Mice bacteria. Medical search. Frequent questions

People have been finding bacterial DNA on the human eye but no one has presented experimental proof that these bacteria actually live there," says senior co-author Rachel Caspi, an immunologist at the National Eye Institute, National Institutes of Health (NIH). (sciencedaily.com)
The NIH investigation began with a strain of lab mice that develop nasty bacterial conjunctivitis -- also known as "pink eye" where the thin mucous membranes that line the inside of the eyelid and cover the whites of the eyes, or "conjunctiva," become inflamed. (sciencedaily.com)
To find out which bacterial species lived on the eyes of their mice, the researchers swabbed samples from the conjunctiva of their mice across a petri dish and waited to see what grew, but even so, they would have missed Corynebacterium mastitidis if not for luck. (sciencedaily.com)
But scientists have realized that such bacteria are only a tiny fraction of the bacterial communities that live in and on our bodies. (vetscite.org)
To tease out the effects of lung microbes compared with gut microbes on lung immunity, the research team looked at 40 healthy, genetically identical mice, comparing bacterial populations in their lungs, tongues and lower intestines. (umich.edu)
Keeping mice and rats away is always important - not just because of the damage they can cause - but also to protect our health from dangerous bacterial threats! (saxonpestmanagement.com)
They trapped closely related wild mice and sampled their bacterial gut microbiomes. (zmescience.com)
We used a mouse model to study the impact of intestinal domination by antibiotic -resistant bacterial species and strains on the colonic mucosa . (bvsalud.org)
Despite the compositional differences in the gut microbiota , the severity of C. difficile infection (CDI) and mortality did not differ significantly between mice colonized with different ampicillin -resistant bacterial species. (bvsalud.org)
Scientists haven't been able to conclusively say whether Staph bacteria hidden in cells are responsible for repeated infections, but if that's the case, then this treatment could put a stop to that by clearing the body of bacterial reservoirs. (theverge.com)
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. (ox.ac.uk)
For the first time, a collection of cultured bacterial strains provides comprehensive information on the mouse gut microbiota: Scientists at the Technical University of Munich were able to isolate, characterize, and archive a hundred strains, including 15 hitherto unknown taxa. (vetscite.org)
Thomas Clavel from ZIEL and colleagues describe a new resource in "Nature Microbiology" which, for the first time, contains a hundred cultured bacterial strains from the mouse gut microbiome. (vetscite.org)
The goal of our work was to take a big initial step towards decoding the cultured fraction of gut bacterial communities in mice. (vetscite.org)
We evaluated interactions between pharyngeal aspiration of single walled CNT (SWCNT) and bacterial pulmonary infection of C57BL/6 mice with Listeria monocytogenes (LM). (cdc.gov)

What I want to know is, if you took mice genetically destined to develop neurodegenerative disease, and you manipulated the microbiome just before the animals start showing signs of damage, could you slow or prevent neurodegeneration? (futurity.org)
The gut microbiome plays a key role in the health of our brains, new research in mice suggests. (futurity.org)
To determine whether the gut microbiome may be playing a causal role, the researchers altered the gut microbiomes of mice predisposed to develop Alzheimer's-like brain damage and cognitive impairment. (futurity.org)
The protective effects of the microbiome shifts were more pronounced in male mice carrying the APOE3 variant than in those with the high-risk APOE4 variant, possibly because the deleterious effects of APOE4 canceled out some of the protection, the researchers say. (futurity.org)
It is vital to remind ourselves that, though the findings are exciting, there are significant differences between the mouse microbiome and our own. (medicalnewstoday.com)
These bacteria, collectively known as the microbiome, appear to have a complex effect on health and disease. (umich.edu)
After confirming that the lung microbiome exists and can be altered by the environment and antibiotics in healthy mice, Dickson and his team looked for a link between the bacteria and the lungs' immune state. (umich.edu)
These bacteria make up the microbiome, which is important in digestion and the immune system. (zmescience.com)
In the same vein, humans don't live in a sterilized box and have a more varied microbiome than lab mice and perhaps the reactions are not comparable. (zmescience.com)
Researchers from the National Institute of Diabetes and Digestive and Kidney Diseases t ested how lab mice with a more natural microbiome would respond to diseases . (zmescience.com)
They took pregnant germ-free mice and they gave some of them a lab mouse microbiome and some a wild mouse microbiome and raised them over several generations. (zmescience.com)
To some degree living in a germ-free or intensely disinfected house in addition to not spending much time outside lowers the number of healthy bacteria and keeps a healthy, diverse microbiome from forming. (zmescience.com)
The microorganisms of the gut microbiome - which is a vital collection of hundreds of species of bacteria, fungi, viruses and other microbes - are in equilibrium in healthy people. (neurosciencenews.com)
Researchers from Oregon State University recently conducted a study and found that high-sugar and high-fat diets cause changes in gut bacteria (microbiome) that appear to lead to a significant decrease in "cognitive flexibility" (the ability to adapt to changes). (askmen.com)
A fecal transplant is the process of transplanting a healthy person's fecal bacteria into a sick person's gut in order to reorganize their microbiome. (askmen.com)
Although the mouse gut microbiome presents a number of similarities with the human microbiome, the work showed that around 20 percent of the strains in the collection prefer colonizing the intestines of mice. (vetscite.org)
It [also] suggests that gut bacteria might enhance currently used noninvasive fecal tests for the detection of colorectal polyps, and even that microbiome-modulating therapies might play a role in prevention of colorectal cancer ," said Gacesa, who won the award for best abstract in the meeting session. (medscape.com)

