• Mice, Mutant Strains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Increased expression of colony-stimulating factor-1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss. (qmul.ac.uk)
  • In last two decades, there have been some remarkable successes of gene therapy approaches on the experimental mice model of MS - experimental autoimmune encephalomyelitis (EAE) which suggests that it is not far that the gene therapy approaches would start in human subjects ensuring the highest levels of safety and efficacy. (benthamscience.com)
  • A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET. (uchicago.edu)
  • Inheritance of immune responsiveness, life span, and disease incidence in interline crosses of mice selected for high or low multispecific antibody production. (santafe.edu)
  • This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fecal 16SV6-V8 rDNA PCR amplicons resolved by temperature gradient gel electrophoresis (TGGE) of five each of low (LIII) and high (HIII) antibody producing mice. (biomedcentral.com)
  • The results suggest that genetically driven low antibody production in mice is associated with gut dysbiosis. (biomedcentral.com)
  • The immune adjuvant effect of olive, soybean and corn oils in Swiss mice immunized with ovalbumin (OVA) plus aluminum hydroxide or emulsified in Marcol, soybean, olive or corn oils was evaluated through the OVA-specific antibodies determined by ELISA and Passive Cutaneous Anaphylaxis. (sld.cu)
  • High (H) and low (L) antibody responder lines of mice separated by selective breeding present a maximal interline difference in antibody (Ab) response to Ag of different specificities (general genetic regulation). (santafe.edu)
  • Examples of such models include mice lineages bi-directionally selected for high and low quantitative antibody responses to a given antigen, but whose altered response extends to antigens unrelated to those employed in the selective process [ 2 ]. (biomedcentral.com)
  • On the other hand, selection III high responder mice (HIII) are more resistant to Trypanosoma cruzi infection than animals of the LIII lineage, a feature which was shown to be gender-specific (females are more resistant than males) and correlated with interferon-γ and nitric oxide production by peritoneal lymph node cells [ 8 ]. (biomedcentral.com)
  • Given several examples of reciprocal influence of gut microbiota and immune system [ 10 ], we investigated whether immunity related and other interline differences between LIII and HIII could have an impact on fecal bacteriome of these mice lineages. (biomedcentral.com)
  • This graph shows the total number of publications written about "Mice, Quaking" by people in Harvard Catalyst Profiles by year, and whether "Mice, Quaking" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Mice, Quaking" by people in Profiles. (harvard.edu)
  • Gene therapy-induced antigen-specific Tregs inhibit neuro-inflammation and reverse disease in a mouse model of multiple sclerosis. (benthamscience.com)
  • Mice homozygous for the mutant autosomal recessive gene, quaking (qk), associated with disorder in myelin formation and manifested by axial tremors. (harvard.edu)
  • Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. (harvard.edu)
  • Fecal DNAs of 4 (2 LIII and 2 HIII) randomly selected mice were submitted to additional PCRs to amplify the 16SV6 rRNA gene (16SV6 rDNA), whose amplicons were subsequently sequenced. (biomedcentral.com)
  • LIII mice were grouped in a single TGGE cluster, displayed a low α-diversity, and were distinguished by low Firmicutes/Bacteroidetes ratio. (biomedcentral.com)
  • In vivo, 8-week old Biozzi mice were subjected to a single intranigral injection of either 3 μg SNCA, lipopolysaccharide (LPS) or serum protein (BSA) and allowed to recover for 24 hours. (ox.ac.uk)
  • Comprised 8-12 weeks-old female mice of Selection III, derived from the original outbred population [ 9 ], and raised at Butantan Institute, SP Brazil, in groups of five animals per cage, under the same temperature and supplied with the same kind and amount of feed and water. (biomedcentral.com)
  • Mice bearing mutant genes which are phenotypically expressed in the animals. (ucdenver.edu)
  • Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin. (harvard.edu)
  • Structural bases for central nervous system malfunction in the quaking mouse: dysmyelination in a potential model of schizophrenia. (harvard.edu)
  • The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY. (uchicago.edu)
  • Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. (uchicago.edu)
  • Tumor necrosis factor (TNF) activity was inhibited during the development of actively-induced, chronic relapsing experimental allergic encephalomyelitis (CREAE) in Biozzi AB/H mice, using a mouse TNF-specific (TN3.19.12) antibody and bivalent human p55 and p75 TNF receptor-immunoglobulin (TNFR-Ig) fusion proteins. (ox.ac.uk)
  • Evidence for the genetic control of antibody affinity from breeding studies with inbred mouse strains producing high and low affinity antibody. (nih.gov)
