle4

Inflammation13

Epididymal adipose tissue3

Metabolic15

Obesity10

Obese mice10

Phenotype5

Uptake3

Tissues3

Metabolism3

Wild-type mice2

Liver4

Knockout mice1

Vascular5

Adipocyte3

Accumulation1

Gene10

Endothelial3

Cells12

White8

Subcutaneous1

Fatty acids1

Mammals1

Lipid1

Genes1

Sono1

Lipolysis1

Anti-inflammatory1

Transgenic3

Humans2

Brown5

C57BL2

Adipocytes2

Bone6

Inflammatory4

Protein3

Diabetes3

Induces1

Normal mice2

Rats5

Extends lifespan1

Nerves2

Findings1

Glucose intolerance1

Adipokines2

Mechanisms2

Significantly2

Generate1