We each have trillions of bacteria in our gut that play a critical role in keeping us healthy, and we believe that the gut microbiota is an untapped source for development of the next generation of drugs," says Ashutosh Mangalam , PhD, UI assistant professor of pathology and lead study author. (uiowa.edu)
Here we demonstrate in mice that, at steady state, the microbiota inhibits the transport of both commensal and pathogenic bacteria from the lumen to a key immune inductive site, the mesenteric lymph nodes (MLNs). (nih.gov)
To test the hypothesis that the residual microbiota influences the severity of colitis caused by infection with Clostridioides difficile , we coinfected mice that were colonized with ampicillin -resistant bacteria with a virulent strain of C. difficile and monitored colonization and pathogenesis . (bvsalud.org)
Herein, we studied the dose effects of widely used food supplement, microalgae spirulina ( Arthrospira platensis ), on the colonic microbiota and physiological responses in healthy male Balb/c mice. (frontiersin.org)
Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
It's increasingly clear that our gut bacteria, or microbiota, can communicate with the human brain," said Magnusson. (askmen.com)

A new study from the lab showed that mice that harbored the butyrate-producing bacteria Roseburia and that also ate a high-fiber diet suffered from less atherosclerosis and had reduced inflammation compared to mice without the bacteria. (wisc.edu)
When inflammatory molecules break off of beneficial bacteria and leech out of the gut and into the bloodstream, they can trigger widespread inflammation. (wisc.edu)
The researchers found that mice hosting Roseburia had lower levels of several markers of inflammation and a reduced extent of atherosclerosis - but only if they ate a high-fiber diet. (wisc.edu)
The bacteria appear to produce their beneficial effect by influencing the levels and function of particular immune system cells that are involved in controlling inflammation. (uiowa.edu)
The researchers led by Mangalam and senior study author Joseph Murray, MD, at Mayo Clinic, are investigating the influence gut bacteria have on inflammation and immune responses outside of the gut. (uiowa.edu)
In the new study, mouse models of MS treated with P. histicola (cultured from the human intestine) had less inflammation overall and less destruction of the myelin sheath that protects nerve fibers than untreated mice. (uiowa.edu)
At the same time, the scientists observed body-wide inflammation in the obese mice, including the knee joints. (medicalnewstoday.com)
Importantly, it also reduced inflammation in the joints, and the knee cartilage of the obese mice was indistinguishable from that of the non-obese control mice. (medicalnewstoday.com)
These findings define a central role for commensals in regulating the migration to the MLNs of CX(3)CR1(hi) mononuclear phagocytes endowed with the ability to capture luminal bacteria, thereby compartmentalizing the intestinal immune response to avoid inflammation. (nih.gov)
We used the model of chronic inflammation that develops spontaneously in the colon of conventional severe combined immunodeficiency (SCID) mice restored with the CD45 RB(high) subset of CD4+T cells isolated from the spleen of normal BALB/c mice. (ox.ac.uk)
CONCLUSIONS: Only SFB bacteria together with a defined SPF mixture were effective in triggering intestinal inflammation in the model of IBD in reconstituted SCID mice, while no colitis was detected in GF mice or in mice colonized either with SPF microflora or monoassociated only with SFB or colonized by Bacteroides distasonis + SFB or Fusobacterium mortiferum + SFB. (ox.ac.uk)
Immune cells that keep the brain free of debris but also contribute to inflammation are the likely culprits behind the concentration and memory problems that sometimes follow one type of chemotherapy, a new study in mice suggests. (news-medical.net)
Combined exposure to carbon nanotube s and bacteria enhances pulmonary inflammation and infectivity. (cdc.gov)

Commensal bacteria influence traits such as weight and behavior. (vetscite.org)
The researchers linked commensal bacteria in mice to the animals' susceptibility to a gut injury. (vetscite.org)
We saw a drop in some commensal bacteria, including F aecalibacterium, in both those with recent pathologies and those who developed them in the future. (medscape.com)

When the researchers directly inoculated eyes of mice not harboring pathogenic bacteria, those mice also began producing higher levels of IL-17, leading the researchers to conclude that Corynebacteria mastitidis was helping the mice maintain immunological balance in the eye. (sciencedaily.com)

Because pure butyrate would quickly be taken up by cells in the upper intestine, Kasahara fed mice a slow-release version that made it intact to the lower guts. (wisc.edu)
Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine. (bvsalud.org)
Electron microscopy of a filamentous, segmented bacterium attached to the small intestine of mice from a laboratory animal colony in Denmark. (ox.ac.uk)
A filamentous, segmented bacterium was observed in the small intestine of the SSC:AH stock of mice from the Statens Seruminstitut (Denmark) animal colony but was absent in golden hamsters and guinea pigs from the same colony. (ox.ac.uk)
Mouse models are extensively used in pharmaceutical and medical research, and it is known that the communities of microbes in their intestine can have a significant impact on the research output. (vetscite.org)
However, there is still insufficient information available about many bacteria inhabiting the intestine of mice. (vetscite.org)
In order to better understand colonization processes in the intestine, bacteria first need to be identified and characterized in detail. (vetscite.org)
Whipple pointed out the existence of great numbers of peculiar rod-shaped bacteria found in extracts of lymph node tissue and lamina propria of the intestine. (medscape.com)