  • This group hypothesized that alterations in oxidative signaling may be involved in the development of EAE and multiple sclerosis (MS). Their laboratory has performed extensive characterization of the nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway and the Nrf2 knockout mice. (nih.gov)
  • Building upon their previous studies, they have extended their characterization of the Nrf2-ARE system in an autoimmune inflammatory model of MS by crossing the Biozzi ABH mice with Nrf2 knockout mice. (nih.gov)
  • Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases ( DISEASE MODELS, ANIMAL ) and to clarify the functions of the genes. (nih.gov)
  • Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. (google.co.uk)
  • However, treatment of Biozzi mice with chronic-progressive experimental autoimmune encephalomyelitis with PD0325901 showed no clinical improvement in comparison to the control group, no reduction in demyelination, nor induction of OPC migration into foci of demyelination. (huji.ac.il)
  • The levels (Abt) and relative affinity (KR) of antibody produced to protein antigens injected in saline have been measured in the 22nd generation of the Biozzi high (Ab/H) and low (Ab/L) antibody-producing mice. (nih.gov)
  • These results substantiate earlier observations that in mice, antibody affinity (KR) and antibody level (Abt) are under independent genetic control. (nih.gov)
  • The genetic control of antibody affinity in mice. (nih.gov)
  • Antibody affinity maturation in selectively bred high and low-affinity mice. (nih.gov)
  • Antibody affinity and clearance function studies in high and low antibody affinity mice. (nih.gov)
  • A strain of mice bred specifically as high or low antibody responders. (nih.gov)
  • AB - The faster degradation of antigen by macrophages in Biozzi low (L) responder mice, compared to Biozzi high (H) responder mice, is thought to be responsible for their lower antibody response. (nih.gov)
  • Mice, SCID" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. (harvard.edu)
  • SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice. (harvard.edu)
  • This graph shows the total number of publications written about "Mice, SCID" by people in Harvard Catalyst Profiles by year, and whether "Mice, SCID" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Mice, SCID" by people in Profiles. (harvard.edu)
  • Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice. (harvard.edu)
  • Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. (ouhsc.edu)
  • In vivo, 8-week old Biozzi mice were subjected to a single intranigral injection of either 3 μg SNCA, lipopolysaccharide (LPS) or serum protein (BSA) and allowed to recover for 24 hours. (ox.ac.uk)
  • Spleen cells from both lines of mice released similar levels of interleukin-1, both spontaneously and in response to lipopolysaccharide. (nih.gov)
  • 8. Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses. (nih.gov)
  • The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. (nih.gov)
  • Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice. (harvard.edu)
  • 1. JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice. (nih.gov)
  • 2. IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation. (nih.gov)
  • 15. β-Elemene inhibits 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin tumorigenesis through suppression of NF-κB-associated signaling events in the mouse skin model. (nih.gov)
  • Transcriptomics confirm the establishment of a liver-immune dual-humanized mouse model after transplantation of a single type of human bone marrow mesenchymal stem cell. (harvard.edu)
  • Kundu M, Raha S, Roy A, Pahan K. Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer. (rush.edu)
  • however, both Ab/H and Ab/L mice were able to mount a high affinity response to protein antigens injected in Freund's complete adjuvant. (nih.gov)
  • By contrast, when groups of mice that had received P. acnes were given endotoxin and bled, higher titres of tumour necrosis factor were found in the sera of L mice. (nih.gov)
  • PMID- 3894222 TI - Macrophage functions in Biozzi mice. (nih.gov)
  • We have measured four functions associated with macrophages to see whether macrophages from L mice were generally more active than those from H mice. (nih.gov)
  • These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. (harvard.edu)
  • Cells from normal H mice gave a stronger oxidative burst when triggered with phorbol myristate acetate, and were more cytotoxic for tumour cells than cells from L mice. (nih.gov)
  • We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing the expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar RNA host gene 9) in small intestinal epithelial cells. (bvsalud.org)
  • Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. (nih.gov)
  • 9. A course of very small doses of DMBA, each of them allegedly with no promoting potency, acts with clear synergistic effect as a strong promoter of DMBA-initiated mouse skin carcinogenesis. (nih.gov)
  • These hybrid mice allowed a direct test of their hypothesis and were crucial for the success of these studies. (nih.gov)