These mice lack an immune molecule called IL-17, which summons immune cells to areas of infection. (sciencedaily.com)
The researchers hypothesized that in common strains of mice, a commensal microbe on the surface of the eye might be setting off an IL-17 response to protect from harmful infection. (sciencedaily.com)
When the newly colonized mice were exposed to Candida and Pseudomonas, they were able to resist the infection. (sciencedaily.com)
The traits often spread from one mouse habitat to the next, suggesting a spreading microbial infection is responsible. (vetscite.org)
Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)
From tiny studios to penthouse suites, New York City apartments are continually invaded by house mice,' said lead author Simon H. Williams, BSc, a research scientist at the Center for Infection and Immunity. (expressdigest.com)
In the U.S., the bacterium Klebsiella pneumoniae is a common cause of urinary tract infection, bloodstream infection and pneumonia. (wustl.edu)
However, NOD1, NOD2, and Rip2 knockout mice were no more susceptible to infection with virulent B. abortus than wild-type mice. (hindawi.com)
People commonly use L. acidophilus for diarrhea from antibiotics, as well as irritable bowel syndrome (IBS), overgrowth of bacteria in the vagina, and an infection caused by the bacteria Helicobacter pylori (H. pylori). (medlineplus.gov)
This organism is morphologically identical to a bacterium found in mice and rats in the USA, but this is the first report of such an infection in Europe. (ox.ac.uk)
Despite this robust inflammatory response, SWCNT pre-exposure significantly decreased the pulmonary clearance of LM measured 3 - 7 days after microbial infection vs PBS/LM treated mice. (cdc.gov)
Failure of SWCNT-exposed mice to clear LM led to a continued elevation in nearly all major chemokines and acute phase cytokines into the later course of infection. (cdc.gov)

The latter explanation involves a major change in thinking because it suggests that traits affected by bacteria can pass from mothers to their offspring in the same manner as traits affected by mouse DNA. (vetscite.org)
A study in mice suggests that Acinetobacter can hide undetected in bladder cells and then reactivate when stimulated by medical intervention. (omnica.com)
Lynch said that the "magnitude and breadth of the protective effect" exerted by the bacteria was surprising, and suggests that L.johnsonii triggers immune pathways that work against a variety of different airborne threats. (the-scientist.com)

The scientists transferred bacteria flora from bears in winter hibernation as well as bears in summer to lab mice that were cultivated to be germ-free. (understandinganimalresearch.org.uk)
Nacho Vivas, lab manager at the Rey Lab in the Bacteriology Department, checks on a group of germ-free mice inside a sterile lab environment. (wisc.edu)
To study butyrate's effect on the gut and atherosclerosis, Kasahara colonized germ-free mice with specific communities of bacteria, either with or without the butyrate-producing Roseburia . (wisc.edu)
Led by Professor Sven Pettersson from the Nanyang Technological University Singapore (NTU Singapore) the international research team reveal that mice with gut microbes had stronger skeletal muscles that can produce more energy when compared to mice without any gut microbes, known as germ-free mice. (nutraingredients.com)
Through a series of strength and movement-related exercises conducted on mice, Pettersson and colleagues found that mice with gut microbes had stronger skeletal muscles that can produce more energy when compared to mice without any gut microbes, known as germ-free mice. (nutraingredients.com)
Evidence for a link between gut microbes and skeletal muscle mass was strengthened when the international research team - from Singapore, Sweden, Switzerland, France, UK, US, and Australia - transplanted gut microbes from standard laboratory mice into germ-free mice. (nutraingredients.com)
Muscle growth and function in the germ-free mice were partially restored following the transplant. (nutraingredients.com)
The study also shed light on the possible link between gut microbes and communication between nerves and muscles, with teams reporting that germ-free mice had reduced levels of key proteins essential for the assembly and function of a neuromuscular junction - a chemical structure that allows a motor nerve cell to communicate with a skeletal muscle fibre. (nutraingredients.com)
Transplanting gut microbes into germ-free mice partially restored the expression of these key proteins to the level observed in mice with gut bacteria, they added. (nutraingredients.com)
"While additional experiments are needed to fully obtain the mechanisms underlying muscle atrophy and dysfunction in the nerve-muscle junction in germ-free mice, the results presented here allow for important and interesting future studies relevant to muscle development, growth and formation of functional nerve-muscle communication," Pettersson said. (nutraingredients.com)
Pettersson and his team conducted three sets of exercise tests on both mice with gut microbes and germ-free mice. (nutraingredients.com)
Left to Right: Muscle of standard laboratory mice, Muscle of germ-free mice, Muscle of germ-free mice transplanted with gut microbes from lab mice. (nutraingredients.com)
Upon examination, the team found that on top of reduced skeletal muscle mass and increased expression of genes linked to muscle atrophy, skeletal muscles in germ-free mice also displayed problems with function and the generation of new mitochondria, whose role is to break down nutrients to form energy for cellular activity. (nutraingredients.com)
But when the researchers transplanted gut microbes from mice to germ-free mice, they found that these mice had their muscle growth and function partially restored, and showed reduced signs of muscle atrophy. (nutraingredients.com)
Germ-free (GF) SCID mice or SCID mice monoassociated with Enterococcus faecalis, SFB (segmented filamentous bacteria), Fusobacterium mortiferum, Bacteroides distasonis, and in combination Fusobacterium mortiferum + SFB or Bacteroides distasonis + SFB were used as recipients. (ox.ac.uk)

Aravinda de Silva from the University of North Carolina and colleagues injected rodents with specially designed protein-studded particles and found the mice produced antibodies against one form, or serotype, of the virus for almost seven months. (cosmosmagazine.com)
The results showed that the mice immunised with any of the new nanoparticle vaccines developed more antibodies and exhibited a better immune response than those that received the control injections. (cosmosmagazine.com)
So we asked the question: 'Can we tag the bacteria with antibodies armed with really potent antibiotics and kill these pathogens inside the cell? (theverge.com)
Altered intestinal barrier in the terminal ileum of mice with severe colitis was documented by immunohistology using antibodies to ZO-1 (zona occludens). (ox.ac.uk)

NIH researchers reporting in the journal Immunity on July 11 found that Corynebacterium mastitidis dwells on the eyes of laboratory mice, and that mice with Corynebacterium could fend off invading pathogenic microbes better than mice without it. (sciencedaily.com)
The researchers' next steps will include finding out more about how these and other bacteria stimulate the local immune response and looking for other bacteria that may also live on the eye. (sciencedaily.com)
A new study in mice by researchers at Washington University School of Medicine in St. Louis has shown that the DNA of bacteria that live in the body can pass a trait to offspring in a way similar to the parents' own DNA. (vetscite.org)
But until now, researchers thought the bacteria that exerted these effects were acquired during a person's life. (vetscite.org)
To prove that this change in antibody levels represented a significant change in the mice that could be thought of as a trait, the researchers fed the mice a chemical they use to characterize the gut's response to injury as part of their studies of inflammatory bowel diseases. (vetscite.org)
In support of a microbial connection between fiber and heart health, researchers at the University of Wisconsin-Madison have identified a particular fatty acid as the mechanism behind certain protective effects of a high-fiber diet in a mouse model. (wisc.edu)
The researchers used mice genetically susceptible to atherosclerosis because mice do not naturally develop the disease. (wisc.edu)
Researchers from the University of Rochester Medical Center in New York set out to explore what links there might be between diet, obesity, gut bacteria, and osteoarthritis. (medicalnewstoday.com)
To begin with, the researchers fed mice a high-fat diet over a 12-week period. (medicalnewstoday.com)
A new mouse study, published by U-M researchers in the American Journal of Respiratory and Critical Care Medicine, shows that bacteria in healthy lungs may play an important role in helping ward off disease. (umich.edu)
While rats are pitted as the demons of New York, researchers at Columbia University warn mice are the real health danger for humans. (expressdigest.com)
The researchers collected 416 mice from residential buildings at seven sites across New York City over a period of one year. (expressdigest.com)
However, the researchers said the sheer scale of Salmonella in New York City mice was startling. (expressdigest.com)
The researchers also monitored the mice's movements for an hour in an open environment to measure the total distance they covered and the amount of time the mice spent standing on their hind legs. (nutraingredients.com)
That's exactly what the researchers did in this study - and it seems to work, at least in mice. (theverge.com)
Now, the researchers have to show that it works against multiple strains of bacteria as well, he says. (theverge.com)
Researchers at the University of Vienna and the Medical University of Vienna have now found possible targets for the early treatment of such damage outside the brain: Bacteria in the gut of premature infants may play a key role. (neurosciencenews.com)
The researchers observed that the mice on the high-sugar and high-fat diets showed decreased physical and mental performance in the tests, with one of the most pronounced changes being decreased cognitive flexibility. (askmen.com)
This is a highly limiting factor for research, because it complicates the annotation of data obtained by molecular techniques, and because it has been shown that gut microbiomes are to some extent specific to their host, and researchers have been using strains of other origin in mouse models. (vetscite.org)
For the first time, the researchers were able to characterize new bacteria with important functional properties: For example Flintibacter butyricum produces the short-chain fatty acid butyrate from both sugars and proteins - a rare property in the realm of intestinal bacteria. (vetscite.org)

Until now, it has been thought that these effects stemmed from the so-called gut-lung axis - the indirect effects of intestinal bacteria on the lungs and the body's overall immune response. (umich.edu)
Our results suggest that the virulence mechanisms enabling CDI and epithelial destruction outweigh the relatively minor impact of less-virulent antibiotic -resistant intestinal bacteria on the outcome of CDI. (bvsalud.org)
However only a handful of mouse intestinal bacteria have been made publicly available and fully characterized so far. (vetscite.org)

The antibacterial activities of Bacillus subtilis FHC 402-derived antibacterial factor (BAF) and hexametaphosphate (HP) and the combined effects of BAF and HP were examined on the growth of 15 strains of bacteria causing food poisoning and spoilage. (elsevierpure.com)

Antibiotic treatment had no significant effect on neurodegeneration in female mice. (futurity.org)
All three of these fatty acids were scarce in mice with gut microbiomes altered by antibiotic treatment, and undetectable in mice without gut microbiomes. (futurity.org)
To find out, his team exposed the healthy mice to a commonly used antibiotic, ceftriaxone. (umich.edu)
New York City house mice carry antibiotic-resistant bacteria that has caused life-threatening gastroenteritis in people, a new study warns. (expressdigest.com)
However, in the absence of Myd88 or under conditions of antibiotic-induced dysbiosis, non-invasive bacteria were trafficked to the MLNs in a CCR7-dependent manner, and induced both T-cell responses and IgA production. (nih.gov)
What's truly different here is that - unlike the related antibiotic rifampicin - the linked antibody-antibiotic unit can kill Staphylococcus bacteria inside cells. (theverge.com)
Because the antibiotic is only active inside infected cells, it won't wipe out the other bacteria - beneficial bacteria - with drugs distributed more broadly in the body. (theverge.com)

Members of this microbial community produce vitamins, help us digest food, prevent the overgrowth of harmful bacteria, and regulate the immune system, among other benefits. (futurity.org)
An overgrowth in the gastrointestinal tract of the bacteria Klebsiella in preterm babies was associated with an increased presence of certain immune cells and the development of neurological damage. (neurosciencenews.com)

The lab mouse strain C57BL/6 that was used for this study. (zmescience.com)
It could also explain why certain results in mice are not reproducible between labs , despite using the same strain of mice and other conditions. (zmescience.com)
About half of people infected with a hypervirulent, drug-resistant strain of the bacterium die. (wustl.edu)
The wild-type strain C57BL/6 mice were purchased from the Federal University of Minas Gerais (UFMG, Belo Horizonte, Brazil). (hindawi.com)

We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm bacteria, actively dispersed S. pneumoniae, which were more virulent in invasive disease, upregulated genes involved in carbohydrate metabolism. (lu.se)

The mice were genetically modified to express a mutant form of the human brain protein tau, which builds up and causes damage to neurons and atrophy of their brains by 9 months of age. (futurity.org)
When such genetically modified mice were raised under sterile conditions from birth, they did not acquire gut microbiomes, and their brains showed much less damage at 40 weeks of age than the brains of mice harboring normal mouse microbiomes. (futurity.org)
In the short term, the findings may help scientists eliminate a significant "bug" in studies of genetically engineered mice. (vetscite.org)
The authors found that even though the mice were genetically identical to each other, the bacteria in their lungs varied greatly. (umich.edu)
Laboratory mice have been bred to be genetically similar for reproducible results . (zmescience.com)
NOD1, NOD2, and RIP2 genetically deficient mice (NOD1 −/− , NOD2 −/− , and RIP2 −/− ) were kindly gifted by Dr. Richard Flavell (Yale University) and maintained in the animal facility of the University of São Paulo (FMRP/USP). (hindawi.com)

Many kinds of animals can carry the bacteria in their urine, including rodents like mice and rats. (cdc.gov)
That's what happens when ticks carry the bacteria that causes Lyme disease from wild mice to people. (cdc.gov)

If that mouse running around your home at night has a deer tick on it, you and your family may be exposed to Lyme disease. (actionpest.com)

See PHIL 21806, which is at a higher magnification, enabling you to observe the presence of intact, magenta-stained, Mycobacterium bovis bacteria, from which the BCG vaccine was derived. (cdc.gov)

We gave young mice antibiotics for just a week, and we saw a permanent change in their gut microbiomes, their immune responses, and how much neurodegeneration related to a protein called tau they experienced with age," says senior author David M. Holtzman, a professor of neurology at Washington University School of Medicine in St. Louis. (futurity.org)
A course of antibiotics at 2 weeks of age, however, permanently changed the composition of bacteria in their microbiomes. (futurity.org)
While the link between antibiotics and inflammatory lung disease has been blamed on the drugs' effect on gut bacteria, Dickson wondered if these drugs could also affect the bacteria in healthy lungs. (umich.edu)
The longer the mice received the antibiotics, the more altered their lung bacteria were," says Dickson. (umich.edu)
Because antibiotics affect both gut and lung bacteria, "we can't just assume it's due to a gut-lung axis," Dickson adds. (umich.edu)
Our study raises the possibility that serious infections - including those resistant to antibiotics - may be passed from these mice to humans, although further research is needed to understand how often this happens, if at all. (expressdigest.com)
While infections with the bacterium can be easily treated in some, Klebsiella has a dangerous flip side: It also is frequently resistant to antibiotics, making it extraordinarily difficult to treat in others. (wustl.edu)
Scientists at Genentech have armed the body's immune system warriors with antibiotics - which means that bacteria that hide from drugs inside cells are now targets. (theverge.com)
it actually helped mice clear staph infections at a stage when conventional antibiotics normally stop being effective. (theverge.com)
When combined, the drug becomes far better at specifically targeting staph at specifically targeting Staph bacteria compared with conventional antibiotics. (theverge.com)

Yersinia kristensenii is a species of bacteria. (wikipedia.org)

This impressive study represents a big step towards one of the great dreams of synthetic biology: rationally programming cells, in this case bacteria, to exhibit complex, dynamic, and beneficial behaviors in a host organism," Michael Elowitz, whose Caltech lab builds synthetic genetic circuits and who was not involved in the work, wrote in an email to The Scientist. (lifeboat.com)

Known as butyrate, this fatty acid is produced by certain bacteria in the gut as they digest plant fiber. (wisc.edu)
In particular, patients with MS had lower levels of certain bacteria, including Prevotella . (uiowa.edu)

In previous work in mice, Claudia Gravekamp of the Albert Einstein College of Medicine in New York had shown that weakened listeria bacteria colonise tumour tissue but not healthy tissue. (newscientist.com)
Her team is trying to understand whether the dust bacteria colonise the gut themselves, or simply change the colonization patterns of the existing microbes. (the-scientist.com)

Our data show that excessive growth of the bacterium Klebsiella and the associated elevated γδ-T-cell levels can apparently exacerbate brain damage," explains Lukas Wisgrill, Neonatologist from the Division of Neonatology, Pediatric Intensive Care Medicine and Neuropediatrics at the Department of Pediatric and Adolescent Medicine at the Medical University of Vienna. (neurosciencenews.com)

However, reduced production of TNF- α was detected in bone-marrow-derived macrophages (BMDM) from NOD1, NOD2, and Rip2 KO mice compared to C57BL/6. (hindawi.com)

Mice that hosted Roseburia but that ate a low-fiber diet were not protected, because without fiber the bacteria produced little butyrate. (wisc.edu)
Mice fed a slow-release form of butyrate itself were also protected from atherosclerosis, pointing to the molecule as a key arbiter of the fiber-heart link. (wisc.edu)
Those mice were then fed diets either rich or lacking in fiber, which Roseburia processes into butyrate. (wisc.edu)
To determine if butyrate was the true cause of Roseburia 's protective effects, Kasahara fed the fatty acid to mice without any butyrate-producing bacteria. (wisc.edu)

0.05) by 22% at 12 h of cultivation compared with cultures of sulphate-reducing bacteria from the bowel lumen of healthy mice. (muni.cz)
The sulphate-reducing bacteria from mice with colitis also had a slightly higher generation time (14.29 h) and exponential growth phase (22.24 h) compared with cultures from healthy mice. (muni.cz)
Could healthy gut bacteria hold the key to a new way of treating multiple sclerosis? (uiowa.edu)
their bowels were overrun with pro-inflammatory bacteria and had a distinct lack of healthy, probiotic bacteria, such as Bifidobacteria . (medicalnewstoday.com)
This subtle but important change in diet promoted the growth of healthy bacteria and produced a marked reduction in pro-inflammatory bacteria. (medicalnewstoday.com)
But a new study in mice shows that bacteria in healthy lungs may play an important role in helping ward off disease. (umich.edu)
The lack of exposure to enough healthy bacteria may leave the immune system of lab mice compromised and not such a good model for human disease. (zmescience.com)
As such, lab mice do not react to medication the same way that mice with a healthy community of gut bacteria would. (zmescience.com)
The opportunistic bacterium Acinetobacter baumannii rarely sickens healthy people but causes serious infections in hospitalized patients. (omnica.com)

Lactobacillus acidophilus (L. acidophilus) is a type of probiotic ("good" bacteria) found in the human gut, mouth, and vagina, and also in certain foods. (medlineplus.gov)

The aim of this research was to evaluate the presence of sulphate-reducing bacteria isolated from the intestines of mice, study their growth, calculate and compare the kinetic growth properties on the model of dextran sulphate sodium induced ulcerative colitis in the mice. (muni.cz)
We have billions of bacteria living in our intestines. (medicalnewstoday.com)

Bacteria are most familiar through their roles in harmful infections. (vetscite.org)
C. difficile infections, meanwhile, are most commonly contracted from bacteria in hospitals, and yet this study emphasized how much it could also be spread in the by the mice in homes. (expressdigest.com)
Studies of mice in New York from one location showed the tick borne infections were prevalent across a broad area. (danielcameronmd.com)
Most of the time that isn't a problem, but sometimes the bacterium causes serious, repeated infections that can be fatal. (theverge.com)
As a result, one type of resistant staph bacteria - called MRSA - causes over 80,000 infections and 11,285 deaths occur every year. (theverge.com)
That's a big problem because drugs that are normally used against staph infections can take over four hours to work - far longer than it takes for Staph bacteria to move into new cells, he says. (theverge.com)
Additional studies further demonstrated BCG vaccine's protective effects against viral infections , including influenza and herpes simplex virus 2 in mouse models. (cdc.gov)

In several fields of research, scientists have been confronted intermittently with the sudden, unexplained appearance of new or altered traits in mice. (vetscite.org)
When the scientists housed mice with low levels of the antibody with mice that had high levels of the antibody, all of the mice ended up with low antibody levels in a few weeks. (vetscite.org)
Eventually, the scientists learned that one of the culprits likely responsible for the spread of low antibody levels is a bacterium called Sutterella. (vetscite.org)
That is a possibility raised by a new study in mice conducted by scientists with University of Iowa Health Care and Mayo Clinic in Rochester, Minn. (uiowa.edu)
For the next phase of the study, the scientists started the protocol again: they fattened up mice with a 12-week, high-fat diet. (medicalnewstoday.com)
Scientists are learning more every day about the connection between our health and the bacteria that make their homes inside our bodies. (umich.edu)
Scientists have shown that sex-specific differences in variability depend on individual physical and physiological features in mice, debunking competing theories that either males or females are more variable. (phys.org)
To help account for these differences, the team created an interactive tool that scientists can use to examine sex-based variability across a wide range of traits and procedures in mice. (phys.org)
We will be making our work available to scientists around the world and hope that others will also help to find the pieces to complete the puzzle," said Clavel, who has been researching various bacteria in gut microbiomes at the TU Munich for ten years. (vetscite.org)

Do Mice and rats carry bacteria? (saxonpestmanagement.com)
such as mice and rats. (saxonpestmanagement.com)
In this blog post we'll discuss the dangers posed by an infestation of mice or rats - from how they spread micro-organisms to preventative steps you should take, so keep reading! (saxonpestmanagement.com)
Mice and rats may not seem like the most lovable creatures, but something that everyone needs to be aware of is that they can sometimes carry bacteria that can cause diseases in humans. (saxonpestmanagement.com)
This is especially true in agricultural areas or places where food or agricultural products are stored for longer periods because mice and rats often heartily feast on these types of items. (saxonpestmanagement.com)
Ultimately it's important to remember mice and rats play important roles in the environment, so be mindful and respectful of them is key. (saxonpestmanagement.com)
Did you know mice and rats sometimes carry diseases? (saxonpestmanagement.com)
By understanding the risks, you can take proactive measures to prevent mice and rats from entering your home and help protect anyone in your home against any potential illnesses they may carry. (saxonpestmanagement.com)
Always remember to practice good hygiene and safety measures, such as using gloves when cleaning areas that mice or rats may inhabit, to minimize any possible risks associated with these bacteria-carrying creatures. (saxonpestmanagement.com)
Mice and rats are often seen as pesky pests that can infiltrate our homes and wreak havoc, but few of us know the real danger these pests are creating. (saxonpestmanagement.com)
In addition to causing property damage, mice and rats carry bacteria that can cause serious illnesses if not caught in time. (saxonpestmanagement.com)
With mice and rats frequenting our homes and communities, it is always best to take precautions to avoid contact with them. (saxonpestmanagement.com)
Not only do mice and rats carry bacteria that can cause severe illnesses such as Hantavirus and salmonella, but mice gnaw through wires, walls, and other materials in search of nesting materials. (saxonpestmanagement.com)
Taking the necessary precautions to avoid mice or rats in your home can help save you from future problems. (saxonpestmanagement.com)
Mice and rats can carry bacteria that can cause several diseases, including salmonella and Hantavirus, so it's important to take preventive measures. (saxonpestmanagement.com)
Small mammals commonly kept as pets can include rodents like rats, mice, hamsters, gerbils, and guinea pigs or other small mammals like hedgehogs, sugar gliders, and rabbits. (cdc.gov)
This parasite is uncommon among small mammals but can infect chinchillas, rats, and mice. (cdc.gov)

We've known for a while that our laboratory mice vary in their gut bacteria," says Dickson. (umich.edu)
Indeed, the wild mice had different gut biota than the laboratory mice. (zmescience.com)
We think that by restoring the natural 'microbial identity' of laboratory mice, we will improve the modeling of complex diseases of free-living mammals, which includes humans and their diseases," said Barbara Rehermann, M.D., chief of the Immunology Section, Liver Diseases Branch, of the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (zmescience.com)

Mice with certain inherited bacteria are susceptible to the injury, which is caused by exposure to a chemical. (vetscite.org)
We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm. (lu.se)

Bacteria in the gut cooperate with the immune system, which in turn monitors gut microbes and develops appropriate responses to them. (neurosciencenews.com)
Dust-borne bacteria from houses with dogs can prevent allergies in mice by changing their gut microbes. (the-scientist.com)
When she fed this bacteria-rich dust to mice, it shifted the microbes in their guts towards species that prevented their immune systems from overreacting to airborne allergens. (the-scientist.com)

The cell growth of bacteria resistant to BAF such as B. subtilis, B. cereus, L. lactis, E. coli and P. fragi was completely inhibited by the combined use of BAF and 0.1% HP. (elsevierpure.com)

Not only do these critters carry fleas and transmit harmful diseases to humans such as typhus or plague, but recent studies suggest that certain species can also spread deadly bacteria within your home. (saxonpestmanagement.com)
Additionally, be sure to wear protective gloves when cleaning up mouse droppings as they may contain harmful toxins that can spread infectious diseases. (saxonpestmanagement.com)
Not only are these pests carriers of harmful diseases, but they can also spread bacteria within your home. (saxonpestmanagement.com)
When these creatures get into your home, they can carry harmful bacteria, microscopic viruses, and tiny parasitic bugs. (actionpest.com)

The experiment was only done in mice and in vitro cells - neither of which are good indicators of a drug's effect on humans. (theverge.com)
Both mice and humans with genetic defects in IFN-γ signaling are highly susceptible to mycobacterial diseases ( Flynn and Chan, 2001 ). (frontiersin.org)

The study, published Aug. 8 in the journal Cell Reports , found that a human gut bacterium, Prevotella histicola , suppresses multiple sclerosis symptoms in a mouse model of this immune-related disease. (uiowa.edu)
These bacteria are invisible to the naked eye, but powerful enough to bring a strong man to his knees with flu-like symptoms. (actionpest.com)
Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study publishing March 7th in the open access journal PLOS Biology by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China. (news-medical.net)

in particular, the bacteria Bacteroides fragilis and Alistipes finegoldii have been found to cause CRC in mouse models, explained Gacesa. (medscape.com)

They are not exposed to the same bacteria that wild mice would be exposed to. (zmescience.com)
This brings wild mice into some fairly nasty places. (actionpest.com)

This bacterium and others found in the low-IgA mice could explain both ways that decreased antibody levels were spreading: Mice that were housed together acquired low antibody levels through normal spread of the bacteria, and mouse mothers passed the same bacteria to their descendants. (vetscite.org)
The most significant of these is Hantavirus, which can be spread by deer mice and white-footed mice when nesting materials or waste products are stirred up. (actionpest.com)
The bacteria that cause leptospirosis spread through the urine of infected animals, which can get into water or soil and survive there for weeks to months. (cdc.gov)

Luckily, there are ways to reduce mice and rat populations naturally, such as removing sources of food, encouraging natural predators like snakes or raptors, and incorporating effective pest control practices. (saxonpestmanagement.com)
The approach enables continual production and release of drugs at disease sites in mice while simultaneously limiting the size, over time, of the populations of bacteria engineered to produce the drugs. (lifeboat.com)

They performed a genetic analysis of their feces, and found that the mice carried a number of bacteria, including C. difficile, E. coli, Shigella, as well as Salmonella. (expressdigest.com)

We have kept bacteria on one side of a line separating the factors that shape our development - the environmental side of that line, not the genetic side," said co-senior author Herbert W. Virgin IV, MD, PhD. "But our results show bacteria stepping over the line. (vetscite.org)
A synthetic genetic circuit programmed into an attenuated Salmonella enterica subspecies can be used to systemically deliver an anti-tumor toxin into mice with cancer. (lifeboat.com)
We still have a lot of gaps in our knowledge about gut microbiomes, but with the publicly available database of cultured mouse gut bacteria and their genetic material, we are now a little closer to our goal," Thomas Clavel from the TUM stated enthusiastically. (vetscite.org)

Good" bacteria such as L. acidophilus can help break down food, absorb nutrients, and fight off "bad" organisms that might cause diseases. (medlineplus.gov)
Chlamydia organisms are obligate intracellular bacteria that must be isolated in tissue culture, mice, or chick embryos. (cdc.gov)

Others carrying different bacteria are less susceptible. (vetscite.org)

Mice from homes in the affluent borough of Chelsea carried the most risky viruses, the study revealed. (expressdigest.com)
Alongside that study, the team also published an analysis which took a closer look at the viruses found in the mice droppings. (expressdigest.com)
Mice from Chelsea, heavier than mice from other sites, also carried more viruses. (expressdigest.com)
Mice can carry many viruses that are also invisible to the naked eye. (actionpest.com)

Oral supplemented nutraceuticals derived from food sources are surmised to improve the human health through interaction with the gastrointestinal bacteria. (frontiersin.org)

To take advantage of this, her team have now armed the bacteria with a radioactive payload - attaching the isotope rhenium-188 to the listeria using a type of antibody. (newscientist.com)
The next step is to test this strategy in mice, as well as other isotopes such as phosphorus-32, which could be incorporated into the cell wall of the bacterium, removing the need for the antibody tether. (newscientist.com)
They were surprised to find that roughly half their mice had low levels in the gut of IgA, an antibody linked to these disorders. (vetscite.org)
When they bred the mice, the offspring whose mothers had low levels of the antibody also had low levels. (vetscite.org)
In mice with low levels of the antibody, the compound caused much more damage. (vetscite.org)
E. coli Labile Toxin A chain antibody LS-C56175 is an unconjugated mouse monoclonal antibody to bacteria E. coli Labile Toxin A chain (C-Terminus). (lsbio.com)

0.01) in the cultures of sulphate-reducing bacteria from mice with ulcerative colitis. (muni.cz)
RESULTS: After the transfer of the CD4+CD45RB(high) T-cell subpopulation to SCID mice severe colitis was present in conventional animals and in mice colonized with a cocktail of SPF microflora plus SFB. (ox.ac.uk)

Further experiments established that the Corynebacterium could cause immune cells from the conjunctiva to release IL-17.Tears from mice with Corynebacterium living in their conjunctivae were more deadly to the pathogens Candida albicans and Pseudomonas, both of which can cause loss of vision when they infect the eye. (sciencedaily.com)

Supplementation with Lactobacillus gasseri NK109 may reduce cognitive impairment in aged mice, while also boosting expression of BDNF, says a new study. (nutraingredients-usa.com)

Finding a link between osteoarthritis and the bacteria in our guts seems unlikely. (medicalnewstoday.com)
Prebiotics - not to be confused with probiotics - cannot be broken down by mouse (or human) guts. (medicalnewstoday.com)
That could be due to the contents of mice guts, a new study reports. (zmescience.com)

This type of bacteria can infect rodents like hamsters, guinea pigs, and gerbils. (cdc.gov)

When such mice were raised under normal, nonsterile conditions, they developed normal microbiomes. (futurity.org)
When middle-aged mice without microbiomes were fed the three short-chain fatty acids, their brain immune cells became more reactive, and their brains showed more signs of tau-linked damage. (futurity.org)

In fact, changes in our bacteria have even been linked to inflammatory lung diseases. (umich.edu)
Mice were evaluated 8-12 weeks after the cell transfer for clinical and morphological signs of inflammatory bowel disease (IBD). (ox.ac.uk)
Viewed under an unknown magnification, this photomicrograph depicted a close view of a murine lung tissue specimen, revealing the presence of a granulomatous inflammatory lesion, after the mouse had been injected with Bacillus Calmette-Guérin (BCG) vaccine. (cdc.gov)

Living in a sterile, controlled environment make lab mice not such a good model for human diseases. (zmescience.com)
The lab mice raised in a sterile environment were more vulnerable to disease and cancers. (zmescience.com)

To test their vaccine, de Silva and his team immunised 31 mice with either a control injection or one of five different formulations of their nanoparticle cocktail, which used particles of different shapes and sizes between 55 by 70 and 200 by 200 nanometres. (cosmosmagazine.com)

Anatomy16

Organisms96

Diseases5

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes63

Disciplines and Occupations6

Technology, Industry, Agriculture4

Information Science4

Health Care18

Geographicals1

Bacterial15

Microbiome17

Microbiota6

Inflammation13

Commensal bacteria3

Pathogenic bacteria1

Intestine8

Infection12

Suggests3

Germ-free15

Antibodies4

Researchers20

Intestinal bacteria3

Strains1

Antibiotic7

Overgrowth2

Strain4

Virulent1

Genetically6

Carry the bacteria2

Lyme1

Mycobacterium1

Antibiotics10

Species of bacteria1

Beneficial1

Certain bacteria2

Colonise2

Klebsiella1

C57BL1

Butyrate4

Healthy9

Probiotic1

Intestines2

Infections7

Scientists9

Rats17

Laboratory mice3

Exposure2

Microbes3

Resistant1

Harmful4

Humans2

Symptoms3

Bacteroides1

Wild mice2

Spread3

Populations2

Difficile1

Genetic3

Organisms2

Susceptible1

Viruses4

Gastrointestinal1

Antibody6

Colitis2

Deadly1

Cognitive impairment1

Guts3

Infect1

Microbiomes2

Inflammatory3

Sterile2

Vaccine1